2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Reactive Oxygen Species (ROS) Apoptosis CDK
  4. SB-1295

SB-1295 is an orally active CDK9/T1 inhibitor (IC50=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer.

For research use only. We do not sell to patients.

SB-1295

SB-1295 Chemical Structure

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Description

SB-1295 is an orally active CDK9/T1 inhibitor (IC50=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer[1].

IC50 & Target

IC50: 0.17 μM (CDK9/T1)[1].
Cellular Effect
Cell Line Type Value Description References
HCT-116 GI50
5.1 μM
Compound: 2b; SB-1295, DD-35
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
HEK293 GI50
90.32 μM
Compound: 2b; SB-1295, DD-35
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
MIA PaCa-2 GI50
6.07 μM
Compound: 2b; SB-1295, DD-35
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 37302342]
Molecular Weight

443.88

Formula

C23H22ClNO6
SMILES

OC1=C2C(OC(/C=C/C3=CC=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)C[N+](C)([O-])CC4)C(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SB-1295 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-1295SB1295SB 1295Reactive Oxygen Species (ROS)ApoptosisCDKCyclin dependent kinaseHCT 116MIA PaCa-2cancerROSInhibitorinhibitorinhibit

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