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Cat. No.: HY-155065

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SB-1295

SB-1295 is an orally active CDK9/T1 inhibitor (IC₅₀=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₂ClNO₆
Molecular Weight:443.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (246 KB)

SB-1295 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.17 μM (CDK9/T1)^[1].

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	5.1 μM Compound: 2b; SB-1295, DD-35	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
HEK293	GI₅₀	90.32 μM Compound: 2b; SB-1295, DD-35	Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
MIA PaCa-2	GI₅₀	6.07 μM Compound: 2b; SB-1295, DD-35	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]

Chemical Information

Molecular Weight 443.88
Formula C₂₃H₂₂ClNO₆
SMILES

OC1=C2C(OC(/C=C/C3=CC=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)C[N+](C)([O-])CC4)C(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.