Cranberry Extract
Based on 1 Customer Validation
Cranberry Extract is the extract of Cranberry, with content of 25% -50% Proanthocyanidins. Cranberry Extract exhibits anti-virus and antimicrbiol activity. Cranberry Extract suppresses fungal growth and biofilm formation. Cranberry Extract reduces NF-κB p65 phosphorylation, and PI3K/AKT signaling; increases caspase-8/9 activity to induce apoptosis, modulates oxidative stress, inflammation, and lipid profiles. Cranberry Extract exerts antiproliferative effects and induces cell cycle arrest. Cranberry Extract can be used for the research of infection and cancers.
For research use only. We do not sell to patients.
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
Cranberry extract suppresses cariogenic pathogenicity features of Streptococcus mutans and Candida albicans dual-species biofilms[1].
Cranberry extract (20 h) protects HepG2 liver cells from t-BOOH-induced oxidative stress by reducing antioxidant enzyme over-activation, MDA levels, and modulating cell signaling pathways[1].
Cranberry extract reduces pro-inflammatory mediator production and NF-κB activation in pre-incubated Caco-2/15 intestinal cells[1].
Cranberry extract exerts anti-proliferative activity against KB nasopharyngeal carcinoma cells, but not against AW13516 tongue squamous cell carcinoma cells[1].
Cranberry extract induces apoptosis in DU145 human prostate adenocarcinoma cells by increasing caspase-8 and caspase-9 activities[1].
Cranberry extract (200 µg/mL; 48 h) exhibits selective antiproliferative activity against human KB, HT-29, HCT116, SW620, RWPE-1, RWPE-2, and 22Rv1 cancer cell lines[2].
Cranberry Extract inhibits growth of vancomycin-resistant Enterococcus faecium, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli[4].
Cranberry extract (0.0050-0.10% (v/v); 4 h) significantly inhibits cupric sulfate-induced TBARS formation in isolated human LDL[6].
Cranberry extract (0.0050-0.10% (v/v); 4 h) significantly reduces cupric sulfate-induced relative electrophoretic mobility of isolated human LDL[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KB, CAL27, HT-29, HCT116, SW480, SW620, RWPE-1, RWPE-2, 22Rv1
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Concentration:200 µg/mL
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Incubation Time:48 h
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Result:Inhibited proliferation of KB oral cancer cells by 60%.
Inhibited proliferation of CAL27 oral cancer cells by 8%.
Inhibited proliferation of HT-29 colon cancer cells by 78%.
Inhibited proliferation of HCT116 colon cancer cells by 56%.
Inhibited proliferation of SW620 colon cancer cells by 35%.
Showed no inhibition of SW480 colon cancer cells.
Inhibited proliferation of 22Rv1 prostate cancer cells by 85%.
Inhibited proliferation of RWPE-1 prostate cancer cells by 65%.
Inhibited proliferation of RWPE-2 prostate cancer cells by 65%.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Solid
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Color Orange to reddish brown
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SMILES
[Cranberry Extract]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Seeram NP, et al. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem. 2004;52(9):2512-2517. [Content Brief]
[3]. Lee IT, et al. Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes. Diabet Med. 2008 Dec;25(12):1473-7. [Content Brief]
[5]. Gbinigie OA, et al. Cranberry Extract for Symptoms of Acute, Uncomplicated Urinary Tract Infection: A Systematic Review. Antibiotics (Basel). 2020;10(1):12. Published 2020 Dec 25. [Content Brief]
[6]. Wilson T, et al. Cranberry extract inhibits low density lipoprotein oxidation. Life Sci. 1998;62(24):PL381-PL386. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cranberry Extract Related Classifications
HY-N13200 Related Classifications
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