Cat. No.: HY-17635A

Leniolisib phosphate

(Synonyms: CDZ173 phosphate)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

For research use only. We do not sell to patients.

Purity: 98.88%
CAS No.: 1354691-97-6
Formula: C₂₁H₂₈F₃N₆O₆P
Molecular Weight:548.45

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Leniolisib phosphate Chemical Structure

CAS No.: 1354691-97-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

IC₅₀ & Target^[1]

PI3Kδ

11 nM (IC₅₀)

PI3Kα

280 nM (IC₅₀)

PI3Kβ

480 nM (IC₅₀)

PI3Kγ

2.57 nM (IC₅₀)

DNA-PK

880 nM (IC₅₀)

All PI3K Isoforms :

In Vitro

Expression of APDS mutant p110δ in cell lines and patient-derived lymphocytes lead to increased pathway activity, measured as phosphorylation of AKT or S6, which is suppressed by Leniolisib phosphate in a concentration dependent way^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1354691-97-6
Appearance Solid
Molecular Weight 548.45
Formula C₂₁H₂₈F₃N₆O₆P
Color White to off-white
SMILES

CCC(N1C[C@H](CC1)NC2=C3CN(CCC3=NC=N2)C4=CC(C(F)(F)F)=C(N=C4)OC)=O.O=P(O)(O)O
Synonyms

CDZ173 phosphate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Mol Syst Biol

Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics. [Abstract]

2024 Jan;20(1):28-55. PMID: 38177929

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (182.33 mM; Need ultrasonic)

DMSO : 100 mg/mL (182.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8233 mL

9.1166 mL

18.2332 mL

5 mM

0.3647 mL

1.8233 mL

3.6466 mL

10 mM

0.1823 mL

0.9117 mL

1.8233 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rao V, et al. Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine: NEJM. ISSN 0028-4793; 1533-4406 [Content Brief]

[2]. Hoegenauer K, et al. Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2017 Aug 25;8(9):975-980. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.8233 mL	9.1166 mL	18.2332 mL	45.5830 mL
	5 mM	0.3647 mL	1.8233 mL	3.6466 mL	9.1166 mL
	10 mM	0.1823 mL	0.9117 mL	1.8233 mL	4.5583 mL
	15 mM	0.1216 mL	0.6078 mL	1.2155 mL	3.0389 mL
	20 mM	0.0912 mL	0.4558 mL	0.9117 mL	2.2792 mL
	25 mM	0.0729 mL	0.3647 mL	0.7293 mL	1.8233 mL
	30 mM	0.0608 mL	0.3039 mL	0.6078 mL	1.5194 mL
	40 mM	0.0456 mL	0.2279 mL	0.4558 mL	1.1396 mL
	50 mM	0.0365 mL	0.1823 mL	0.3647 mL	0.9117 mL
	60 mM	0.0304 mL	0.1519 mL	0.3039 mL	0.7597 mL
	80 mM	0.0228 mL	0.1140 mL	0.2279 mL	0.5698 mL
	100 mM	0.0182 mL	0.0912 mL	0.1823 mL	0.4558 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Leniolisib phosphate

1 Cited Publications

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Leniolisib phosphate

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Publications Citing Use of MedChemExpress (MCE) Leniolisib phosphate

All PI3K Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Leniolisib phosphate Related Classifications

HY-17635A Related Classifications