Propentofylline-d6
Propentofylline-d6 (HWA 285-d6) is the d6-labeled Propentofylline (HY-107203). Propentofylline (HWA 285) is an orally active, blood-brain barrier-penetrant phosphodiesterase inhibitor, with an IC50 of 20 μM for cGMP-stimulated PDE II. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
For research use only. We do not sell to patients.
- CAS No.: 1216516-37-8
- Formula: C15H16D6N4O3
- Molecular Weight:312.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[5]|
PDE Ⅱ |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1216516-37-8
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Unlabeled CAS 55242-55-2
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Molecular Weight 312.40
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Formula C15H16D6N4O3
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SMILES
C(CC)N1C2=C(N(C)C(=O)N(C(C(C(CC(C)=O)([2H])[2H])([2H])[2H])([2H])[2H])C2=O)N=C1
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Synonyms
HWA 285-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Noble S, et al. Propentofylline. CNS Drugs. 1997 Sep;8(3):257-264.
[2]. Parkinson FE, et al. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen Pharmacol. 1994 Oct;25(6):1053-8. [Content Brief]
[3]. Goto M, et al. Effects of propentofylline on disorder of learning and memory in rodents. Jpn J Pharmacol. 1987 Nov;45(3):373-8. [Content Brief]
[4]. Rother M, et al. Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials. Dement Geriatr Cogn Disord. 1998;9 Suppl 1:36-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Propentofylline-d6 Related Classifications
HY-107203S Related Classifications
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Keywords
- Propentofylline-d6
- 1216516-37-8
- HWA 285-d6
- Isotope-Labeled Compounds
- Phosphodiesterase (PDE)
- Adenosine Receptor
- P1 receptor
- adenosine transporter
- mouse leukemic L1210/B23.1 cells
- cyclic nucleotide phosphodiesterase
- adenosine receptor
- human blood mononuclear cells
- mouse astroglial cells
- rat peritoneal macrophages
- rat hippocampal neurons
- rat carcinosarcoma Walker 256 cells
- microglial cells
- Inhibitor
- inhibitor
- inhibit