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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
238 Results for "
ulcerative
" in MedChemExpress (MCE) Product Catalog:
Products (238)
238 Results for "ulcerative" in MCE Product Catalog:
Research Areas:
Carbenoxolone disodium (Standard) is the analytical standard of Carbenoxolone disodium (HY-B1367). This product is intended for research and analytical applications. Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD . Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication . Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.
Cat. No.: HY-P3419A
Research Areas:
Cat. No.: HY-W008766
CAS No.: 5022-65-1
Target:
Cat. No.: HY-174287
CAS No.: 3066895-41-5
Target:
Research Areas:
Keap1-IN-2 (Compound 164) is a KEAP1 inhibitor (IC50: 2 nM). Keap1-IN-2 indirectly activates Nrf2 by inhibiting KEAP1, thereby enhancing the antioxidant capacity of cells. Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2 by blocking KEAP1-mediated Nrf2 degradation. Keap1-IN-2 can be used to study diseases associated with oxidative stress, such as inflammatory bowel disease, Crohn's disease, and immune diseases such as ulcerative colitis .
Cat. No.: HY-W010066
CAS No.: 28822-73-3
Category:
Metabolic Disease Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Disease markers Phenols Polyphenols Nervous System Disorder Disease Research Fields
Target:
Cat. No.: HY-W010435R
CAS No.: 110-93-0
Synonyms: 6-Methyl-5-hepten-2-one (Standard)
Cat. No.: HY-107831R
CAS No.: 13110-96-8
Target:
Research Areas:
5-Acetylsalicylic acid (Standard) is the analytical standard of 5-Acetylsalicylic acid (HY-107831). This product is intended for research and analytical applications. 5-Acetylsalicylic acid is the derivate of Aspirin (HY-14654), with anti-inflammatory property. 5-Acetylsalicylic acid is the active metabolite of Sulfasalazine (HY-14655) and its production is regulated by beneficial bacteria in the gut but is confined to the intestinal tract. 5-Acetylsalicylic acid exhibits a mild cytotoxicity effect on B16F10 cells. 5-Acetylsalicylic acid can be used for the study of inflammatory bowel disease (IBD) such as ulcerative colitis (UC) .
Synonyms: HE 3286; NE-3107
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis . Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-10863S2
Synonyms: AEA-15NN; Arachidonoyl ethanolamide-15NN
Cat. No.: HY-172871
CAS No.: 3053104-47-2
Research Areas:
Anti-inflammatory agent 102 (Compound 11a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 102 exerts its anti-inflammatory effect by blocking the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. Anti-inflammatory agent 102 has significant anti-inflammatory activity and can inhibit the release of NO, ROS, and inflammatory factors (such as IL-6, TNF-α, IL-1β). Anti-inflammatory agent 102 can be used in the study of inflammatory diseases such as ulcerative colitis (UC) .
Cat. No.: HY-W782193
CAS No.: 55320-91-7
Synonyms: 6-Methyl-5-hepten-2-one-d5
Cat. No.: HY-P73734
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TP63; Chronic ulcerative Stomatitis Protein; Prev. TP73L; Tumor Protein P53-Competing Protein; Prev. TP53CP; Transformation-Related Protein 63; Prev. TP53L; Tumor Protein P73-Like; P73L; Tumor Protein 63; P73H; Amplified In Squamous Cell Carcinoma; P51; C
Species:
Human
Source:
Sf9 insect cells
Target:
Cat. No.: HY-125387
CAS No.: 1628439-59-7
Target:
Research Areas:
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .
Category:
Stilbenes Rheum officinale Baill. Phenols Plants Disease Research Fields Polygonaceae Extract Cancer
Target:
Cat. No.: HY-N6189
CAS No.: 1815632-13-3
Target:
Endogenous Metabolite COX p38 MAPK NF-κB NOD-like Receptor (NLR) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related
Research Areas:
MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis .
Cat. No.: HY-N7635
CAS No.: 14162-53-9
Synonyms: β-D-Glucopyranosyl oleanolate
Category:
Triterpenes Terpenoids Amaranthaceae Extract Other Diseases Plants Other Families Extract Disease Research Fields Achyranthes bidentata
Target:
NO Synthase COX Interleukin Related Claudin p38 MAPK Akt PI3K
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
