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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
359 Results for "
Triglycerides
" in MedChemExpress (MCE) Product Catalog:
Products (359)
359 Results for "Triglycerides" in MCE Product Catalog:
Cat. No.: HY-146398
CAS No.: 189299-03-4
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AMPK activator 6 (Compound GC) reduces lipid content and activates the AMPK pathway in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase in triglyceride (TG) , total cholesterol (TC), low-density lipoprotein-C (LDL-C), and other biochemical indices in blood serum. AMPK activator 6 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome .
Cat. No.: HY-161985
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PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity .
Cat. No.: HY-187422
CAS No.: 440120-55-8
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RS-2982 is a retinoic acid receptor-related orphan receptor A (RORA) agonist. RS-2982 enhances the promoter activity of MIR122 via the RORA binding site, and promotes the expression and secretion of MIR122. RS-2982 reduces the expression of hepatic triglyceride biosynthetic enzymes, hepatic lipotoxicity, hepatic fibrosis and body weight in diet-fed mice, while improving insulin resistance. RS-2982 can be used in the research of non-alcoholic steatohepatitis .
Cat. No.: HY-19227
CAS No.: 153655-35-7
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BM 170249 is a peroxisome proliferator, particularly in the perivenous region of the central acini in the liver. BM 170249 significantly reduces serum triglyceride and cholesterol levels in rats. BM 170249 strongly induces the activity of key enzymes in the peroxisome fatty acid β-oxidation system (such as acyl-CoA oxidase AOX, multifunctional enzyme PH, and thiolase PT), but leads to decreased activity of catalase and uricase in peroxisome components. BM 170249 could be used in lipid-lowering studies .
Cat. No.: HY-B1804S
CAS No.: 65402-55-3
Synonyms: Trioctanoin-13C3; Glyceryl trioctanoate-13C3
Cat. No.: HY-P992470
Synonyms: ARGX-116; NN5058
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Cat. No.: HY-W007648
CAS No.: 3196-73-4
Synonyms: β-Alanine methyl ester hydrochloride
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Methyl 3-aminopropanoate hydrochloride (β-Alanine methyl ester hydrochloride) is a β-alanine derivative with antioxidant activity. Methyl 3-aminopropanoate hydrochloride reduces oxidation-related changes in Glycine max soybean oil and degummed Glycine max soybean oil at frying temperatures, including the loss of olefinic protons and bis-allylic protons as well as the formation of polymerized triglycerides. Methyl 3-aminopropanoate hydrochloride contributes to the synthesis of the Bcl-2 inhibitor probe Nap-4 .
Cat. No.: HY-101563R
CAS No.: 1616392-22-3
Synonyms: GSK3326595 (Standard); EPZ015938 (Standard)
GSK3326595 (Standard) is the analytical standard of GSK3326595 (HY-101563). This product is intended for research and analytical applications. GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma .
Synonyms: 5-(4-Phenylbutoxy)psoralen
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Psora-4 (5-(4-Phenylbutoxy) psoralen) is a selective Kv1.3 blocker (Kd = 3 nM). Psora-4 increases mitochondrial ROS production, activates stress response genes including daf-16 targets and heat shock proteins, reduces triglyceride accumulation, extends lifespan and healthspan in C. elegans, and increases resistance to Paraquat-induced oxidative stress. Psora-4 can be used for research on psoriasis and obesity .
Cat. No.: HY-110381R
CAS No.: 1962931-71-0
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JNJ-DGAT2-A (Standard) is the analytical standard of JNJ-DGAT2-A (HY-110381). This product is intended for research and analytical applications. JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis .
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Tiadenol is an orally effective lipid-lowering compound and peroxisome proliferator. Tiadenol promotes peroxisome-associated fatty acid metabolism, and its induction of the activities of enzymes such as palmitoyl-CoA hydrolase, carnitine acetyl-transferase and catalase is mainly associated with de novo protein synthesis. The triglyceride-lowering effect of Tiadenol is not accompanied by increased activities of lipoprotein lipase (LPL) and hepatic lipase (HL), and it reduces VLDL Apo E. Tiadenol can be used in studies related to lipid metabolism, peroxisome proliferation and hyperlipoproteinemia .
Cat. No.: HY-128393R
CAS No.: 537-40-6
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Natural Products Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Plants Endogenous metabolite Araliaceae Extract
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Reference Standards PI3K Akt E-Selectin Apoptosis MMP MEK ERK
Cat. No.: HY-128393S2
Cat. No.: HY-153507
CAS No.: 1137671-16-9
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DGAT1-IN-4 is a potent, orally active, and selective DGAT1 inhibitor with an IC50 of 17 nM. DGAT1-IN-4 exhibits >588-fold selectivity over DGAT2. DGAT1-IN-4 suppresses intracellular triglyceride synthesis in mouse myoblast cells. DGAT1-IN-4 suppresses body weight gain in diet-induced obese dogs. DGAT1-IN-4 can be used for the research of obesity .
Cat. No.: HY-17504BS2
Synonyms: ZD 4522-13C,d3 sodium; X-Plended-13C,d3 sodium; Crestor-13C,d3 sodium
Cat. No.: HY-17504R
CAS No.: 147098-20-2
Synonyms: Rosuvastatin hemicalcium (Standard); ZD 4522 Calcium (Standard)
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Rosuvastatin (Calcium) (Standard) is the analytical standard of Rosuvastatin (Calcium). This product is intended for research and analytical applications. Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
Cat. No.: HY-17504S
Rosuvastatin-d6 calcium is the deuterated-labeled Rosuvastatin Calcium (HY-17504). Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
Cat. No.: HY-182250
CAS No.: 2505339-87-5
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BR103354 is an orally active, selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 14 nM against hFAP. BR103354 restores the levels of phosphorylated ERK and Glut1 that are reduced by co-treatment with hFGF21 and FAP, decreases non-fasting blood glucose concentrations, improves glucose tolerance, and reduces hepatic triglyceride content. BR103354 ameliorates hepatic steatosis and hepatic fibrosis. BR103354 can be used in the research of type 2 diabetes and non-alcoholic steatohepatitis .
Cat. No.: HY-D1005A6
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 2200 (Average)
Cat. No.: HY-E70277
CAS No.: 71425-89-3
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Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a Ki of 0.3 μM, and inhibits DGAT2 activity with an IC50 of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
