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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
416 Results for "
proline editing
" in MedChemExpress (MCE) Product Catalog:
Products (416)
416 Results for "proline editing" in MCE Product Catalog:
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1 Cited Publications
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Velagliflozin proline hydrate is the clinical form of Velagliflozin (HY-109018). Velagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations .
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Velagliflozin proline is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin proline reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations .
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1-(Anilinocarbonyl)proline can be used to identify dual action probes in a cell model of Huntington .
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Amino acids Chenopodiaceae Extract Beta vulgaris Linn. Plants Disease Research Fields Cancer
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Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. N-Propargylglycine covalently modifies enzyme-bound FAD and active site lysine, causing enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine induces UPRmt, upregulates mitochondrial chaperones and YME1L1, enhances mitochondrial proteostasis, blocks astrocytic L-proline consumption, and abolishes L-proline’s ATP-maintaining and viability-protective effects. N-Propargylglycine stimulates neural processes, increases brain proline, hydroxyproline, and sarcosine levels, partially normalizes Huntington’s disease whole brain transcriptomes. N-Propargylglycine reduces hyperoxaluria, prevents calcium oxalate stone formation, reduces kidney tubular damage, and restores weight and survival in Grhpr knockout mice. N-Propargylglycine can be used for the research of breast cancer, neurodegenerative disorders, Huntington’s disease, and primary hyperoxaluria type 2 .
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology
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1 Cited Publications
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology
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1 Cited Publications
Cat. No.: HY-130999
CAS No.: 141205-32-5
Category:
Natural Products Marine algae Marine natural products Plants Other Families Extract Disease Research Fields Inflammation/Immunology Lyngbya majuscule
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1 Cited Publications
Cat. No.: HY-P77380
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: HRG; Histidine-proline-Rich Glycoprotein; Histidine Rich Glycoprotein; Histidine-proline Rich Glycoprotein; HPRG; Thrombophilia Due To Elevated HRG; Histidine-Rich Glycoprotein; THPH11; HRGP
Species:
Human
Source:
HEK293
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Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
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UNC9512 is a selective 53BP1 inhibitor with an IC50 of 0.46 μM, and a Kd values of 0.17 μM. UNC9512 binds 53BP1 and its tandem Tudor domain, disrupts histone H4 interaction, and inhibits 53BP1 activity. UNC9512 can be used as a probe for DNA damage repair and Gene editing .
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Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes .
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Arecaidine hydrobromide is a GABA transport system inhibitor. Arecaidine hydrobromide inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1 . Arecaidine hydrobromide inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats . Arecaidine hydrobromide inhibits hPAT1-mediated L-[ 3H]proline uptake in cells. Arecaidine hydrobromide can be used in research related to neurological diseases .
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1 Cited Publications
Cat. No.: HY-W050044
CAS No.: 2133-34-8
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1 Cited Publications
Cat. No.: HY-P71917
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: P4HB; Protein Disulfide Isomerase Family A, Member 1; Prev. ERBA2L; Cellular Thyroid Hormone-Binding Protein; Prev. PO4DB; Prolyl 4-Hydroxylase, Beta Polypeptide; PDIA1; Collagen Prolyl 4-Hydroxylase Beta; PDI; Procollagen-proline, 2-Oxoglutarate 4-Dioxyg
Species:
Human
Source:
E. coli
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1 Cited Publications
Cat. No.: HY-P77934
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: FAP; Prolyl Endopeptidase FAP; Fibroblast Activation Protein Alpha; Dipeptidyl Peptidase FAP; Seprase; FAPalpha; DPPIV; SIMP; 170 KDa Melanoma Membrane-Bound Gelatinase; CDNA FLJ60298, Highly Similar To Seprase; Gelatine Degradation Protease FAP; Fibroblast Activation Protein, Alpha; Integral Membrane Serine Protease; Serine Integral Membrane Protease; Post-proline Cleaving Enzyme; FAPA; Surface-Expressed Protease
Species:
Mouse
Source:
HEK293
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Cat. No.: HY-Y0252S
CAS No.: 201740-83-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
