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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
141 Results for "
MRPs
" in MedChemExpress (MCE) Product Catalog:
Products (141)
141 Results for "MRPs" in MCE Product Catalog:
Referencia número: HY-N1423S
No. CAS: 1201918-15-1
Synonyms: RTA 744; WP 744; WP 769 hydrochloride
Target:
Áreas de investigación:
Berubicin (RTA 744) hydrochloride is a Doxorubicin (HY-15142A) analog that can cross the blood-brain barrier. Berubicin hydrochloride inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). Berubicin hydrochloride exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. Berubicin hydrochloride can be used in the study of tumors related to the nervous system .
Synonyms: (S)-(-)-Verapamil hydrochloride
Áreas de investigación:
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .
Target:
Áreas de investigación:
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .
Referencia número: HY-P10856
No. CAS: 3085809-95-3
Target:
Áreas de investigación:
Referencia número: HY-D1078
No. CAS: 127770-45-0
Target:
Referencia número: HY-W353102
No. CAS: 1806-98-0
Category:
Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology Steroids
Target:
Áreas de investigación:
Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors .
Referencia número: HY-W013105
No. CAS: 338950-81-5
Synonyms: N-Cholylglycine sodium salt, 98%
Referencia número: HY-162753
No. CAS: 2351940-23-1
Target:
Áreas de investigación:
ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 μM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer .
Target:
Áreas de investigación:
LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor .
Synonyms: RTA 744 free base; WP 744 free base; WP 769
Target:
Áreas de investigación:
Berubicin (RTA 744 free base) is a Doxorubicin (HY-15142A) analog that can cross the blood-brain barrier. Berubicin inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). Berubicin exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. Berubicin can be used in the study of tumors related to the nervous system .
Referencia número: HY-121088
No. CAS: 348148-51-6
Target:
Áreas de investigación:
Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability .
Referencia número: HY-156701
No. CAS: 1428988-21-9
Target:
Áreas de investigación:
BAY-1128688 is a selective, orally active aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC50 of 1.4 nM. BAY-1128688 inhibits OATP, BSEP, MRP4, NTCP, UGT1A1, MRP2, and MRP3. BAY-1128688 induces reactive oxygen species (ROS) production, inhibits the mitochondrial electron transport chain, and increases circulating androsterone, etiocholanolone, dihydrotestosterone, and serum bilirubin concentrations. BAY-1128688 alters bilirubin disposition, leading to elevated plasma bilirubin, independent of liver injury. BAY-1128688 can be used in research on endometriosis and polycystic ovary syndrome .
Referencia número: HY-N4108
No. CAS: 33676-00-5
Category:
Phyllanthus urinaria Linn. Lignans Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Euphorbiaceae Extract
Target:
Referencia número: HY-RS08675
Target:
Áreas de investigación:
MRPS11 Human Pre-designed siRNA Set A contains three designed siRNAs for MRPS11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Áreas de investigación:
PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine .
Referencia número: HY-W702907
No. CAS: 1346599-56-1
Target:
Áreas de investigación:
DM-4103 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4103 inhibits the ability of human liver transporters NTCP, BSEP, MRP2, MRP3, MRP4 (IC50 values are 16.3, 4.15, 51.0, 44.6, 4.26 μM, respectively) and bile acid transport in SCHH cells. DM-4103 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD) .
Referencia número: HY-16773
No. CAS: 1098189-15-1
Synonyms: GS-9451
Target:
Áreas de investigación:
Vedroprevir (GS-9451) is an inhibitor for HCV NS3/4A protease with an IC50 of 3.2 nM. Vedroprevir is also an inhibitor for breast cancer resistant protein (BCRP) with an IC50 of 1.4 μM. Vedroprevir inhibits P-gp, MRP1 and MRP2 with IC50 of 34, 14.9 and 12 μM, respectively. Vedroprevir exhibits good pharmacokinetic characteristics in rats and dogs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
