Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
125 Results for "
integration
" in MedChemExpress (MCE) Product Catalog:
Products (125)
125 Results for "integration" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P704313
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WNT5A; Wnt Family Member 5A; HWNT5A; Wingless-Type MMTV integration Site Family, Member 5A; WNT-5A Protein; Protein Wnt-5a; Wingless-Type MMTV integration Site Family Member 5A Variant 2; Epididymis Secretory Sperm Binding Protein; Protein Wnt
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P700065AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF3; Heparin-Binding Growth Factor 3; Prev. INT2; Proto-Oncogene Int-2; HBGF-3; Oncogene INT2; Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus integration Site (V-Int-2) Oncogene Homolog); FGF-3; V-INT2 Murine Mammary Tumor Virus integration Site
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P701745
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIM1; Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1; Prev. PIM; Pim-1 Oncogene; Serine/Threonine-Protein Kinase Pim-1; Oncogene PIM1; Pim-1 Proto-Oncogene, Serine/Threonine Kinase; Pim-1 Oncogene (Proviral integration Site 1)
Species:
Human
Source:
E. coli
1
1
1 Cited Publications
Cat. No.: HY-N0390S5
CAS No.: 159663-16-8
Synonyms: L-Glutamic acid 5-amide-1-13C
1
1 Cited Publications
Cat. No.: HY-N0390S8
CAS No.: 204451-48-9
Synonyms: L-Glutamic acid 5-amide-15N2
Cat. No.: HY-160807
CAS No.: 2769152-95-4
Target:
Research Areas:
DBM-GGFG-NH-O-CO-Exatecan (Example 4, Compound 14) is a conjugate of an ADC drug toxin molecule and a linker. DBM-GGFG-NH-O-CO-Exatecan is a complete antibody-drug conjugate intermediate that integrates a potent camptothecin-based toxin, a cleavable peptide linker (GGFG), and a reactive terminus that can directly conjugate to antibodies .
Target:
Research Areas:
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .
Cat. No.: HY-159828
CAS No.: 2568911-72-6
Synonyms: VH-499; VH4011499
Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection .
Cat. No.: HY-163319
CAS No.: 3032667-94-7
NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death .
Cat. No.: HY-164574
CAS No.: 2565792-45-0
Research Areas:
BCN-DOTA is a cyclooctyne-linked DOTA chelator. BCN-DOTA integrates BCN and DOTA, enabling conjugation with azide-functionalized groups via the click chemistry properties of BCN, while binding to metal ions through the coordination capacity of DOTA. BCN-DOTA can serve as a radionuclide-drug conjugate (RDC) to target specific biomolecules, cells or tissues after radiolabeling with zirconium-89. BCN-DOTA is applicable to research related to PET imaging and targeted therapy .
Cat. No.: HY-E0225
The 0.5 mL SBS Rack is a 96-well biobank storage rack suitable for -80°C environments. It can hold 0.5 mL externally threaded cryogenic vials with 2D codes on the bottom, and supports automated sample tracking, detection, and laboratory information system integration. The 0.5 mL SBS Rack can be used with camera-based reading devices to scan and log biobank vials with 2D codes into databases, enabling rapid identification of aliquoted samples .
Target:
Research Areas:
IDE 2 is a cell-permeable inducer of definitive endoderm differentiation that induces the differentiation of mouse and human embryonic stem cells into definitive endoderm. IDE2 activates the TGF‑β/Nodal signaling pathway, induces Smad2 phosphorylation, and increases Sox17 and FoxA2 expression. Endoderm induced by IDE 2 integrates into the developing gut tube, expresses gut tube markers, and differentiates into pancreatic progenitor cells. IDE 2 can be used for research related to directed endoderm differentiation of embryonic stem cells .
Cat. No.: HY-177119
Research Areas:
ZBP1 Covalent PROTAC-1 is a covalent PROTAC degrader targeting ZBP1, with a DC50 of 25.69 nM. ZBP1 Covalent PROTAC-1 integrates a ZBP1-binding DNA aptamer, a linker containing covalent NASA, and an E3 ligase-recruiting moiety to guide ubiquitin-proteasome system-mediated degradation of ZBP1. ZBP1 Covalent PROTAC-1 exhibits inhibitory activity against necroptosis signaling pathways and inflammatory responses. ZBP1 Covalent PROTAC-1 can be used for research on viral pneumonia .
Target:
Research Areas:
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration .
Target:
Research Areas:
Sulforhodamine 101 DHPE is a fluorescent probe made from the conjugation of the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE to sulforhodamine 101, a red fluorescent dye that displays excitation/emission spectra of 586/605 nm, respectively. It integrates into phospholipid bilayers and has been used for imaging of solid supported lipid bilayers, detection of protein-ligand binding on bilayers, and to monitor colocalization of lipid probes in liposomes via resonance energy transfer (RET).
Synonyms: 1-P-GPA
Target:
Cat. No.: HY-W591393
CAS No.: 2669097-31-6
Target:
Research Areas:
H-L-Lys (4-N3-Z)-OH hydrochloride is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. H-L-Lys (4-N3-Z)-OH hydrochloride enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. H-L-Lys (4-N3-Z)-OH hydrochloride serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
