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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
407 Results for "
indole ester
" in MedChemExpress (MCE) Product Catalog:
Products (407)
407 Results for "indole ester" in MCE Product Catalog:
Cat. No.: HY-P702162
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IDO1; indoleamine-Pyrrole 2,3-Dioxygenase; Prev. INDO; Indolamine 2,3 Dioxygenase; Prev. IDO; indole 2,3-Dioxygenase; IDO-1; indoleamine 2,3-Dioxygenase 1; indoleamine-Pyrrole 2,3 Dioxygenase
Species:
Others
Source:
E. coli
Cat. No.: HY-P70679
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IDO1; indoleamine-Pyrrole 2,3-Dioxygenase; Prev. INDO; Indolamine 2,3 Dioxygenase; Prev. IDO; indole 2,3-Dioxygenase; IDO-1; indoleamine 2,3-Dioxygenase 1; indoleamine-Pyrrole 2,3 Dioxygenase
Species:
Human
Source:
E. coli
Cat. No.: HY-P72616
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IDO1; indoleamine-Pyrrole 2,3-Dioxygenase; Prev. INDO; Indolamine 2,3 Dioxygenase; Prev. IDO; indole 2,3-Dioxygenase; IDO-1; indoleamine 2,3-Dioxygenase 1; indoleamine-Pyrrole 2,3 Dioxygenase
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P702163
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IDO1; indoleamine-Pyrrole 2,3-Dioxygenase; Prev. INDO; Indolamine 2,3 Dioxygenase; Prev. IDO; indole 2,3-Dioxygenase; IDO-1; indoleamine 2,3-Dioxygenase 1; indoleamine-Pyrrole 2,3 Dioxygenase
Species:
Others
Source:
E. coli
Cat. No.: HY-115004
CAS No.: 1006604-91-6
Target:
Research Areas:
MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1) that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability (14-21%) and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites .
Cat. No.: HY-W115741S1
Research Areas:
1-Phenylethanamine-d3 hydrochloride is the deuterated-labeled 1-Phenylethanamine hydrochloride. 1-Phenylethanamine is a potential central nervous system stimulant and a related compound of β-phenylethylamine. Due to the replacement of its benzene ring with an indole group, its brain glycogenolytic activity is significantly reduced. Therefore, 1-Phenylethanamine can be used to study the impact of the chemical structure of phenylethylamine derivatives on central nervous system activity. In addition, 1-Phenylethanamine can also be used to synthesize the tyrosine kinase (tyrosine kinase) inhibitor CLM3 (HY-164413).
Cat. No.: HY-L0107V
13,236 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders.
In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.
Cat. No.: HY-124253
CAS No.: 1147823-21-9
SMDC818909 is an indole amide-derived uncompetitive inhibitor targeting p97 AAA+ ATPase, with an IC50 of 3.5 μM and a Ka of 9.1 μM. SMDC818909 binds to the D2 ATPase domain of p97, preferentially associates with the ADP-bound conformation of p97, allosterically blocks the ATP hydrolysis cycle of p97, and inhibits its mediated intracellular protein homeostasis regulatory function. SMDC818909 is applied to the research and development of p97-targeted antitumor drugs, as well as studies on cancer-related proteotoxic stress mechanisms .
Cat. No.: HY-L071
594 compounds
Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.
MCE designs a unique collection of 594 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).
Target:
Research Areas:
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
Research Areas:
1-Naphthylacetamide is an orally active nonsteroidal anti-inflammatory agent (NAIA) and also an indole-type auxin plant growth regulator. 1-Naphthylacetamide inhibits inflammatory response-related pathways and modulates plant hormone signaling, exhibiting anti-inflammatory, local anesthetic, antispasmodic, analgesic, and diuretic activities. 1-Naphthylacetamide promotes plant cell expansion, differentiation, and fruit enlargement. Additionally, 1-Naphthylacetamide induces central nervous system (CNS) depression in mice, characterized by reduced spontaneous activity, decreased irritability, decreased muscle tone, and attenuated ear-cuff reflex, ipsilateral flexor reflex, and corneal reflex [1][2].
Cat. No.: HY-W115741S
CAS No.: 474267-40-8
Synonyms: (±)-1-Phenylethylamine-d3; DL-alpha-Methylbenzylamine-d3
Cat. No.: HY-W001160R
CAS No.: 1953-54-4
Cat. No.: HY-118197
CAS No.: 130007-52-2
Target:
Research Areas:
L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors.
Cat. No.: HY-126638
CAS No.: 75731-43-0
Synonyms: NSC 324645
Category:
Alkaloids Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Indole Alkaloids
Target:
Cat. No.: HY-N9164
CAS No.: 62874-52-6
Cat. No.: HY-Y0136S1
CAS No.: 927182-31-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
