4988 Results for "

expression

" in MedChemExpress (MCE) Product Catalog:
Products (4988)

4988 Results for "expression" in MCE Product Catalog:

Kaempferol-3-O-glucorhamnoside
Kaempferol-3-O-glucorhamnoside
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Cat. No.: HY-N0208
CAS No.: 40437-72-7
Category:  

Flavonols Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Santalaceae Thesium chinense Turcz.

Target:  

p38 MAPK NF-κB TNF Receptor Interleukin Related PGE synthase Reactive Oxygen Species (ROS) Bacterial

Kaempferol-3-O-glucorhamnoside is a flavonoid compound. Kaempferol-3-O-glucorhamnoside can be extracted from T. chinense Turcz. Kaempferol-3-O-glucorhamnoside inhibits the phosphorylation of NF-κB and MAPK kinases. Kaempferol-3-O-glucorhamnoside suppresses the expression of cytokines (TNF-α, IL-6, IL-1β and PGE2) and reduces ROS levels. Kaempferol-3-O-glucorhamnoside ameliorates pulmonary edema and alleviates oxidative stress in the lungs and cells of mice exposed to Klebsiella pneumoniae. Kaempferol-3-O-glucorhamnoside possesses anti-inflammatory properties. Kaempferol-3-O-glucorhamnoside can be used in studies related to Klebsiella pneumoniae infection (pneumonia) .
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Liensinine (Standard)
Liensinine (Standard)
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Cat. No.: HY-N0484R
CAS No.: 2586-96-1
Category:  

Alkaloids other families Phenols Polyphenols Plants Alkaloid Dimers

Target:  

Reference Standards Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt

Liensinine (Standard) is the analytical standard of Liensinine (HY-N0484). This product is intended for research and analytical applications. Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke .
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Vincristine (Standard)
Vincristine (Standard)
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Cat. No.: HY-N0488AR
CAS No.: 57-22-7
Synonyms: Leurocristine (Standard); NSC-67574 (Standard); 22-Oxovincaleukoblastine (Standard)
Category:  

Apocynaceae Alkaloids Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Reference Standards Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Standard) is the analytical standard of Vincristine (HY-N0488A). This product is intended for research and analytical applications. Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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Vincristine-d3 sulfate
Vincristine-d3 sulfate
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Cat. No.: HY-N0488S
CAS No.: 1246817-10-6
Synonyms: Leurocristine-d3 sulfate; NSC-67574-d3 sulfate; 22-Oxovincaleukoblastine-d3 sulfate
Vincristine-d3 sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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Vincristine-d6 sulfate
Vincristine-d6 sulfate
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Cat. No.: HY-N0488S2
Synonyms: Leurocristine-d6 sulfate; NSC-67574-d6 sulfate; 22-Oxovincaleukoblastine-d6 sulfate
Vincristine-d6 (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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Monotropein (Standard)
Monotropein (Standard)
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Cat. No.: HY-N0648R
CAS No.: 5945-50-6
Category:  

Iridoids Pyrola calliantha H. Andr. Terpenoids Pyrolaceae Rubiaceae Plants Morinda officinalis How

Target:  

Reference Standards Interleukin Related Heme Oxygenase (HO) Keap1-Nrf2 NF-κB Apoptosis

Monotropein (Standard) is the analytical standard of Monotropein. This product is intended for research and analytical applications. Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .
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L-Asparagine-13C4,15N2,d8
L-Asparagine-13C4,15N2,d8
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Cat. No.: HY-N0667S
CAS No.: 1217464-18-0
L-Asparagine- 13C4, 15N2,d8 is the 13C-labeled and 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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L-Asparagine-13C4,15N2
L-Asparagine-13C4,15N2
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Cat. No.: HY-N0667S7
CAS No.: 781596-75-6
Synonyms: (-)-Asparagine-13C4,15N2; Asn-13C4,15N2; Asparamide-13C4,15N2
L-Asparagine- 13C4, 15N2 ((-)-Asparagine- 13C4, 15N2) is the 13C and 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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Daphnoretin (Standard)
Daphnoretin (Standard)
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Cat. No.: HY-N0699R
CAS No.: 2034-69-7
Synonyms: Dephnoretin (Standard); Thymelol (Standard)
Category:  

Monophenols Thymelaeaceae Coumarins Phenols Phenylpropanoids Plants Wikstroemia indica

Target:  

Reference Standards PKC NOD-like Receptor (NLR) Apoptosis HBV Caspase Akt JNK PI3K CDK Influenza Virus Bcl-2 Family

Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin (HY-N0699). This product is used for research and analytical applications. Daphnoretin is a protein kinase C (PKC) activator that can inhibit the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK, inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.
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Micheliolide (Standard)
Micheliolide (Standard)
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Cat. No.: HY-N0847R
CAS No.: 68370-47-8
Category:  

Other Monoterpenes other families Terpenoids Plants

Target:  

Reference Standards NF-κB PI3K Akt TGF-beta/Smad

Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .
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Alisol A (Standard)
Alisol A (Standard)
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Cat. No.: HY-N0853R
CAS No.: 19885-10-0
Category:  

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Plants Alismataceae

Target:  

Reference Standards AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related

Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
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Schisanhenol (Standard)
Schisanhenol (Standard)
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Cat. No.: HY-N0859R
CAS No.: 69363-14-0
Synonyms: Schizanhenol (Standard); Gomisin-K3 (Standard)
Category:  

Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.

Target:  

UGT Reference Standards Cholinesterase (ChE) Tau Protein SOD Sirtuin

Schisanhenol (Standard) (Schizanhenol (Standard)) is the analytical standard of Schisanhenol (HY-N0859). This product is intended for research and analytical applications. Schisanhenol, a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration.
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Artepillin C (Standard)
Artepillin C (Standard)
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Cat. No.: HY-N10319R
CAS No.: 72944-19-5
Category:  

Ketones, Aldehydes, Acids Plants Compositae Artemisia capillaris Thunb.

Target:  

Reference Standards TRP Channel Necroptosis Epigenetic Reader Domain

Artepillin C (Standard) is the analytical standard of Artepillin C (HY-N10319). This product is intended for research and analytical applications. Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 μM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce apoptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation .
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Monascuspiloin
Monascuspiloin
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Cat. No.: HY-N12124
CAS No.: 1011244-19-1
Synonyms: Monascinol
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Fatty Acid Synthase (FASN) Akt mTOR AMPK Androgen Receptor Caspase Apoptosis Autophagy

Monascuspiloin (Monascinol) is an orally active compound extracted from red mold-fermented rice, with multiple biological activities including anti-androgenic, anti-inflammatory, hypolipidemic, and anti-cancer properties. Monascuspiloin attenuates the PI3K/Akt/mTOR signaling pathway, enhances AMPK phosphorylation, downregulates FASN/SREBP2, induces apoptosis, G2/M phase arrest and autophagy in prostate cancer cells, interferes with dihydrotestosterone-receptor binding, enhances radiation-induced DNA damage, stimulates endoplasmic reticulum stress, and alleviates hepatic oxidative stress. Monascuspiloin regulates hepatic metabolic pathways and modulates the expression of genes and proteins related to hepatic lipid metabolism. Monascuspiloin can be used in studies related to prostate cancer and alcoholic liver injury .
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(E)-3',6-Disinapoylsucrose
(E)-3',6-Disinapoylsucrose
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Cat. No.: HY-N1414
CAS No.: 139891-98-8
Category:  

Simple Phenylpropanols Polygalaceae Phenols Polyphenols Phenylpropanoids Plants Polygala tenuifolia Willd.

Target:  

Trk Receptor NF-κB Amyloid-β

(E)-3',6-Disinapoylsucrose is an orally active, blood-brain barrier permeable neuroprotective agent that inhibits Aβ protein aggregation. (E)-3',6-Disinapoylsucrose exerts anxiolytic, anti-inflammatory and cognitive-enhancing effects. (E)-3',6-Disinapoylsucrose regulates the TrkB/BDNF signaling pathway, inhibits the expression of NF-κB p65, reduces pro-inflammatory cytokine levels, and alleviates neuronal damage. (E)-3',6-Disinapoylsucrose also enhances the functions of central 5-HT and noradrenergic systems, thereby improving spatial learning and memory abilities and reducing anxiety-like behaviors. (E)-3',6-Disinapoylsucrose can be used for the research of related diseases such as Alzheimer's disease, depression, memory impairment and anxiety disorder .
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Cinnamtannin D1
Cinnamtannin D1
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Cat. No.: HY-N16465
CAS No.: 97233-06-2
Category:  

Phenols Polyphenols Plants Lauraceae Lindera glauca (Siebold & Zucc.) Blume

Target:  

Apoptosis Reactive Oxygen Species (ROS) STAT

Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) .
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Clausenidin
Clausenidin
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Cat. No.: HY-N16771
CAS No.: 28384-44-3
Category:  

Rutaceae Coumarins Phenylpropanoids Plants Clausena excavata N. L. Burman

Target:  

Caspase Apoptosis Bcl-2 Family Bacterial VEGFR

Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3, caspase-8 and caspase-9, upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer .
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Pseudoginsenoside RT4
Pseudoginsenoside RT4
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Cat. No.: HY-N17685
CAS No.: 98474-77-2
Category:  

Panax vietnamensis Ha & Grushv. Plants Araliaceae Saccharides Monosaccharides

Target:  

Interleukin Related Bacterial TNF Receptor

Pseudoginsenoside RT4 is an orally active anti-inflammatory agent. Pseudoginsenoside RT4 can be isolated from Panax pseudoginseng subsp. Himalaicus, Panax vietnamensis Ha et Grushv, and Panax quinquefolius L. Pseudoginsenoside RT4 reduces the levels of TNF-α, IL-6, and IL-1β, elevates the level of IL-10, improves the histopathological features of colon tissue, maintains the ultrastructure of colonic epithelium, protects the integrity of cell monolayers, increases the expression of tight junction proteins, raises the total content of short-chain fatty acids, corrects intestinal flora disorder, reduces the disease activity index score, restores colon length, and decreases the spleen index. Pseudoginsenoside RT4 exhibits hepatoprotective effects. Pseudoginsenoside RT4 can be used in studies related to ulcerative colitis .
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6-Methoxymellein
6-Methoxymellein
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Cat. No.: HY-N19791
CAS No.: 13410-15-6
Category:  

Monophenols Coumarins Phenols Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Phenylpropanoids Plants Umbelliferae

Target:  

NF-κB Fungal Interleukin Related

6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 +/CD24 − breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .
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Eriodictyol-7-O-glucoside
Eriodictyol-7-O-glucoside
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Cat. No.: HY-N3847
CAS No.: 38965-51-4
Synonyms: Eriodictyol 7-O-β-D-glucoside
Category:  

Flavonoids Labiatae Flavonones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Petalostemun purpureum

Target:  

Keap1-Nrf2

Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is an Nrf2 activator. Eriodictyol-7-O-glucoside exhibits significant scavenging effects on both hydroxyl radicals and superoxide anions, with IC50 values of 0.28 mM and 0.30 mM, respectively. Eriodictyol-7-O-glucoside increases the nuclear localization of Nrf2 and induces the expression of the Nrf2/ARE-dependent genes. Eriodictyol-7-O-glucoside provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. Eriodictyol-7-O-glucoside demonstrates neuroprotective efficacy in a rat model of focal cerebral ischemia (MCAO). Eriodictyol-7-O-glucoside can be used for the study of stroke .
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