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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
316 Results for "
Nrf2 inducer
" in MedChemExpress (MCE) Product Catalog:
Products (316)
316 Results for "Nrf2 inducer" in MCE Product Catalog:
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3 Cited Publications
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(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
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Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .
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3 Cited Publications
Synonyms: Diferuloylmethane (Standard); Natural Yellow 3 (Standard); Turmeric yellow (Standard)
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2 Cited Publications
Synonyms: L-Sulforaphane
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2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
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2 Cited Publications
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2
2 Cited Publications
Cat. No.: HY-N11849
CAS No.: 135248-05-4
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2
2 Cited Publications
Synonyms: Isoquercetin (Standard); Quercetin 3-glucoside (Standard)
Category:
Flavonols Flavonoids Phenols Polyphenols Plants Apocynum venetum Linn. Apocynaceae Extract
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2 Cited Publications
Cat. No.: HY-N0526
CAS No.: 53209-27-1
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Triterpenes Terpenoids Amaranthaceae Extract Other Diseases Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields
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2 Cited Publications
Cat. No.: HY-N0745
CAS No.: 94596-28-8
Category:
Natural Products Umbelliferae Extract Dicerothamnus rhinocerotis Plants Disease Research Fields Inflammation/Immunology
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2 Cited Publications
Cat. No.: HY-N2473
CAS No.: 94367-42-7
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2 Cited Publications
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DI-1859 is a DCN1 and cullin 3 inhibitor with a Ki of <1 nM against human DCN1. DI-1859 forms a covalent bond with Cys115 of DCN1, cleaves its dimethylamino group, disrupts the DCN1-UBC12 interaction, and selectively inhibits the neddylation modification of cullin 3 relative to other cullins. DI-1859 inactivates CRL3, promotes the accumulation of NRF2 and SLC7A11, upregulates the expression of HO-1 and NQO1, reduces reactive oxygen species (ROS) levels, enhances insulin signaling, promotes insulin secretion, activates RhoA, regulates the phosphorylation of AKT, without completely blocking the neddylation modification of cullin 3 or restoring the expression of IRS-1. DI-1859 can be used in the research of Acetaminophen (HY-66005)-induced hepatotoxicity, hyperglycemia, metabolic dysfunction-associated steatotic liver disease, insulin resistance, breast cancer and lung cancer .
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2 Cited Publications
Synonyms: (-)-Cephaeline; NSC 32944 free base
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2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
