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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
101 Results for "
pc12
" in MedChemExpress (MCE) Product Catalog:
Products (101)
101 Results for "pc12" in MCE Product Catalog:
Cat. No.: HY-W839203
CAS No.: 37070-48-7
Synonyms: 1,2-Didocosanoyl-sn-glycero-3-phosphocholine; pc(22:0/22:0)
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22:0 PC (1,2-Didocosanoyl-sn-glycero-3-phosphocholine), a type of phosphatidylcholine, functions as a lung surfactant and is characterized as an amphipathic molecule predominantly found in the outer leaflets of biological membrane bilayers.
Cat. No.: HY-K3003
DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells, etc. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
Cat. No.: HY-N12170
CAS No.: 903559-03-5
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Cat. No.: HY-183384
CAS No.: 143723-64-2
5'-Cholesteryl phosphoramidite is an antisense oligonucleotide conjugate targeting the p75 nerve growth factor receptor. 5'-Cholesteryl phosphoramidite downregulates the mRNA and protein levels of p75. 5'-Cholesteryl phosphoramidite enhances the cellular uptake efficiency of conjugated phosphorothioate oligonucleotides in differentiated PC12 cells .
Cat. No.: HY-110166R
CAS No.: 77422-99-2
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PD 90780 (Standard) is the analytical standard of PD 90780 (HY-110166). This product is intended for research and analytical applications. PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
Cat. No.: HY-183437
CAS No.: 1522345-35-2
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MAO-B-IN-57 is a selective MAO-B inhibitor with an IC50 of 41.38 nM against human MAO-B. MAO-B-IN-57 shows no significant in vitro cytotoxicity and can significantly increase the survival rate of PC12 cells damaged by 6-OHDA. MAO-B-IN-57 can be used in studies related to Parkinson's disease .
Cat. No.: HY-124152
CAS No.: 173043-84-0
Synonyms: Methyl-3,4-dephostatin
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3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase .
Cat. No.: HY-180327
CAS No.: 313051-12-6
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NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion .
Cat. No.: HY-N21699
CAS No.: 1927024-53-0
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Other Terpenoids Terpenoids Hypericaceae Extract Hypericum uralum Buch.-Ham. & D. Don Plants
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Cat. No.: HY-N18211
CAS No.: 1613615-07-8
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Cat. No.: HY-145547S
Synonyms: 14:0 Lyso PE-d27; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE-d27; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine-d27
Cat. No.: HY-N21802
CAS No.: 1922084-93-2
Cat. No.: HY-W700834
CAS No.: 1216708-84-7
Cat. No.: HY-10071R
CAS No.: 146986-50-7
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Reference Standards ROCK NADPH Oxidase mTOR Reactive Oxygen Species (ROS) NF-κB Apoptosis Akt Autophagy PAK Ras
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Y-27632 (Standard) is the analytical standard of Y-27632 (HY-10071). This product is intended for research and analytical applications. Y-27632 is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .
Cat. No.: HY-180155
CAS No.: 3105470-83-2
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Keap1-Nrf2 Cholinesterase (ChE) Interleukin Related TNF Receptor Reactive Oxygen Species (ROS) Heme Oxygenase (HO) Quinone Reductase
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Keap1/Nrf2/ARE activator 2 is an activator of Keap1/Nrf2/ARE pathway and non-competitively inhibits AChE with an IC50 of 14.79 μM and a Ki of 1.35 μM. Keap1/Nrf2/ARE activator 2 promotes Nrf2 nuclear translocation, leading to antioxidant gene upregulation and enhanced cellular defense against oxidative stress. Keap1/Nrf2/ARE activator exhibits robust neuroprotection against both H2O2- and Scopolamine (SCA) (HY-N0296)-induced injury in PC12 cells. Keap1/Nrf2/ARE activator 2 ameliorates memory impairment and the neuro-inflammation associated with SCA-initiated cognitive dysfunction in a zebrafish model. Keap1/Nrf2/ARE activator 2 can be used for the research of Alzheimer's disease .
Cat. No.: HY-N17920A
CAS No.: 655225-30-2
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Cat. No.: HY-W040172
CAS No.: 79645-39-9
Synonyms: 1,2-Di-O-hexyl-sn-glycero-3-phosphocholine
Cat. No.: HY-W340113
CAS No.: 3355-27-9
Synonyms: 1,2-Dipentadecanoyl-sn-glycero-3-phosphocholine
Cat. No.: HY-157687
CAS No.: 56782-46-8
Synonyms: 1,2-Dielaidoyl-sn-glycero-3-phosphocholine
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18:1 (Δ9-Trans) PC (1,2-Dielaidoyl-sn-glycero-3-phosphocholine) is a phosphoglyceride with two unsaturated acyl chains. The product line is designed to offer compounds with different physical properties, including short chain (C3-C8, water soluble and hygroscopic), saturated, polyunsaturated and mixed acid PCs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
