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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
153 Results for "
primary human
" in MedChemExpress (MCE) Product Catalog:
Products (153)
153 Results for "primary human" in MCE Product Catalog:
Cat. No.: HY-174638
Target:
Research Areas:
Human IL13RA1 mRNA encodes the human interleukin 13 receptor subunit alpha 1 (IL13RA1) protein, a subunit of the interleukin 13 receptor. IL13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. It has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Cat. No.: HY-P7669
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like Kinase; BRK-3; primary Pulmonary Hyp
Species:
Human
Source:
HEK293
Cat. No.: HY-P70212
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GADD45B; Growth Arrest And DNA-Damage-Inducible Beta; Prev. MYD118; DKFZP566B133; GADD45BETA; Growth Arrest And DNA-Damage-Inducible, Beta; Growth Arrest And DNA Damage-Inducible Protein GADD45 Beta; Myeloid Differentiation primary Response; Myeloid Diffe
Species:
Human
Source:
E. coli
Cat. No.: HY-P703947
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like Kinase; BRK-3; primary Pulmonary Hyp
Species:
Human
Source:
HEK293
Cat. No.: HY-P11000A
Research Areas:
INF7TAT acetate is an amphipathic cell-penetrating peptide that mediates intracellular delivery of CRISPR ribonucleoproteins. INF7TAT acetate achieves endosomal escape via the INF7 fragment and cell binding via the TAT fragment. It enables intracellular delivery into primary human T cells and hematopoietic stem and progenitor cells, facilitating gene knockout and AAV-mediated homology-directed repair. INF7TAT acetate can be used for genome editing-related research .
Cat. No.: HY-W319584
CAS No.: 55275-64-4
Target:
Research Areas:
AMP-404 is an Imexon (HY-15385)-derived antitumor agent with dual functions as a cytotoxin and growth inhibitor. AMP-404 exerts significant cytotoxic effects against various sensitive, drug-resistant and primary human tumor cells, including myeloma, breast cancer, melanoma, ovarian cancer and sarcoma cells. AMP-404 effectively inhibits the growth of rat PIE 2-3 sarcoma in vivo and exhibits remarkable in vivo efficacy .
Cat. No.: HY-P72855
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like Kinase; BRK-3; primary Pulmonary Hyp
Species:
Human
Source:
HEK293
Cat. No.: HY-180898
Target:
Research Areas:
AHL-7160 is a molecular glue degrader targeting DGKα, with an IC50 value of 12 nM against the human protein. AHL-7160 rapidly recruits DGKα to the plasma membrane, blocks DGKα-mediated phosphatidic acid production, and induces proteasome-dependent degradation of DGKα with full proteome selectivity. AHL-7160 enhances primary T cell-mediated glioblastoma cell killing. AHL-7160 can be used in related research on glioblastoma .
Cat. No.: HY-P990827
Cat. No.: HY-175780
CAS No.: 1465291-19-3
Target:
Research Areas:
CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48 μM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-γ, IL-2 and TNF-α) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research .
Cat. No.: HY-180131
CAS No.: 1312993-34-2
Synonyms: ASB17061
Target:
Research Areas:
INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects .
Cat. No.: HY-159650
CAS No.: 2724937-55-5
Target:
Research Areas:
EOS-984 is a macrocyclic diamine equilibrative nucleoside transporter 1 (ENT1) inhibitor. EOS984 inhibits ENT1 and ENT1-mediated nucleoside transport, restricting adenosine entry into cells via ENT1, thereby attenuating ATP-derived adenosine-mediated T cell immunosuppression and restoring primary human T cell proliferation. EOS984 can be used in research related to ENT1-mediated nucleoside transport, adenosine-related immunosuppression, and tumor immunity .
Cat. No.: HY-D0967
CAS No.: 146368-15-2
Cat. No.: HY-P11638
Target:
Research Areas:
Cat. No.: HY-P11638A
Target:
Research Areas:
Cat. No.: HY-P5307
Synonyms: INF7-A5K-TAT
Target:
Research Areas:
Cat. No.: HY-P5307A
Synonyms: INF7-A5K-TAT acetate
Target:
Research Areas:
Cat. No.: HY-P99952
CAS No.: 2249927-04-4
Synonyms: SCT400
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Cat. No.: HY-P705526
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PPP1R15A; Myeloid Differentiation primary Response Protein MyD116 Homolog; Protein Phosphatase 1 Regulatory Subunit 15A; Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A; GADD34; Growth Arrest And DNA-Damage-Inducible 34; Growth Arrest And DNA Da
Species:
Human
Source:
E. coli
Synonyms: Genistein 7-O-glucuronide
Target:
Research Areas:
Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
