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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3555 Results for "
fluorogenic caspace-3 substrate
" in MedChemExpress (MCE) Product Catalog:
Products (3555)
3555 Results for "fluorogenic caspace-3 substrate" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: RDEA-594 sodium
연구분야:
Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
5
5 Cited Publications
Cat. No.: HY-P2373
CAS No.: 133876-92-3
Target:
연구분야:
Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases .
5
5 Cited Publications
Target:
연구분야:
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .
5
Target:
연구분야:
Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research [3].
5
5 Cited Publications
Synonyms: AKR-501; E5501; YM477
Target:
Avatrombopag (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag mimics the biological activities of TPO. Avatrombopag increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A [3].
5
5 Cited Publications
Synonyms: AKR-501 maleate; E5501 maleate; YM477 maleate
Avatrombopag (AKR-501) maleate is an orally active, non-peptide thrombopoietin receptor (TPO receptor) agonist (EC50: 3.3 nM). Avatrombopag maleate mimics the biological activity of TPO. Avatrombopag maleate increases platelet production by activating intracellular signaling systems and promotes the production of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate is a substrate for cytochrome P450 (CYP) 2C9 and CYP3A [3].
5
5 Cited Publications
Synonyms: AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride
Target:
연구분야:
Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A [3].
5
5 Cited Publications
Synonyms: Succinyl-CoA sodium
Category:
Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
5
5
5 Cited Publications
Cat. No.: HY-W017443
CAS No.: 5794-13-8
5
5 Cited Publications
Synonyms: SGK3-PROTAC1
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), a chemical probe, is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) .
4
4 Cited Publications
Cat. No.: HY-D1670
CAS No.: 68542-93-8
4
4 Cited Publications
Cat. No.: HY-P2377
CAS No.: 219137-85-6
Target:
연구분야:
4
4 Cited Publications
Cat. No.: HY-W015495
CAS No.: 5988-19-2
4
4 Cited Publications
Synonyms: α-(Methylamino)isobutyric acid
Target:
연구분야:
MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na +-dependent manner .
4
4 Cited Publications
Cat. No.: HY-W013093
CAS No.: 19817-92-6
Synonyms: UTP trisodium salt; Uridine 5'-triphosphate trisodium salt
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
4
4 Cited Publications
Synonyms: Sodium p-aminohippurate; p-Aminohippuric acid sodium salt
Target:
연구분야:
Aminohippurate sodium (Sodium p-aminohippurate) is a renal tubular transport inhibitor and a substrate for organic anion transporters. Aminohippurate sodium inhibits renal tubular reabsorption of phosphate and promotes increased urinary phosphate excretion. Aminohippurate sodium inhibits renal tubular reabsorption of vitamin C as well as the transport of glucose .
4
4 Cited Publications
Synonyms: Triptycene-1,4-quinone
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling [3].
4
4 Cited Publications
연구분야:
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects .
4
4 Cited Publications
Cat. No.: HY-W017386
CAS No.: 3715-31-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
