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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
APAP
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "APAP" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: APAP-Cys TFA
Target:
Áreas de investigación:
Paracetamol-cysteine TFA (APAP-Cys TFA) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) .
1
1 Cited Publications
Synonyms: APAP-glu
Target:
Referencia número: HY-N3431
No. CAS: 20196-89-8
Referencia número: HY-170495
No. CAS: 3099659-64-7
Target:
Áreas de investigación:
HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models .
Referencia número: HY-139093
No. CAS: 53446-10-9
Synonyms: APAP-Cys
Target:
Áreas de investigación:
Paracetamol-cysteine (APAP-Cys) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) .
Referencia número: HY-N7697C
No. CAS: 127171-88-4
Target:
Áreas de investigación:
2,4'-Dihydroxybenzophenone ((Z)-SU4312) exhibited estrogenic activities. 2,4'-Dihydroxybenzophenone has oral bioactivity that can effectively protect C57BL/6J mice from Acetaminophen (HY-66005, APAP)-induced hepatotoxicity .
Referencia número: HY-173564
No. CAS: 2758171-54-7
Target:
Áreas de investigación:
DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC50 = 0.16 μM) with low nanomolar EC50 values of 0.14 μM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis .
Referencia número: HY-113083R
No. CAS: 16110-10-4
Synonyms: APAP-glu (Standard)
Category:
Referencia número: HY-N11433
No. CAS: 1950581-97-1
Target:
Referencia número: HY-N12426
No. CAS: 2763686-96-8
Category:
Plant Lignans Phenylpropanoids Schisandraceae Extract Kadsura coccinea (Lem.) A. C. Smith Extract
Target:
Referencia número: HY-N12706
No. CAS: 2763689-78-5
Category:
Plant Lignans Phenylpropanoids Schisandraceae Extract Kadsura coccinea (Lem.) A. C. Smith Extract
Target:
Referencia número: HY-D3008
No. CAS: 3032633-52-3
Referencia número: HY-N15535
No. CAS: 871720-22-8
Target:
Referencia número: HY-156431
Target:
Áreas de investigación:
Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces TNF-α expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells .
Referencia número: HY-168327
Target:
Áreas de investigación:
LH10 is a fexaramine-based agonist for FXR with an EC50 of 0.14 μM. LH10 exhibits liver protection efficacy, ameliorates the alpha naphthylisothiocyanate (ANIT)-induced cholestasis, APAP (HY-66005)-induced acute liver injury and non-alcoholic steatohepatitis (NASH) in mouse models .
Referencia número: HY-113083A
Synonyms: APAP-glu potassium
Target:
Áreas de investigación:
Acetaminophen glucuronide potassium (APAP-glu potassium) is the inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen glucuronide potassium can be used as a biomarker to measure glucuronidation activity or hepatic drug metabolism capacity .
Referencia número: HY-W725454
No. CAS: 118-57-0
Target:
Áreas de investigación:
Acetaminosalol, a merged ester NSAID–APAP hybrid, is a metabolite of Benorylate (HY-107795) and a prodrug of Acetaminophen (HY-66005) and Aalicylic acid (HY-B0167). Acetaminosalol can be used for the research of acute rheumatism .
Referencia número: HY-N6998A
No. CAS: 435278-17-4
Target:
Referencia número: HY-183995
Áreas de investigación:
SH-26 is a PHD1 PROTAC degrader with DC50s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively. SH-26 recruits CRBN to induce PHD1 degradation via the ubiquitin-proteasome system. SH-26 attenuates APAP (HY-66005)-triggered ROS accumulation, mitochondrial dysfunction, and NLRP3 inflammasome activation. SH-26 can be used for the research of acute liver injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
