APAP

By Targets:	AMPK (1) Apoptosis (1) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (4) Endogenous Metabolite (4) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (1) Fluorescent Dye (1) FXR (2) HDAC (1) Interleukin Related (2) Keap1-Nrf2 (1) Necroptosis (1) PD-1/PD-L1 (1) Phosphatase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (1) Infection (1) Inflammation/Immunology (7) Metabolic Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113083

Acetaminophen glucuronide APAP-glu	Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N3431

Kaempferol-7-O-rhamnoside	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)	Cardiovascular Disease
Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure .

HY-139093A

Paracetamol-cysteine TFA 1 Publications Verification APAP-Cys TFA	Drug Derivative	Others
Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) .

HY-170495

HDAC6 degrader-5	HDAC Apoptosis Interleukin Related	Inflammation/Immunology
HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC₅₀ of 4.95 nM and a DC₅₀ of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models .

HY-139093

Paracetamol-cysteine APAP-Cys	Drug Derivative	Others
Paracetamol-cysteine is a Paracetamol (HY-66005)-cysteine Paracetamol protein (HY-139093A) adduct (PPA), which is formed when Paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .

HY-N7697C

Chitohexaose hexahydrochloride	Toll-like Receptor (TLR) Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia .

HY-128435

2,4'-Dihydroxybenzophenone-1	Estrogen Receptor/ERR	Metabolic Disease
2,4'-Dihydroxybenzophenone ((Z)-SU4312) exhibited estrogenic activities. 2,4'-Dihydroxybenzophenone has oral bioactivity that can effectively protect C57BL/6J mice from Acetaminophen (HY-66005, APAP)-induced hepatotoxicity .

HY-173564

DW34	Epigenetic Reader Domain Necroptosis	Inflammation/Immunology
DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC₅₀ = 0.16 μM) with low nanomolar EC₅₀ values of 0.14 μM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis .

HY-N12706

Heilaohuguosu G	Endogenous Metabolite	Endocrinology
Heilaohuguosu G (compound 7) is a cyclolignan with hepatoprotective activity. Heilaohuguosu G against APAP toxicity with cell survival rates at 10 μM of 45.7% in HepG-2 cells .

HY-113083R

Acetaminophen glucuronide (Standard) APAP-glu (Standard)	Reference Standards Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N11433

Celosin L	Others	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-N12426

Heilaohuguosu F	Endogenous Metabolite	Metabolic Disease
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-D3008

ALP Green	Phosphatase Fluorescent Dye	Metabolic Disease
ALP Green (Probe 4) is an amphiphilic ALP fluorescent probe (Em = 550 nm). ALP Green can be used in the research of APAP (HY-66005)-induced liver injury .

HY-N15535

Cuneataside E	Others	Cancer
Cuneataside E is a phenylpropanoid glycoside compound found in Lespedeza cuneata. Cuneataside E exhibits hepatoprotective activity against the toxicity induced by N-acetyl-p-aminophenol (APAP) in the human hepatocellular carcinoma cell line HepG2. Cuneataside E is promising for research of liver diseases .

HY-156431

Anti-inflammatory agent 61	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces TNF-α expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells .

HY-168327

LH10	FXR	Inflammation/Immunology
LH10 is a fexaramine-based agonist for FXR with an EC₅₀ of 0.14 μM. LH10 exhibits liver protection efficacy, ameliorates the alpha naphthylisothiocyanate (ANIT)-induced cholestasis, APAP (HY-66005)-induced acute liver injury and non-alcoholic steatohepatitis (NASH) in mouse models .

HY-172598

Keap1-Nrf2-IN-28	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-28 (SG16) is an orally active Keap1-Nrf2 inhibitor. Keap1-Nrf2-IN-28 shows antioxidant capability and induces the upregulation of Nrf2, HO-1, GCLM, and Akr1c1. Keap1-Nrf2-IN-28 attenuates APAP (HY-66005)-induced acute liver injury .

HY-113083A

Acetaminophen glucuronide potassium APAP-glu potassium	Drug Metabolite	Others
Acetaminophen glucuronide potassium (APAP-glu potassium) is the inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen glucuronide potassium can be used as a biomarker to measure glucuronidation activity or hepatic drug metabolism capacity .

HY-W725454

Acetaminosalol	Drug Metabolite Drug Intermediate	Inflammation/Immunology
Acetaminosalol, a merged ester NSAID–APAP hybrid, is a metabolite of Benorylate (HY-107795) and a prodrug of Acetaminophen (HY-66005) and Aalicylic acid (HY-B0167). Acetaminosalol can be used for the research of acute rheumatism .

HY-N6998A

6-epi-Paederosidic acid	Others	Infection Cancer
6-epi-Paederosidic acid is a cyclopentanoid monoterpene glycoside found in the aerial parts of Paederia foetida L. 6-epi-Paederosidic acid does not exhibit cytotoxic activity against human tumor cells, hepatoprotective activity against APAP (HY-66005)-induced cellular toxicity, or inhibitory activity against LPS (HY-D1056)-induced nitric oxide production in murine microglia .

Cat. No.	Product Name	Type

HY-D3008

ALP Green	Fluorescent Dye
ALP Green (Probe 4) is an amphiphilic ALP fluorescent probe (Em = 550 nm). ALP Green can be used in the research of APAP (HY-66005)-induced liver injury .

Cat. No.	Product Name	Target	Research Area

HY-139093

Paracetamol-cysteine APAP-Cys	Drug Derivative	Others
Paracetamol-cysteine is a Paracetamol (HY-66005)-cysteine Paracetamol protein (HY-139093A) adduct (PPA), which is formed when Paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113083

Acetaminophen glucuronide APAP-glu	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N3431

Kaempferol-7-O-rhamnoside	Flavonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Chimonanthus nitens Oliv. Plants Disease Research Fields Source Classification Calycanthaceae	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)
Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure .

HY-N7697C

Chitohexaose hexahydrochloride	Structural Classification Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Source Classification	Toll-like Receptor (TLR) Interleukin Related Reactive Oxygen Species (ROS)
Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia .

HY-N12706

Heilaohuguosu G	Lignans Phenylpropanoids Kadsura coccinea (Lem.) A. C. Smith Plants Schisandraceae Source Classification	Endogenous Metabolite
Heilaohuguosu G (compound 7) is a cyclolignan with hepatoprotective activity. Heilaohuguosu G against APAP toxicity with cell survival rates at 10 μM of 45.7% in HepG-2 cells .

HY-113083R

Acetaminophen glucuronide (Standard) APAP-glu (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N11433

Celosin L	Triterpenes Terpenoids Celosia cristata L. Amaranthaceae Plants Source Classification	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-N12426

Heilaohuguosu F	Lignans Phenylpropanoids Kadsura coccinea (Lem.) A. C. Smith Plants Schisandraceae Source Classification	Endogenous Metabolite
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-N15535

Cuneataside E	Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides Source Classification	Others
Cuneataside E is a phenylpropanoid glycoside compound found in Lespedeza cuneata. Cuneataside E exhibits hepatoprotective activity against the toxicity induced by N-acetyl-p-aminophenol (APAP) in the human hepatocellular carcinoma cell line HepG2. Cuneataside E is promising for research of liver diseases .

HY-N6998A

6-epi-Paederosidic acid	Structural Classification Iridoids Terpenoids Rubiaceae Plants Source Classification Paederia foetida L.	Others
6-epi-Paederosidic acid is a cyclopentanoid monoterpene glycoside found in the aerial parts of Paederia foetida L. 6-epi-Paederosidic acid does not exhibit cytotoxic activity against human tumor cells, hepatoprotective activity against APAP (HY-66005)-induced cellular toxicity, or inhibitory activity against LPS (HY-D1056)-induced nitric oxide production in murine microglia .

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HY-P74590

	RYBP Protein, Human (sf9, His-GST) RING1 and YY1-binding protein; APAP-1; RYBP; DEDAF; YEAF1	Human	Sf9 insect cells
	RYBP Protein, a crucial regulatory factor, complexes with metalloproteinases like collagenases, inhibiting their activity by irreversibly binding to catalytic zinc cofactors.This interaction, notably with MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, highlights RYBP's pivotal role in finely regulating extracellular matrix remodeling and proteolytic processes across diverse physiological contexts.RYBP Protein, Human (sf9, His-GST) is the recombinant human-derived RYBP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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HY-P82052

	RYBP Antibody (YA1797) AAP1; APAP1; cb337; DEDAF; RYBP; rybpa; YEAF1	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	RYBP Antibody (YA1797) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RYBP.

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APAP

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