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Results for "

CD38

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CD1 (1) CD28 (1) CD3 (2) CD38 (34) LAG-3 (1) Tim3 (1) ADC Antibody (2) Apoptosis (6) Calcium Channel (2) Drug Derivative (1) Endogenous Metabolite (2) ERK (1) Fc Receptor (FcR) (1) HDAC (1) Influenza Virus (1) NADPH Oxidase (1) PD-1/PD-L1 (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) TNF Receptor (1) Toll-like Receptor (TLR) (1) TRP Channel (2) Tyrosinase (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (5) Endocrinology (2) Infection (2) Inflammation/Immunology (16) Metabolic Disease (5) Neurological Disease (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: CD38 CD1 CD28 CD19 CD20 CD22 Transferrin Receptor CD3 P-selectin CD6 CD2 CD276/B7-H3 CD73 c-Kit LAG-3 L-Selectin CTLA-4 CD47 ALCAM/CD166 Neprilysin E-Selectin Scavenger Receptor Class B type I (SR-BI） FLT3 Tim3 CD44 Anaplastic lymphoma kinase (ALK) CD74 Human leukocyte immunoglobulin (Ig)-like receptors (LILR) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123999

CD38 inhibitor 1 Maximum Cited Publications 12 Publications Verification	CD38	Metabolic Disease
CD38 inhibitor 1 (compound 78c) is a potent *CD38* inhibitor with IC₅₀s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38 .

HY-P9915

Daratumumab Maximum Cited Publications 11 Publications Verification Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414	CD38 ADC Antibody	Inflammation/Immunology Cancer
Daratumumab (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-N0640

Kuromanin chloride Maximum Cited Publications 10 Publications Verification Chrysontemin; Cyanidin 3-O-glucoside chloride	CD38	Neurological Disease Metabolic Disease
Kuromanin chloride (Chrysontemin) is derived from mulberry leaves and has the effect of increasing blood sugar concentration and maintaining lipid metabolism balance to reduce obesity. Kuromanin chloride can inhibit CD38 enzymatic activities .

HY-129522

Sulfo-ara-F-NMN 5+ Cited Publications CZ-48	Toll-like Receptor (TLR)	Neurological Disease
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting *CD38* (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .

HY-P9976

Isatuximab 1 Publications Verification ch38SB19; hu38SB19; SAR-650984	CD38 Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme *CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis* without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-P9915A

*Daratumumab (Anti-CD38)* Maximum Cited Publications 11 Publications Verification Anti-Human CD38, Human Antibody (PBS)	ADC Antibody CD38	Cancer
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P99616

Felzartamab MOR-202	CD38	Cancer
Felzartamab (MOR-202) is a human monoclonal antibody that targets *CD38* and can be used in multiple myeloma research .

HY-P990273

*Anti-Mouse CD38* Antibody (NIMR5)**	CD38 ERK CD1 Apoptosis	Inflammation/Immunology Cancer
Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse *CD38* IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer .

HY-150508

MK-0159 1 Publications Verification	CD38	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
MK-0159 is an orally active, potent and selective *CD38* inhibitor, with IC₅₀ values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD ⁺ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .

HY-P9976A

*Isatuximab (anti-CD38)* 1 Publications Verification	CD38 Apoptosis	Cancer
Isatuximab (anti-CD38) is a monoclonal antibody that targets the transmembrane receptor and extracellular enzyme CD38, a protein highly expressed in hematological malignancies, including multiple myeloma. Isatuximab (anti-CD38) exhibits anti-tumor activity through multiple biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell phagocytosis, and non-crosslinking direct induction of apoptosis. Isatuximab (anti-CD38) also directly inhibits the extracellular enzyme activity of CD38, which is related to many cellular functions .

HY-P991490

ISB2001	CD38 CD3 TNF Receptor	Cancer
ISB2001 is a trispecific antibody targeting *CD38, CD3* and BCMA. ISB2001 effectively counteracts tumor immune escape mechanisms caused by antigen downregulation, antigen loss, soluble factor competition and other factors. ISB2001 is applicable to relevant research on multiple myeloma and relapsed/refractory multiple myeloma .

HY-144987

RBN013209 1 Publications Verification	CD38 LAG-3 Tim3 PD-1/PD-L1	Inflammation/Immunology Cancer
RBN013209 is an orally active small molecule inhibitor of *CD38* with an IC₅₀ of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD ⁺ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .

HY-129997

Luteolinidin chloride 1 Publications Verification	CD38 NADPH Oxidase Tyrosinase	Cardiovascular Disease
Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent *CD38* inhibitor (K_i=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC₅₀=3.7 μM) and blocks the production of melanin .

HY-N7395

Cyclic ADP-ribose 1 Publications Verification cADPR	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-P99744

Modakafusp alfa TAK-573	CD38	Inflammation/Immunology Cancer
Modakafusp alfa (TAK-573) is a humanized, *anti-CD38* IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to *CD38*-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice .

HY-P99730

Mezagitamab 1 Publications Verification TAK-079	CD38 Apoptosis	Inflammation/Immunology Cancer
Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .

HY-144988

CD38 inhibitor 2	CD38	Cancer
CD38 inhibitor 2 is a potent *CD38* inhibitor (IC₅₀ = 0.01 ~ 0.1 μΜ).

HY-134358A

Ara-F-NAD+ sodium	CD38	Neurological Disease
Ara-F-NAD+ sodium is an arabino analogue of NAD ⁺. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .

HY-RS02240

Cd38 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd38 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd38 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd38 Mouse Pre-designed siRNA Set A Cd38 Mouse Pre-designed siRNA Set A

HY-P991183

SAR-442257	CD28 CD38 CD3	Cancer
SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting *CD38* and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .

HY-113512

17-HDHA	Influenza Virus	Inflammation/Immunology
17-HDHA is a DHA-derived specialized proresolving mediator (SPM). 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27 ⁺ CD38 ⁺ antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells .

HY-P990747

Lumrotatug CM-313	CD38	Inflammation/Immunology
Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990037

Erzotabart GEN3014	CD38	Inflammation/Immunology Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to *CD38* molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-N7395A

Cyclic ADP-ribose ammonium 1 Publications Verification cADPR ammonium	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-RS02241

Cd38 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd38 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd38 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd38 Rat Pre-designed siRNA Set A Cd38 Rat Pre-designed siRNA Set A

HY-RS02239

CD38 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD38 Human Pre-designed siRNA Set A contains three designed siRNAs for CD38 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD38 Human Pre-designed siRNA Set A CD38 Human Pre-designed siRNA Set A

HY-134358

Ara-F-NAD+	CD38	Neurological Disease
Ara-F-NAD+ is an arabino analogue of NAD ⁺. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor .

HY-120255

17(R)-HDHA 17(R)-HDoHE	Drug Derivative	Inflammation/Immunology
17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27(+)CD38(+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells .

HY-171417

6-Alkyne-F-araNAD	CD38	Cancer
6-Alkyne-F-araNAD is an irreversible inhibitor of *CD38. 6-Alkyne-F-araNAD helps other fluorescent probes (such as SR101−F-araNMN) to more clearly observe the localization of intracellular CD38* .

HY-N0640R

Kuromanin chloride (Standard) Chrysontemin (Standard); Cyanidin 3-O-glucoside chloride (Standard)	Reference Standards CD38	Neurological Disease Metabolic Disease
Kuromanin (chloride) (Standard) is the analytical standard of Kuromanin (chloride). This product is intended for research and analytical applications. Kuromanin chloride (Chrysontemin) is derived from mulberry leaves and has the effect of increasing blood sugar concentration and maintaining lipid metabolism balance to reduce obesity. Kuromanin chloride can inhibit CD38 enzymatic activities .

HY-P991461

AMG-424 XmAb968	CD38	Cancer
AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .

HY-119648A

(E/Z)-CCR-11	CD38	Inflammation/Immunology
(E/Z)-CCR-11 (Comp 12) is a selective *CD38* inhibitor, with an IC₅₀ of 20.8 μM against CD38 cyclase. (E/Z)-CCR-11 promotes increases in cellular NAD+ levels and interferon γ .

HY-164628

CD38-IN-5	CD38	Cancer
CD38-IN-5 (compound 1) is a *CD38* inhibitor that selectively inhibits CD38 hydrolase with an IC₅₀ of 4.0 μM. CD38-IN-5 does not inhibits CD38 cyclase. CD38-IN-5 is highly effective at promoting NK cell-mediated tumor toxicity. CD38-IN-5 increases NADH+ and IFNγ levels in activated PBMCs. CD38-IN-5 can be used for the study of cancer .

HY-186178

CD38-IN-6	CD38	Metabolic Disease Inflammation/Immunology
CD38-IN-6 is an orally active *CD38* inhibitor. CD38-IN-6 regulates NAD ⁺ metabolite levels in the liver of aged obese mice by increasing NAD ⁺ and NMN levels, and decreasing NAM and ADPR levels. CD38-IN-6 alleviates inflammatory responses in mice. CD38-IN-6 can be used for research related to obesity and inflammation .

HY-101780A

Tinostamustine hydrochloride EDO-S101 hydrochloride; NL-101 hydrochloride	HDAC	Cancer
Tinostamustine hydrochloride (EDO-S101 hydrochloride) is a compound with anti-multiple myeloma activity and the ability to promote CD38 expression. Tinostamustine hydrochloride enhances the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab by increasing the acetylation level of histone H3. Tinostamustine hydrochloride can increase the expression of MICA and MICB, thereby activating NK cells. Tinostamustine hydrochloride can significantly delay tumor growth and improve the survival rate of mice .

HY-P991715

Sanritatug SG-301	CD38	Inflammation/Immunology
Sanritatug is an anti-CD38 IgG1κ antibody, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991462

GBR-1342	CD38	Cancer
GBR-1342 is a human bispecific antibody (bsAb) targeting CD38 & CD3. GBR-1342 inhibits the activity of Daudi, RAJI, RPMI8226, IM-9, and NCI-H929 cancer cell lines. GBR-1342 can be used in myeloma research .

HY-P991913

CID-103 TSK011010	CD38	Cardiovascular Disease Inflammation/Immunology
CID-103 (TSK011010) is an anti-CD38 antibody that recognizes a unique epitope on CD38. CID-103 can be used in research on immune thrombocytopenia .

HY-181543

CVN14	CD38	Neurological Disease
CVN14 is a potent, selective and brain-penetrant *CD38* inhibitor with human IC₅₀ 19 nM, mouse IC₅₀ 2.4 nM. CVN14 binds uncompetitively to form a complex with *CD38* and ADPR, and inhibits *CD38* enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases .

HY-P992455

SAR442085	CD38 Fc Receptor (FcR) Apoptosis	Cancer
SAR442085 is an Fc-engineered anti-CD38 monoclonal antibody with a K_d of 0.2 nM for human CD38. SAR442085 inhibits CD38, induces apoptosis, and triggers antibody-dependent cellular cytotoxicity and phagocytosis in CD38-expressing tumor cells. SAR442085 binds allelic variants of FcγRIIa and FcγRIIIa, enhances NK cell activation, degranulation and cytokine secretion, and exerts anti-tumor activity in human Fc receptor transgenic mice. SAR442085 can be used in the research of multiple myeloma .

HY-P991914

FTL004	CD38 Apoptosis	Cancer
FTL004 is an anti-CD38 monoclonal antibody. FTL004 exhibits enhanced Proapoptotic activity and displays stronger ADCC against CD38 ⁺ malignant cells. FTL004 can be used for the research of multiple myeloma and non-Hodgkin lymphoma[1].

HY-182345

NOTA-MK0159	CD38	Cancer
NOTA-MK0159 is a NOTA (HY-134418) and MK0159 (HY-150508) conjugate. NOTA-MK0159 inhibits human and mouse *CD38* with IC₅₀ values of 72.58 and 7.55 nM. NOTA-MK0159 coupled with radioactive elements acts as a imaging agent with specific uptake in CD38-positive multiple myeloma cells, enabling noninvasive whole-body assessment of CD38 expression in multiple myeloma xenografts. NOTA-MK0159 can be used for the research of multiple myeloma .

Cat. No.	Product Name	Target	Research Area

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to *CD38* molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9915

Daratumumab Maximum Cited Publications 11 Publications Verification Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414	CD38 ADC Antibody	Inflammation/Immunology Cancer
Daratumumab (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P9976

Isatuximab 1 Publications Verification ch38SB19; hu38SB19; SAR-650984	CD38 Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme *CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis* without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-P9915A

*Daratumumab (Anti-CD38)* Maximum Cited Publications 11 Publications Verification Anti-Human CD38, Human Antibody (PBS)	ADC Antibody CD38	Cancer
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific *anti-CD38* monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P99616

Felzartamab MOR-202	CD38	Cancer
Felzartamab (MOR-202) is a human monoclonal antibody that targets *CD38* and can be used in multiple myeloma research .

HY-P990273

*Anti-Mouse CD38* Antibody (NIMR5)**	CD38 ERK CD1 Apoptosis	Inflammation/Immunology Cancer
Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse *CD38* IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer .

HY-P9976A

*Isatuximab (anti-CD38)* 1 Publications Verification	CD38 Apoptosis	Cancer
Isatuximab (anti-CD38) is a monoclonal antibody that targets the transmembrane receptor and extracellular enzyme CD38, a protein highly expressed in hematological malignancies, including multiple myeloma. Isatuximab (anti-CD38) exhibits anti-tumor activity through multiple biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell phagocytosis, and non-crosslinking direct induction of apoptosis. Isatuximab (anti-CD38) also directly inhibits the extracellular enzyme activity of CD38, which is related to many cellular functions .

HY-P991490

ISB2001	CD38 CD3 TNF Receptor	Cancer
ISB2001 is a trispecific antibody targeting *CD38, CD3* and BCMA. ISB2001 effectively counteracts tumor immune escape mechanisms caused by antigen downregulation, antigen loss, soluble factor competition and other factors. ISB2001 is applicable to relevant research on multiple myeloma and relapsed/refractory multiple myeloma .

HY-P99744

Modakafusp alfa TAK-573	CD38	Inflammation/Immunology Cancer
Modakafusp alfa (TAK-573) is a humanized, *anti-CD38* IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to *CD38*-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice .

HY-P99730

Mezagitamab 1 Publications Verification TAK-079	CD38 Apoptosis	Inflammation/Immunology Cancer
Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .

HY-P991183

SAR-442257	CD28 CD38 CD3	Cancer
SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting *CD38* and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .

HY-P990747

Lumrotatug CM-313	CD38	Inflammation/Immunology
Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990037

Erzotabart GEN3014	CD38	Inflammation/Immunology Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

HY-P991461

AMG-424 XmAb968	CD38	Cancer
AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .

HY-P991715

Sanritatug SG-301	CD38	Inflammation/Immunology
Sanritatug is an anti-CD38 IgG1κ antibody, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991462

GBR-1342	CD38	Cancer
GBR-1342 is a human bispecific antibody (bsAb) targeting CD38 & CD3. GBR-1342 inhibits the activity of Daudi, RAJI, RPMI8226, IM-9, and NCI-H929 cancer cell lines. GBR-1342 can be used in myeloma research .

HY-P991913

CID-103 TSK011010	CD38	Cardiovascular Disease Inflammation/Immunology
CID-103 (TSK011010) is an anti-CD38 antibody that recognizes a unique epitope on CD38. CID-103 can be used in research on immune thrombocytopenia .

HY-P992455

SAR442085	CD38 Fc Receptor (FcR) Apoptosis	Cancer
SAR442085 is an Fc-engineered anti-CD38 monoclonal antibody with a K_d of 0.2 nM for human CD38. SAR442085 inhibits CD38, induces apoptosis, and triggers antibody-dependent cellular cytotoxicity and phagocytosis in CD38-expressing tumor cells. SAR442085 binds allelic variants of FcγRIIa and FcγRIIIa, enhances NK cell activation, degranulation and cytokine secretion, and exerts anti-tumor activity in human Fc receptor transgenic mice. SAR442085 can be used in the research of multiple myeloma .

HY-P991914

FTL004	CD38 Apoptosis	Cancer
FTL004 is an anti-CD38 monoclonal antibody. FTL004 exhibits enhanced Proapoptotic activity and displays stronger ADCC against CD38 ⁺ malignant cells. FTL004 can be used for the research of multiple myeloma and non-Hodgkin lymphoma[1].

Recombinant Proteins Recommended:

CD38

Species:	Human (11) Rat (2) Mouse (2) Cynomolgus (1) Rabbit (1)
Tag:	His (11) Avi (2) Flag (1) Fc (6)
Source:	HEK293 (17)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78650

	*FITC-Labeled CD38* Protein, Human (HEK293, His)** CD38; T10; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with C-His labeled tag.

HY-P701286

	*FITC-Labeled CD38* Protein, Human (HEK293, Fc)** CD38; T10; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with Fc labeled tag.

HY-P70731A

	CD38 Protein, Human (HEK293, His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70731

	CD38 Protein, Human (HEK293, His, solution) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His, solution) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70044

	CD38 Protein, Mouse (HEK293, Fc) rMuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Mouse	HEK293
	CD38 protein is pivotal in synthesizing crucial second messengers, cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP). cADPR participates in glucose-induced insulin secretion, and NAADP functions as a calcium mobilizer. CD38 also displays cADPR hydrolase activity, showcasing its multifunctionality. CD38 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70022

	CD38 Protein, Human (HEK293, Fc) rHuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, Fc) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70074

	CD38 Protein, Cynomolgus (HEK293, His) rCynADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, His; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Cynomolgus	HEK293
	The CD38 protein plays multifaceted roles in cell signaling and is critical for the synthesis of cyclic ADP-ribose (cADPR) as a possible second messenger in glucose-induced insulin secretion. CD38 also promotes calcium mobilization through the synthesis of niacin adenine dinucleotide phosphate (NAADP+) and exhibits cADPR hydrolase activity. CD38 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72732

	CD38 Protein, Mouse (HEK293, His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; T10; CD38	Mouse	HEK293
	CD38 protein is pivotal in synthesizing crucial second messengers, cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP). cADPR participates in glucose-induced insulin secretion, and NAADP functions as a calcium mobilizer. CD38 also displays cADPR hydrolase activity, showcasing its multifunctionality. CD38 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72896

	CD38 Protein, Rabbit (HEK293, His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; ADPRC 1; CD38	Rabbit	HEK293
	CD38 protein performs diverse functions, synthesizing cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion. It produces nicotinate-adenine dinucleotide phosphate (NAADP+), mobilizing calcium ions through 2'-phospho-cADPR and nicotinic acid, along with NADP+ and nicotinic acid. Additionally, CD38 acts as a cADPR hydrolase. CD38 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD38 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72897

	CD38 Protein, Rat (HEK293, Fc) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; ADPRC 1; CD38	Rat	HEK293
	CD38 protein plays diverse roles, synthesizing key second messengers: cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion and nicotinate-adenine dinucleotide phosphate (NAADP) as a calcium mobilizer.Its cADPR hydrolase activity adds to its versatility.Notably, CD38 also regulates osteoclastic bone resorption, likely by producing cADPR and initiating a calcium ion signal through ryanodine receptor activation.CD38 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704467

	CD38-Serum Albumin Protein, Human (HEK293, His) rHuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293

HY-P70892

	IL-17RA Protein, Human (HEK293, His) ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293
	IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F. IL-17RA Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags.

HY-P704262

	CD38 Protein, Human (HEK293, mFc) VISTA; B7-H5; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, mFc) is the recombinant human-derived CD38 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P704942

	CD38 Protein, Human (HEK293, His-Flag) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293

HY-P72356

	CD38 Protein, Human (Biotinylated, HEK293, His-Avi) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD38 protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag.

HY-P704994

	CD38 Protein, Human (Biotinylated, HEK293, Fc-Avi) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293

HY-P70077

	CD38 Protein, Rat (HEK293, His) rRtADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, His ; 17-1A; 323/A3; ACSTD1; CD326; EGP-2; EGP314; EGP40; EpCAM; MOC31; TACST-1; TACSTD1; TROP1	Rat	HEK293
	CD38 protein plays diverse roles, synthesizing key second messengers: cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion and nicotinate-adenine dinucleotide phosphate (NAADP) as a calcium mobilizer.Its cADPR hydrolase activity adds to its versatility.Notably, CD38 also regulates osteoclastic bone resorption, likely by producing cADPR and initiating a calcium ion signal through ryanodine receptor activation.CD38 Protein, Rat (HEK293, His) is the recombinant rat-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

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Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (5) Rat (1) Mouse (1)
Application:	IHC-P (5) ICC/IF (3) IP (1) WB (6) ELISA (5)
Isotype:	IgG,Kappa (1) IgG (1) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (6) Biotin (2)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86482

	CD38 Antibody (YA6174) CD38; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD antigen CD38	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	CD38 Antibody (YA6174) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD38.

HY-P80386

	CD38 Antibody (YA540)	WB, IHC-P, ICC/IF	Human
	CD38 Antibody (YA540) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD38.

HY-P87684

	CD38 Antibody (YA7369)	WB, IHC-P, ICC/IF, ELISA	Human
	CD38 Antibody (YA7369) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to CD38.

HY-P84239

	CD38 Antibody (YA3936) T10; ADPRC 1	WB, IHC-P, ELISA	Human
	CD38 Antibody (YA3936) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD38.

HY-P84239A

	CD38 Antibody (YA3936)(PBS only) T10; ADPRC 1	WB, IHC-P, ELISA	Human
	CD38 Antibody (YA3936) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD38.

HY-P85392

	TNK1 Antibody (YA5084) TNK1; Non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1	WB, ELISA	Human
	TNK1 Antibody (YA5084) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TNK1.