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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
131 Results for "
CPT
" in MedChemExpress (MCE) Product Catalog:
Products (131)
131 Results for "CPT" in MCE Product Catalog:
149
Forschungsgebiete:
Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
149
149 Publications Verification
Art. -Nr.: HY-50202A
CAS. Nr.: 828934-41-4
Synonyms: (R)-(+)-Etomoxir sodium salt
Forschungsgebiete:
Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .
81
81 Cited Publications
Art. -Nr.: HY-16562
CAS. Nr.: 97682-44-5
Synonyms: (+)-Irinotecan; CPT-11; VAL-413free base
Target:
Forschungsgebiete:
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
81
81 Cited Publications
Art. -Nr.: HY-16562A
CAS. Nr.: 100286-90-6
Synonyms: (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413
Category:
Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer
Target:
81
81 Cited Publications
Art. -Nr.: HY-16568
CAS. Nr.: 136572-09-3
Synonyms: (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate
Target:
Forschungsgebiete:
Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity .
70
70 Cited Publications
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
62
62 Cited Publications
Art. -Nr.: HY-N0197
CAS. Nr.: 21967-41-9
Synonyms: Baicalein 7-O-β-D-glucuronide
52
52 Cited Publications
Forschungsgebiete:
C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM . C75 is a potent CPT1A activator .
13
13 Cited Publications
Synonyms: TLR3-IN-1
Target:
Forschungsgebiete:
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .
12
12 Cited Publications
Target:
Forschungsgebiete:
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM .
7
Forschungsgebiete:
Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina .
7
Forschungsgebiete:
Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina .
5
5 Cited Publications
Target:
Forschungsgebiete:
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.
4
4 Cited Publications
Art. -Nr.: HY-N2593
CAS. Nr.: 32507-66-7
3
3 Cited Publications
Target:
Forschungsgebiete:
CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist that activates TLR3, TLR8, and TLR9.
3
3 Cited Publications
Art. -Nr.: HY-16482
CAS. Nr.: 250694-07-6
2
2 Cited Publications
Synonyms: Malonyl coenzyme A lithium
Forschungsgebiete:
Malonyl CoA (Malonyl Coenzyme A) lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). High Malonyl CoA lithium concentrations suppress fatty acid oxidation, while low Malonyl CoA lithium concentrations are permissive for fat oxidation .
2
2 Cited Publications
Synonyms: TLR8-specific antagonist
Target:
Forschungsgebiete:
CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.
2
2 Cited Publications
Art. -Nr.: HY-50670
CAS. Nr.: 942999-61-3
Forschungsgebiete:
DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC50 values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity .
1
1 Cited Publications
Synonyms: 8-CPT-2'-O-Me-cAMP sodium
Target:
Forschungsgebiete:
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca 2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
