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Isoforms Recommended:	CYP1A2 CYP1

Results for "

CYP1A2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (5) Acetyl-CoA Carboxylase (1) ADC Payload (1) Androgen Receptor (1) Antibiotic (2) Apoptosis (5) Aryl Hydrocarbon Receptor (4) Bacterial (8) Bcl-2 Family (1) Calcium Channel (3) Carbonic Anhydrase (1) Caspase (1) CaSR (1) Cathepsin (1) Cholinesterase (ChE) (2) COX (8) Cytochrome P450 (60) Drug Derivative (1) Drug Isomer (2) Drug Metabolite (8) EGFR (1) Endogenous Metabolite (10) Environmental Pollutants (1) Estrogen Receptor/ERR (2) Ferroptosis (1) Fungal (1) G protein-coupled Bile Acid Receptor 1 (1) GABA Receptor (2) GLUT (1) Glycosidase (1) GnRH Receptor (1) HBV (1) HIV (1) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (2) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Lipoxygenase (1) MDM-2/p53 (1) MetAP (1) mGluR (1) Microtubule/Tubulin (1) mTOR (1) NF-κB (2) NOD-like Receptor (NLR) (1) P-glycoprotein (2) Parasite (3) Phosphodiesterase (PDE) (1) Potassium Channel (4) Pregnane X Receptor (PXR) (1) PROTACs (1) Proton Pump (1) Reactive Oxygen Species (ROS) (3) Reference Standards (12) RET (1) Ribosomal S6 Kinase (RSK) (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) URAT1 (2) Urease (1) α-synuclein (1) β-catenin (1) β-glucuronidase (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (3) Endocrinology (4) Infection (17) Inflammation/Immunology (20) Metabolic Disease (20) Neurological Disease (25)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

106

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0476

Phenacetin 1 Publications Verification Acetophenetidin	COX	Inflammation/Immunology
Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-111052

AZD7325	GABA Receptor Cytochrome P450	Neurological Disease Inflammation/Immunology
AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (K_i=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes . AZD7325 is a moderate CYP1A2* and* a potent CYP3A4 inducer in vitro . AZD7325 has the potential for the investigation of anxiety and dravet syndrome . PAM: positive allosteric modulator.

HY-N0043

Ginsenoside Rd 1 Publications Verification Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits CYP2D6, *CYP1A2, CYP3A4, and CYP2C9, with IC₅₀*s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-111338

Tacrine 5+ Cited Publications	Cholinesterase (ChE)	Neurological Disease
Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC₅₀ = 109 nM) and also acts as an active substrate for *CYP1A2*. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease .

HY-N0482

Phillyrin Maximum Cited Publications 8 Publications Verification	Cytochrome P450 Influenza Virus Bacterial	Infection Inflammation/Immunology Cancer
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat *CYP1A2* and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .

HY-W011956

6-Hydroxymelatonin	Drug Metabolite Endogenous Metabolite	Neurological Disease Metabolic Disease
6-Hydroxymelatonin is the main metabolite of melatonin (HY-B0075) after being metabolized by CYP1A2 and can cross the blood-brain barrier. 6-Hydroxymelatonin has strong free radical scavenging ability and antioxidant activity, and can alleviate oxidative damage caused by various neurotoxins. 6-Hydroxymelatonin can cause oxidative DNA damage in the presence of copper ions through a "non-quinone" type redox cycling mechanism .

HY-19340

TMS Maximum Cited Publications 9 Publications Verification (E)-2,3',4,5'-tetramethoxystilbene	Cytochrome P450	Cancer
TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC₅₀ of 6 nM and a K_i value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC₅₀=300 nM) and CYP1A2 (IC₅₀=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity .

HY-Y0110

2-Naphthol 1 Publications Verification	Environmental Pollutants Endogenous Metabolite	Others
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-30152

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

HY-18063

ML252	Potassium Channel Cytochrome P450	Neurological Disease
ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC₅₀s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC₅₀s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant .

HY-17614

Ezutromid SMT C1100; BMN 195; VOX-C1100	Cytochrome P450	Others
Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC₅₀ of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC₅₀ of 5.4 μM .

HY-N5132

(-)-Fenchone	Cytochrome P450	Others
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes CYP2A6 and CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP2B6 .

HY-G0007

Omeprazole sulfone 2 Publications Verification Omeprazole sulphone	Drug Metabolite Cytochrome P450 Aryl Hydrocarbon Receptor	Inflammation/Immunology
Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or *CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2* expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-B1012

Quinestrol W-3566	Estrogen Receptor/ERR Cytochrome P450 GnRH Receptor	Metabolic Disease Endocrinology
Quinestrol (W-3566) is an orally effective synthetic estrogen compound that acts on CYP3A4, *CYP1A2, and GnRH*. Quinestrol interferes with GnRH release and disrupts the hypothalamic-pituitary-ovarian axis. Quinestrol downregulates the gene expression of follicle-stimulating hormone β and luteinizing hormone β, induces oxidative stress, damages reproductive organs, reduces sperm density and motility, increases sperm malformation rate, and alters the levels of sex hormones such as testosterone, luteinizing hormone, estradiol, and progesterone. Quinestrol can be used in studies related to reproductive function regulation .

HY-128914

Tubulysin	ADC Payload Microtubule/Tubulin Apoptosis	Cancer
Tubulysin is a microtubule destabilizer that binds to the β-tubulin peptide site adjacent to the vinca alkaloid binding site and inhibits tubulin polymerization. Tubulysin induces apoptosis and exhibits antiproliferative activity against a variety of human cancer cells, including multidrug-resistant strains. Tubulysin can be conjugated to antibodies via a disulfide-containing quaternary ammonium linker for ADC synthesis . Tubulysin is applicable to tumor-related research .

HY-W013268

(S)-(+)-N-3-Benzylnirvanol (+)-N-3-Benzylnirvanol	Cytochrome P450	Metabolic Disease
(S)-(+)-N-3-Benzylnirvanol ((+)-N-3-Benzylnirvanol) is a selective and competitive cytochrome P450 (CYP) isoform CYP2C19 inhibitor with a K_i of 250 nM. (S)-(+)-N-3-Benzylnirvanol has low activity against CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 .

HY-N1050

Zederone	mTOR Ribosomal S6 Kinase (RSK) Bacterial	Infection Neurological Disease Cancer
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC₅₀s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD₅₀ value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis .

HY-W010195

2,6-Dimethylquinoline	Cytochrome P450	Others
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a *CYP1A2* inhibitor with an IC₅₀ of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC₅₀ of 480 µM .

HY-120868

TP-004 1 Publications Verification	MetAP	Metabolic Disease Cancer
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC₅₀ of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis .

HY-N2382

Polyphyllin H 1 Publications Verification	Cytochrome P450 P-glycoprotein	Metabolic Disease Cancer
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of *CYP1A2* (IC₅₀ = 6.44 μM, competitive), CYP2D6 (IC₅₀ = 13.88 μM, competitive) and CYP3A4 (IC₅₀ = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .

HY-N6023

Thermopsoside	Cytochrome P450 Pregnane X Receptor (PXR)	Others
Thermopsoside is a CYP450 isoenzyme inhibitor and PXR activator. Thermopsoside inhibits CYP3A4, CYP2C19, CYP2D6 and CYP2C9 with IC₅₀ values of 6.0 μM, 9.5 μM, 12.0 μM and 32.0 μM, respectively .

HY-117026

LKY-047 1 Publications Verification	Cytochrome P450	Metabolic Disease Inflammation/Immunology
LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC₅₀ of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A .

HY-132845

Utreloxastat PTC857	α-synuclein Cytochrome P450 Ferroptosis Lipoxygenase	Neurological Disease
Utreloxastat (PTC857) is an orally active and blood-brain barrier-permeable 15-lipooxygenase inhibitor. Utreloxastat is a weak inhibitor of *CYP1A2* and 2B6 with an IC₅₀ of >5.3 μM. Utreloxastat reduces oxidative stress and inhibits the consumption of reduced glutathione and ferroptosis. Utreloxastat can be used in the study of neurodegenerative diseases characterized by high levels of oxidative stress and mitochondrial pathology, such as amyotrophic lateral sclerosisc .

HY-W267897

7-Benzyloxy-4-(trifluoromethyl)coumarin 7-BFC	Cytochrome P450	Others
7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies .

HY-B0476S

Phenacetin-d5 Acetophenetidin-d₅	COX	Inflammation/Immunology
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-Y0110S1

2-Naphthol-d7	Endogenous Metabolite	Others
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-B0476R

Phenacetin (Standard) 1 Publications Verification Acetophenetidin (Standard)	Reference Standards COX	Inflammation/Immunology
Phenacetin (Standard) is the analytical standard of Phenacetin. This product is intended for research and analytical applications. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-116780A

Prothipendyl hydrochloride	Cytochrome P450	Neurological Disease
Prothipendyl hydrochloride is a tricyclic azaphenothiazine neuroleptic agent. Prothipendyl hydrochloride is a substrate of the CYP isozymes CYP1A2, CYP2D6, CYP2C19 and CYP3A4. Prothipendyl hydrochloride has sedating and psychomotorically damping effects. Prothipendyl hydrochloride can be used for psychomotoric agitation, sleep disorder and anxiety research .

HY-W045990

2,7-Dimethylnaphthalene	Cytochrome P450	Metabolic Disease
2,7-Dimethylnaphthalene is a selective cytochrome P450 1A2 (CYP1A2) enzyme inhibitor with an IC₅₀ of 65 μM. 2,7-Dimethylnaphthalene can be used for the research of metabolic disease .

HY-N8382

Chalepensin	Cytochrome P450 Parasite Insecticide	Infection
Chalepensin is a nematicide and CYP inhibitor. Chalepensin inhibits CYP2A6, CYP1A1, *CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4* to varying degrees, with IC₅₀ values of 82.3 μM, 2.86 μM, 3.01 μM, 0.21 μM, 6.58 μM, 1.67 μM, 61.1 μM, and 61.7 μM, respectively. Chalepensin potently and selectively kills third-stage infective larvae of Strongyloides venezuelensis .

HY-W074537

P7-2104	Phosphodiesterase (PDE)	Neurological Disease
P7-2104 is a blood-brain barrier-permeable, selective PDE7A inhibitor with an IC₅₀ of 31 nM. P7-2104 shows selectivity for hERG channels and most CYP450 subtypes. P7-2104 can be used for PDE7-targeted PET neuroimaging studies and research related to neurodegenerative diseases, when labeled with ¹¹C or ¹⁸F .

HY-W275481

γ-Dodecanolactone	Cytochrome P450	Others
γ-Dodecanolactone is a γ-lactone compound. γ-Dodecanolactone exhibits inhibitory activity against *CYP1A2* with an IC₅₀ value of 58 µM and a pIC₅₀ value of 4.24. γ-Dodecanolactone can be used in the research of diseases related to the CYP1A2 enzyme .

HY-W777979

Frutinone A	Cytochrome P450 Bacterial	Infection
Frutinone A is a *CYP1A2* inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant .

HY-N3090

Peucedanol	Cytochrome P450	Metabolic Disease
Peucedanol is a non-competitive inhibitor of CYP3A4 with a K_i value of 4.07 μM and a competitive inhibitor of *CYP1A2* and CYP2D6 with K_i values of 3.39 μM and 6.77 μM, respectively .

HY-RS03442

CYP1A2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP1A2 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP1A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP1A2 Human Pre-designed siRNA Set A CYP1A2 Human Pre-designed siRNA Set A

HY-B0352A

(S)-Mirtazapine (S)-Org3770; (S)-6-Azamianserin	5-HT Receptor	Neurological Disease
(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT₂ receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2 .

HY-W015697

3-Methylquinoline	Cytochrome P450	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC₅₀ of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors .

HY-N1882

4,5-Dimethoxycanthin-6-one	Cytochrome P450	Metabolic Disease
4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of *CYP1A2*-mediated phenacetin O-deethylation with an IC₅₀ value of 1.7μM and a K_i value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae) .

HY-B0476S1

Phenacetin-13C	COX	Inflammation/Immunology
Phenacetin- ¹³C is the ¹³C labeled Phenacetin . Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-131495

(S)-6-O-Desmethylnaproxen (S)-6-Desmethyl Naproxen	COX	Inflammation/Immunology
(S)-6-O-Desmethylnaproxen ((S)-6-Desmethyl Naproxen) is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen). (S)-6-O-Desmethylnaproxen is formed from (S)-naproxen by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.

HY-155732

NPD-2975	Parasite	Infection
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC₅₀0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC₅₀ values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .

HY-D0144

Resorufin methyl ether Methoxyresorufin	Cytochrome P450	Others
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

HY-RS16640

Cyp1a2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cyp1a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cyp1a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cyp1a2 Mouse Pre-designed siRNA Set A Cyp1a2 Mouse Pre-designed siRNA Set A

HY-RS23074

Cyp1a2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cyp1a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cyp1a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cyp1a2 Rat Pre-designed siRNA Set A Cyp1a2 Rat Pre-designed siRNA Set A

HY-146177

CYP3A4 enzyme-IN-1	Bacterial Cytochrome P450	Infection
CYP3A4 enzyme-IN-1 (compound 59) is a potent antibacterial agent, with a MIC of 1 μg/mL for MRSA. CYP3A4 enzyme-IN-1 exhibits low to moderate inhibitory effects on CYP1A2, CYP2E1, CYP2D6, and CYP3A4 enzymes .

HY-124158

KR-60436	Proton Pump	Metabolic Disease
KR-60436 is a reversible H ⁺/K ⁺-ATPase inhibitor. KR-60436 can potently inhibit the metabolism of CYP1A2 substrates .

HY-G0007R

Omeprazole sulfone (Standard) Omeprazole sulphone (Standard)	Reference Standards Drug Metabolite Cytochrome P450 Aryl Hydrocarbon Receptor	Infection Cancer
Omeprazole sulfone (Standard) is the analytical standard of Omeprazole sulfone. This product is intended for research and analytical applications. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or *CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2* expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-W010195R

2,6-Dimethylquinoline (Standard)	Reference Standards Cytochrome P450	Others
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM .

HY-175836

CYP1B1-IN-12	Cytochrome P450 Apoptosis	Cancer
CYP1B1-IN-12 is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 6.05 nM. CYP1B1-IN-12 demonstrates remarkable selectivity, exceeding 1600-fold and 16,000-fold over CYP1A1 and CYP1A2, respectively. CYP1B1-IN-12 can enhance Paclitaxel (HY-B0015)-mediated apoptosis and restore Paclitaxel sensitivity in A549/Taxol-resistant cells. CYP1B1-IN-12 can inhibit the epithelial-mesenchymal transition process and reduce cells migration and invasion. CYP1B1-IN-12 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) .

HY-100644

Trimethoprim N-oxide Trimethoprim 1-N-oxide	Drug Metabolite	Infection
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes .

Cat. No.	Product Name	Target	Research Area

HY-P11832

CaSR agonist peptide-1	CaSR	Endocrinology
CaSR agonist peptide-1 is a human calcium-sensing receptor (CaSR) agonist. CaSR agonist peptide-1 activates CaSR by binding to it. CaSR agonist peptide-1 can be used in studies related to secondary hyperparathyroidism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0043

Ginsenoside Rd 1 Publications Verification Gypenoside VIII	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits CYP2D6, *CYP1A2, CYP3A4, and CYP2C9, with IC₅₀*s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N0482

Phillyrin Maximum Cited Publications 8 Publications Verification	Infection Oleaceae Classification of Application Fields Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 Influenza Virus Bacterial
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat *CYP1A2* and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .

HY-W011956

6-Hydroxymelatonin	Structural Classification Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Drug Metabolite Endogenous Metabolite
6-Hydroxymelatonin is the main metabolite of melatonin (HY-B0075) after being metabolized by CYP1A2 and can cross the blood-brain barrier. 6-Hydroxymelatonin has strong free radical scavenging ability and antioxidant activity, and can alleviate oxidative damage caused by various neurotoxins. 6-Hydroxymelatonin can cause oxidative DNA damage in the presence of copper ions through a "non-quinone" type redox cycling mechanism .

HY-Y0110

2-Naphthol 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-30152

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	Monophenols other families Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

HY-N5132

(-)-Fenchone	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Other Diseases Umbelliferae Plants Vernonia Schreb. Disease Research Fields Source Classification	Cytochrome P450
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes CYP2A6 and CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP2B6 .

HY-22024

5-Hydroxyflavone 2 Publications Verification 5-OH-Flavone	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavones Phenols Plants Disease Research Fields Source Classification Cancer	Cytochrome P450
5-Hydroxyflavone (5-OH-Flavone) is a flavonoid compound that undergoes oxidation-mediated conversion to 5,7-dihydroxyflavone and 5,6,7-trihydroxyflavone by human cytochrome P450 enzymes .

HY-N1050

Zederone	Terpenoids Sesquiterpenes Plants Curcuma elata Roxb. Source Classification Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK) Bacterial
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC₅₀s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD₅₀ value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis .

HY-W010195

2,6-Dimethylquinoline	Alkaloids Chrysanthemum × morifolium (Ramat.) Hemsl. Classification of Application Fields Other Diseases Quinoline Alkaloids Umbelliferae Plants Disease Research Fields Source Classification	Cytochrome P450
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a *CYP1A2* inhibitor with an IC₅₀ of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC₅₀ of 480 µM .

HY-N2382

Polyphyllin H 1 Publications Verification	Structural Classification other families Plants Steroids Source Classification	Cytochrome P450 P-glycoprotein
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of *CYP1A2* (IC₅₀ = 6.44 μM, competitive), CYP2D6 (IC₅₀ = 13.88 μM, competitive) and CYP3A4 (IC₅₀ = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .

HY-N6023

Thermopsoside	Structural Classification Flavonoids Classification of Application Fields Flavones Astragalus microcephalus Willd. Other Diseases Phenols Polyphenols Plants Compositae Disease Research Fields Source Classification	Cytochrome P450 Pregnane X Receptor (PXR)
Thermopsoside is a CYP450 isoenzyme inhibitor and PXR activator. Thermopsoside inhibits CYP3A4, CYP2C19, CYP2D6 and CYP2C9 with IC₅₀ values of 6.0 μM, 9.5 μM, 12.0 μM and 32.0 μM, respectively .

HY-W045990

2,7-Dimethylnaphthalene	Structural Classification Natural Products Rosaceae Pyracantha fortuneana (Maxim.) H.L.Li Plants Source Classification	Cytochrome P450
2,7-Dimethylnaphthalene is a selective cytochrome P450 1A2 (CYP1A2) enzyme inhibitor with an IC₅₀ of 65 μM. 2,7-Dimethylnaphthalene can be used for the research of metabolic disease .

HY-N8382

Chalepensin	Structural Classification Natural Products Haloxylon ammodendron (C. A. Mey.) Bunge Amaranthaceae Plants Source Classification	Cytochrome P450 Parasite Insecticide
Chalepensin is a nematicide and CYP inhibitor. Chalepensin inhibits CYP2A6, CYP1A1, *CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4* to varying degrees, with IC₅₀ values of 82.3 μM, 2.86 μM, 3.01 μM, 0.21 μM, 6.58 μM, 1.67 μM, 61.1 μM, and 61.7 μM, respectively. Chalepensin potently and selectively kills third-stage infective larvae of Strongyloides venezuelensis .

HY-N6065

Praeruptorin A 3 Publications Verification (+)-Praeruptorin A	Structural Classification Classification of Application Fields Coumarins Salvia hypargeia Fisch. & C.A.Mey. Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Calcium Channel Drug Isomer Cytochrome P450 iGluR Apoptosis
Praeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension .

HY-W777979

Frutinone A	Hydroleaceae Polygala fruticosa P.J.Bergius Polygalaceae Coumarins Phenylpropanoids Plants Source Classification	Cytochrome P450 Bacterial
Frutinone A is a *CYP1A2* inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant .

HY-N3090

Peucedanol	Carpesium cernuum L. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Cytochrome P450
Peucedanol is a non-competitive inhibitor of CYP3A4 with a K_i value of 4.07 μM and a competitive inhibitor of *CYP1A2* and CYP2D6 with K_i values of 3.39 μM and 6.77 μM, respectively .

HY-N1882

4,5-Dimethoxycanthin-6-one	Alkaloids Simaroubaceae Classification of Application Fields Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	Cytochrome P450
4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of *CYP1A2*-mediated phenacetin O-deethylation with an IC₅₀ value of 1.7μM and a K_i value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae) .

HY-W010195R

2,6-Dimethylquinoline (Standard)	Alkaloids Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Quinoline Alkaloids Umbelliferae Plants Source Classification	Reference Standards Cytochrome P450
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM .

HY-N0482R

Phillyrin (Standard)	Structural Classification Oleaceae Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Source Classification	Reference Standards Cytochrome P450 Influenza Virus Bacterial
Phillyrin (Standard) is the analytical standard of Phillyrin. This product is intended for research and analytical applications. Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .

HY-30152R

Xanthotoxol (Standard) 8-Hydroxypsoralen (Standard)	Structural Classification Monophenols other families Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	Reference Standards 5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite
Xanthotoxol (Standard) is the analytical standard of Xanthotoxol. This product is intended for research and analytical applications. Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC₅₀s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation .

HY-W011956R

6-Hydroxymelatonin (Standard)	Structural Classification Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Endogenous Metabolite
6-Hydroxymelatonin (Standard) is the analytical standard of 6-Hydroxymelatonin. This product is intended for research and analytical applications. 6-Hydroxymelatonin is the main metabolite of melatonin (HY-B0075) after being metabolized by CYP1A2 and can cross the blood-brain barrier. 6-Hydroxymelatonin has strong free radical scavenging ability and antioxidant activity, and can alleviate oxidative damage caused by various neurotoxins. 6-Hydroxymelatonin can cause oxidative DNA damage in the presence of copper ions through a "non-quinone" type redox cycling mechanism.

HY-N0043R

Ginsenoside Rd (Standard) Gypenoside VIII (Standard)	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Reference Standards NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd (Standard) is the analytical standard of Ginsenoside Rd. This product is intended for research and analytical applications. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-W142473

1,2-Dimethylnaphthalene	Structural Classification Natural Products Leguminosae Tamarindus indica L. Plants Source Classification	Cytochrome P450
1,2-Dimethylnaphthalene is a CYP1A2 inhibitor with an IC₅₀ of 5.5 μM and a pIC₅₀ of 5.26 .

HY-Y0110R

2-Naphthol (Standard)	Structural Classification Monophenols Microorganisms Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Naphthol (Standard) is the analytical standard of 2-Naphthol. This product is intended for research and analytical applications. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

Cat. No.	Product Name	Chemical Structure

HY-B0476S

Phenacetin-d5
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-Y0110S1

2-Naphthol-d7
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-B0476S1

Phenacetin-13C
Phenacetin- ¹³C is the ¹³C labeled Phenacetin . Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-B0352AS

(S)-Mirtazapine-d3
(S)-Mirtazapine-d₃ is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].

HY-W707708

N-(4-Ethoxyphenyl)acetamide-2,2,2-d3
N-(4-Ethoxyphenyl)acetamide-2,2,2-d₃ is the deuterium labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-G0007S

Omeprazole sulfone-d3

Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-G0007S1

Omeprazole sulfone-13C,d3

Omeprazole sulfone- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-Y0110S

2-Naphthol-d8
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81245

	Cytochrome P450 1A2 Antibody (YA3505) Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; CYP1A2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase; P450 1A2.	WB, ICC/IF, FC	Human
	Cytochrome P450 1A2 Antibody (YA3505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 1A2.

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Cat. No.	Product Name		Classification

HY-B1012

Quinestrol W-3566		Alkynes
Quinestrol (W-3566) is an orally effective synthetic estrogen compound that acts on CYP3A4, *CYP1A2, and GnRH*. Quinestrol interferes with GnRH release and disrupts the hypothalamic-pituitary-ovarian axis. Quinestrol downregulates the gene expression of follicle-stimulating hormone β and luteinizing hormone β, induces oxidative stress, damages reproductive organs, reduces sperm density and motility, increases sperm malformation rate, and alters the levels of sex hormones such as testosterone, luteinizing hormone, estradiol, and progesterone. Quinestrol can be used in studies related to reproductive function regulation .

HY-16247

Apoptone HE3235		Alkynes
Apoptone (HE3235) is an orally active 3β-androstanediol analog. Apoptone reduces the expression of androgen receptor (Androgen receptor) and decreases intratumoral androgen levels. Apoptone exhibits anticancer activity against castration-resistant prostate cancer .

HY-119578

Imiprothrin		Alkynes
Imiprothrin is an inducer that induces *CYP1A2* and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .

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