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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
221 Results for "
Cyclopamine
" in MedChemExpress (MCE) Product Catalog:
Products (221)
221 Results for "Cyclopamine" in MCE Product Catalog:
56
Category:
Alkaloids Veratrum nigrum Linn. Liliaceae Pyridine Alkaloids Plants Endogenous metabolite Disease Research Fields Cancer Steroids
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44
44 Cited Publications
SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
44
44 Cited Publications
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
44
44 Cited Publications
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
32
32 Cited Publications
Cat. No.: HY-P0023
CAS No.: 161552-03-0
32
32 Cited Publications
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
17
17 Cited Publications
Synonyms: Debio-025; DEB-025
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Research Areas:
7
7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Research Areas:
4
4 Cited Publications
4
4 Cited Publications
4
4 Cited Publications
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3
3 Cited Publications
Cat. No.: HY-P0257
CAS No.: 170809-51-5
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Research Areas:
3
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2
2
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist .
2
Taladegib is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers .
2
2 Cited Publications
Category:
Vaccaria segetalis (Neck.) Garcke Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae
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2
2 Cited Publications
Cat. No.: HY-P0231
CAS No.: 1088543-62-7
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Research Areas:
2
2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
