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Results for "

E6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) ADC Antibody (1) Akt (1) Amyloid-β (1) Antibiotic (8) Apoptosis (15) Arenavirus (2) Autophagy (1) Bacterial (3) Bcl-2 Family (8) Biochemical Assay Reagents (19) c-Met/HGFR (1) Calcium Channel (2) Calmodulin (1) Caspase (2) CDK (6) Ceramidase (2) CHIKV (2) Dengue Virus (1) DNA/RNA Synthesis (4) Drug Derivative (7) Endogenous Metabolite (3) Enteropeptidase (1) Enterovirus (2) Environmental Pollutants (3) Eukaryotic Initiation Factor (eIF) (1) FAAH (3) Filovirus (2) FKBP (1) Flavivirus (1) Fluorescent Dye (2) Fungal (3) Glutathione Peroxidase (2) HCV (1) Herbicide (1) HPV (3) HSV (2) IFNAR (3) Influenza Virus (8) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (7) Keap1-Nrf2 (1) LDLR (1) MAGL (1) Melanocortin Receptor (1) Microtubule/Tubulin (2) MOFs (5) Myosin (1) Na+/K+ ATPase (1) Nucleoside Antimetabolite/Analog (2) Orthopoxvirus (7) Parasite (8) PARP (2) PD-1/PD-L1 (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phosphoramidites (1) Photosensitizer (5) Potassium Channel (1) PROTACs (3) RAR/RXR (1) Reactive Oxygen Species (ROS) (3) Reference Standards (8) Renin (1) RSV (2) SARS-CoV (67) Sec61 (2) Ser/Thr Protease (1) Sodium Channel (1) STAT (8) TAM Receptor (1) TNF Receptor (2) Transmembrane Glycoprotein (1) Virus Protease (14)
By Research Areas:	Cancer (46) Cardiovascular Disease (7) Endocrinology (2) Infection (89) Inflammation/Immunology (13) Metabolic Disease (6) Neurological Disease (11)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Hypoxanthine (1) Phosphoramidites (1)

152

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13594

Chlorin e6 15+ Cited Publications CE6	MOFs Bcl-2 Family Caspase PARP Apoptosis Fluorescent Dye	Infection Cancer
Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer .

HY-B0497

Niclosamide Maximum Cited Publications 40 Publications Verification BAY2353	Environmental Pollutants Antibiotic Parasite STAT	Infection Cancer
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-B1123

Auranofin Maximum Cited Publications 40 Publications Verification SKF-39162	Bacterial SARS-CoV	Infection Inflammation/Immunology Cancer
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC₅₀ of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC₅₀ of 4.2 μM for monkey kidney Vero E6 cells.

HY-120599

Sabizabulin 4 Publications Verification VERU-111; ABI-231	Microtubule/Tubulin Apoptosis HPV	Cancer
VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC₅₀ of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer .

HY-119283

CAY10499 1 Publications Verification MAGL-IN-5	MAGL FAAH SARS-CoV Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC₅₀ values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities .

HY-B0497C

Niclosamide olamine Maximum Cited Publications 40 Publications Verification BAY2353 olamine	Environmental Pollutants Antibiotic STAT Parasite	Infection Cancer
Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research . Niclosamide olamin is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-116073

L-Penicillamine	Acyltransferase	Infection Cancer
L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss) .

HY-16477

Talaporfin sodium 4 Publications Verification ME2906; Mono-L-aspartyl chlorin E6; NPE6	Photosensitizer	Cancer
Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) .

HY-113794

DSHS00884 1 Publications Verification SSYA10-001	Filovirus	Infection
DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC₅₀ of 10 μM .

HY-W854659

Chlorin e6 trisodium 15+ Cited Publications CE6 trisodium	Photosensitizer	Cancer
Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions .

HY-P99183

Abituzumab EMD 525797; DI17E6	Integrin	Cancer
Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .

HY-137475

Chlorin e6 trimethyl ester 1 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT) .

HY-153121

Leritrelvir RAY1216	SARS-CoV	Infection
Leritrelvir (RAY1216) is an orally active SARS-CoV-2 main protease slow-tight inhibitor with a K_i of 8.6 nM .

HY-136933

Gitoxin	Na+/K+ ATPase	Cardiovascular Disease
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-120997

E6 Berbamine Berbamine p-nitrobenzoate	Calmodulin Myosin Phosphodiesterase (PDE)	Cardiovascular Disease Cancer
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia .

HY-163901

E6-272	HPV Apoptosis	Infection Cancer
E6-272 is a human papillomavirus 16 (HPV 16) inhibitor. E6-272 induces Apoptosis. E6-272 inhibits the proliferation of HPV-positive cells. E6-272 can be used in the research of cervical cancer .

HY-Y0248

(E,E)-Farnesol trans,trans-Farnesol; (2E,6E)-Farnesol	Fungal	Infection
(E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .

HY-16952

Bepridil 5+ Cited Publications (±)-Bepridil; Org 5730	Calcium Channel Sodium Channel SARS-CoV	Infection Cardiovascular Disease
Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells .

HY-B0497R

Niclosamide (Standard) BAY2353 (Standard)	Reference Standards STAT Parasite Antibiotic	Infection Cancer
Niclosamide (Standard) is the analytical standard of Niclosamide. This product is intended for research and analytical applications. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-160506

PRO-6E	PROTACs c-Met/HGFR Apoptosis	Cancer
PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)) .

HY-151482

SARS-CoV-2 Mpro-IN-2	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent M ^pro inhibitor (IC₅₀=0.40 μM) with good anti-SARS-CoV-2 activity (EC₅₀=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies .

HY-158189

TPP-Ce6	Photosensitizer Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Cancer
TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma ^[6].

HY-172265

FKBP12 PROTAC FM4	PROTACs FKBP	Cancer
FKBP12 PROTAC FM4 is a PROTAC degrader of FKBP12, with a DC50 value of 0.09-0.22 nM. FKBP12 PROTAC FM4 inhibits global protein synthesis, induces apoptosis, and selectively reduces the viability of cervical cancer cells expressing *MTH1*-E6 and FKBP12 ^F36V-tagged SARS1. FKBP12 PROTAC FM4 is applicable to research related to HPV-positive cervical cancer .

HY-100072

(2E,4E,6Z)-Methyl deca-2,4,6-trienoate Methyl (2E,4E,6Z)-decatrienoate	Others	Infection
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) is the aggregation pheromone of the brown-winged green bug, Plautia stali. (2E,4E,6Z)-Methyl deca-2,4,6-trienoate exposed to daylight in solutions and/or on dispensers used for field trapping can readily isomerize to form complex mixtures of isomers, thus causing a concern about lure stability and longevity .

HY-133927

(2E,6E)-3,7-Dimethyltrideca-2,6-dien-12-yn-1-ol	Biochemical Assay Reagents	Others
(2E,6E)-3,7-Dimethyltrideca-2,6-dien-12-yn-1-ol is a isoprenoid analogue . (2E,6E)-3,7-Dimethyltrideca-2,6-dien-12-yn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0497B

Niclosamide monohydrate BAY2353 monohydrate	STAT Antibiotic Parasite	Infection Cancer
Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-B1123R

Auranofin (Standard) SKF-39162 (Standard)	Bacterial SARS-CoV Reference Standards	Infection Inflammation/Immunology Cancer
Auranofin (Standard) is the analytical standard of Auranofin. This product is intended for research and analytical applications. Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2 μM for monkey kidney Vero E6 cells.

HY-P10428

E6AP-mimicking peptide	HPV	Infection
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a K_i of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture .

HY-B0497A

Niclosamide sodium BAY2353 sodium	Antibiotic STAT Parasite	Infection Cancer
Niclosamide (BAY2353) sodium is an orally active antihelminthic agent used in parasitic infection research . Niclosamide sodium is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide sodium has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-DY1092

Chlorin e6 (solution) CE6 (solution)	Caspase Apoptosis Fluorescent Dye PARP Bcl-2 Family	Cancer
Chlorin e6 (solution) (Ce6 (solution)) is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer . Solvent and concentration: DMSO: 10 mM The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-172223

3-Deazaguanosine C3Guo	SARS-CoV	Infection
3-Deazaguanosine (C3Guo) has potent antiviral activity against SARS-CoV-2 (EC₅₀: 1.14 μM, CC₅₀: >200 μM for Vero E6 cells). 3-Deazaguanosine prevents COVID-19 pneumonia .

HY-179251

BDGR-651	CHIKV	Infection
BDGR-651 is an efficient and selective inhibitor of the Chikungunya virus (CHIKV) with an EC₅₀ in NHDF cells of 0.86 μM, and the therapeutic index (SI) of 22.1. BDGR-651 exhibits dose-dependent protective effects when infecting Vero E6 cells, with its EC₅₀ being 6 μM. BDGR-651 can be used for research on CHIKV infection .

HY-B0497S2

Niclosamide-d3 BAY2353-d₃	Isotope-Labeled Compounds Antibiotic STAT Parasite	Infection Cancer
Niclosamide-d₃ (BAY2353-d₃) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-169977

CKP-25	SARS-CoV	Infection
CKP-25 is an inhibitor for the interaction between Spike RBD-ACE2, that prevents the virus from entering the host cell, thereby reducing the replication and virus infection. CKP-25 inhibits SARS-CoV-2 with IC₅₀ of 3.5 μM in Vero E6 cell .

HY-155121

SARS-CoV-2-IN-56	SARS-CoV	Infection
SARS-CoV-2-IN-56 (Compound 63) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-56 has antiviral activity. SARS-CoV-2-IN-56 inhibits SARS-CoV-2 in Vero E6 cells, with an IC₅₀ of 0.7 μM .

HY-155119

SARS-CoV-2-IN-54	SARS-CoV	Infection
SARS-CoV-2-IN-54 (Compound 2) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-54 has antiviral activity. SARS-CoV-2-IN-54 inhibits SARS-CoV-2 in Vero E6 cells, with an IC₅₀ of 21.4 μM .

HY-159961

SARS-CoV-2 Mpro-IN-34	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC₅₀ of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC₅₀ of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC₅₀ of 0.103 μM .

HY-W749519

(E,E)-Farnesol-13C3 trans,trans-Farnesol-¹³C₃; (2E,6E)-Farnesol-¹³C₃	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
(E,E)-Farnesol- ¹³C₃ (trans,trans-Farnesol- ¹³C₃) is the ¹³C-labeled (E,?E)?-?Farnesol (HY-Y0248). (E, E)-Farnesol (trans,trans-Farnesol;(2E,6E)-Farnesol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-141841

SARS-CoV-2-IN-7	SARS-CoV	Infection
SARS-CoV-2-IN-7 inhibits viral replication with a nanomolar IC₅₀ value (844 nM) in SARS-CoV-2-infected Vero E6 cells.

HY-B0497G

Niclosamide BAY2353	Antibiotic Parasite STAT	Cancer
Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-16477A

Talaporfin ME2906 free acid; Mono-L-aspartyl chlorin E6 free acid; NPE6 free acid	Photosensitizer	Cancer
Talaporfin sodium, can be used in intraoperative photodynamic therapy (PDT) with a 664-nm semiconductor laser, was evaluated for efficacy and safety in treating primary malignant parenchymal brain tumors .

HY-175024

MC12	SARS-CoV Virus Protease	Infection
MC12 is a thiazole-based derivative and a SARS-CoV-2 main protease inhibitor (IC₅₀: 77.7 nM). MC12 exhibits inhibitory effects on both SARS-CoV and SARS-CoV-2 main proteases, with low cytotoxicity and good stability. MC12 can be used in the research of anti-COVID-19 drugs .

HY-N15215

Antiviral agent 64	Enterovirus Influenza Virus RSV HSV	Infection Cancer
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀ of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-N3445

Jaceidin triacetate	SARS-CoV	Infection
Jaceidin triacetate(compound 54) is a natural compound isolated formmarulabark.Jaceidin triacetatecan inhibitSARS-CoV-2 Mpro, with theIC₅₀of 11.9μM.Jaceidin triacetateinhibits the replication of Sars-Cov-2 Viral in Vero-E6 cells .

HY-156325

SARS-CoV-2-IN-62	SARS-CoV	Infection
SARS-CoV-2-IN-62 (Compound R3b) is an inhibitor of SARS-CoV-2 replication and has low cytotoxicity. SARS-CoV-2-IN-62 inhibits viral replication in Vero E6 cells and Calu-3 cells, with EC₅₀ values of 2.97 μM and 3.82 μM, respectively .

HY-156337

SARS-CoV-2-IN-63	SARS-CoV	Infection
SARS-CoV-2-IN-63 (Compound R3e) is an inhibitor of SARS-CoV-2 replication and has low cytotoxicity. SARS-CoV-2-IN-63 inhibits viral replication in Vero E6 cells and Calu-3 cells, with EC₅₀ values of 1.99 μM and 1.92 μM, respectively .

HY-B0497BS

Niclosamide-13C6 monohydrate BAY2353-13C6 monohydrate	STAT Parasite Antibiotic	Cancer
Niclosamide- ¹³C₆ (monohydrate) is the ¹³C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells ^[6].

HY-169434

LTB Lon-TK-BMS-1	PD-1/PD-L1	Cancer
LTB is a prodrug formed by coupling glycolysis inhibitor (Lonidamine (HY-B0486)) with PD1/PDL1 blocker (BMS-1 (HY-19991)) by thioketal linkage. LTB can further encapsulate photosensitizer chlorine e6 (Ce6) (HY-13594) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) by self-assembly .

HY-155540

SARS-CoV-2 3CLpro-IN-14	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti-SARS-CoV-2 activity (EC₅₀ = 0.18 μM) and low cytotoxicity (CC₅₀ > 50 μM) in Vero E6 cells .

HY-155981

SARS-CoV-2 3CLpro-IN-18	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent SARS-CoV-2 3CLpro inhibitor (IC₅₀s: 0.478 μM). SARS-CoV-2 3CLpro-IN-18 inhibits SARS-CoV-2 in Vero E6 cells (EC₅₀= 2.499 μM) with low cytotoxicity (CC₅₀ > 200 μM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1028

Pantethine 5 Publications Verification D-Pantethine; LBF disulfide	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite SARS-CoV
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration ^[6].

HY-B1513

α-Cyclodextrin 2 Publications Verification	Structural Classification Zea mays L. Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharides Source Classification	Environmental Pollutants SARS-CoV Microtubule/Tubulin
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .

HY-N2127

Pinostrobin 3 Publications Verification	Monophenols Flavonoids other families Classification of Application Fields Flavonones Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases ^[6] .

HY-136933

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-N15215

Antiviral agent 64	Structural Classification Monophenols Phenols Alpinia officinarum Hance Plants Source Classification Zingiberaceae	Enterovirus Influenza Virus RSV HSV
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC₅₀ of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-N3445

Jaceidin triacetate	Sclerocarya birrea (A.Rich.) Hochst. Flavonoids Flavones Plants Source Classification Anacardiaceae	SARS-CoV
Jaceidin triacetate(compound 54) is a natural compound isolated formmarulabark.Jaceidin triacetatecan inhibitSARS-CoV-2 Mpro, with theIC₅₀of 11.9μM.Jaceidin triacetateinhibits the replication of Sars-Cov-2 Viral in Vero-E6 cells .

HY-B1028R

Pantethine (Standard) D-Pantethine (Standard); LBF disulfide (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite SARS-CoV
Pantethine (Standard) is the analytical standard of Pantethine. This product is intended for research and analytical applications. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration ^[6].

HY-121020

Arcapillin	Structural Classification Flavonoids Flavones Plants Compositae Artemisia capillaris Thunb. Source Classification	SARS-CoV
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 M_pro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS) .

HY-154858A

Undecaprenol (2E,6E,10E,14E,18E,22E,26E,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaen-1-ol	Lipid	Biochemical Assay Reagents
Undecaprenol is a prenol .

HY-109088

Enexasogaol trans-6-Shogaol; (E)-[6]-Shogaol	Zingiber officinale Roscoe Structural Classification Monophenols Phenols Plants Source Classification Zingiberaceae	Drug Derivative
Enexasogaol (trans-6-Shogaol; (E)-[6]-Shogaol) is the derivative of Shogaol (HY-14616) found in Ginger (Zingiber officinale Rosc). Enexasogaol can be used for the research of cancer .

HY-N8997

5-Hydroxy-1,7-diphenyl-4E,6E-dien-3-heptanone	Natural Products Classification of Application Fields Other Diseases Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae	Others
5-Hydroxy-1,7-diphenyl-4E,6E-dien-3-heptanone is a diarylheptanoid that can be found in dried rhizomes of Alpinia officinarum (Liangjiang) .

HY-N2160A

*(E)-6'''-Feruloylspinosin*	Structural Classification Polysaccharides Actaea dahurica Turcz. ex Fisch. & C. A. Mey. Plants Rhamnaceae Saccharides Source Classification	Drug Derivative
(E)-6'''-Feruloylspinosin (Compound 3) is a flavonoid found in the seeds of Ziziphus jujuba Mill var. spinosa. (E)-6'''-Feruloylspinosin is a rotatable isomer of 6'''-Feruloylspinosin (HY-N2160) .

HY-128430A

(2E,6E)-Farnesyl acetate	Structural Classification Terpenoids Sesquiterpenes Cananga odorata Plants Annonaceae Source Classification	Drug Derivative
(2E,6E)-Farnesyl acetate is a natural sesquiterpene.

HY-N18114

*rel-(E)-6,7-Transdihydroxyligustilide*	Structural Classification Polygonaceae Other Phenylpropanoids Phenylpropanoids Fallopia multiflora (Thunb.) Harald. Plants Source Classification	Calcium Channel
rel-(E)-6,7-Transdihydroxyligustilide is a compound found in the dried tuberous roots of Polygonum multiflorum. rel-(E)-6,7-Transdihydroxyligustilide inhibits Ca ²⁺‑ATPase in calmodulin-deficient human erythrocyte membranes. rel-(E)-6,7-Transdihydroxyligustilide is used for the research of hyperlipidemia .

HY-N17221

(2E,6Z)-8,9-Dihydroxy-N-isobutyldeca-2,6-dienamide	Structural Classification Natural Products Acmella oleracea (L.) R. K. Jansen Asteraceae Plants Source Classification	Drug Derivative
(2E,6Z)-8,9-Dihydroxy-N-isobutyldeca-2,6-dienamide is a natural alkaloid.

HY-N12888

4E,6Z,10Z-Hexadecatrien-1-ol	Natural Products Animals Source Classification	Others
4E,6Z,10Z-Hexadecatrien-1-ol is the component of insect sex pheromone components of the cocoa pod borer (Conopomorpha cramerella, or Acrocercop cramerella), which plays a role in attracting male moths .

HY-N18265

(4E,6E,12E)-3-Hydroxy-4,6,12-tetradecatriene-8,10-diyn-1-yl acetate	Structural Classification Natural Products Plants Compositae Source Classification Erythrina sigmoidea Hua	Others
(4E,6E,12E)-3-Hydroxy-4,6,12-tetradecatriene-8,10-diyn-1-yl acetate is a polyacetylene found in rhizomes of Atractylodes chinensis. (4E,6E,12E)-3-Hydroxy-4,6,12-tetradecatriene-8,10-diyn-1-yl acetate inhibits RANKL-induced osteoclast differentiation. (4E,6E,12E)-3-Hydroxy-4,6,12-tetradecatriene-8,10-diyn-1-yl acetate can be used for the research of osteoporosis .

HY-N18257

(4E,6E,12E)-4,6,12-Tetradecatriene-8,10-diyn-1-ol	Structural Classification Natural Products Atractylodes koreana (Nakai) Kitam. Asteraceae Plants Source Classification	Others
(4E,6E,12E)-4,6,12-Tetradecatriene-8,10-diyn-1-ol (Compound 4a) is a natural product that can be isolated from the rhizomes of Atractylis koreana .

HY-N17219

(2E,7E)-6,9-Dihydroxy-N-isobutyldeca-2,7-dienamide	Structural Classification Natural Products Acmella oleracea (L.) R. K. Jansen Asteraceae Plants Source Classification	Drug Derivative
(2E,7E)-6,9-Dihydroxy-N-isobutyldeca-2,7-dienamide is a natural alkaloid.

HY-180615

(5Z,13E)-6,9Alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate 15-Dehydro-prostaglandin I2	Structural Classification Natural Products Endogenous metabolite Source Classification	Drug Derivative
(5Z,13E)-6,9Alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate (15-Dehydro-prostaglandin I2) is an analogue of prostaglandin I2 .

HY-N12512A

Oldenlandoside I (E)-6-O-p-Coumaroyl scandoside methyl ester	Structural Classification Iridoids Terpenoids Rubiaceae Plants Hedyotis diffusa Willd. Source Classification

HY-N17783

rel-Sanleng acid	Structural Classification Ketones, Aldehydes, Acids Rubiaceae Plants Oldenlandia corymbosa L. Source Classification	Endogenous Metabolite
(9R,10S,7E)-6,9,10-trihydroxyoctadec-7-enoic acid (compound 17) is a selectively oxidized lipid compound that can be isolated from Hedyotis corymbosa. (9R,10S,7E)-6,9,10-trihydroxyoctadec-7-enoic acid can be used to distinguish Hedyotis corymbosa from the closely related species Hedyotis diffusa.

Cat. No.	Product Name	Chemical Structure

HY-Y0248AS

(E,E)-Farnesol-d6
(E,E)-Farnesol-d₆ (trans,trans-Farnesol-d₆) is deuterium labeled (E,E)-Farnesol (HY-Y0248). (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness .

HY-B0497S2

Niclosamide-d3
Niclosamide-d₃ (BAY2353-d₃) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-W749519

(E,E)-Farnesol-13C3
(E,E)-Farnesol- ¹³C₃ (trans,trans-Farnesol- ¹³C₃) is the ¹³C-labeled (E,?E)?-?Farnesol (HY-Y0248). (E, E)-Farnesol (trans,trans-Farnesol;(2E,6E)-Farnesol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-B0497BS

Niclosamide-13C6 monohydrate

Niclosamide- ¹³C₆ (monohydrate) is the ¹³C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells ^[6].

HY-W769206

Talaporfin-13C4,15N
Talaporfin- ¹³C₄, ¹⁵N (ME2906 (free acid)- ¹³C₄, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Talaporfin (HY-16477A). Talaporfin sodium, can be used in intraoperative photodynamic therapy (PDT) with a 664-nm semiconductor laser, was evaluated for efficacy and safety in treating primary malignant parenchymal brain tumors .

HY-W779542

(2E,4E,6E)-2,4,6-Nonatrienal-13C2
(2E,4E,6E)-2,4,6-Nonatrienal- ¹³C₂ is ¹³C labeled (2E,4E,6E)-2,4,6-Nonatrienal.

HY-W742150

4-Dehydroxy-3-dehydro-pitavastatin lactone-d5
4-Dehydroxy-3-dehydro-pitavastatin lactone-d₅ is the deuterium labeled (S,E)-6-(2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-5,6-dihydro-2H-pyran-2-one (Pitavastatin Impurity） (HY-Z3610).

HY-W653905

Amantadine-d15 hydrochloride

Amantadine-d₁₅ hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research ^[6].

Cat. No.	Product Name	Target	Research Areas	Chemical Structure