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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
333 Results for "
Factor D
" in MedChemExpress (MCE) Product Catalog:
Products (333)
333 Results for "Factor D" in MCE Product Catalog:
144
144 Publications Verification
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .
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6 Cited Publications
Synonyms: 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid
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Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
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2 Cited Publications
Synonyms: ALXN2050; ACH 0145228; ACH-5228
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Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
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2 Cited Publications
Cat. No.: HY-P80900
Synonyms: SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription Factor 1
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1 Cited Publications
Cat. No.: HY-P4245
CAS No.: 88546-74-1
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1 Cited Publications
Cat. No.: HY-N4253
CAS No.: 173792-61-5
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1 Cited Publications
Cat. No.: HY-W014049
CAS No.: 66036-77-9
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1 Cited Publications
Cat. No.: HY-B2246S
CAS No.: 2687961-04-0
Synonyms: (R)-Carnitine-d9 chloride; Levocarnitine-d9 chloride
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .
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1 Cited Publications
Cat. No.: HY-P701103
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Hepatocyte growth Factor-like protein; MST1; Macrophage stimulatory protein; Macrophage-stimulating protein; MSP; D3F15S2; DNF15S2; HGFL; Macrophage Stimulating Protein/Macrophage Stimulating 1 [Hepatocyte Growth Factor-like] ; Macrophage Stimulating Prot
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
