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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
Forskolin
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "Forskolin" in MCE Product Catalog:
224
224 Publications Verification
Synonyms: Coleonol; Colforsin; HL 362
Category:
Labiatae Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Inflammation/Immunology Endocrinology Pueraria montana (Lour.) Merr.
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Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea .
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2 Cited Publications
Cat. No.: HY-P1237
CAS No.: 127869-51-6
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Cardiovascular Disease Neurological Disease Metabolic Disease
2
2 Cited Publications
Cat. No.: HY-P1237A
CAS No.: 1966153-17-2
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
2
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Arachidonylcyclopropylamide (ACPA) is a potent and selective CB1 receptors agonist. Arachidonylcyclopropylamide inhibits forskolin-stimulated cAMP production in CHO cells transfected with human cannabinoid CB1 receptors (IC50=2 nM) .
Synonyms: Colforsin dapropate hydrochloride
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NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts .
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Desmethyl cariprazine is a major active metabolite of cariprazine, with activities at human dopamine receptors and serotonin receptors, showing a pEC50 of 8.90 at human D2 receptors, a pEC50 of 8.09 at D3 receptors, and a pEC50 of 6.28 at 5-HT1A receptors. Desmethyl cariprazine inhibits forskolin-induced cAMP production at D2, D3 and 5-HT1A receptors, and suppresses serotonin-induced Ca 2+ release at 5-HT2B receptors. Desmethyl cariprazine is applicable to research related to schizophrenia, bipolar disorder type I and bipolar disorder.
Cat. No.: HY-15371R
CAS No.: 66575-29-9
Synonyms: Coleonol (Standard); Colforsin (Standard); HL 362 (Standard)
Synonyms: L768242
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GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB2) agonist. GW405833 has EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values of 16.1 μM and 4772 nM for CB1. GW-405833 also exhibits non-competitive CB1 antagonist, exerting its analgesic and and anti-inflammatory effect through a CB1 receptor (rather than CB2) dependent mechanism. GW-405833 can significantly inhibit the production of cAMP stimulated by Forskolin (HY-15371). GW405833 inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF) .
Cat. No.: HY-P2197
CAS No.: 1784687-32-6
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L-796778 acetate is a selective agonist of the sst3 receptor. In CHO-K1 cells expressing the hsst3 receptor, L-796778 acetate is a partial agonist that inhibits Forskolin (HY-15371)-stimulated cAMP production with an IC50 value of 18 nM. L-796778 acetate has anticonvulsant effect .
Cat. No.: HY-15371G
CAS No.: 66575-29-9
Synonyms: Coleonol (GMP); Colforsin (GMP); HL 362 (GMP)
Cat. No.: HY-P2249
CAS No.: 2245073-05-4
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Cat. No.: HY-P1250
CAS No.: 311309-27-0
Synonyms: Neuropeptide VF(124-131)(human); Neuropeptide NPVF (human)
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Manoyl oxide is a labdane-type diterpenoid. Manoyl oxide is the precursor of Forskolin (HY-15371) .
Cat. No.: HY-149933
CAS No.: 871978-21-1
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AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility .
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CB-25 is a ligand of CB1 cannabinoid receptors, acting as a partial agonist. CB-25 enhances Forskolin (HY-15371)-induced cAMP formation in cancer cells but not hCB1-CHO cells .
Cat. No.: HY-123335
CAS No.: 217480-25-6
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L-796778 is an agonist of the hsst3 receptor. In CHO-K1 cells expressing the hsst3 receptor, L-796778 is a partial agonist that inhibits forskolin (HY-15371)-stimulated cAMP production with an IC50 value of 18 nM .
Cat. No.: HY-N3902
CAS No.: 473981-11-2
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Cat. No.: HY-139486
CAS No.: 2049973-02-4
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AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
