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Hydroperoxides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ACSL Family (1) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (2) Drug Derivative (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) Ferroptosis (6) Fluorescent Dye (4) Fungal (1) Glutathione Peroxidase (3) HIV Protease (1) Interleukin Related (1) Liposome (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Parasite (1) PGC-1α (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (6) TRP Channel (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (5) Endocrinology (1) Infection (3) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (2)

By Targets:

ACSL Family (1)

Apoptosis (2)

Bacterial (2)

Biochemical Assay Reagents (2)

Drug Derivative (1)

Endogenous Metabolite (3)

Epigenetic Reader Domain (1)

Ferroptosis (6)

Fluorescent Dye (4)

Fungal (1)

Glutathione Peroxidase (3)

HIV Protease (1)

Interleukin Related (1)

Liposome (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (1)

Parasite (1)

PGC-1α (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (6)

TRP Channel (1)

By Research Areas:

Cancer (3)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (5)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110406A

(±)13-HpODE 1 Publications Verification 13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide	Endogenous Metabolite	Others
(±)13-HpODE (13-hydroperoxylinoleic acid) is a racemic mixture of hydroperoxides, which is produced by the oxidation of linoleic acid by lipoxygenase .

HY-118159

Diphenyl-1-pyrenylphosphine DPPP	Fluorescent Dye	Others
Diphenyl-1-pyrenylphosphine (DPPP) is a functional organic molecule with both fluorescent properties and metal coordination ability, which is commonly used in materials and coordination chemistry research. Upon exposure to ultraviolet light, Diphenyl-1-pyrenylphosphine undergoes photoinduced phosphorus atom oxidation to form O-DPPP, triggering a transition from aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ). Diphenyl-1-pyrenylphosphine reacts stoichiometrically with lipid hydroperoxides to produce fluorescent diphenyl-1-pyrenylphosphine oxide. Diphenyl-1-pyrenylphosphine can insert into cell membranes to monitor lipid peroxidation processes in living cells .

HY-161929

GPX4 activator 2	Glutathione Peroxidase Ferroptosis	Cardiovascular Disease
GPX4 activator 2 is a GPX4 activator with a K_a value of 0.426 μM for human GPX4. GPX4 activator 2 reduces lipid hydroperoxide levels, prevents lipid peroxide accumulation, and inhibits ferroptosis. GPX4 activator 2 rescues cell death induced by Erastin (HY-15763). GPX4 activator 2 exerts cardioprotective effects in a mouse model of doxorubicin (HY-15142A)-induced myocardial injury .

HY-133079

Ascorbyl tetra-2-hexyldecanoate tetra-isopalmitoyl Ascorbic acid; IPAA; Tetrahexyldecyl Ascorbate	Prostaglandin Receptor	Endocrinology
Ascorbyl tetra-2-hexyldecanoate (tetra-isopalmitoyl Ascorbic acid; IPAA) is a lipophilic derivative of vitamin C (L-ascorbic acid). Ascorbyl tetra-2-hexyldecanoate (100 μM ) can prevent the decrease in viability of HaCaT keratinocytes induced by UVB, hydrogen peroxide, or tert-butyl hydroperoxide, and reduce the production of IL-1α and prostaglandin E2 (PGE2). Topical application of ascorbyl tetra-2-hexyldecanoate (1%) increases epidermal viability thickness, stratum corneum water content, and skin smoothness, and reduces skin roughness in hairless mice. Ascorbyl tetra-2-hexyldecanoate can be used to develop skin whitening agents in the beauty industry.

HY-114524

(E)-4-Oxo-2-nonenal 1 Publications Verification 4-ONE	TRP Channel	Cardiovascular Disease
(E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist .

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-118149A

(±)9-HpODE	Bacterial Fungal Parasite	Infection
(±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens .

HY-118149

9(S)-HpODE 9-D-Hydroperoxylinoleic acid	Endogenous Metabolite	Metabolic Disease
9(S)-HpODE is produced by the action of arachidonate 5-LO on linoleic acid. It can be further metabolized by potato hydroperoxide dehydratase to colneleic acid.

HY-139381

MitoEbselen-2 chloride MitoPeroxidase 2	Apoptosis	Metabolic Disease
MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death .

HY-N1506

Ganodermanontriol	Epigenetic Reader Domain p38 MAPK	Cancer
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity .

HY-130323

13-HPOT	Bacterial	Infection
13-HPOT is a linolenic acid hydroperoxide and an antibacterial agent. 13-HPOT interacts with lipid representatives of bacterial inner membranes. 13-HPOT exerts dose-dependent in vitro antibacterial activity against Pectobacterium carotovorum, Pseudomonas syringae pv. syringae DC3000, and Xanthomonas translucens pv. translucens .

HY-P2976

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .

HY-D1412

LPd peroxida probe-1 1 Publications Verification	Ferroptosis	Others
LPd peroxida probe-1, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a variety of cell pathophysiologies. LPd peroxida probe-1 reduces lipid hydroperoxides to lipid alcohols and is used for imaging lipid hydroperoxides in living cells .

HY-W113433

3-Hydroxybenzeneethanol	Reactive Oxygen Species (ROS)	Inflammation/Immunology
3-Hydroxybenzeneethanol is a phenethyl alcohol antioxidant. 3-Hydroxybenzeneethanol can inhibit ROS production induced by cumene hydroperoxide. 3-Hydroxybenzeneethanol can be used for the research of inflammation .

HY-155852

Lepadin H	Ferroptosis Apoptosis ACSL Family Glutathione Peroxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces GPX4 and SLC7A11 levels, increases p53 and ACSL4 expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G₂/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma .

HY-165097

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC 15(S)-HpETE-SAPC; 15(S)-Hydroperoxyeicostetraenoic acid-SAPC	Reactive Oxygen Species (ROS)	Others
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC (15(S)-HpETE-SAPC) is a compound studied for the cytotoxicity of phosphatidylcholine hydroperoxides. Its cytotoxicity is exerted through the decomposition of hydroperoxides to produce toxic compounds.

HY-114541

Coumarin-7-pinacolboronate	Fluorescent Dye	Others
Coumarin-7-pinacolboronate is a fluorescent probe. Taking hydrogen peroxide for instance, Coumarin-7-pinacolboronate and HOO- undergo a nucleophilic reaction to produce INT1. The chemical reaction mechanisms are nearly identical for the reactions of Coumarin-7-pinacolboronate with hydrogen peroxide, hypochlorous acid, peroxynitrite, and tyrosine hydroperoxide, respectively .

HY-159928

Neuroprotective agent 8	Reactive Oxygen Species (ROS) PGC-1α NOD-like Receptor (NLR)	Neurological Disease
Neuroprotective agent 8 (compound AA-9) is an oral active neuroprotective agent by *anti-oxidative* stress and anti-inflammation. Neuroprotective agent 8 activates PGC-1α and inhibits NLRP3** in the rat MCAO ischemic stroke model .

HY-N17539

Inoterpene E	Others	Others
Inoterpene E is a lanostane-type triterpene with a hydroperoxide group.Inoterpene E can be found in the sclerotia of Inonotus obliquus .

HY-D3447

LPd peroxida probe-2	Fluorescent Dye Ferroptosis	Others
LPd peroxida probe-2 (Compound I-1) is a lipid peroxidation fluorescent indicator (Ex = 488 nm, Em = 535 nm). LPd peroxida probe-2 undergoes fluorescence spectral changes in response to lipid hydroperoxides and can be used for Ferroptosis detection and cell imaging.

HY-E71031

*Allene oxide* synthase, Parthenium argentatum**	Biochemical Assay Reagents	Others
Allene oxide synthase, Parthenium argentatum (EC 4.2.1.92) is a potent anti-oxidant enzyme to remove lipid hydroperoxides in biological samples. Allene oxide synthase, Parthenium argentatum (EC 4.2.1.92) converts lipoxygenase derived fatty acid hydroperoxides to unstable allene epoxides.

HY-N17495

Luteolin 7-O-(6-O-malonyl-β-D-glucoside)	Others	Metabolic Disease
Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is an orally active flavonoid free radical scavenger. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) scavenges free radicals, inhibits the activity elevation of aspartate aminotransferase and alanine aminotransferase in mouse plasma, as well as the elevation of liver lipid hydroperoxide content. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is applicable for liver injury research .

HY-N17846

Dimethyl lithospermate	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Dimethyl lithospermate is an antioxidant. Dimethyl lithospermate scavenges DPPH free radicals and inhibits free radical generation. Dimethyl lithospermate also protects hepatocytes from tert-butyl hydroperoxide (t-BHP)-induced oxidative damage. Dimethyl lithospermate can be used in oxidative damage-related research .

HY-160800

Bilirubin ditaurine BR-DT	Drug Derivative	Inflammation/Immunology
Bilirubin ditaurine (BR-DT) is a mimetic compound of conjugated bilirubin. Bilirubin ditaurine can completely prevent the oxidation of phosphatidylcholine induced by reactive oxygen species in multilayer liposomes or micelles. Bilirubin ditaurine does not significantly decompose 18:2-OOH on its own, but it can greatly accelerate the decomposition of 18:2-OOH catalyzed by copper ions. Bilirubin ditaurine can be used to study the detoxification effect of conjugated bilirubin .

HY-183567

Ferroptosis-IN-27	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease
Ferroptosis-IN-27 is a glutathione peroxidase (GPx) mimetic. Ferroptosis-IN-27 inhibits oxidative stress, reduces intracellular ROS levels, decreases lipid peroxidation and alleviates ferrous ion overload, thereby inhibiting ferroptosis and protecting cardiomyocytes from Doxorubicin (HY-15142A)-induced injury. Ferroptosis-IN-27 can be used in studies related to Doxorubicin-induced cardiotoxicity .

HY-N17673

Avenanthramide 1c	Biochemical Assay Reagents	Others
Avenanthramide 1c is a free radical scavenger and antioxidant. Avenanthramide 1c scavenges DPPH free radicals. Avenanthramide 1c inhibits azo-initiated linoleic acid peroxidation. Avenanthramide 1c exerts antioxidant effects. Avenanthramide 1c exhibits an antagonistic interaction with Avenanthramide 2f in the DPPH free radical scavenging system .

HY-185056

Ferfluor-1	Ferroptosis Fluorescent Dye	Cardiovascular Disease Neurological Disease
Ferfluor-1 is a Ferroptosis inhibitor (EC₅₀ of 57 nM in HT108 cells; EC₅₀ of 75 nM in OS-RC-2 cells; EC₅₀ of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models .

HY-P11143A

IL4RPep-1 acetate 1 Publications Verification	Interleukin Related Liposome	Cancer
IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors .

Cat. No.	Product Name	Type

HY-118159

Diphenyl-1-pyrenylphosphine DPPP	Fluorescent Dye
Diphenyl-1-pyrenylphosphine (DPPP) is a functional organic molecule with both fluorescent properties and metal coordination ability, which is commonly used in materials and coordination chemistry research. Upon exposure to ultraviolet light, Diphenyl-1-pyrenylphosphine undergoes photoinduced phosphorus atom oxidation to form O-DPPP, triggering a transition from aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ). Diphenyl-1-pyrenylphosphine reacts stoichiometrically with lipid hydroperoxides to produce fluorescent diphenyl-1-pyrenylphosphine oxide. Diphenyl-1-pyrenylphosphine can insert into cell membranes to monitor lipid peroxidation processes in living cells .

Diphenyl-1-pyrenylphosphine

DPPP

Fluorescent Dye

Diphenyl-1-pyrenylphosphine (DPPP) is a functional organic molecule with both fluorescent properties and metal coordination ability, which is commonly used in materials and coordination chemistry research. Upon exposure to ultraviolet light, Diphenyl-1-pyrenylphosphine undergoes photoinduced phosphorus atom oxidation to form O-DPPP, triggering a transition from aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ). Diphenyl-1-pyrenylphosphine reacts stoichiometrically with lipid hydroperoxides to produce fluorescent diphenyl-1-pyrenylphosphine oxide. Diphenyl-1-pyrenylphosphine can insert into cell membranes to monitor lipid peroxidation processes in living cells .

HY-D1412

LPd peroxida probe-1 1 Publications Verification	Fluorescent Dye
LPd peroxida probe-1, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a variety of cell pathophysiologies. LPd peroxida probe-1 reduces lipid hydroperoxides to lipid alcohols and is used for imaging lipid hydroperoxides in living cells .

Cat. No.	Product Name	Target	Research Area

HY-P10258

KRES peptide	Peptides	Cardiovascular Disease Inflammation/Immunology
KRES peptide is an apolipoprotein with 4 amino acid residues. KRES peptide interacts with lipids, reduces lipoprotein lipid hydroperoxides (LOOH), activates antioxidant enzymes associated with high-density lipoprotein. KRES peptide exhibits anti-inflammatory and anti-atherogenic properties. KRES peptide is orally active .

HY-P11143A

IL4RPep-1 acetate 1 Publications Verification	Interleukin Related Liposome	Cancer
IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors .

Ganodermanondiol	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

(±)9-HpODE	Infection other families Classification of Application Fields Animals Ketones, Aldehydes, Acids Plants Disease Research Fields Source Classification	Bacterial Fungal Parasite
(±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens .

9(S)-HpODE 9-D-Hydroperoxylinoleic acid	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
9(S)-HpODE is produced by the action of arachidonate 5-LO on linoleic acid. It can be further metabolized by potato hydroperoxide dehydratase to colneleic acid.

Ganodermanontriol	Other Terpenoids Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Epigenetic Reader Domain p38 MAPK
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity .

Lepadin H	Structural Classification Alkaloids Animals Marine natural products Other marine organisms Quinoline Alkaloids Source Classification	Ferroptosis Apoptosis ACSL Family Glutathione Peroxidase Reactive Oxygen Species (ROS)
Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces GPX4 and SLC7A11 levels, increases p53 and ACSL4 expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G₂/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma .

Inoterpene E	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	Others
Inoterpene E is a lanostane-type triterpene with a hydroperoxide group.Inoterpene E can be found in the sclerotia of Inonotus obliquus .

Luteolin 7-O-(6-O-malonyl-β-D-glucoside)	Structural Classification Flavonoids Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Other Flavonoids Source Classification	Others
Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is an orally active flavonoid free radical scavenger. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) scavenges free radicals, inhibits the activity elevation of aspartate aminotransferase and alanine aminotransferase in mouse plasma, as well as the elevation of liver lipid hydroperoxide content. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is applicable for liver injury research .

Dimethyl lithospermate	Structural Classification Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Source Classification	Reactive Oxygen Species (ROS)
Dimethyl lithospermate is an antioxidant. Dimethyl lithospermate scavenges DPPH free radicals and inhibits free radical generation. Dimethyl lithospermate also protects hepatocytes from tert-butyl hydroperoxide (t-BHP)-induced oxidative damage. Dimethyl lithospermate can be used in oxidative damage-related research .

Avenanthramide 1c	Structural Classification Avena sativa Linn. Gramineae Phenols Polyphenols Plants Source Classification	Biochemical Assay Reagents
Avenanthramide 1c is a free radical scavenger and antioxidant. Avenanthramide 1c scavenges DPPH free radicals. Avenanthramide 1c inhibits azo-initiated linoleic acid peroxidation. Avenanthramide 1c exerts antioxidant effects. Avenanthramide 1c exhibits an antagonistic interaction with Avenanthramide 2f in the DPPH free radical scavenging system .

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