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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
Keap1 inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "Keap1 inhibitor" in MCE Product Catalog:
573
573 Publications Verification
Synonyms: (1S,3R)-RSL3
Research Areas:
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
138
138 Cited Publications
Synonyms: Diferuloylmethane; Natural Yellow 3; Turmeric yellow
79
23
23 Cited Publications
Target:
Research Areas:
KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .
8
Category:
Rutaceae Extract Alkaloids Evodia rutaecarpa (Juss.) Benth. Plants Disease Research Fields Cancer Indole Alkaloids
Target:
7
7 Cited Publications
Synonyms: Methylmaleic acid; Citraconate
6
Category:
Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Disease Research Fields Inflammation/Immunology Berberidaceae Extract
Target:
4
4 Cited Publications
Cat. No.: HY-N0806
CAS No.: 14215-86-2
4
4 Cited Publications
Cat. No.: HY-P75897
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Keap1; Kelch-Like Protein 19; Kelch Like ECH Associated Protein 1; MGC10630; KLHL19; MGC20887; INrf2; MGC1114; Kelch-Like ECH-Associated Protein 1; MGC4407; KIAA0132; MGC9454; Kelch-Like Family Member 19; Keap1 Delta C; Cytosolic inhibitor Of Nrf2; INRF2
Species:
Human
Source:
Sf9 insect cells
3
3 Cited Publications
Synonyms: Diferuloylmethane (Standard); Natural Yellow 3 (Standard); Turmeric yellow (Standard)
3
Research Areas:
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .
3
3 Cited Publications
Target:
Research Areas:
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .
3
3 Cited Publications
Target:
Research Areas:
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
2
2 Cited Publications
Cat. No.: HY-N11849
CAS No.: 135248-05-4
Category:
2
2 Cited Publications
Target:
Research Areas:
Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research .
2
2 Cited Publications
Cat. No.: HY-P702829
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Keap1; Kelch-Like Protein 19; Kelch Like ECH Associated Protein 1; MGC10630; KLHL19; MGC20887; INrf2; MGC1114; Kelch-Like ECH-Associated Protein 1; MGC4407; KIAA0132; MGC9454; Kelch-Like Family Member 19; Keap1 Delta C; Cytosolic inhibitor Of Nrf2; INRF2
Species:
Mouse
Source:
E. coli
2
2
1
1
1 Cited Publications
Cat. No.: HY-P2048
CAS No.: 1627580-64-6
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
MOTS-c (human) is a mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
