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Mcl1-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (13) Bacterial (1) Bcl-2 Family (26) Beta-lactamase (1) c-Myc (1) Carbonic Anhydrase (1) Caspase (3) CDK (1) Ceramidase (1) ERK (1) LPL Receptor (1) Necroptosis (1) PDGFR (1) Pim (1) PROTACs (1) Reference Standards (1) Ser/Thr Kinase (1) SF3B1 (1) STAT (2) Survivin (1)
By Research Areas:	Cancer (27) Infection (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112218

MIK665 15+ Cited Publications S-64315	Bcl-2 Family	Cancer
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 *(MCL1)* inhibitor . MIK665 has an IC₅₀ of 1.81 nM for MCL1 .

HY-15191

Sabutoclax 1 Publications Verification BI-97C1	Bcl-2 Family	Cancer
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC₅₀s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression .

HY-12468

A-1210477 Maximum Cited Publications 19 Publications Verification	Bcl-2 Family Apoptosis	Cancer
A-1210477 is a potent and selective inhibitor of *MCL-1* with a K_i of 0.45 nM . A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner .

HY-125877

PROTAC Mcl1 degrader-1 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively *Mcl-1* (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC₅₀ of 0.54 μM .

HY-16669

*Mcl1-IN-1*	Bcl-2 Family	Cancer
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC₅₀=2.4 µM).

HY-162858

BRD-810	Bcl-2 Family Caspase Apoptosis	Cancer
BRD-810 is a potent and selective *MCL1* inhibitor with a K_d of 0.3 nM. BRD-810 can specifically block the BH3 binding groove of MCL1, while having little effect on other anti-apoptotic proteins (such as Bcl-2, Bcl-xL). BRD-810 effectively destroys the MCL1-BAK complex (IC₅₀ = 1.2 nM) in cancer cells, rapidly activates Caspase and induces cell apoptosis. BRD-810 can be used in the research of various cancers such as hematological tumors and solid tumors .

HY-122627

CLZ-8	Bcl-2 Family Apoptosis	Cancer
CLZ-8 (Compound 8) is an orally active *Mcl-1-PUMA* interface inhibitor, with a K_i of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells .

HY-138697

S65487 VOB560	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560), a potent and selective BCL-2 inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities .

HY-101778

ML311 EU-5346	Bcl-2 Family	Cancer
ML311 is a potent and selective inhibitor of the *Mcl-1/Bim* interaction.

HY-N8146

Bruceantinol	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK	Infection Cancer
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of *MCL-1*, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-138697A

S65487 sulfate VOB560 sulfate	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, is a proagent of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities .

HY-158783

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .

HY-163681

Zamzetoclax	Bcl-2 Family	Cancer
Zamzetoclax (compound 1) is a potential *Mcl-1* inhibitor .

HY-167881

MLS-0053105	Bcl-2 Family	Cancer
MLS-0053105, a chloromaleimide, is a selective BFL-1 inhibitor with an IC₅₀ of 0.4 µM for Bfl-1/F-Bid. MLS-0053105 shows over 10 times less potent inhibition of Bcl-W, Bcl-2, and Bcl-XL and no activity against Bcl-B and Mcl-1 .

HY-164460

AZD1897	Pim	Cancer
AZD1897 is a PIM1, PIM2, and PIM3 inhibitor with IC₅₀ values of less than 3 nM for these three PIM kinases. AZD1897 exhibits anticancer activity and synergistically inhibits the activity of acute myeloid leukemia (AML) cells in combination with Capivasertib (HY-15431). This synergistic inhibitory effect is achieved through the inhibition of the mTOR and *MCL1* pathways .

HY-12826

IMB-XH1	Beta-lactamase Bcl-2 Family Bacterial	Cancer
IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) . IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC₅₀s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively .

HY-144430

Bcl-2/Mcl-1-IN-1	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-1 (compound 3) is a Bcl-2/Mcl-1 inhibitor, with K_is of 1.19 μM and 4.53 μM for *Mcl-1* and *Bcl-2, respectively. Bcl-2/Mcl-1-IN-1* can be used for the research of cancer .**

HY-N17676

3-Tridecylphenol	Bcl-2 Family	Cancer
3-Tridecylphenol is a cardanol. 3-Tridecylphenol can be isolated from K. hookeriana. 3-Tridecylphenol shows K_i values of >23 μM and >33 μM in BclxL/Bak and *Mcl-1/Bid* displacement assays, respectively. 3-Tridecylphenol can be used in cancer research .

HY-124846

MI-223	Bcl-2 Family	Cancer
MI-223 is a *Mcl-1 regulator (K_d* = 160 nM). MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer .

HY-138697B

S65487 hydrochloride VOB560 hydrochloride	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a proagent of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities .

HY-155012

Mcl-1 inhibitor 16	Bcl-2 Family	Cancer
Mcl-1 inhibitor 16 (Compound 9) is a mitochondrial targeting Platinum-based inhibitor of *Mcl-1*. Mcl-1 inhibitor 1 induces Bax/Bak-dependent apoptosis in cancer cells. Mcl-1 inhibitor 16 can be used alone or together with ABT-199 (HY-15531) and shows anti-tumor activity .

HY-130261

*Mcl-1 antagonist 1*	Bcl-2 Family	Cancer
Mcl-1 antagonist 1 is a *Mcl-1* protein antagonist extracted from patent WO2019173181, compound 200 .

HY-164452

A-1155905	Bcl-2 Family Apoptosis Caspase	Cancer
A-1155905 is a *MCL-1* inhibitor (IC₅₀=33.5 nM; K_i=0.58 nM) with anticancer activity. A-1155905 selectively binds to *MCL-1* with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of *MCL-1*-dependent cell lines is caspase-dependent and occurs via apoptosis .

HY-170763B

*(-)-Mcl-1* inhibitor 22**	Bcl-2 Family Apoptosis	Cancer
(-)-Mcl-1 inhibitor 22 (compound 38) is an *Mcl-1* inhibitor that works by blocking the interaction between *Mcl-1* and pro-apoptotic proteins, reducing the anti-apoptotic activity of *Mcl-1*. (-)-Mcl-1 inhibitor 22 can be used in cancer research .

HY-116220

Mcl1-IN-14	Others	Others
Mcl1-IN-14 (compound 5) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. Mcl1-IN-14 covalently targets the non-catalytic lysine side chain of Mcl-1 and has higher potency than non-covalent counterparts, which can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.

HY-15867

Meayamycin B (+)-MeayamycIN B	SF3B1 Bcl-2 Family Apoptosis	Cancer
Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic *Mcl-1_S* and downregulates *Mcl-1_L* at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer .

HY-101778R

ML311 (Standard) EU-5346 (Standard)	Reference Standards Bcl-2 Family	Cancer
ML311 (Standard) (EU-5346 (Standard)) is the analytical standard of ML311 (HY-101778). This product is intended for research and analytical applications. ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.

HY-183601

Mcl-1-IN-22	Bcl-2 Family Apoptosis	Cancer
Mcl-1-IN-22 is a selective *Mcl-1* inhibitor with a K_i of 0.015 μM. Mcl-1-IN-22 binds selectively to Mcl-1, disrupts the *Mcl-1/Bak* complex to release free Bak, triggering intrinsic apoptosis. Mcl-1-IN-22 can be used for the research of ovarian cancer .

HY-181587

PDGFRA/CAIX/XII-IN-1	PDGFR Carbonic Anhydrase STAT Akt ERK Apoptosis Caspase	Cancer
PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC₅₀ of 20 nM against PDGFRA, a K_i of 93.3 nM against CA IX, and a K_i of 80.0 nM against CA XII. PDGFRA/CAIX/XII-IN-1 binds to the ATP-binding pocket of PDGFRA and blocks the downstream STAT3, AKT and ERK1/2 signaling pathways. PDGFRA/CAIX/XII-IN-1 induces G0/G1 cell cycle arrest and endogenous apoptosis (Apoptosis), including cleavage of PARP-1, caspase-9 and caspase-3, activation of caspase 3/7, and down-regulation of *Mcl-1*. PDGFRA/CAIX/XII-IN-1 exhibits antiproliferative activity in eosinophilic leukemia cells. PDGFRA/CAIX/XII-IN-1 can be used for the research of leukemia .

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of *MCL-1*, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

3-Tridecylphenol	Structural Classification Monophenols Ginkgoaceae Phenols Plants Ginkgo biloba Source Classification	Bcl-2 Family
3-Tridecylphenol is a cardanol. 3-Tridecylphenol can be isolated from K. hookeriana. 3-Tridecylphenol shows K_i values of >23 μM and >33 μM in BclxL/Bak and *Mcl-1/Bid* displacement assays, respectively. 3-Tridecylphenol can be used in cancer research .

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Mcl1-IN-1

Inhibitors & Agonists

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