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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1148 Results for "
Mycobacterium tuberculosis topoisomerase-I
" in MedChemExpress (MCE) Product Catalog:
Products (1148)
1148 Results for "Mycobacterium tuberculosis topoisomerase-I" in MCE Product Catalog:
713
713 Publications Verification
Synonyms: Hydroxydaunorubicin hydrochloride; ADR
427
427 Cited Publications
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PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .
88
88 Cited Publications
Cat. No.: HY-16562
CAS No.: 97682-44-5
Synonyms: (+)-Irinotecan; CPT-11; VAL-413free base
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Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
88
88 Cited Publications
Cat. No.: HY-16568
CAS No.: 136572-09-3
Synonyms: (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate
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Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity .
88
88 Cited Publications
Cat. No.: HY-16562A
CAS No.: 100286-90-6
Synonyms: (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413
Category:
Nyssaceae Extract Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Disease Research Fields Cancer
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79
79 Cited Publications
Synonyms: 7-Ethyl-10-hydroxycamptothecin
75
75 Cited Publications
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
66
66 Cited Publications
Cat. No.: HY-135748A
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .
57
57 Cited Publications
Synonyms: R403323; TMC207 fumarate; R207910 fumarate
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Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.
57
57 Cited Publications
Synonyms: TMC207; R207910
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Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .
52
52 Cited Publications
Synonyms: Agrept; Agrimycin; Streptomycin A
Category:
41
41 Cited Publications
Synonyms: SKF 104864A hydrochloride; NSC 609669 hydrochloride
Category:
Nyssaceae Extract Alkaloids Monophenols Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Plants Disease Research Fields Cancer
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41
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Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .
40
40 Cited Publications
Cat. No.: HY-B0330B
CAS No.: 177325-13-2
Synonyms: (-)-Ofloxacin hydrochloride
Research Areas:
Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer .
38
38 Cited Publications
Synonyms: Lupatic acid; Betulic acid
35
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35
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Anti-inflammation/Immunoregulatory Disease Research Antibacterial Other Antibiotics Infection Microorganisms Plant Cell Culture Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields
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25
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Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .
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Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
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Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
