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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
98 Results for "
Nrf2 signaling pathway activator
" in MedChemExpress (MCE) Product Catalog:
Products (98)
98 Results for "Nrf2 signaling pathway activator" in MCE Product Catalog:
147
147 Publications Verification
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .
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Category:
Plants Endogenous metabolite Human Gut Microbiota Metabolites other families Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology
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12 Cited Publications
Cat. No.: HY-N0103A
CAS No.: 145572-44-7
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10 Cited Publications
Cat. No.: HY-N0028
CAS No.: 79916-77-1
Category:
Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology
Target:
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Category:
Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Cancer Indole Alkaloids
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6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
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5 Cited Publications
Cat. No.: HY-N6953
CAS No.: 107390-08-9
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4
4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
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4 Cited Publications
Synonyms: γ-Glu-Cys TFA
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Research Areas:
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .
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2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
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1 Cited Publications
Cat. No.: HY-N0513
CAS No.: 22255-40-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
