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Results for "

O2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADC Linker (4) Adenylate Cyclase (1) Akt (6) Aldose Reductase (1) Amino Acid Derivatives (2) AMPK (2) Amyloid-β (8) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (24) Aquaporin (1) Autophagy (5) Bacterial (15) Bcl-2 Family (1) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (35) Calcium Channel (3) CaMK (1) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Caspase (6) CDK (1) Cholinesterase (ChE) (10) Collagen (1) Complement System (1) COX (3) DNA/RNA Synthesis (16) Drug Derivative (7) Drug Intermediate (5) Drug Metabolite (2) E3 Ligase Ligand-Linker Conjugates (1) EGFR (2) Endogenous Metabolite (27) Environmental Pollutants (2) Epigenetic Reader Domain (2) ERK (5) Ferroptosis (2) Fluorescent Dye (28) Fungal (6) Glutathione Peroxidase (1) HDAC (3) Heme Oxygenase (HO) (2) Hemoglobin (2) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) Histone Acetyltransferase (2) Histone Demethylase (1) HIV Protease (1) HSV (1) Huntingtin (3) iGluR (1) Influenza Virus (3) Insecticide (2) Interleukin Related (4) Isotope-Labeled Compounds (13) JNK (1) Keap1-Nrf2 (9) KMO (1) Lactate Dehydrogenase (1) Ligands for Target Protein for PROTAC (1) Liposome (1) LOX-1 (1) Melanocortin Receptor (4) mGluR (1) Mitochondrial Metabolism (2) MOFs (1) Monoamine Oxidase (5) mTOR (6) nAChR (2) NADPH Oxidase (4) Necroptosis (2) Neurokinin Receptor (3) NF-κB (4) NO Synthase (3) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (2) Nucleoside Antimetabolite/Analog (74) P2Y Receptor (1) p38 MAPK (5) PAI-1 (1) Parasite (4) PARP (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phosphoglycerate Dehydrogenase (PHGDH) (1) Phosphoramidites (6) Photosensitizer (3) Photosystem II (1) Phytohormone (2) PI3K (1) PKC (1) Potassium Channel (2) PPAR (2) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (2) Pyroptosis (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (54) Reference Standards (20) Reverse Transcriptase (1) ROS Kinase (2) SARS-CoV (2) Ser/Thr Protease (1) Sirtuin (2) SOD (2) STAT (1) Tau Protein (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) TRP Channel (3) Tyrosinase (1) URAT1 (1) VD/VDR (1) Virus Protease (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (111) Cardiovascular Disease (32) Endocrinology (2) Infection (27) Inflammation/Immunology (63) Metabolic Disease (61) Neurological Disease (53)
Click Chemistry:	ADC Synthesis (1) Labeling and Fluorescence Imaging (1) Azide (10) Alkynes (3)
Oligonucleotides:	Thymine Nucleotide (1) Adenosine (21) Guanosine (8) Nucleotide Analogs (9) Adenine (2) Antisense Oligonucleotides (3) Guanine (1) Cytidine (5) Adenine Nucleotide (1) Cytidine Nucleotide (1) Guanine Nucleotide (1) Nucleoside Analogs (63) Uridine (19) Inosine (5) Cytosine (2) Uracil (1) Phosphoramidites (6)

377

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1776

Spermidine Maximum Cited Publications 19 Publications Verification	Endogenous Metabolite	Metabolic Disease
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-15475

UK-5099 Maximum Cited Publications 53 Publications Verification PF-1005023	Mitochondrial Metabolism	Cancer
UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

HY-P2902

Glucose oxidase 5+ Cited Publications	Endogenous Metabolite	Cancer
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation ^[2] .

HY-B1776A

Spermidine hydrochloride Maximum Cited Publications 19 Publications Verification	Endogenous Metabolite	Metabolic Disease
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-10535

Evofosfamide 5+ Cited Publications TH-302	Apoptosis	Cancer
Evofosfamide (TH-302) is a hypoxia-activated proagent with IC₅₀ of 10 μM and 1000 μM in hypoxia (N₂) and normoxia (21% O₂), respectively.

HY-108298

Perfluorodecalin PP 5; Perfluorodecahydronaphthalene	Biochemical Assay Reagents	Others
Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears ^[2]. Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O₂-carrier and used as artificial blood . Perfluorodecalin enhances bone regeneration and cell viability .

HY-W051271

Titanium(IV) oxide Titanium dioxide	Environmental Pollutants Reactive Oxygen Species (ROS) Photosensitizer	Others
Titanium(IV) oxide is a photosensitizer and photocatalyst. Titanium(IV) oxide can be used as a pharmaceutical excipient such as a flow aid, coating agent, sunscreen, colorant, etc. Pharmaceutical excipients or pharmaceutical excipients refer to other chemical substances used in the pharmaceutical process other than the drug ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations that can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism and elimination (ADME) process of co-administered drugs. Titanium(IV) oxide can use light energy to generate electron-hole pairs to degrade pollutants. Photons excite electrons in TiO₂ to generate active oxygen species (such as ·OH and ·O₂ ^-), thereby oxidizing and mineralizing pollutants such as organic compounds and heavy metals. TiO₂ can be used in the research of environmental remediation fields such as water treatment, air purification and self-cleaning materials ^[2] .

HY-13619

Efaproxiral 1 Publications Verification RSR13	Hemoglobin	Infection Cancer
Efaproxiral (RSR13) is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy ^[2] .

HY-109110

Avasopasem manganese GC-4419; M-40419	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O₂ ^- to hydrogen peroxide (H₂O₂),* arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer .

HY-B1776R

Spermidine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-129109

NBD-Pen	Fluorescent Dye	Inflammation/Immunology Cancer
NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λ_ex: 470 nm, λ_em: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H₂O₂, ClO ^-, O₂ ^-?, and ?OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma .

HY-N0501

11-oxo-mogroside V 1 Publications Verification	Reactive Oxygen Species (ROS)	Metabolic Disease
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O₂ ^-, *H₂O₂* and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-E70014

FAD-dependent glucose dehydrogenase FAD-GDH; Glucose 1-dehydrogenase	Endogenous Metabolite	Others
FAD-dependent glucose dehydrogenase (EC 1.1.5.9), or glucose dehydrogenase (FAD)/Pseudomonas glucose dehydrogenase. FAD-dependent glucose dehydrogenase is insensitive to O2 and displays high substrate specificity to glucose and thus is especially attractive enzymes for use in glucose biosensor applications .

HY-137683A

*Guanosine 5'-O-2-thiodiphosphate trisodium* GDPβS trisodium	Adenylate Cyclase	Cardiovascular Disease
Guanosine 5'-O-(2-thiodiphosphate) trisodium (GDPβS trisodium) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O-(2-thiodiphosphate) trisodium acts as an inhibitor of adenylyl cyclase (AC) with a K_i value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cerebral cortex membranes of rodent models, Guanosine 5'-O-(2-thiodiphosphate) trisodium partially activates AC with an EC₅₀ of 400 nM. Guanosine 5'-O-(2-thiodiphosphate) trisodium prevents norepinephrine-induced nitric oxide release in ventricular myocytes ^[2] .

HY-40145

1-Boc-3-iodoazetidine	Drug Intermediate	Others
1-Boc-3-iodoazetidine acts as a bifunctional additive for lithium-oxygen (Li-O₂) batteries and can be used to enhance the performance of Li-O₂ batteries. 1-Boc-3-iodoazetidine is applied in the synthesis of C3-functionalized azetidines and C2-functionalized azetidines via a lithium/iodine exchange or β-elimination/lithiation reaction sequence ^[2].

HY-13619A

Efaproxiral sodium 1 Publications Verification RSR13 sodium	Hemoglobin	Infection Cancer
Efaproxiral (RSR13) sodium is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral sodium decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy ^[2] .

HY-W012313

2,2'-Anhydrouridine 2,2'-Cyclouridine; O2,2'-Cyclouridine	Drug Intermediate Nucleoside Antimetabolite/Analog	Others
2,2'-Anhydrouridine (2,2'-Cyclouridine) is a nucleoside analog. 2,2'-Anhydrouridine is an important intermediate in the synthesis of other nucleoside-related compounds ^[2].

HY-W048491

*2′-O-(2-Methoxyethyl)adenosine*	DNA/RNA Synthesis Drug Derivative	Others
2′-O-(2-Methoxyethyl)adenosine is an ATP (HY-B2176) derivative. 2′-O-(2-Methoxyethyl)adenosine can be used for oligonucleotide synthesis .

HY-W048495

*2'-O-(2-Methoxyethyl)-uridine*	Nucleoside Antimetabolite/Analog	Cancer
2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-115386

MitoTEMPOL 3 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2 ^-to H2O2 .

HY-B1776S

Spermidine-d6 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents ^[2].

HY-159854

C14-O2	Liposome	Cancer
C14-O2 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .

HY-P1012

[Sar9,Met(O2)11]-Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

HY-152684

*2′-O-2-Propyn-1-ylguanosine*	Nucleoside Antimetabolite/Analog	Others
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1156A

HKSOX-1m (5/6-mixture) hydrobromide 2 Publications Verification	Reactive Oxygen Species (ROS) Fluorescent Dye	Others
HKSOX-1m (5/6-mixture) hydrobromide is a O₂ fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O₂ over a broad range of pH, strong oxidants, and abundant reductants found in cells .

HY-B1776AS

Spermidine-d8 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-W010417

4-Thiouracil	Reactive Oxygen Species (ROS)	Others
4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O2. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy .

HY-N2153

*Apigenin-7-O-(2G-rhamnosyl)gentiobioside*	Others	Others
Apigenin-7-O-(2G-rhamnosyl)gentiobioside is a flavone glycosides from Lonicera gracilipes var. glandulosa .

HY-174866

BT-O2C	Histone Acetyltransferase Epigenetic Reader Domain PROTACs	Cancer
BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC₅₀ ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5). BT-O2C can be used for research on cancer. (Pink: p300 Ligand (HY-174868); Blue: CRBN Ligand (HY-W023573); Black: Linker; CRBN Ligand+Linker (HY-174869)) .

HY-150175

HKSOX-1	Fluorescent Dye	Inflammation/Immunology
HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O₂ ^•−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O₂ ^•−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O₂ ^•− roles in inflammation, mitochondrial stress, and other physiological processes .

HY-170938

AChE-IN-82	Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX LOX-1	Neurological Disease
AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC₅₀s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, *COX-2* and 5-LOX with IC₅₀s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H₂ O₂ .

HY-W048496

*2'-O-(2-Methoxyethyl)-cytidine*	Nucleoside Antimetabolite/Analog	Cancer
2'-O-(2-Methoxyethyl)-cytidine is a synthetic oligonucleotide derived from uridine. 2'-O-(2-Methoxyethyl)-cytidine has good hybridization properties and high stability, and can be used in the research of oligonucleotide chemotherapeutic agents .

HY-W013794

Salcomine N,N′-Bis(salicylidene)ethylenediaminocobalt(II)	Influenza Virus	Infection
Salcomine (N,N’-Bis(salicylidene)ethylenediaminocobalt II) is a carrier of O₂ and oxidation catalysts. Salcomine has anti-influenza virus activity .

HY-116694

Digallic acid	Apoptosis Reactive Oxygen Species (ROS) Reverse Transcriptase Xanthine Oxidase URAT1	Infection Metabolic Disease Inflammation/Immunology Cancer
Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC₅₀: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus ^[2] .

HY-D3002

ONOO-/O2- tracker probe	Fluorescent Dye	Metabolic Disease
ONOO-/O2- tracker probe is a dual-responsive near-infrared fluorescent probe. ONOO-/O2- tracker probe will only emit a strong fluorescence signal when both peroxynitrite (ONOO⁻) and superoxide anion (O₂•⁻), the two key reactive oxygen/nitrogen species, are present simultaneously. ONOO-/O2- tracker probe can be used as a biomarker detection tool for drug-induced liver injury (DILI) .

HY-154285

*3’-O-(2-Methoxyethyl) uridine*	Nucleoside Antimetabolite/Analog	Cancer
3’-O-(2-Methoxyethyl) uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-152516

*2’-O-(2-Methoxyethyl) inosine*	Nucleoside Antimetabolite/Analog	Cancer
2’-O-(2-Methoxyethyl) inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-154434

*3’-O-(2-Methoxyethyl)-5-methyluridine*	Nucleoside Antimetabolite/Analog	Cancer
3’-O-(2-Methoxyethyl)-5-methyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis .

HY-119038

ML-7	Endogenous Metabolite	Cardiovascular Disease
ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury .

HY-D1156

HKSOX-1m (5/6-mixture)	Reactive Oxygen Species (ROS) Fluorescent Dye	Others
HKSOX-1m (5/6-mixture) is a O₂ fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O₂ over a broad range of pH, strong oxidants, and abundant reductants found in cells .

HY-114809

AL-1	Reactive Oxygen Species (ROS) NADPH Oxidase	Inflammation/Immunology Cancer
AL-1 is a potent O2 ^- generation inhibitor (IC₅₀ = 7.6 μM) through the inhibition of leukocytic NADPH oxidase. AL-1 inhibits 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced H₂O₂ production. AL-1 reduces tumor incidence in ICR mouse skin. AL-1 can be used for research on oxidative stress-related diseases including cancer .

HY-P3782

(Met(O2)35)-Amyloid β-Protein (1-42)	Amyloid-β	Others
(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide .

HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

HY-151650

N3-O2Oc-O2Oc-OH	ADC Linker	Others
N3-O2Oc-O2Oc-OH is a click chemistry reagent containing an azide . N3-O2Oc-O2Oc-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-D1065

NIR-H2O2	Fluorescent Dye	Inflammation/Immunology
NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. NIR-H2O2 has both absorption and emission in the NIR region. NIR-H2O2 responds to H₂O₂ with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-H2O2 is capable of imaging endogenously produced H₂O₂ in living cells and mice .

HY-N7161

*3-O-(2'E,4'E-Decadienoyl)-ingenol*	Others	Others
3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC₅₀s of 8.22 μM and 6.67 μM, respectively .

HY-D3000

NIR-RED ROS-H2O2 Probe	Fluorescent Dye	Metabolic Disease
NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI) .

HY-128930

*6-O-2-Propyn-1-yl-D-galactose*	ADC Linker	Cancer
6-O-2-Propyn-1-yl-D-galactose is a nonclaevable glycolinker for the functionalization of cytotoxic agents and applications in antibody-agent conjugation. 6-O-2-Propyn-1-yl-D-galactose is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-117457

BPIC	DNA/RNA Synthesis	Cancer
BPIC is a DNA intercalator agent and also an anti-cancer agent. BPIC scavenge ∙OH, ∙O2(-), and NO free radicals .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1776

Spermidine Maximum Cited Publications 19 Publications Verification	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-N0115

Gastrodin 15+ Cited Publications Gastrodine	Natural Products Gastrodia elata Bl. Neurological Disease Classification of Application Fields Anti-aging Orchidaceae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Ferroptosis
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H₂O₂-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia ^[2] .

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants Disease Research Fields	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-B1776A

Spermidine hydrochloride Maximum Cited Publications 19 Publications Verification	Natural Products other families Animals Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Piperaceae Plants Inflammation/Immunology Disease Research Fields Piper nigrum Linn. Source Classification	Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research ^[2].

HY-N0515

Ophiopogonin D 1 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-N1318

Salvigenin 5+ Cited Publications Psathyrotin	Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis ^[2].

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells ^[2] .

HY-B1776R

Spermidine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-N2736

3′,4′,7-Trihydroxyflavone 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields Source Classification	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and COX-1 (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice ^[2] .

HY-N0501

11-oxo-mogroside V 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Source Classification Food Research	Reactive Oxygen Species (ROS)
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O₂ ^-, *H₂O₂* and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-N2565

Rosamultin 1 Publications Verification	Infection Triterpenes Classification of Application Fields Terpenoids Rosaceae Potentilla anserina Linn. Plants Disease Research Fields Source Classification	HIV Protease Apoptosis
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against HIV-1 protease . Rosamultin has the potential for treating H₂O₂-induced oxidative stress injury through its antioxidant and antiapoptosis effects ^[2].

HY-W012313

2,2'-Anhydrouridine 2,2'-Cyclouridine; O2,2'-Cyclouridine	Infection Classification of Application Fields Disease Research Fields	Drug Intermediate Nucleoside Antimetabolite/Analog
2,2'-Anhydrouridine (2,2'-Cyclouridine) is a nucleoside analog. 2,2'-Anhydrouridine is an important intermediate in the synthesis of other nucleoside-related compounds ^[2].

HY-107858

Veratryl alcohol 1 Publications Verification 3,4-Dimethoxybenzyl alcohol	Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields	Endogenous Metabolite Bacterial
Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H₂O₂ and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy ^[2] .

HY-N3558

Ceanothic acid Emmolic acid	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Bacterial
Ceanothic acid (Emmolic acid) is an orally active pentacyclic triterpenoid. Ceanothic acid inhibits the growth of various oral bacteria, including Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia. Ceanothic acid scavenges DPPH and H₂O₂ free radicals. Ceanothic acid inhibits acetic acid (HY-Y0319)-induced writhing response, xylene-induced ear swelling, and carrageenan-induced paw swelling in mice. Ceanothic acid can be used in research related to oral bacterial infections, ovarian cancer, liver cancer, and liver injury ^[2].

HY-N1677

2,6-Dimethoxy-1,4-benzoquinone	Infection Quinones other families Classification of Application Fields Metabolic Disease Benzene Quinones Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Akt mTOR Bacterial Fungal AMPK
2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H₂O₂ generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness ^[2] .

HY-N6964

Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside	Flavonols Flavonoids Classification of Application Fields Ginkgoaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Ginkgo biloba Source Classification	Others
Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside) is one of the major antioxidants of Ginkgo biloba leaves .

HY-N7880

Salvianolic acid Y	Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS)
Salvianolic acid Y is a phenolic acid with the same planar structure as Salvianolic acid B. Salvianolic acid Y rescues cell injury by H₂O₂ .

HY-126061

1,7-Dimethyluric acid	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Neurological Disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Source Classification	Biochemical Assay Reagents Drug Metabolite
1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H₂O₂, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions ^[2] .

HY-N5119

*Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside*	Flavonoids other families Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds .

HY-N9529

*Kaempferol 3-O-(2′′-O-α-rhamnosyl-6′′-O-malonyl-β-glucoside)*	Flavonols Flavonoids Classification of Application Fields Leguminosae Clitoria ternatea Linn. Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Kaempferol 3-O-(2′′-O-α-rhamnosyl-6′′-O-malonyl-β-glucoside) is a flavonoid glycoside compound .

HY-N5021

Anhydrosafflor yellow B AHSYB	Quinones Simple Phenylpropanols Carthamus tinctorius L. Phenols Polyphenols Benzene Quinones Phenylpropanoids Plants Compositae Source Classification	Others
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H₂O₂-induced cytotoxicity in cultured PC12 cells and primary neuronal cells .

HY-N2153

*Apigenin-7-O-(2G-rhamnosyl)gentiobioside*	Flavonoids Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray Disease Research Fields Source Classification	Others
Apigenin-7-O-(2G-rhamnosyl)gentiobioside is a flavone glycosides from Lonicera gracilipes var. glandulosa .

HY-125919

Vulpinic acid	Plants Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS) Bacterial Endogenous Metabolite
Vulpinic acid, a lichen metabolite, decreases H₂O₂-induced ROS production, oxidative stress and oxidative stress-related damages in human umbilical vein endothelial cells (HUVEC). Vulpinic acid is active against staphylococci, enterococci, and anaerobic bacteria.Vulpinic acid has the potential for atherosclerosis research ^[2].

HY-N2627

Isorhamnetin 3-O-robinobioside	Structural Classification Flavonols Flavonoids Cactaceae Opuntia ficus-indica (L.) Mill. Plants Source Classification	Others
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-116694

Digallic acid	Pistacia lentiscus var. Chia Phenols Polyphenols Plants Anacardiaceae Source Classification	Apoptosis Reactive Oxygen Species (ROS) Reverse Transcriptase Xanthine Oxidase URAT1
Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC₅₀: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus ^[2] .

HY-N7697E

Chitotriose trihydrochloride	Polysaccharides Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitotriose trihydrochloride is an orally active chitooligosaccharide with antioxidant activities. Chitotriose trihydrochloride inhibits hydroxylation of benzoate to salicylate by H₂O₂ in the presence of Cu ²⁺ (IC₅₀ value of 80 μM) .

HY-N0540R

Cynaroside (Standard) 10+ Cited Publications Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Structural Classification Flavonoids Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N3287

Methyl 3-hydroxy-4,5-dimethoxybenzoate	Infection Monophenols Classification of Application Fields Phenols Euphorbiaceae Plants Macaranga sinensis (Baill.) Muell. Arg. Disease Research Fields Source Classification	Bacterial Fungal Reactive Oxygen Species (ROS)
Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant that can be isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H₂O₂ .

HY-N0515R

Ophiopogonin D (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Steroids Source Classification	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-101193R

Zinc Protoporphyrin (Standard) Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration ^[2]. Zinc Protoporphyrin has anti-cancer activity .

HY-N11538

*Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside*	Flavonoids Classification of Application Fields Polygonaceae Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Polygonum capitatum Buch.-Ham. ex D. Don Prodr Source Classification	Others
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury .

HY-N15756

N-Demethylsinomenine	Alkaloids Other Alkaloids Plants Menispermaceae Source Classification	Reactive Oxygen Species (ROS)
N-Demethylsinomenine is a morphinane alkaloid that can be isolated from Sinomenium acutum. N-Demethylsinomenine has a protective effect against H₂O₂-induced cell injury. N-Demethylsinomenine can be used in the research of diseases such as Alzheimer's disease .

HY-N2442

Methylophiopogonone B	Natural Products other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Methylophiopogonone B, a homoisoflavonoidal compound that could be isolated from Ophiopogonis Tiber, could scavenge •OH and H₂O₂ in vitro to a certain extent ^[2].

HY-N8788

Baicalein 7-O-β-D-ethylglucuronide	Flavonoids Flavones Labiatae Plants Medicago truncatula Gaertn. Source Classification	Others
Baicalein 7-O-β-D-ethylglucuronide is a natural flavone glycoside that can be extracted from Scutellaria baicalensis Georgi. Baicalein 7-O-β-D-ethylglucuronide has antioxidant activity. Baicalein 7-O-β-D-ethylglucuronide inhibits FeSO₄-Cys-induced lipid peroxidation of liver homogenate. Baicalein 7-O-β-D-ethylglucuronide also shows strong cytoprotective effect on H₂O₂-induced oxidative damage of human umbilical vein endothelial cells ^[2].

HY-N2203A

Vitexin2''-O-p-trans-coumarate	Flavonoids Flavones Leguminosae Plants Trigonella foenum-graecum Linn. Source Classification	Others
Vitexin2''-O-p-trans-coumarate is a flavonoid, can be isolated from the Et acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum. Vitexin2''-O-p-trans-coumarate strongly promotes 2BS cell proliferation induced by H₂O₂ .

HY-N7161

*3-O-(2'E,4'E-Decadienoyl)-ingenol*	Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Source Classification	Others
3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC₅₀s of 8.22 μM and 6.67 μM, respectively .

HY-N7168

*3-O-(2'E ,4'E-Decadienoyl)-20-O-acetylingenol*	Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Source Classification	Others
3-O-(2'E ,4'E-Decadienoyl)-20-O-acetylingenol is a ingenol-type diterpenoid that contains a 2,4-decadienoyloxy group .

HY-N10784

*Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside*	Structural Classification Flavonols Flavonoids Croton jatrophoides Pax Plants Fagaceae Source Classification	Insecticide
Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside is a acylated keampferol glucoside. Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside can be isolated from the leaves of O. dentata, acts as a repellent against a fouling organism, the blue mussel M. edulis .

HY-B1776AR

Spermidine hydrochloride (Standard)	Structural Classification Natural Products other families Animals Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N1318R

Salvigenin (Standard) Psathyrotin (Standard)	Structural Classification Monophenols Flavonoids other families Flavones Phenols Plants Source Classification	Reference Standards Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis ^[2].

HY-N2190

Hederagenin 28-O-beta-D-glucopyranosyl ester	Cardiovascular Disease Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Others
Hederagenin 28-O-beta-D-glucopyranosyl ester, a triterpenoid saponin isolated from Ilex cornuta, exhibits protective effects against H₂O₂-induced myocardial cell injury .

HY-N3464

Isopedicin	Flavonoids Flavonones Plants Annonaceae Source Classification Fissistigma oldhamii (Hemsl.) Merr.	Phosphodiesterase (PDE)
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .

HY-N15711

Ganoleucoin R	Triterpenes Microorganisms Terpenoids Source Classification	Reactive Oxygen Species (ROS)
Ganoleucoin R is a triterpenoid compound that can be isolated from Ganoderma leucocontextum. Ganoleucoin R exerts a protective effect against H₂O₂-induced oxidative damage and can promote neurite outgrowth in PC12 cells. Ganoleucoin R possesses neuroprotective and neurogenic activities, and can be used in the research of neurodegenerative diseases .

HY-N2410R

N-trans-Feruloyltyramine (Standard) N-feruloyltyramine (Standard); Moupinamide (Standard)	Alkaloids Structural Classification Other Alkaloids Phenols Polyphenols Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research ^[2].

HY-N9953

Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside	Quinones Anthraquinones Polygonaceae Rheum rhabarbarum Linnaeus Plants Source Classification	Others
Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside, an anthraquinone glucoside, can be isolated from Rheum undulatum L. Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside has potent DPPH radical and ?O₂ ^- scavenging activity .

HY-N16417

Elsinochrome C	Quinones Structural Classification Microorganisms Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .

HY-N0501R

11-oxo-mogroside V (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Source Classification	Reference Standards Reactive Oxygen Species (ROS)
11-oxo-mogroside V (Standard) is the analytical standard of 11-oxo-mogroside V. This product is intended for research and analytical applications. 11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O2-, H2O2 and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-N7166

*3-O-(2'E,4'Z-Decadienoyl)ingenol*	Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Source Classification	Complement System
3-O-(2'E,4'Z-Decadienoyl)ingenol is a natural diterpene that exhibits significant anticomplement activity with an IC₅₀ of 89.5 μM .

HY-N7168A

*3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol*	Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Source Classification	Others
3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol (compound 6) is a diterpene that can be isolated from Euphorbia kansui. 3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol shows cleavage inhibition activity of individual Xenopus cells at the blastular stage .

Cat. No.	Product Name	Chemical Structure

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-B1776S

Spermidine-d6 1 Publications Verification
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents ^[2].

HY-B1776AS

Spermidine-d8 hydrochloride
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N0486S10

L-Leucine-18O2
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-13619S

Efaproxiral-d6
Efaproxiral (RSR13)-d₆ is the deuterium labeled Efaproxiral (HY-13619). Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy ^[2] .

HY-W777959

Azasetron Hydrochloride-13C,d3

Azasetron Hydrochloride- ¹³C,d₃ is the deuterium and ¹³C-labeled Azasetron (HY-B0019). Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .

HY-N7092S21

D-Fructose-18O-2
D-Fructose- ¹⁸O-2 is the ¹⁸O labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .

HY-B0389S31

D-Glucose-18O-2
D-Glucose- ¹⁸O-2 is the ¹⁸O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule

HY-W721191

O-2-Amino-2-methylpropyl bilastine-d6
O-2-Amino-2-methylpropyl bilastine-d₆ is the deuterium labeled O-tert-Butyl-dimethylsilyl curcumin.

HY-W777322

3,4-Dihydroxybenzeneacetic acid-13C,18O2
3,4-Dihydroxybenzeneacetic acid- ¹³C, ¹⁸O₂ is the ¹³C- and ¹⁸O-labeled labeled 3,4-Dihydroxybenzeneacetic acid (HY-W001080). 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.

HY-W767399

8-Bromo-2'-deoxyguanosine-13C,15N2

8-Bromo-2'-deoxyguanosine- ¹³C, ¹⁵N2 is the ¹³C- and ¹⁵N-labeled 8-Bromo-2'-deoxyguanosine (HY-W011168). 8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H₂O₂-Cl ^--Br ^- system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation ^[2] .

HY-W008048S

2',3'-O-Isopropylideneadenosine-13C5

2',3'-O-Isopropylideneadenosine- ¹³C₅ is the ¹³C-labeled 2',3'-O-Isopropylideneadenosine (HY-W008048). 2',3'-O-Isopropylideneadenosine is a nucleoside compound and also a Golgi-targeting moiety. 2',3'-O-Isopropylideneadenosine constitutes a furanose ribose group that undergoes cyclization at the O (2') and O (3') atoms. As a component of the fluorescent probe TPE-Ade, 2',3'-O-Isopropylideneadenosine enables specific Golgi localization for fluorescence imaging. 2',3'-O-Isopropylideneadenosine participates in the synthesis of aggregation-induced emission (AIE) fluorescent probes ^[2].

HY-W738271

Veratryl alcohol-13C

Veratryl alcohol- ¹³C (3,4-Dimethoxybenzyl alcohol- ¹³C) is the ¹³C-labeled Veratryl alcohol (HY-107858). Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H2O2 and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy ^[2] .

HY-W768213

2'-Deoxyguanosine monohydrate-13C5

2'-Deoxyguanosine monohydrate- ¹³C₅ is the ¹³C-labeled 2'-Deoxyguanosine monohydrate (HY-D0185). 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer .

HY-166873S

Fluvoxamine-d3
Fluvoxamine-d₃ is deuterium labeled (Z)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-(2-aminoethyl) oxime (Fluvoxamine Impurity) .

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