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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
269 Results for "
S4
" in MedChemExpress (MCE) Product Catalog:
Products (269)
269 Results for "S4" in MCE Product Catalog:
6
6 Publications Verification
製品番号: HY-P990679
Target:
4
Target:
研究分野:
GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity .
3
3 Cited Publications
製品番号: HY-163316
CAS 番号: 3030697-87-8
研究分野:
SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD +. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .
2
2 Cited Publications
Target:
研究分野:
CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .
2
2 Cited Publications
別名: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone
Category:
Microorganisms Neurological Disease Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer
Target:
2
2 Cited Publications
別名: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Category:
Alkaloids Immune System Disorder Pyrrole Alkaloids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
製品番号: HY-W011927S
CAS 番号: 2483831-28-1
別名: Bisphenol S (4,4'-Sulfonyldiphenol)-d8
1
1 Cited Publications
製品番号: HY-B0105B
CAS 番号: 142128-57-2
別名: (-)-Ketoconazole; (-)-Ketoconazol; (-)-R 41400
Target:
Levoketoconazole ((-)-Ketoconazole) is the 2S,4R enantiomer derived from racemic Ketoconazole (HY-B0105). Levoketoconazole is a potent and orally active cortisol synthesis inhibitor. Levoketoconazole inhibits key steps in cortisol and testosterone synthesis by inhibiting CYP11B1, CYP11A1, and CYP17A1. Levoketoconazole can be used for research on endogenous Cushing’s syndrome .
1
1 Cited Publications
Target:
研究分野:
KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively .
別名: (2S,4R)-R-63373
Target:
研究分野:
(2S,4R)-Hydroxy Itraconazole ((2S,4R)-R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
製品番号: HY-W007573
CAS 番号: 34582-32-6
Target:
研究分野:
製品番号: HY-41882
CAS 番号: 90719-32-7
別名: (-)-4-Benzyl-2-oxazolidinone
製品番号: HY-40354C
CAS 番号: 1092578-47-6
Target:
研究分野:
(3S,4S)-Tofacitinib is the less active S-enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.
製品番号: HY-111532B
純度: 98.15%
Target:
(3S,4S)-A2-32-01 (compound 24 (S,S)) is the low/inactive (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protease (ClpP) inhibitor. (3S,4S)-A2-32-01 is applicable for oncology and microbiology research .
別名: SAF312; Vanilloid receptor antagonist 1
Target:
研究分野:
Libvatrep (SAF312) is a non-competitive TRPV1 antagonist with an IC50 of 0.35-0.69 µM in HEK293T cells. It binds to the vanilloid pocket and an allosteric site, preventing S4/S5 conformational changes and channel opening. Libvatrep can be used for research on ocular surface pain and eye pain after photorefractive keratectomy [4].
製品番号: HY-P990796
Target:
製品番号: HY-123414
CAS 番号: 1235406-09-3
別名: PF-05196233
Target:
研究分野:
GX-936 (PF-05196233) is a selective Nav1.7 inhibitor. GX-936 binds to the activated VSD4, forms a bidentate salt bridge with the R4 of the S4 helix, traps VSD4 in the activated state, and prevents the channel from recovering from the inactivated state. GX-936 can be used in studies related to pain .
Target:
研究分野:
PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity .
製品番号: HY-P5664
CAS 番号: 847871-00-5
Category:
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
