74 Results for "

Sophora alopecuroides L.

" in MedChemExpress (MCE) Product Catalog:
Products (74)

74 Results for "Sophora alopecuroides L." in MCE Product Catalog:

23
Oxymatrine
Oxymatrine
0 Images
23 Publications Verification
Cat. No.: HY-N0158
CAS No.: 16837-52-8
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

TGF-beta/Smad Apoptosis

Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .
loading...
    loading...
View All Sizes
19
Matrine
Matrine
0 Images
19 Cited Publications
Cat. No.: HY-N0164
CAS No.: 519-02-8
Synonyms: Matridin-15-one; Vegard; α-Matrine
Category:  

Leguminosae Extract Plants Sophora flavescens Aiton Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Inflammation/Immunology Cancer

Target:  

PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .
loading...
    loading...
View All Sizes
8
Aloperine
Aloperine
0 Images
8 Cited Publications
Cat. No.: HY-13516
CAS No.: 56293-29-9
Purity:  ≥98.0%
Category:  

Infection Alkaloids Piperidine Alkaloids Sophora alopecuroides L Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Autophagy Filovirus HIV

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .
loading...
    loading...
View All Sizes
6
Sophoridine
Sophoridine
0 Images
6 Cited Publications
Cat. No.: HY-N1373
CAS No.: 6882-68-4
Category:  

Alkaloids Pyridine Alkaloids Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Apoptosis

Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .
loading...
    loading...
View All Sizes
6
Oxysophocarpine
Oxysophocarpine
0 Images
6 Cited Publications
Cat. No.: HY-N0746
CAS No.: 26904-64-3
Category:  

Alkaloids Piperidine Alkaloids Sophora alopecuroides L Leguminosae Extract Plants Disease Research Fields Cancer

Target:  

Others

Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .
loading...
    loading...
View All Sizes
4
Sophoricoside
Sophoricoside
0 Images
4 Cited Publications
Cat. No.: HY-N0423
CAS No.: 152-95-4
Category:  

Flavonoids Sophora japonica (L.) Schott Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Others

Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.
loading...
    loading...
View All Sizes
4
Kushenol A
Kushenol A
0 Images
4 Cited Publications
Cat. No.: HY-N2278
CAS No.: 99217-63-7
Synonyms: Leachianone E
Category:  

Flavonoids Flavonones Phenols Polyphenols Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Tyrosinase Glycosidase

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .
loading...
    loading...
View All Sizes
3
Sophoraflavanone G
Sophoraflavanone G
0 Images
3 Cited Publications
Cat. No.: HY-N1231
CAS No.: 97938-30-2
Synonyms: Kushenol F
Category:  

Flavonoids Flavonones Phenols Polyphenols Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Apoptosis

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .
loading...
    loading...
View All Sizes
2
Kushenol E
Kushenol E
0 Images
2 Cited Publications
Cat. No.: HY-N2463
CAS No.: 99119-72-9
Category:  

Flavonoids Flavonones Phenols Polyphenols Leguminosae Extract  Moghania philippinensis (Merr. Et Rolfe) L. Plants Disease Research Fields Cancer

Target:  

Indoleamine 2,3-Dioxygenase (IDO)

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity .
loading...
    loading...
View All Sizes
1
Sophoramine
Sophoramine
0 Images
1 Cited Publications
Cat. No.: HY-N3198A
CAS No.: 6882-66-2
Synonyms: (-)-Sophoramine
Category:  

Alkaloids Other Diseases Pyridine Alkaloids Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields

Target:  

Adrenergic Receptor

Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias .
loading...
    loading...
View All Sizes
1
Kushenol I
Kushenol I
0 Images
1 Cited Publications
Cat. No.: HY-N2286
CAS No.: 99119-69-4
Category:  

Flavanonols Flavonoids Phenols Polyphenols Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

Others

Kushenol I is a natural compound isolated from the roots of Sophora flavescens .
loading...
    loading...
View All Sizes
Trifolirhizin
Trifolirhizin
0 Images
Cat. No.: HY-N0616
CAS No.: 6807-83-6
Category:  

Flavonoids Leguminosae Extract Plants Trifolium pratense Linn. Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Other Flavonoids Cancer

Target:  

Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB

Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC50 value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .
loading...
    loading...
View All Sizes
(-​)​-Maackiain
(-​)​-Maackiain
0 Images
Cat. No.: HY-N6051
CAS No.: 2035-15-6
Category:  

Infection Monophenols Terpenoids Phenols Diterpenoids Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields

Target:  

Fungal NOD-like Receptor (NLR) NF-κB

(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .
loading...
    loading...
View All Sizes
Oxysophoridine
Oxysophoridine
0 Images
Cat. No.: HY-N1402
CAS No.: 54809-74-4
Synonyms: Sophoridine N-oxide
Category:  

Alkaloids Pyridine Alkaloids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis

Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .
loading...
    loading...
View All Sizes
(2S)-2'-Methoxykurarinone
(2S)-2'-Methoxykurarinone
0 Images
Cat. No.: HY-N1746
CAS No.: 270249-38-2
Synonyms: 2'-O-Methylkurarinone
Category:  

Metabolic Disease Leguminosae Extract Plants Sophora flavescens Aiton Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

RANKL/RANK Parasite NF-κB Heme Oxygenase (HO) Akt JNK p38 MAPK Reactive Oxygen Species (ROS)

(2S)-2'-Methoxykurarinone (2'-O-Methylkurarinone) is a flavanone natural product found in the roots of Sophora flavescens, possessing anti-sepsis, inhibitory effects on osteoclast differentiation and bone resorption, anti-inflammatory, and anti-Plasmodium activities. (2S)-2'-Methoxykurarinone exhibits an EC50 = 2.4 μM against the FCR-3 strain of Plasmodium falciparum. In sepsis models, (2S)-2'-Methoxykurarinone modulates immune cell function and inhibits inflammation and oxidative stress. In bone-related models, (2S)-2'-Methoxykurarinone blocks osteoclast differentiation and bone resorption, and inhibits RANKL-mediated Akt, p38, and JNK signaling pathways. In skin inflammation models, (2S)-2'-Methoxykurarinone inhibits NF-κB pathway activation, upregulates HO-1 expression, and suppresses CCL27 chemokine production in HaCaT cells. (2S)-2'-Methoxykurarinone is useful for research on osteoporosis, sepsis, inflammatory skin diseases (such as atopic dermatitis and allergic contact dermatitis), and malaria .
loading...
    loading...
View All Sizes
Lehmannine
Lehmannine
0 Images
Cat. No.: HY-N8091
CAS No.: 58480-54-9
Category:  

Infection Alkaloids Piperidine Alkaloids Sophora alopecuroides L Leguminosae Extract Plants Disease Research Fields

Target:  

Bacterial

Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities .
loading...
    loading...
View All Sizes
Allomatrine
Allomatrine
0 Images
Cat. No.: HY-N0050
CAS No.: 641-39-4
Synonyms: (+)-Allomatrine
Category:  

Alkaloids Piperidine Alkaloids Sophora japonica L. Leguminosae Extract Plants

Target:  

Others

Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors .
loading...
    loading...
View All Sizes
Sophoranone
Sophoranone
0 Images
Cat. No.: HY-N2529
CAS No.: 23057-55-8
Synonyms: (-)-Sophoranone; Sophoranon
Category:  

Flavonoids Flavonones Sophora tonkinensis Gagnep. Leguminosae Extract Plants

Target:  

Cytochrome P450 Reactive Oxygen Species (ROS) Apoptosis ERK p38 MAPK Endogenous Metabolite

Sophoranone ((-)-Sophoranone; Sophoranon) is an orally active competitive inhibitor of CYP2C9 (IC50 = 0.966 μM) and CYP3A4. Sophoranone is a prenylated flavonoid isolated from the roots of Sophora subprostrata. Sophoranone induces apoptosis by increasing reactive oxygen species (ROS) and opening the mitochondrial channel, while upregulating myogenic genes to promote muscle regeneration. Sophoranone can be used for research on asthma, leukemia, and paralytic strabismus .
loading...
    loading...
View All Sizes
Sophorabioside
Sophorabioside
0 Images
Cat. No.: HY-N5096
CAS No.: 2945-88-2
Category:  

Flavonoids Sophora japonica (L.) Schott Other Diseases Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Isoflavones

Target:  

Others

Sophorabioside is a flavonoid-glycoside isolated from Sophora japonica .
loading...
    loading...
View All Sizes
Kushenol W
Kushenol W
0 Images
Cat. No.: HY-N8097
CAS No.: 254886-76-5
Category:  

Infection Flavonoids Flavonones Phenols Polyphenols Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields

Target:  

Bacterial

Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .
loading...
    loading...
View All Sizes
Assay Types