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Results for "

TK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (1) Apoptosis (23) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcium Channel (1) Casein Kinase (1) Caspase (4) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (5) Drug Intermediate (2) EGFR (23) Endogenous Metabolite (5) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (2) FLT3 (3) Fluorescent Dye (1) Glutathione S-transferase (1) Herbicide (2) Histone Demethylase (1) HSV (5) Isotope-Labeled Compounds (4) JAK (2) Keap1-Nrf2 (1) Microtubule/Tubulin (1) mRNA (1) Nucleoside Antimetabolite/Analog (6) Orthopoxvirus (1) PD-1/PD-L1 (2) Phosphorylase (1) PKA (2) PKC (2) Reference Standards (2) Ribosomal S6 Kinase (RSK) (2) ROCK (2) SGK (2) SHP2 (3) Small Interfering RNA (siRNA) (7) Topoisomerase (2) Transketolase (8) Trk Receptor (1) Tyrosinase (1) VEGFR (1) VZV (1) Wnt (1)
By Research Areas:	Cancer (55) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (5)
Oligonucleotides:	Chemokine & Receptors (1) Nucleoside Analogs (2) Uridine (2) Rat Pre-designed siRNA Sets (2) mRNA (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNAs (7)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0377

Liquiritigenin Maximum Cited Publications 14 Publications Verification 4',7-Dihydroxyflavanone	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology Cancer
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-107430

Oxythiamine 3 Publications Verification Hydroxythiamin	Apoptosis Endogenous Metabolite	Cancer
Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-W008491

TK-112690	Phosphorylase	Inflammation/Immunology Cancer
TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC₅₀ of 12.5 μM and human small intestinal UPase with an IC₅₀ of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis .

HY-122903

TK216 5+ Cited Publications	DNA/RNA Synthesis	Cancer
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-112889B

Oxythiamine diphosphate ammonium 1 Publications Verification	Transketolase	Metabolic Disease
Oxythiamin diphosphate ammonium is a potent transketolase (TK) inhibitor .

HY-16339

N3PT 2 Publications Verification N3-pyridyl thiamine	Transketolase	Cancer
N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an K_d value of 22 nM (Apo-TK, transketolase lacking bound thiamine) .

HY-107430A

Oxythiamine chloride hydrochloride 3 Publications Verification Hydroxythiamine chloride hydrochloride	Apoptosis Endogenous Metabolite	Cancer
Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-W342664

2'-Deoxy-2'-fluoro-5-iodouridine FIRU	Nucleoside Antimetabolite/Analog HSV	Cancer
2'-Deoxy-2'-fluoro-5-iodouridine (FIRU) is a nucleoside analog. When labeled with ¹²³I, 2'-Deoxy-2'-fluoro-5-iodouridine accumulates highly selectively in tumors expressing the *HSV1-tk* gene. Radiolabeled 2'-Deoxy-2'-fluoro-5-iodouridine enables imaging of adenovirus-mediated HSV1-tk suicide gene transfer .

HY-112889

Oxythiamine diphosphate	Transketolase	Metabolic Disease
Oxythiamin diphosphate is a potent transketolase (TK) inhibitor .

HY-132302

Hu7691	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 is an orally active, selective Akt inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 inhibits tumor growth and enables decrease of cutaneous toxicity in mice .

HY-17422S1

Acyclovir-d4 Aciclovir-d₄; Acycloguanosine-d₄	Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic	Infection Cancer
Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-151483

TK-129	Wnt Histone Demethylase	Cardiovascular Disease
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC₅₀=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease .

HY-151604

Transketolase-IN-3	Transketolase	Others
Transketolase-IN-3 is a potent transketolase (TK) inhibitor. Transketolase-IN-3 has herbicidal activity and has inhibitory effects against Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). Transketolase-IN-3 can be used for the research of herbicides .

HY-114327

D-Ribose 1,5-diphosphate R15P	Endogenous Metabolite Drug Intermediate Biochemical Assay Reagents	Others
D-Ribose 1,5-diphosphate (R15P) is a metabolic intermediate and enzyme substrate. Purified *Tk-E2b2* converts D-Ribose 1,5-diphosphate into Ribulose-1,5-bisphosphate, with a specific activity of 32.3 μmol min ^-1 mg ^-1[1] .

HY-D2415

BODIPY-FL staurosporine	Fluorescent Dye	Others
BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

HY-139731

Transketolase-IN-1	Transketolase Herbicide	Others
Transketolase-IN-1 is a transketolase inhibitor and a herbicide. Transketolase-IN-1 inhibits weed growth and exhibits safety for maize and wheat at specified application rates. Transketolase-IN-1 can be used for the research of weed control in wheat and maize fields .

HY-122903B

(+)-TK216	DNA/RNA Synthesis	Cancer
(+)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor .

HY-117143

TK05 1 Publications Verification	Glutathione S-transferase	Inflammation/Immunology
TK05 is a potent and selective inhibitor of leukotriene C₄ synthase (LTC4S) with an IC₅₀ of 95 nM .

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .

HY-E70075

α-Glycerophosphate Dehydrogenase-Triosephosphate GDH-TIM; GDH-TPI	Transketolase	Metabolic Disease
α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerol phosphate dehydrogenase (GDH) and triphosphate isomerase (TIM). α-Glycerophosphate Dehydrogenase-Triosephosphate can be used to determine the activity of transketolase (TK) in hemolytic substances of red blood cells to evaluate vitamin B deficiency .

HY-W353804

2′-Deoxy-β-L-uridine	Nucleoside Antimetabolite/Analog	Infection
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase .

HY-128710

2'-Fluorothymidine 2'-Deoxy-2'-fluoro-5-Methyluridine	Nucleoside Antimetabolite/Analog	Cancer
2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC₅₀ of 1.1 μM against hCNT1 and an IC₅₀ of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research .

HY-118304B

AKN-028 acetate	FLT3 Apoptosis Caspase	Cancer
AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 acetate inhibits FLT3 autophosphorylation. AKN-028 acetate induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 acetate induces apoptosisby activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).

HY-122903S

TK216-d4	Isotope-Labeled Compounds DNA/RNA Synthesis	Cancer
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-107430B

Oxythiamine chloride Hydroxythiamine chloride	Apoptosis	Cancer
Oxythiamine (Hydroxythiamine) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-128606

Thiamine diphosphate analog 1	Endogenous Metabolite Transketolase	Neurological Disease Metabolic Disease
Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease .

HY-173571

TK-685	SHP2 Apoptosis	Cancer
TK-685 is an orally active, selective, and allosteric SHP2 inhibitor with an IC₅₀ of 2.1 nM. TK-685 inhibits esophageal cancer cell proliferation and induced apoptosis by targeting SHP2-mediated AKT and ERK signaling pathways .

HY-151259

TK4b	JAK	Cancer
TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC₅₀s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis .

HY-107430AR

Oxythiamine chloride hydrochloride (Standard) Hydroxythiamine chloride hydrochloride (Standard)	Apoptosis Reference Standards Endogenous Metabolite	Cancer
Oxythiamine chloride hydrochloride (Standard) is the analytical standard of Oxythiamine chloride hydrochloride (HY-107430A). This product is intended for research and analytical applications. Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-122903A

(-)-TK216	DNA/RNA Synthesis	Cancer
(-)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity .

HY-169436

Lon-TK	PD-1/PD-L1
Lon-TK is a glycolysis inhibitor + linker conjugate of LTB (HY-169434). LTB is an intelligent responsive prodrug that connects Lonidamine (Lon) (HY-B0486) and a PD-L1 inhibitor (BMS-1, HY-19991) through a thioketal linker. It significantly inhibits the glycolytic metabolism of tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK shows potential for application in photodynamic-enhanced immunotherapy research .

HY-P1768

Urechistachykinin I Uru-TK I	Bacterial	Infection
Urechistachykinin I (Uru-TK I), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .

HY-RS23490

Tk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tk1 Rat Pre-designed siRNA Set A Tk1 Rat Pre-designed siRNA Set A

HY-146471

EGFR-IN-51	EGFR Apoptosis	Cancer
EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC₅₀ values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis .

HY-144445

NSC114126	EGFR	Cancer
NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases .

HY-178442

EGFR-IN-179	EGFR	Cancer
EGFR-IN-179 (Compound 8d) is an EGFR inhibitor (IC₅₀: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK). EGFR-IN-179 has anticancer activity against non-small cell lung cancer .

HY-149022

HSV-1/HSV-2-IN-1	HSV Orthopoxvirus	Infection
HSV-1/HSV-2-IN-1 (compound 7d) is a HSV-1 and HSV-2 inhibitor, with EC₅₀s of 7.6, 7.6, 4, and 12 μM for HSV-1 (KOS), HSV-2 (G), HSV-1 TK ^- KOS ACV ^r and vaccinia virus in human embryonic lung fibroblast cell cultures .

HY-118304

AKN-028	FLT3 Apoptosis Caspase	Cancer
AKN-028, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC₅₀ value of 6 nM. AKN-028 inhibits FLT3 autophosphorylation. AKN-028 induces dose-dependent cytotoxic response (mean IC₅₀=1 μM). AKN-028 induces apoptosisby activation of caspase 3. AKN-028 can be used in research of acute myeloid leukemia (AML) .

HY-132302A

Hu7691 free base	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 free base is an orally active, selective Akt inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice .

HY-173573

TK-684	Apoptosis SHP2	Cancer
TK-684 is a potent and selective allosteric SHP2 inhibitor with IC₅₀ values of 2.1, ＞1000 nM for SHP2 ^WT, SHP22 ^PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK .

HY-158762

TK-642	SHP2	Cancer
TK-642 is a highly active, selective, orally activity SHP2 inhibitor based on pyrazole and pyrazine (IC₅₀=2.7 nmol/L). TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer .

HY-126218

HSV-TK substrate	HSV	Cancer
HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity .

HY-169435

TK-OH	Drug Intermediate	Cancer
TK-OH is the linker of LTB (HY-169434). TK-OH can be used for the research of cancers .

HY-161927

EGFR-TK-IN-4	EGFR Apoptosis	Cancer
EGFR-TK-IN-4 (compound 10k) is a potent and selective *EGFR-TK* inhibitor. EGFR-TK-IN-4 can induce apoptosis . EGFR-TK-IN-4 has antitumor activity .

HY-158018

EGFR-TK-IN-2	EGFR	Cancer
EGFR-TK-IN-2 (compound 10b) is *EGFR-TK* inhibitor with the IC₅₀ of 0.16 μM. EGFR-TK-IN-2 inhibits cell growth .

HY-172156

EGFR-TK-IN-5	EGFR	Cancer
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl-pyrazoline derivative. EGFR-TK-IN-5 exhibits strong inhibitory activity and stability against EGFR. EGFR-TK-IN-5 can be used in the study of cancer .

HY-163860

EGFR-TK-IN-3	EGFR	Cancer
EGFR-TK-IN-3 (3) is an EGFR TK inhibitor, with an IC₅₀ of 2.33 μM against Erlotinib (HY-50896)-resistant A549 cells .

HY-151258

TK4g	JAK	Cancer
TK4g is a Janus kinase (JAK) inhibitor with the IC₅₀ values of 12.61 nM and 15.80 nM for JAK2 and JAK3, respectively. TK4g can be used in lymphoid-derived diseases and leukemia cancer research .

HY-RS14556

TK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TK1 Human Pre-designed siRNA Set A contains three designed siRNAs for TK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TK1 Human Pre-designed siRNA Set A TK1 Human Pre-designed siRNA Set A

HY-RS24088

Tk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tk2 Rat Pre-designed siRNA Set A Tk2 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-D2415

BODIPY-FL staurosporine

Fluorescent Dye

BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

Cat. No.	Product Name	Target	Research Area

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .

HY-P3633

Locustatachykinin II Lom-TK II	Peptides	Neurological Disease
Locustatachykinin II (Lom-TK II) is an insect neuropeptide with homology to peptides of the vertebrate tachykinin family. Locustatachykinin II can be used for the research of insect endocrine .

HY-P1768

Urechistachykinin I Uru-TK I	Bacterial	Infection
Urechistachykinin I (Uru-TK I), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .

HY-P1763

Urechistachykinin II Uru-TK II	Bacterial	Infection
Urechistachykinin II (Uru-TK II), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0377

Liquiritigenin Maximum Cited Publications 14 Publications Verification 4',7-Dihydroxyflavanone	Neurological Disease Classification of Application Fields Plants Flavonoids Microorganisms Leguminosae Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Estrogen Receptor/ERR
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-107430

Oxythiamine 3 Publications Verification Hydroxythiamin	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-107430A

Oxythiamine chloride hydrochloride 3 Publications Verification Hydroxythiamine chloride hydrochloride	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-114327

D-Ribose 1,5-diphosphate R15P	Microorganisms Source Classification	Endogenous Metabolite Drug Intermediate Biochemical Assay Reagents
D-Ribose 1,5-diphosphate (R15P) is a metabolic intermediate and enzyme substrate. Purified *Tk-E2b2* converts D-Ribose 1,5-diphosphate into Ribulose-1,5-bisphosphate, with a specific activity of 32.3 μmol min ^-1 mg ^-1[1] .

HY-107430AR

Oxythiamine chloride hydrochloride (Standard) Hydroxythiamine chloride hydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Apoptosis Reference Standards Endogenous Metabolite
Oxythiamine chloride hydrochloride (Standard) is the analytical standard of Oxythiamine chloride hydrochloride (HY-107430A). This product is intended for research and analytical applications. Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation .

Recombinant Proteins Recommended:

Species:	Human (5) Mouse (1) Cynomolgus (1) Canine (1)
Tag:	His (6) Tag Free (1) Avi (2) Fc (1)
Source:	HEK293 (5) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701864

	TKT Protein, Human TKT; Transketolase; TK	Human	E. coli
	TKT proteins are essential for catalyzing the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor. This process is facilitated by the formation of a covalent intermediate with the cofactor thiamine pyrophosphate. TKT Protein, Human is the recombinant human-derived TKT protein, expressed by E. coli , with tag free.

HY-P701863

	TKT Protein, Human (His) TKT; Transketolase; TK	Human	E. coli
	TKT proteins are essential for catalyzing the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor. This process is facilitated by the formation of a covalent intermediate with the cofactor thiamine pyrophosphate. TKT Protein, Human (His) is the recombinant human-derived TKT protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71074

	Thymidine kinase 1/TK1 Protein, Human (HEK293, His) Thymidine kinase; cytosolic; TK1	Human	HEK293
	The thymidine kinase 1/TK1 protein acts as a cell surface receptor in the FCGRT protein. This receptor promotes the transfer of passive humoral immunity from mother to newborn by selectively binding to monomeric immunoglobulin gamma in milk. Thymidine kinase 1/TK1 Protein, Human (HEK293, His) is the recombinant human-derived Thymidine kinase 1/TK1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78125

	FGFR-2 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) FGF R2a; FGFR2 alpha; KGFR; CD332; BBDS; BEK; BFR-1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FLJ98662	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78131

	FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGF R2a; FGFR2 alpha; KGFR; CD332; BBDS; BEK; BFR-1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FLJ98662	Human	HEK293
	The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P701043

	Thymidine kinase 1/TK1 Protein, Canine (His) Thymidine kinase; EC 2.7.1.21; thymidine kinase-1	Canine	E. coli
	The thymidine kinase 1/TK1 protein acts as a cell surface receptor in the FCGRT protein. This receptor promotes the transfer of passive humoral immunity from mother to newborn by selectively binding to monomeric immunoglobulin gamma in milk. Thymidine kinase 1/TK1 Protein, Canine (His) is the recombinant canine-derived Thymidine kinase 1/TK1 protein, expressed by E. coli , with C-His labeled tag.

HY-P70043

	TYRO3/DTK Protein, Mouse (HEK293, hFc) rMuTyrosine-protein kinase receptor TYRO3/DTK, Fc; Tyrosine-protein kinase receptor TYRO3; ETK2; tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF	Mouse	HEK293
	TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation.Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules.TYRO3/DTK Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P703815

	TYRO3/DTK Protein, Cynomolgus (HEK293, His) rMuTyrosine-protein kinase receptor TYRO3/DTK, Fc; Tyrosine-protein kinase receptor TYRO3; ETK2; tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF	Cynomolgus	HEK293
	TYRO3/DTK Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TYRO3/DTK protein, expressed by HEK293, with C-His tag.

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Cat. No.	Product Name	Chemical Structure

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-122903S

TK216-d4
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-W770090

CF 1743-d7
CF 1743-d₇ is the deuterium labeled Cf1743 (HY-107025). Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC₅₀ of 3.3 μM for VZV thymidine kinase (TK) .

HY-N0377S

Liquiritigenin-d4
Liquiritigenin-d₄ (4',7-Dihydroxyflavanone-d₄) is the deuterium labeled Liquiritigenin (HY-N0377). Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (2) Mouse (2) Monkey (1)
Application:	IHC-P (2) ICC/IF (1) IF-Tissue (1) IP (2) WB (4) FC (1)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5) Biotin (2)
Clonality:	Monoclonal (4) Recombinant (4)
Modification:	Unmodified (4)

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HY-P82450

	Thymidine Kinase Antibody (YA2195) EC 2.7.1.21; KITH; TK-1; TK1; Thymidine kinase 1; cytosolic	WB, IP	Human
	Thymidine Kinase Antibody (YA2195) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thymidine Kinase.

HY-P82450A

	Thymidine Kinase Antibody (YA2195)(PBS only) EC 2.7.1.21; KITH; TK-1; TK1; Thymidine kinase 1; cytosolic	WB, IP	Human
	Thymidine Kinase Antibody (YA2195) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thymidine Kinase.

HY-P87127

	Transketolase Antibody (YA6820) EC 2.2.1.1 antibody; FLJ34765 antibody; TK antibody; TKT 1 antibody; TKt antibody; TKT_HUMAN antibody; TKT1 antibody; Transketolase (Wernicke Korsakoff syndrome) antibody; Transketolase antibody;	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat, Monkey
	Transketolase Antibody (YA6820) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transketolase.

HY-P84934

	NCOA4 Antibody (YA4630) 70 kDa androgen receptor activator antibody; 70 kDa androgen receptor coactivator antibody; 70 kDa AR activator antibody; 70 kDa AR-activator antibody; Androgen receptor coactivator 70 kD antibody; Androgen receptor coactivator 70 kDa protein antibody; Androgen receptor-associated protein of 70 kDa antibody; ARA 70 antibody; ARA70 antibody; DKFZp762E1112 antibody; ELE 1 antibody; ELE1 antibody; ELE1/ret TK antibody; NCOA 4 antibody; NCoA-4 antibody; NCOA4 antibody; NCOA4_HUMAN antibody; Nuclear receptor coactivator 4 antibody; Papillary thyroid carcinoma 3 antibody; PTC 3 antibody; PTC3 antibody; RET activating gene ELE1 antibody; Ret activating protein ELE1 antibody; Ret-activating protein ELE1 antibody; RFG antibody	WB	Human
	NCOA4 Antibody (YA4630) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NCOA4.

HY-P84935

	NCOA4 Antibody (YA4631) 70 kDa androgen receptor activator antibody; 70 kDa androgen receptor coactivator antibody; 70 kDa AR activator antibody; 70 kDa AR-activator antibody; Androgen receptor coactivator 70 kD antibody; Androgen receptor coactivator 70 kDa protein antibody; Androgen receptor-associated protein of 70 kDa antibody; ARA 70 antibody; ARA70 antibody; DKFZp762E1112 antibody; ELE 1 antibody; ELE1 antibody; ELE1/ret TK antibody; NCOA 4 antibody; NCoA-4 antibody; NCOA4 antibody; NCOA4_HUMAN antibody; Nuclear receptor coactivator 4 antibody; Papillary thyroid carcinoma 3 antibody; PTC 3 antibody; PTC3 antibody; RET activating gene ELE1 antibody; Ret activating protein ELE1 antibody; Ret-activating protein ELE1 antibody; RFG antibody	IHC-P, IF-Tissue	Human, Mouse, Rat
	NCOA4 Antibody (YA4631) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NCOA4.

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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-W342664

2'-Deoxy-2'-fluoro-5-iodouridine FIRU		Nucleoside Analogs Uridine
2'-Deoxy-2'-fluoro-5-iodouridine (FIRU) is a nucleoside analog. When labeled with ¹²³I, 2'-Deoxy-2'-fluoro-5-iodouridine accumulates highly selectively in tumors expressing the *HSV1-tk* gene. Radiolabeled 2'-Deoxy-2'-fluoro-5-iodouridine enables imaging of adenovirus-mediated HSV1-tk suicide gene transfer .

HY-W353804

2′-Deoxy-β-L-uridine		Nucleoside Analogs Uridine
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase .

HY-RS23490

Tk1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14556

TK1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TK1 Human Pre-designed siRNA Set A contains three designed siRNAs for TK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24088

Tk2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17628

Tk2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14557

TK2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TK2 Human Pre-designed siRNA Set A contains three designed siRNAs for TK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174787

Human ACKR3 mRNA		mRNA Chemokine & Receptors
Human ACKR3 mRNA encodes the human atypical chemokine receptor 3 (ACKR3) protein, a member of the G-protein coupled receptor family. ACKR3 is a typical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.

HY-RS14559

TKT Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TKT Human Pre-designed siRNA Set A contains three designed siRNAs for TKT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17046

Tk1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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