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Top I

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By Targets:	ADC Payload (4) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (4) ATM/ATR (1) Bacterial (1) Bcl-2 Family (1) c-Met/HGFR (1) Caspase (1) Checkpoint Kinase (Chk) (1) DNA/RNA Synthesis (4) Drug-Linker Conjugates for ADC (1) EGFR (1) IAP (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (1) Survivin (1) Topoisomerase (22)
By Research Areas:	Cancer (23) Infection (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

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Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148819

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT	ADC Payload Topoisomerase	Cancer
NH2-bicyclopentane-7-MAD-MDCPT (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT is used in research on lung adenocarcinoma and melanoma .

HY-171124

Tilatamig samrotecan AZD9592	Antibody-Drug Conjugates (ADCs) EGFR c-Met/HGFR Topoisomerase DNA/RNA Synthesis	Cancer
Tilatamig samrotecan (AZD9592) is an anti-EGFR/c-MET antibody-drug conjugate (ADC). Tilatamig samrotecan consists of an anti-EGFR/c-MET antibody with the drug-linker conjugate being AZ14170133 (HY-145399) (a topoisomerase I (TOP1i) inhibitor payload). Tilatamig samrotecan induces multiple DNA damage response pathway markers (like ATM, ATR, γH2AX). Tilatamig samrotecan selectively binds to EGFR and c-MET, delivering the cytotoxic payload. Tilatamig samrotecan exerts anti-tumor activity in vivo. Tilatamig samrotecan can be used for non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) research .

HY-171689

Puxitatug samrotecan AZD 8205; P-Sam	Antibody-Drug Conjugates (ADCs) Topoisomerase	Cancer
Puxitatug samrotecan (AZD 8205) is a B7-H4-directed antibody-drug conjugate (ADC) bearing a Topoisomerase I inhibitor (TOP1i) payload. Puxitatug samrotecan improves HR ⁺/HER2 ^- breast cancer .

HY-U00248A

LMP744 hydrochloride MJ-III65 hydrochloride; NSC706744 hydrochloride	Topoisomerase	Cancer
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .

HY-175203

Topi MF-6	Topoisomerase ADC Payload	Cancer
Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 can be used as an ADC payload .

HY-148819A

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride	ADC Payload Topoisomerase	Cancer
NH2-bicyclopentane-7-MAD-MDCPT hydrochloride (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is used in research on lung adenocarcinoma and melanoma .

HY-U00248

LMP744 MJ-III65; NSC706744	Topoisomerase	Cancer
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .

HY-168489

OBI-992 drug-linker	Drug-Linker Conjugates for ADC	Cancer
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992 .

HY-160005

LMP517 NSC 781517	Topoisomerase DNA/RNA Synthesis	Cancer
LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and *TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA* damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer .

HY-18350

Indimitecan LMP776	Topoisomerase	Cancer
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities .

HY-118581

Coralyne chloride 1 Publications Verification	Topoisomerase	Cancer
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .

HY-118911

ATM Inhibitor-10	ATM/ATR	Cancer
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC₅₀: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors .

HY-126142

Top1 inhibitor 1	Topoisomerase ADC Payload	Cancer
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC₅₀ value of 29 nM .

HY-175700

YCJ-02	Topoisomerase Apoptosis	Cancer
YCJ-02 is a selective Topoisomerase I (Top I) inhibitor. YCJ-02 can inhibit cell proliferation and induce apoptosis and G2/M phase arrest. YCJ-02 can induce DNA damage and increaseγ-H2AX levels. YCJ-02 can promote Top I deqradation via a ubiquitin/26S proteasome pathway. YCJ-02 increases the expressions of pro-apoptotic proteins Bad, Bax, and cleaved caspase-3. YCJ-02 shows broad-spectrum antitumor activity. YCJ-02 can be used for the research of cancer, such as intrahepatic cholangiocarcinoma (ICC) .

HY-118942

Topovale ARC 111	Topoisomerase	Cancer
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .

HY-W008874

meso-Tetra(4-pyridyl)porphine	Topoisomerase	Cancer
meso-Tetra(4-pyridyl)porphine (Compound 10) is a porphyrin derivative. meso-Tetra(4-pyridyl)porphine is a weak inhibitor of human topoisomerase I (Top1) with an EC₅₀ value greater than 50 µM. meso-Tetra(4-pyridyl)porphine can be used in tumor research .

HY-143265

Topoisomerase I inhibitor 2	Topoisomerase Apoptosis Caspase	Cancer
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits *Top1* activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect .

HY-18350A

Indimitecan hydrochloride LMP776 hydrochloride	Topoisomerase	Cancer
Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities .

HY-168739

Topoisomerase I inhibitor 17	Topoisomerase Reactive Oxygen Species (ROS) Apoptosis Survivin Bcl-2 Family IAP DNA/RNA Synthesis	Cancer
Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, γH2AX). Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice .

HY-121866

CP-84364	Topoisomerase	Cancer
Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC₅₀ of 7.25 μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities.

HY-RS14890

TOP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Topoisomerase	Others
TOP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TOP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP1 Human Pre-designed siRNA Set A TOP1 Human Pre-designed siRNA Set A

HY-146437

Topoisomerase I inhibitor 6	Topoisomerase	Cancer
Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .

HY-120638

BMS-250749	Topoisomerase	Cancer
BMS-250749 is a topoisomerase I (Top I) inhibitor of the fluoroglycosyl-3,9-difluoroindolecarbazole class. BMS-250749 exhibits potent cytotoxicity and selectivity, and shows curative antitumor activity against Lewis lung cancer. BMS-250749 exhibits broad-spectrum antitumor activity superior to CPT-11 in certain preclinical xenograft models. .

HY-N15249

4"-Isovalerylspiramycin I Isovalerylspiramycin I; Shengjimycin E	Topoisomerase DNA/RNA Synthesis Checkpoint Kinase (Chk) Apoptosis Bacterial	Infection Cancer
4"-Isovalerylspiramycin I (Isovalerylspiramycin I) is a topoisomerase 1 (TOP1) inhibitor and an antitumor agent. 4"-Isovalerylspiramycin I directly binds to *TOP1, suppresses DNA replication, and induces DNA damage. 4"-Isovalerylspiramycin I downregulates phosphorylated CHEK1* and the ATR/CHEK1 DNA damage repair pathway, blocks DNA repair, and augments DNA damage. 4"-Isovalerylspiramycin I suppresses proliferation, migration, and invasion of osteosarcoma cells. 4"-Isovalerylspiramycin I induces apoptosis and cell cycle arrest in osteosarcoma cells. 4"-Isovalerylspiramycin I exerts antibacterial activity against methicillin-resistant Staphylococcus aureus. 4"-Isovalerylspiramycin I can be used for the research of osteosarcoma, upper respiratory bacterial infections, and methicillin-resistant Staphylococcus aureus infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15249

4"-Isovalerylspiramycin I Isovalerylspiramycin I; Shengjimycin E	Structural Classification Natural Products Microorganisms Source Classification	Topoisomerase DNA/RNA Synthesis Checkpoint Kinase (Chk) Apoptosis Bacterial
4"-Isovalerylspiramycin I (Isovalerylspiramycin I) is a topoisomerase 1 (TOP1) inhibitor and an antitumor agent. 4"-Isovalerylspiramycin I directly binds to *TOP1, suppresses DNA replication, and induces DNA damage. 4"-Isovalerylspiramycin I downregulates phosphorylated CHEK1* and the ATR/CHEK1 DNA damage repair pathway, blocks DNA repair, and augments DNA damage. 4"-Isovalerylspiramycin I suppresses proliferation, migration, and invasion of osteosarcoma cells. 4"-Isovalerylspiramycin I induces apoptosis and cell cycle arrest in osteosarcoma cells. 4"-Isovalerylspiramycin I exerts antibacterial activity against methicillin-resistant Staphylococcus aureus. 4"-Isovalerylspiramycin I can be used for the research of osteosarcoma, upper respiratory bacterial infections, and methicillin-resistant Staphylococcus aureus infection .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (4)
Application:	IHC-P (2) ICC/IF (4) IHC-F (2) WB (4) FC (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (1) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84061

	Topoisomerase I Antibody (YA3758) TopI	WB, ICC/IF, FC	Human, Mouse
	Topoisomerase I Antibody (YA3758) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase I.

HY-P84061A

	Topoisomerase I Antibody (YA3758)(PBS only) TopI	WB, ICC/IF, FC	Human, Mouse
	Topoisomerase I Antibody (YA3758) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase I.

HY-P82492

	Topoisomerase I Antibody (YA2237) Top1; DNA Topoisomerase 1; DNA Topoisomerase I	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Topoisomerase I Antibody (YA2237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase I.

HY-P82492A

	Topoisomerase I Antibody (YA2237)(PBS only) Top1; DNA Topoisomerase 1; DNA Topoisomerase I	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Topoisomerase I Antibody (YA2237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase I.

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TOP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TOP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TOP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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