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Results for "

ULK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ULK (41) AAK1 (2) Akt (5) AMPK (8) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (17) Aurora Kinase (1) Autophagy (26) Bcl-2 Family (5) Bcr-Abl (1) Beclin1 (1) Biochemical Assay Reagents (1) CaMK (2) Casein Kinase (5) Caspase (1) CDK (5) Cyclin G-associated Kinase (GAK) (1) Environmental Pollutants (1) Ephrin Receptor (1) ERK (1) FAK (1) Ferroptosis (2) FGFR (1) GSK-3 (4) HIV (1) HSP (1) IKK (3) Interleukin Related (3) IRAK (4) Itk (1) Kinesin (1) LIM Kinase (LIMK) (2) MAP4K (2) MAPKAPK2 (MK2) (1) MELK (1) MHC (1) Mitophagy (1) mTOR (1) NF-κB (3) p38 MAPK (2) PARP (1) PD-1/PD-L1 (1) PI3K (1) PROTACs (4) Ras (1) Reactive Oxygen Species (ROS) (5) Reference Standards (5) RIP kinase (1) Salt-inducible Kinase (SIK) (2) Sirtuin (1) Small Interfering RNA (siRNA) (10) TGF-beta/Smad (2) TGF-β Receptor (1) TNF Receptor (3) Wee1 (1)
By Research Areas:	Cancer (43) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (11) Metabolic Disease (6) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (4) siRNAs (10)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: ULK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16966

SBI-0206965 35+ Cited Publications	ULK AMPK Autophagy Apoptosis	Cancer
SBI-0206965 is a potent, selective and cell permeable autophagy kinase *ULK1* inhibitor with IC₅₀s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation .

HY-13018

MRT67307 25+ Cited Publications	IKK ULK Autophagy	Inflammation/Immunology Cancer
MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC₅₀s of 160 and 19 nM, respectively . MRT67307 also inhibits *ULK1* and *ULK2* with IC₅₀s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells .

HY-147141

HS-276 2 Publications Verification	IRAK TNF Receptor Casein Kinase Interleukin Related	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .

HY-114490

ULK-101 5+ Cited Publications	ULK	Cancer
ULK-101 is a potent and selective *ULK1* inhibitor, with IC₅₀ values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress .

HY-100006

MRT68921 25+ Cited Publications	ULK Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family	Cancer
MRT68921 is a potent *NUAK1/ULK1* dual inhibitor. MRT68921 inhibits *ULK1* and *ULK2* with IC₅₀ values of 2.9 nM and 1.1 nM, respectively. MRT68921 can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 can be used for the research of cancer, such as breast cancer .

HY-10249

GSK-690693 Maximum Cited Publications 42 Publications Verification	Akt AMPK Autophagy	Cancer
GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC₅₀s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation .

HY-100006A

MRT68921 dihydrochloride 25+ Cited Publications	ULK Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family	Cancer
MRT68921 dihydrochloride is a potent *NUAK1/ULK1* dual inhibitor. MRT68921 dihydrochloride inhibits *ULK1* and *ULK2* with IC₅₀ values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer .

HY-130665

TL12-186 1 Publications Verification	PROTACs CDK	Cancer
TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, *ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A* (IC₅₀=73 nM) and CDK9/cyclin T1 (IC₅₀=55 nM) .

HY-160699

DCC-3116 1 Publications Verification	ULK Ras Autophagy	Cancer
DCC-3116 is an orally active *ULK1/2* inhibitor. DCC-3116 can inhibit autophagy in lung cancer cells by inhibiting KRAS ^G12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects .

HY-D0195

Acesulfame potassium	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Acesulfame potassium is a synthetic sweetener. Long-term use of Acesulfame potassium can affect cognitive function, possibly by altering the neurometabolic functions in mice. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1* pathway,* which may be related to immune evasion in cancer cells. Acesulfame potassium can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion .

HY-N0559

Kirenol 1 Publications Verification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and *AMPK-mTOR-ULK1* pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .

HY-124729

BL-918 3 Publications Verification	ULK Autophagy	Neurological Disease
BL-918 is an orally active UNC-51-like kinase 1 (ULK1) activator with an EC₅₀ of 24.14 nM. BL-918 exerts its cytoprotective autophagic effect by targeting ULK complex. BL-918 has the potential for Parkinson’s disease (PD) treatment .

HY-101923

LYN-1604 5+ Cited Publications	ULK Autophagy Apoptosis	Cancer
LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC) .

HY-137742

SBP-7455	ULK Autophagy	Cancer
SBP-7455 is a potent, high affinity and orally active dual *ULK1/ULK2* autophagy inhibitor with IC₅₀s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits *ULK1/2* enzymatic activity and can be used for triple-negative breast cancer (TNBC) research .

HY-101923B

LYN-1604 dihydrochloride 5+ Cited Publications	ULK Autophagy Apoptosis	Cancer
LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC) .

HY-148065

FMF-06-098-1	PROTACs Wee1 CDK AAK1 ULK MELK Itk IRAK Ephrin Receptor FGFR MAP4K p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-137506

XST-14 2 Publications Verification	ULK p38 MAPK TGF-β Receptor Anaplastic lymphoma kinase (ALK) CaMK Apoptosis	Cancer
XST-14 is a potent, competitive and highly selective *ULK1* inhibitor with an IC₅₀ of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects .

HY-179089

SBP-1750	ULK	Cancer
SBP-1750 is an orally active *ULK* inhibitor and an ATG13 degrader. SBP-1750 strongly inhibits *ULK1/2* activity, with IC₅₀ values of 8 and 50 nM, respectively. SBP-1750 induces ATG13 degradation, with an EC₅₀ value of 114 nM. SBP-1750 can inhibit autophagy in cancer cells and induce cell death. SBP-1750 can be used in cancer research, such as for pancreatic cancer .

HY-N4176

Ginkgolide K	Autophagy	Neurological Disease
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Cancer
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .

HY-115570

GW406108X 1 Publications Verification GW108X	Kinesin ULK Autophagy	Cancer
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against *ULK1* with a pIC₅₀ of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK .

HY-119137

AMDE-1	Autophagy AMPK	Cancer
AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer .

HY-162100

MR-2088	ULK Autophagy	Cancer
MR-2088 is a reversible, ATP-competitive, and selective *ULK1/2* inhibitor with pEC₅₀ values of 8.3 and 8.7 respectively. MR-2088 effectively inhibits autophagic flux and demonstrates a synergistic antiproliferative effect with Trametinib (HY-10999) (MEK inhibitor) in vitro. MR-2088 can be used for non-small lung cell cancer (NSCLC) research .

HY-N0867

13-Oxyingenol-13-dodecanoate	HIV ULK Bcl-2 Family	Infection Cancer
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of *ULK1* to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

HY-148063

DB0614	PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) LIM Kinase (LIMK) ULK	Metabolic Disease
DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))

HY-158408

NZ-66	ULK Mitophagy	Neurological Disease
NZ-66 is a UNC-51-like kinase 1 (ULK1) targeting chimera, which is used to achieve proximity-induced and ULK1-dependent degradation of mitochondria. NZ-66 induces mitophagy. NZ-66 is potential for attenuating neurodegenerative disorders .

HY-13018A

MRT67307 hydrochloride	IKK ULK Autophagy	Inflammation/Immunology Cancer
MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC₅₀s of 160 and 19 nM, respectively . MRT67307 hydrochloride also inhibits *ULK1* and *ULK2* with IC₅₀s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells .

HY-124729A

(Rac)-BL-918	ULK Autophagy	Neurological Disease
(Rac)-BL-918 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1), inducing cytoprotective autophagy for Parkinson’s disease treatment .

HY-136479

F0911-7667	Sirtuin	Cancer
F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments .

HY-125199

ULK-100	ULK	Cancer
ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC₅₀ value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma) .

HY-143466

ULK1-IN-2	FAK ULK AMPK Apoptosis Autophagy	Cancer
ULK1-IN-2 (compound 3s) is a potent *ULK1* inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC₅₀ of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer) .

HY-RS15452

Ulk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ULK	Others
Ulk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ulk1 Mouse Pre-designed siRNA Set A Ulk1 Mouse Pre-designed siRNA Set A

HY-RS15451

ULK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ULK	Others
ULK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ULK1 Human Pre-designed siRNA Set A ULK1 Human Pre-designed siRNA Set A

HY-161850

ULK1-IN-3	ULK Apoptosis PARP Autophagy NF-κB AMPK Akt Reactive Oxygen Species (ROS)	Cancer
ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of *ULK1. ULK1-IN-3 inhibits cell cycle, autophagy* and induces apoptosis, oxidative stress in colon cancer cell lines .

HY-100006B

MRT68921 hydrochloride	ULK Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family	Cancer
MRT68921 hydrochloride is a potent *NUAK1/ULK1* dual inhibitor. MRT68921 hydrochloride inhibits *ULK1* and *ULK2* with IC₅₀ values of 2.9 nM and 1.1 nM, respectively. MRT68921 hydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 hydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 hydrochloride can be used for the research of cancer, such as breast cancer .

HY-13018B

MRT67307 dihydrochloride	IKK ULK Autophagy	Inflammation/Immunology Cancer
MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC₅₀s of 160 and 19 nM, respectively . MRT67307 dihydrochloride also inhibits *ULK1* and *ULK2* with IC₅₀s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells .

HY-117413

SR-17398	ULK	Cancer
SR-17398 is an inhibitor for Unc-51-Like Kinase 1 (ULK1) with an IC₅₀ of 22.4 μM .

HY-101923A

LYN-1604 hydrochloride	ULK Autophagy Apoptosis	Cancer
LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC₅₀=18.94 nM) for the research of triple negative breast cancer (TNBC) .

HY-RS15456

Ulk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ulk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ulk2 Rat Pre-designed siRNA Set A Ulk2 Rat Pre-designed siRNA Set A

HY-RS15454

ULK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ULK	Others
ULK2 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ULK2 Human Pre-designed siRNA Set A ULK2 Human Pre-designed siRNA Set A

HY-RS19647

Ulk3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ulk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ulk3 Mouse Pre-designed siRNA Set A Ulk3 Mouse Pre-designed siRNA Set A

HY-RS15458

ULK4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ULK4 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ULK4 Human Pre-designed siRNA Set A ULK4 Human Pre-designed siRNA Set A

HY-RS15455

Ulk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ULK	Others
Ulk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ulk2 Mouse Pre-designed siRNA Set A Ulk2 Mouse Pre-designed siRNA Set A

HY-RS15457

ULK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ULK3 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ULK3 Human Pre-designed siRNA Set A ULK3 Human Pre-designed siRNA Set A

HY-RS15453

Ulk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ulk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ulk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ulk1 Rat Pre-designed siRNA Set A Ulk1 Rat Pre-designed siRNA Set A

HY-168507

SG31	Autophagy	Cancer
SG31 is a potent autophagy activator via the AMPK/ULK1-dependent pathway .

HY-W550739

Acesulfame	PD-1/PD-L1 ERK mTOR Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Acesulfame is a synthetic sweetener. Long-term use of Acesulfame can affect cognitive function. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1* pathway,* which may be related to immune evasion in cancer cells. Acesulfame can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion .

HY-181699

ULK1-IN-5	ULK	Cancer
ULK1-IN-5 (Compound D1) is a selective *ULK1* inhibitor with an IC₅₀ of 14.91 nM. ULK1-IN-5 functionally inhibits the kinase activity of *ULK1. ULK1-IN-5 reduces the phosphorylation level of ATG13. ULK1-IN-5 exerts antiproliferative effects on cervical cancer cells. ULK*1-IN-5 is applicable to relevant research on cervical cancer .

HY-181668

ULK1-IN-4	ULK	Cancer
ULK1-IN-4 (compound 12i) is a *ULK1* inhibitor with an IC₅₀ of 4.7 μM against human *ULK1, and it exhibits selectivity for Aurora A/Aurora B* kinases. ULK1-IN-4 forms a covalent bond with the thiol group of the Cys182 residue of *ULK1, thereby inhibiting the kinase activity of ULK1. ULK*1-IN-4 inhibits the growth of colorectal cancer cells and exerts tumor-suppressive activity in a mouse model of colorectal cancer .

HY-181742

ULK1/2-IN-1	ULK PI3K Autophagy	Cancer
ULK1/2-IN-1 is a tissue-targeted *ULK1/2* inhibitor conjugated to the RGR (CRGRRST) tumor neovasculature-homing peptide. ULK1/2-IN-1 mediates autophagy inhibition and induces cytotoxicity in endothelial cells. ULK1/2-IN-1 can be used for the research of tumor-targeted autophagy inhibitors .

Cat. No.	Product Name

HY-L029

Autophagy Compound Library

1,956 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 1,956 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0559

Kirenol 1 Publications Verification	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and *AMPK-mTOR-ULK1* pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .

HY-N4176

Ginkgolide K	Ginkgoaceae Terpenoids Diterpenoids Plants Ginkgo biloba Source Classification	Autophagy
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of *ULK1* to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

HY-N0559R

Kirenol (Standard)	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Reference Standards Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

Recombinant Proteins Recommended:

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703314

	ULK3 Protein, Human (sf9, His, GST) Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3; ULK3; Homo sapiens; Human; Kinase; Serine/threonine-protein kinase; Transferase; 2.7.11.1	Human	Sf9 insect cells
	ULK3 Protein, Human (sf9, His, GST) is the recombinant human-derived ULK3, expressed by sf9 insect cells , with His, GST labeled tag. ,

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Host:	Mouse (4) Rabbit (7)
Reactivity:	Human (11) Rat (8) Mouse (7)
Application:	IHC-P (3) ICC/IF (5) IP (2) WB (11) FC (4) ELISA (5)
Isotype:	IgG, Kappa (1) IgG (6) IgG1 (4)
Conjugation:	Non-conjugated (11)
Clonality:	Monoclonal (8) Recombinant (4)
Modification:	Phosphorylated (3) Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80366

	ULK1 Antibody (YA019) 1 Publications Verification	WB, IHC-P	Human, Mouse, Rat
	ULK1 Antibody (YA019) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ULK1.

HY-P84640

	ULK3 Antibody (YA4337)	WB, IHC-P, ICC/IF, FC	Human, Rat
	ULK3 Antibody (YA4337) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ULK3.

HY-P84640A

	ULK3 Antibody (YA4337)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Rat
	ULK3 Antibody (YA4337) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ULK3.

HY-P81065

	*Phospho-ULK1 (Ser556) Antibody (YA908)* ATG1; ATG1A; hATG1; ULK1; UNC51;	WB	Human, Mouse
	Phospho-ULK1 (Ser556) Antibody (YA908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ULK1 (Ser556).

HY-P82610

	ULK3 Antibody (YA2355) Serine/threonine-protein kinase ULK3; ULK3; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3	WB	Human
	ULK3 Antibody (YA2355) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ULK3.

HY-P87849

	*Phospho-ULK1 (Ser556) Antibody (YA7534)*	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-ULK1 (Ser556) Antibody (YA7534) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-ULK1 (Ser556).

HY-P86119

	ULK1 Antibody (YA5811) ULK1; KIAA0722; Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ULK1 Antibody (YA5811) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ULK1.

HY-P82610A

	ULK3 Antibody (YA2355)(PBS only) Serine/threonine-protein kinase ULK3; ULK3; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3	WB	Human
	ULK3 Antibody (YA2355) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ULK3.

HY-P86165

	*Phospho-ULK1(Ser757) Antibody (YA5857)* ULK1; KIAA0722; Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-ULK1(Ser757) Antibody (YA5857) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ULK1(Ser757).

HY-P84665

	ULK2 Antibody (YA4362) ATG1B; Unc51.2	WB, FC, ELISA	Human, Mouse, Rat
	ULK2 Antibody (YA4362) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ULK2.

HY-P84665A

	ULK2 Antibody (YA4362)(PBS only) ATG1B; Unc51.2	WB, FC, ELISA	Human, Mouse, Rat
	ULK2 Antibody (YA4362) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ULK2.

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