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Results for "

amine reactive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reactive Oxygen Species (ROS) (2) ADC Linker (17) Biochemical Assay Reagents (132) DNA Alkylator/Crosslinker (3) DNA Stain (2) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (2) E3 Ligase Ligand-Linker Conjugates (2) Exosomes (1) Fluorescent Dye (59) GABA Receptor (2) Histone Demethylase (2) Isotope-Labeled Compounds (5) Ligands for E3 Ligase (2) Liposome (7) Monoamine Oxidase (3) PROTAC Linkers (14) Reference Standards (1)
By Research Areas:	Cancer (45) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (7) Metabolic Disease (4) Neurological Disease (4)
Click Chemistry:	TCO (1) DBCO (2) PROTAC Synthesis (2) Azide (5) BCN (1) Alkynes (2)
Oligonucleotides:	Pegylated Lipids (5) Phospholipids (3)

243

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Amine N-methyltransferase Reactive Oxygen Species (ROS) Trace Amine-associated Receptor (TAAR) VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W019543

Disuccinimidyl suberate Crosslinker Maximum Cited Publications 14 Publications Verification	Biochemical Assay Reagents	Cancer
Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697

DSG Crosslinker 4 Publications Verification Disuccinimidyl glutarate	Biochemical Assay Reagents	Inflammation/Immunology
DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329

BS3 Crosslinker 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-42360

SMCC 1 Publications Verification	ADC Linker	Cancer
SMCC is a protein crosslinker. SMCC contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses .

HY-118759

DSP Crosslinker 2 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329A

BS3 Crosslinker disodium 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-D0799

Sulfo-NHS-LC-Biotin sodium 5+ Cited Publications	Fluorescent Dye	Others
Sulfo-NHS-LC-Biotin sodium is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.

HY-D1041

ICG NHS ester ICG-OSu	Fluorescent Dye	Cancer
ICG NHS ester (ICG-OSu) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes .

HY-126349

DTSSP Crosslinker	ADC Linker	Others
DTSSP Crosslinker is a crosslinker reactive with primary amines. DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-D0048

5-TAMRA-SE 2 Publications Verification 5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester	Fluorescent Dye	Others
5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability (Ex/Em = 565/580 nm).

HY-W879045

Endo-BCN-PEG5-amine Endo-BCN-PEG5-NH2	Biochemical Assay Reagents	Others
Endo-BCN-PEG5-amine (Endo-BCN-PEG5-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-D1046

Dabcyl acid, SE Dabcyl, SE	Fluorescent Dye	Others
Dabcyl acid, SE is the amine-reactive form of Dabcyl acid (DABCYL) (HY-D1045), and is widely used in the preparation of fluorescent probes containing DABCYL .

HY-W590569

Azido-PEG12-amine	Biochemical Assay Reagents	Others
Azido-PEG12-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG arm increases solubility in aqueous media.

HY-W441013

DSPE-PEG1000-NHS	Liposome	Others
DSPE-PEG1000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG1000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG1000-NHS can be used in the study of drug delivery .

HY-141175

TCO-PNB ester	Biochemical Assay Reagents	Others
TCO-PNB ester is an amine-reactive building block used for modification of amine-containing molecule. TCO-PNB ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group .

HY-D2746

Cy5.5 bis-NHS ester	Fluorescent Dye	Others
Cy5.5 bis-NHS ester is a reactive cyanine dye containing NHS ester which can be used to label amine groups in peptides, proteins, and oligonucleotides.

HY-W012971

5-Amino-1-pentanol	Biochemical Assay Reagents	Others
5-Amino-1-pentanol is a linker containing a hydroxyl group and amine group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-147117

NHS-SS-Ac	Biochemical Assay Reagents	Others
NHS-SS-Ac is an amine-reactive product synthesized from acetic acid .

HY-D1050

DNP-X, SE 1 Publications Verification 6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester	Fluorescent Dye	Metabolic Disease
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-W190915

4,7,10,13,16-Pentaoxanonadecane-1,19-diamine	Biochemical Assay Reagents	Others
4,7,10,13,16–Pentaoxanonadecane-1,19-diamine is a PEG based linker with two terminal amine groups. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-W1048843A

4-Arm PEG5000-NH2 4-Arm PEG5000-amine	Biochemical Assay Reagents	Others
4-Arm PEG5000-NH2 (4-Arm PEG5000-amine) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048525

8-Arm PEG5000-NH2 8-Arm PEG5000-amine	Biochemical Assay Reagents	Others
8-Arm PEG5000-NH2 (8-Arm PEG5000-Amine) is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-D1372

Cyanine3 amine hydrochloride	Fluorescent Dye	Others
Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-W800839

TCO-PEG4-TFP ester	Biochemical Assay Reagents	Others
TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.

HY-D0135

12-(7-Nitrobenzofurazan-4-ylamino)dodecanoic acid	Fluorescent Dye	Others
12-(7-Nitrobenzofurazan-4-ylamino)dodecanoic acid is an amine-reactive fluorescent dye .

HY-D1372A

Cyanine3 amine TFA	Fluorescent Dye	Others
Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-W1048843B

4-Arm PEG10000-NH2 4-Arm PEG10000-amine	Biochemical Assay Reagents	Others
4-Arm PEG10000-NH2 (4-Arm PEG10000-amine) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W998707

TAMRA amine, 5-isomer hydrochloride	Fluorescent Dye	Others
TAMRA amine, 5-isomer hydrochloride is a rhodamine dye with excitation/emission maximum 553/575 nm. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-D1089

6-JOE, SE	Fluorescent Dye	Others
6-JOE, SE is an amine-reactive fluorescent probe and is suitable for postsynthetic labeling of amino-modified oligonucleotides .

HY-W1048519A

4-Arm PEG10000-NH2 hydrochloride 4-Arm PEG10000-amine HCL salt	Biochemical Assay Reagents	Others
4-Arm PEG10000-NH2 (4-Arm PEG100000-amine) hydrochloride is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-D0799A

Sulfo-NHS-LC-Biotin	Fluorescent Dye	Others
Sulfo-NHS-LC-Biotin is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.

HY-W190918

endo-BCN-PEG4-amine	Biochemical Assay Reagents	Others
endo-BCN-PEG4-amine is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-W879025

Endo-BCN-PEG8-amine Endo-BCN-PEG8-NH2	Biochemical Assay Reagents	Others
Endo-BCN-PEG8-amine (Endo-BCN-PEG8-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-D1607

BODIPY FL SSE	Fluorescent Dye	Others
BODIPY FL SSE is a potent fluorescent dye. BODIPY FL SSE is used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY FL SSE can reactive with primary amines on biomolecules to emit green fluorescence. (λ_ex=502 nm, λ_em=511 nm) .

HY-D1611

BODIPY FL-C5 NHS Ester	Fluorescent Dye	Others
BODIPY FL-C5 NHS Ester is a green-fluorescent dye that is reactive with primary amines on biomolecules such as peptides, proteins, modified nucleotides and biopolymers .

HY-130547A

BS2G Crosslinker	DNA Alkylator/Crosslinker	Cancer
BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W1048547J

HOOC-PEG40000-NH2 HOOC-PEG40000-amine	PROTAC Linkers	Others
HOOC-PEG40000-NH2 (HOOC-PEG40000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W101722

tert-Butyl (9-aminononyl)carbamate	PROTAC Linkers	Cancer
tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-130547

BS2G Crosslinker disodium	DNA Alkylator/Crosslinker	Cancer
BS2G Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-D1469

5-Carboxyrhodamine 6G succinimidyl ester R6G-SE	Fluorescent Dye	Others
5-Carboxyrhodamine 6G succinimidyl ester (R6G-SE) is an amine reactive fluorescent dye .

HY-D1112

TFAX 546,SE triethylammonium	Fluorescent Dye	Others
TFAX 546,SE triethylammonium, an amine reactive yellow fluorescent dye, can forms bright and photostable conjugates with proteins and antibodies .

HY-156384

SCO-PEG4-NHS	Biochemical Assay Reagents	Others
SCO-PEG4-NHS is a NH₂ reactive compound .

HY-D1049

DNP-X acid 6-((2,4-Dinitrophenyl)amino)hexanoic acid	Fluorescent Dye	Metabolic Disease
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-W020546

DBCO-amine TFA 1 Publications Verification	Biochemical Assay Reagents	Others
DBCO-amine TFA is a simple building block containing a DBCO moiety and an amine group. Amine is very reactive with NHS ester. DBCO is commonly used for copper-free Click Chemistry reactions.

HY-W749072

BP Fluor 568 NHS ester	Fluorescent Dye	Others
BP Fluor 568 NHS ester is an amine-reactive, orange fluorescent dye routinely used to label proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules (Ex/Em: 578 nm/602 nm) .

HY-131097

Malachite green isothiocyanate	Fluorescent Dye	Others
Malachite green isothiocyanate is an amine-reactive probe that reacts with amines to give the corresponding thiourea. Malachite green isothiocyanate is a reagent that has been used for the measurement of concentration of protein .

HY-W879044

Endo-BCN-PEG15-amine Endo-BCN-PEG15-NH2	Biochemical Assay Reagents	Others
Endo-BCN-PEG15-amine (Endo-BCN-PEG15-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-W093254A

Poly(ethylene glycol) bis(carboxymethyl) ether (MW 250)	Biochemical Assay Reagents	Others
Poly(ethylene glycol) bis(carboxymethyl) ether (MW 250) is an amine-reactive crosslinking agent .

HY-W093254B

Poly(ethylene glycol) bis(carboxymethyl) ether (MW 600)	Biochemical Assay Reagents	Others
Poly(ethylene glycol) bis(carboxymethyl) ether (MW 600) is an amine-reactive crosslinking agent .

HY-132270

FAM amine, 5-isomer	Fluorescent Dye	Others
FAM amine, 5-isomer is a fluorescein linker that undergoes enzymatic transamination. The addition of the amine group makes the compound more reactive with carboxylic acids, activated NHS ester and other carbonyl groups.

Cat. No.	Product Name	Type

HY-111496

Sulfo-NHS-SS-Biotin sodium 4 Publications Verification	Fluorescent Dye
Sulfo-NHS-SS-biotin sodium is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin sodium can be used for the labeling and purifying of cell-surface protein .

HY-D1041

ICG NHS ester ICG-OSu	Fluorescent Dye
ICG NHS ester (ICG-OSu) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes .

HY-110210

BODIPY-FL NHS ester

BODIPY FL,SE

Fluorescent Dye

BODIPY FL NHS ester (BODIPY FL, SE) is a cell membranes-penatrable amine-reactive fluorescent probe. The maximum excitation/emission wavelength of the BODIPY-FL NHS ester are 502/511 nm, respectively. BODIPY-FL NHS ester has high stability and is insensitive to the polarity, pH and type of solvent, and can maintain stable fluorescence properties under different environmental conditions. BODIPY-FL NHS ester can be used for the synthesis of protease substrates, live cell imaging, protein labeling and immunoassay .

HY-D0048

5-TAMRA-SE 2 Publications Verification 5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester	Fluorescent Dye
5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability (Ex/Em = 565/580 nm).

HY-D1389

Sulfo-CY-5.5 NHS ester tripotassium 1 Publications Verification Sulfo-Cyanine5.5 NHS ester tripotassium	Fluorescent Dye
Sulfo-CY-5.5 NHS ester (Sulfo-Cyanine5.5 NHS ester) tripotassium is an amine-reactive ester of sulfonated far-red Cyanine5.5 fluorophore, which can be used to label antibodies, proteins, etc., as well as for in vivo NIR imaging .

HY-D0049

6-TAMRA-SE 1 Publications Verification 6-TAMRA-NHS ester; 6-Carboxytetramethylrhodamine N-succinimidyl ester	Fluorescent Dye
6-TAMRA-SE (6-TAMRA-NHS ester) is a fluorescent dye carrying the amine reactive group. 6-TAMRA-SE is one of the traditional fluorophores used for automated DNA sequencing .

HY-15941

5(6)-FITC

2 Publications Verification

Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers

Fluorescent Dye

5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .

HY-15940

5(6)-Carboxyfluorescein 5 Publications Verification 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers	Fluorescent Dye
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .

HY-D2367

Rhodamine B NHS ester 1 Publications Verification N-Hydroxysuccinimidyl rhodamine B ester	Fluorescent Dye
Rhodamine B NHS ester (N-Hydroxysuccinimidyl rhodamine B ester) is an amine-reactive fluorescent probe (λex/λem: 564/589 nm, respectively). Rhodamine B NHS ester could react with Glycine (HY-Y0966) .

HY-D1046

Dabcyl acid, SE Dabcyl, SE	Fluorescent Dye
Dabcyl acid, SE is the amine-reactive form of Dabcyl acid (DABCYL) (HY-D1045), and is widely used in the preparation of fluorescent probes containing DABCYL .

HY-D0026

AMCA,SE 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester	Fluorescent Dye
AMCA,SE (7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester) is a bright blue fluorescent dye. AMCA,SE reacts with amino groups and is excited by ultraviolet light. AMCA,SE can be used for amine reactive labeling (Ex/Em = 354/440 nm) .

HY-D2746

Cy5.5 bis-NHS ester	Fluorescent Dye
Cy5.5 bis-NHS ester is a reactive cyanine dye containing NHS ester which can be used to label amine groups in peptides, proteins, and oligonucleotides.

HY-D1085

AMCA-X SE	Fluorescent Dye
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .

HY-D1050

DNP-X, SE 1 Publications Verification 6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester	Fluorescent Dye
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-DY1072

ICG NHS ester (solution) ICG-OSu (solution)	Fluorescent Dye
ICG NHS ester (ICG-OSu) (solution) is a near-infrared fluorescent agent ICG derivative. ICG NHS ester is amine-reactive and has been widely used to design in vivo imaging probes . Solvent and concentration: DMSO: 10 mM

HY-130736

Janelia Fluor® 549, SE

JF549, SE; JF549, NHS

Fluorescent Dye

Janelia Fluor® 549, SE (JF549, SE) is a cell-permeable fluorescent dye with an NHS ester (succinimidyl ester (SE)) reactive group. NHS esters react with primary amines and are commonly used to conjugate dyes to proteins, antibodies, amine-modified oligonucleotides, and other molecules. Janelia Fluor® 549, SE also acts as a ligand for self-labeling tags such as HaloTag and SNAP-tag, and can be used in live-cell imaging studies (Ex/Em = 549 nm/571 nm) .\n

HY-D1372

Cyanine3 amine hydrochloride	Fluorescent Dye
Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-D0135

12-(7-Nitrobenzofurazan-4-ylamino)dodecanoic acid	Fluorescent Dye
12-(7-Nitrobenzofurazan-4-ylamino)dodecanoic acid is an amine-reactive fluorescent dye .

HY-D1372A

Cyanine3 amine TFA	Fluorescent Dye
Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-W998707

TAMRA amine, 5-isomer hydrochloride	Fluorescent Dye
TAMRA amine, 5-isomer hydrochloride is a rhodamine dye with excitation/emission maximum 553/575 nm. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-D1089

6-JOE, SE	Fluorescent Dye
6-JOE, SE is an amine-reactive fluorescent probe and is suitable for postsynthetic labeling of amino-modified oligonucleotides .

HY-D0799A

Sulfo-NHS-LC-Biotin	Fluorescent Dye
Sulfo-NHS-LC-Biotin is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.

HY-D2771

BP Fluor 405 NHS ester

Fluorescent Dye

BP Fluor 405 NHS Ester is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 405 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection. BP Fluor 405 conjugates can also be used for the detection of abundance targets.

HY-D1352A

Sulfo-Cyanine7 NHS ester TEA	Fluorescent Dye
Sulfo-Cyanine7 NHS ester (TEA) is an amine-reactive succinimide ester. Sulfo-Cyanine7 NHS ester (TEA) reagent allows to prepare sulfo-Cyanine7-labeled biomolecules, such as proteins, with ease. Dye labeled molecules can be subsequently used for various research and agent design related experiments.

HY-D2956

BC-GLA-NHS

CLIP-GLA-NHS

Fluorescent Dye

BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-D1607

BODIPY FL SSE	Fluorescent Dye
BODIPY FL SSE is a potent fluorescent dye. BODIPY FL SSE is used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY FL SSE can reactive with primary amines on biomolecules to emit green fluorescence. (λ_ex=502 nm, λ_em=511 nm) .

HY-D1611

BODIPY FL-C5 NHS Ester	Fluorescent Dye
BODIPY FL-C5 NHS Ester is a green-fluorescent dye that is reactive with primary amines on biomolecules such as peptides, proteins, modified nucleotides and biopolymers .

HY-D0115

7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester	Fluorescent Dye
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is a blue fluorescent dye for labeling proteins and nucleic acids .

HY-W1048843AGL

4-Arm PEG5000-NH2 (GMP Like)

4-Arm PEG5000-amine (GMP Like)

Fluorescent Dye

4-Arm PEG5000-NH2 (GMP Like) (4-Arm PEG5000-amine (GMP Like)) is 4-Arm PEG-NH2 (HY-W1048843A) produced by using GMP like guidelines. GMP like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. 4-Arm PEG5000-NH2 is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-D1469

5-Carboxyrhodamine 6G succinimidyl ester R6G-SE	Fluorescent Dye
5-Carboxyrhodamine 6G succinimidyl ester (R6G-SE) is an amine reactive fluorescent dye .

HY-D1112

TFAX 546,SE triethylammonium	Fluorescent Dye
TFAX 546,SE triethylammonium, an amine reactive yellow fluorescent dye, can forms bright and photostable conjugates with proteins and antibodies .

HY-D1049

DNP-X acid 6-((2,4-Dinitrophenyl)amino)hexanoic acid	Fluorescent Dye
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-132270

FAM amine, 5-isomer	Fluorescent Dye
FAM amine, 5-isomer is a fluorescein linker that undergoes enzymatic transamination. The addition of the amine group makes the compound more reactive with carboxylic acids, activated NHS ester and other carbonyl groups.

HY-D1774

5-ROX-SE	Fluorescent Dye
5-ROX-SE is the amine-reactive form of 5-carboxy-X-rhodamine single isomer.

HY-D2290

Demethoxy-BODIPY TMR NHS ester	Fluorescent Dye
Demethoxy-BODIPY TMR NHS ester is an amine-reactive fluorescent probe, and can be used for the labeling of proteins, peptides, and other molecules .

HY-D2736

BP Light 800 NHS ester	Fluorescent Dye
BP Light 800 NHS ester is an amine reactive hydrophilic fluorochrome . It can be conjugated to antibody with higher D/P ratio and widely used applications including western blotting, microscopy, flow cytometry, and cell based assays.

HY-D2738

BP Fluor 532 NHS ester

Fluorescent Dye

BP Fluor 532 NHS ester is an amine reactive, yellow-emitting dye routinely used to label proteins or antibodies through primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 532 is a bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.

HY-D2768

BP Fluor 430 NHS ester

Fluorescent Dye

BP Fluor 430 NHS Ester is a water-soluble, green-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 430 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection.

HY-D1352

Sulfo-Cyanine7 NHS ester potassium	Fluorescent Dye
Sulfo-Cyanine7 NHS ester potassium is an amine-reactive succinimide ester. Sulfo-Cyanine7 NHS ester reagent allows to prepare sulfo-Cyanine7-labeled biomolecules, such as proteins, with ease. Dye labeled molecules can be subsequently used for various research and agent design related experiments.

HY-D2761

DY-680-NHS ester	Fluorescent Dye
DY-680-NHS ester is an amine reactive hydrophilic fluorochrome. It can be conjugated to an antibody with higher D/P ratio without causing fluorescence quenching and conjugate precipitation, and it is widely used in applications including western blotting, microscopy, flow cytometry, and cell-based assays. The spectrum has an excitation of 690nm and emission at 709nm.

HY-D2757

5(6)-Carboxyrhodamine 110 NHS ester	Fluorescent Dye
5(6)-Carboxyrhodamine 110 NHS Ester is the nonsulfonated analog of the BP Fluor 488 dye. The amine-reactive 5(6)-Carboxyrhodamine 110 NHS ester can be used to create bright and photostable green-fluorescent bioconjugates with excitation/emission maxima ~502/527 nm. The conjugates of this dye often used for Fluorescence Correlation Spectroscopy (FCS).

HY-D2895A

RB-PEG600-NH2 Rhodamine B-PEG600-NH2	Fluorescent Dye
RB-PEG600-NH2 (Rhodamine B-PEG600-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .

HY-D2895H

RB-PEG10000-NH2 Rhodamine B-PEG10000-NH2	Fluorescent Dye
RB-PEG10000-NH2 (Rhodamine B-PEG10000-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .

HY-D2895D

RB-PEG3400-NH2 Rhodamine B-PEG3400-NH2	Fluorescent Dye
RB-PEG3400-NH2 (Rhodamine B-PEG3400-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .

HY-D2895B

RB-PEG1000-NH2 Rhodamine B-PEG1000-NH2	Fluorescent Dye
RB-PEG1000-NH2 (Rhodamine B-PEG1000-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .

HY-D2895

RB-PEG400-NH2 Rhodamine B-PEG400-NH2	Fluorescent Dye
RB-PEG400-NH2 (Rhodamine B-PEG400-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm) .

HY-D2773

5-Carboxyrhodamine 110 NHS ester

Fluorescent Dye

5-Carboxyrhodamine 110 NHS Ester is the nonsulfonated analog of the BP Fluor 488 dye. The amine-reactive 5(6)-Carboxyrhodamine 110 NHS Ester can be used to create bright and photostable green-fluorescent bioconjugates with excitation/emission maxima ~502/527 nm. For many applications, the dye is preferred over 5-(6)-carboxyfluorescein NHS ester or FITC because of its exceptional photostability and fluorescence insensitivity to pH (4-9). Although the mixed isomers of Carboxyrhodamine 110 NHS Ester preferred, routinely used fluorescent dye for labeling proteins, peptides and nucleotides, purification of peptide and nucleotides labeled with 5(6) isomers might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer usually give better resolution in HPLC purification that is often required in the conjugation processes.

HY-D3263

IR 650 NHS ester	Fluorescent Dye
IR 650 NHS ester is a far-red-fluorescent probe with NHS ester. NHS ester is the most popular amine-reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. (Ex=651nm, Em=668 nm)

HY-W998644

PB LC acid	Fluorescent Dye
PB LC acid is a blue-fluorescent dye that is reactive with primary amines on biomolecules such as peptides, proteins, modified nucleotides and biopolymers (Ex/Em = 410/455 nm) .

HY-D3049

5(6)-carbonylated rhodamine 110 NHS ester	Fluorescent Dye
5(6)-carbonylated rhodamine 110 NHS ester is a reactive ester fluorescent reagent based on 5(6)-carbonylated rhodamine 110. NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 502/527 nm).

Cat. No.	Product Name	Type

HY-W441011

DSPE-NHS	Biochemical Assay Reagents
DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. The NHS-ester is reactive with N-terminal of protein/peptide or other amine molecule to form a stable amide linkage. DSPE-NHS labels antibodies. DSPE-NHS can be used to prepare liposomes as agent nanocarrier .

HY-W879045

Endo-BCN-PEG5-amine Endo-BCN-PEG5-NH2	Biochemical Assay Reagents
Endo-BCN-PEG5-amine (Endo-BCN-PEG5-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-W441013

DSPE-PEG1000-NHS	Biochemical Assay Reagents
DSPE-PEG1000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG1000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG1000-NHS can be used in the study of drug delivery .

HY-W1048843A

4-Arm PEG5000-NH2 4-Arm PEG5000-amine	Biochemical Assay Reagents
4-Arm PEG5000-NH2 (4-Arm PEG5000-amine) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048525

8-Arm PEG5000-NH2 8-Arm PEG5000-amine	Biochemical Assay Reagents
8-Arm PEG5000-NH2 (8-Arm PEG5000-Amine) is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-D1021

AA-dUTP sodium salt Aminoallyl-dUTP sodium salt	Biochemical Assay Reagents
AA-dUTP (Aminoallyl-dUTP) sodium salt is a reverse transcriptase and DNA polymerase I substrate with probe precursor activity. AA-dUTP sodium salt undergoes enzymatic incorporation into DNA during cDNA synthesis and nick translation. AA-dUTP sodium salt generates amine-modified DNA, which can be used for labeling with amine-reactive fluorescent dyes .

HY-W1048549A

HOOC-PEG2000-SH HOOC-PEG2000-Thiol	Biochemical Assay Reagents
HOOC-PEG2000-SH (HOOC-PEG2000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048843B

4-Arm PEG10000-NH2 4-Arm PEG10000-amine	Biochemical Assay Reagents
4-Arm PEG10000-NH2 (4-Arm PEG10000-amine) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048519A

4-Arm PEG10000-NH2 hydrochloride 4-Arm PEG10000-amine HCL salt	Biochemical Assay Reagents
4-Arm PEG10000-NH2 (4-Arm PEG100000-amine) hydrochloride is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W879025

Endo-BCN-PEG8-amine Endo-BCN-PEG8-NH2	Biochemical Assay Reagents
Endo-BCN-PEG8-amine (Endo-BCN-PEG8-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-W1048547J

HOOC-PEG40000-NH2

HOOC-PEG40000-amine

Biochemical Assay Reagents

HOOC-PEG40000-NH2 (HOOC-PEG40000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W1048843AGL

4-Arm PEG5000-NH2 (GMP Like)

4-Arm PEG5000-amine (GMP Like)

Biochemical Assay Reagents

HY-W1048549C

HOOC-PEG5000-SH HOOC-PEG5000-Thiol	Biochemical Assay Reagents
HOOC-PEG5000-SH (HOOC-PEG5000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048555B

Mal-PEG3400-SCM

Biochemical Assay Reagents

Mal-PEG3400-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG3400-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .

HY-W250129

2,3,4,5-Tetrafluorobenzoyl chloride

Biochemical Assay Reagents

2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.

HY-131097

Malachite green isothiocyanate	Biochemical Assay Reagents
Malachite green isothiocyanate is an amine-reactive probe that reacts with amines to give the corresponding thiourea. Malachite green isothiocyanate is a reagent that has been used for the measurement of concentration of protein .

HY-W879044

Endo-BCN-PEG15-amine Endo-BCN-PEG15-NH2	Biochemical Assay Reagents
Endo-BCN-PEG15-amine (Endo-BCN-PEG15-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-W093254A

Poly(ethylene glycol) bis(carboxymethyl) ether (MW 250)	Biochemical Assay Reagents
Poly(ethylene glycol) bis(carboxymethyl) ether (MW 250) is an amine-reactive crosslinking agent .

HY-W093254B

Poly(ethylene glycol) bis(carboxymethyl) ether (MW 600)	Biochemical Assay Reagents
Poly(ethylene glycol) bis(carboxymethyl) ether (MW 600) is an amine-reactive crosslinking agent .

HY-140895B

Biotin-PEG10000-Amine Biotin-PEG10000-NH2	Biochemical Assay Reagents
Biotin-PEG10000-Amine (Biotin-PEG10000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-140895C

Biotin-PEG20000-Amine Biotin-PEG20000-NH2	Biochemical Assay Reagents
Biotin-PEG20000-Amine (Biotin-PEG20000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-140895D

Biotin-PEG40000-Amine Biotin-PEG40000-NH2	Biochemical Assay Reagents
Biotin-PEG40000-Amine (Biotin-PEG40000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-141618

5(6)-Carboxyrhodamine 110	Biochemical Assay Reagents
5(6)-Carboxyrhodamine 110 is an amine-reactive fluorescent probe for labeling DNA, cells and proteins (Ex/Em = 498/530 nm) .

HY-W1048519B

4-Arm PEG20000-NH2 hydrochloride 4-Arm PEG20000-amine HCL salt	Biochemical Assay Reagents
4-Arm PEG20000-NH2 (4-Arm PEG20000-amine) hydrochloride is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048519

4-Arm PEG5000-NH2 hydrochloride 4-Arm PEG5000-amine HCL salt	Biochemical Assay Reagents
4-Arm PEG5000-NH2 (4-Arm PEG5000-amine) hydrochloride is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048525B

8-Arm PEG40000-NH2 8-Arm PEG40000-amine	Biochemical Assay Reagents
8-Arm PEG40000-NH2 (8-Arm PEG40000-Amine) is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048526

8-Arm PEG5000-NH2 HCL 8-Arm PEG5000-amine HCL salt	Biochemical Assay Reagents
8-Arm PEG5000-NH2 (8-Arm PEG5000-amine) HCL is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048526A

8-Arm PEG20000-NH2 HCL 8-Arm PEG20000-amine HCL salt	Biochemical Assay Reagents
8-Arm PEG20000-NH2 (8-Arm PEG20000-amine) HCL is a multi-arm PEG derivative with amino groups at each end of the eight arms. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048567E

mPEG40000-SCM	Biochemical Assay Reagents
mPEG40000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567A

mPEG2000-SCM	Biochemical Assay Reagents
mPEG2000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567H

mPEG3400-SCM	Biochemical Assay Reagents
mPEG3400-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W440884

DSPE-PEG3400-Ald	Biochemical Assay Reagents
DSPE-PEG3400-Ald is a self-assemble polyPEG which spontaneously forms lipid bilayer in water. The polymer can be used to prepare nanoparticles or liposomse as a targeted drug carrier, such as mRNA vaccine. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond.

HY-W1049075E

mPEG-pALD (MW 2000)

Biochemical Assay Reagents

mPEG-pALD (MW 2000) is an important unilaterally active PEG derivative whose reactive groups can react with amines, peptides and the N-termini of proteins to form imines containing C=N double bonds, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can be used for reversible PEGylation by reacting with hydrazine or hydrazine to form hydrolyzed acylhydrazone bonds .

HY-W1049075B

mPEG10000-Pald

Biochemical Assay Reagents

mPEG10000-Pald is an important unilaterally active PEG derivative whose reactive groups can react with amines, peptides and the N-termini of proteins to form imines containing C=N double bonds, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can be used for reversible PEGylation by reacting with hydrazine or hydrazine to form hydrolyzed acylhydrazone bonds .

HY-W1048549E

HOOC-PEG20000-SH HOOC-PEG20000-Thiol	Biochemical Assay Reagents
HOOC-PEG20000-SH (HOOC-PEG20000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1049075D

mPEG40000-pALD

Biochemical Assay Reagents

mPEG40000-pALD is an important unilaterally active PEG derivative whose reactive groups can react with amines, peptides and the N-termini of proteins to form imines containing C=N double bonds, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can be used for reversible PEGylation by reacting with hydrazine or hydrazine to form hydrolyzed acylhydrazone bonds .

HY-W1048555D

Mal-PEG10000-SCM

Biochemical Assay Reagents

Mal-PEG10000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG10000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .

HY-W440885

DSPE-PEG5000-Ald

Biochemical Assay Reagents

DSPE-PEG5000-Ald is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond.

HY-W1048555

Mal-PEG1000-SCM

Biochemical Assay Reagents

Mal-PEG1000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG1000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .

HY-155885

mPEG40000-amine mPEG40000-NH2	Biochemical Assay Reagents
mPEG40000-amine (mPEG40000-NH2) is a monofunctional polyPEG with a terminal amine. The coupling between NHS ester and amine produces a stable amide bond. The amine moieties is also reactive with carboxyl in the presence of activating agent .

HY-140895A

Biotin-PEG5000-Amine Biotin-PEG5000-NH2	Biochemical Assay Reagents
Biotin-PEG5000-Amine (Biotin-PEG5000-NH2) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048843C

4-Arm PEG20000-NH2 4-Arm PEG20000-amine	Biochemical Assay Reagents
4-Arm PEG20000-NH2 (4-Arm PEG20000-amine) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048519C

4-Arm PEG40000-NH2 hydrochloride 4-Arm PEG40000-amine HCL salt	Biochemical Assay Reagents
4-Arm PEG40000-NH2 (4-Arm PEG40000-amine) hydrochloride is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048843D

4-Arm PEG40000-NH2 4-Arm PEG40000-amine	Biochemical Assay Reagents
4-Arm PEG40000-NH2 (4-Arm PEG40000-amine) is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-W1048547A

HOOC-PEG2000-NH2

HOOC-PEG2000-amine

Biochemical Assay Reagents

HOOC-PEG2000-NH2 (HOOC-PEG2000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W1048547H

HOOC-PEG1000-NH2

HOOC-PEG1000-amine

Biochemical Assay Reagents

HOOC-PEG1000-NH2 (HOOC-PEG1000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W1048547E

HOOC-PEG20000-NH2

HOOC-PEG20000-amine

Biochemical Assay Reagents

HOOC-PEG20000-NH2 (HOOC-PEG20000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W1048547I

HOOC-PEG3400-NH2

HOOC-PEG3400-amine

Biochemical Assay Reagents

HOOC-PEG3400-NH2 (HOOC-PEG3400-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W1048547C

HOOC-PEG5000-NH2

HOOC-PEG5000-amine

Biochemical Assay Reagents

HOOC-PEG5000-NH2 (HOOC-PEG5000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

HY-W1048547D

HOOC-PEG10000-NH2

HOOC-PEG10000-amine

Biochemical Assay Reagents

HOOC-PEG10000-NH2 (HOOC-PEG10000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .

Cat. No.	Product Name	Target	Research Area

HY-P10940

Ac-RFAAKAA-COOH	Peptides	Inflammation/Immunology
Ac-RFAAKAA-COOH is a cysteine-containing polypeptide with a reactive lysine residue, and serves as a substrate for covalent modification and chemical reactivity assays. Ac-RFAAKAA-COOH forms stable covalent adducts with isothiocyanates, resulting in peptide depletion over time. Ac-RFAAKAA-COOH acts as a model peptide in direct peptide reactivity assays, where its chemical reactivity is evaluated via fluorescamine-based free amine assays. Ac-RFAAKAA-COOH can be used in studies related to allergic contact dermatitis and skin sensitization .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N16025

DOPE-PEG(2000) Amine ammonium	Structural Classification Lipid	Liposome Biochemical Assay Reagents
DOPE-PEG(2000) Amine ammonium is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted agent delivery and is reactive with alkyne to form a triazole ring .

Cat. No.	Product Name	Chemical Structure

HY-B1018AS

Phenelzine-d5 sulfate

Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-118759S

DSP Crosslinker-d8
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker (HY-118759). DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W705390

Disuccinimidyl suberate Crosslinker-d4
Disuccinimidyl suberate Crosslinker-d₄ is the deuterium labeled Disuccinimidyl suberate Crosslinker (HY-W019543). Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697S

DSG Crosslinker-d4
DSG Crosslinker-d₄ (Disuccinimidyl glutarate-d₄) is the deuterium labeled DSG Crosslinker (HY-114697). DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329AS

BS3 Crosslinker-d4 disodium
BS3 Crosslinker-d₄ disodium is the deuterium labeled BS3 Crosslinker. BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547S

BS2G Crosslinker-d4 disodium
BS2G Crosslinker-d₄ disodium is the deuterium labeled BS2G Crosslinker disodium (HY-130547). BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

Cat. No.	Product Name		Classification

HY-W879045

Endo-BCN-PEG5-amine Endo-BCN-PEG5-NH2		BCN
Endo-BCN-PEG5-amine (Endo-BCN-PEG5-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-W590569

Azido-PEG12-amine		Azide
Azido-PEG12-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG arm increases solubility in aqueous media.

HY-141175

TCO-PNB ester		PROTAC Synthesis TCO
TCO-PNB ester is an amine-reactive building block used for modification of amine-containing molecule. TCO-PNB ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group .

HY-D2746

Cy5.5 bis-NHS ester		Azide
Cy5.5 bis-NHS ester is a reactive cyanine dye containing NHS ester which can be used to label amine groups in peptides, proteins, and oligonucleotides.

HY-140339

ANB-NOS		PROTAC Synthesis Azide
ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .

HY-172516

1-Palmitoyl-2-(propargylacetyl)-sn-glycero-3-phosphocholine		Alkynes
1-Palmitoyl-2-(propargylacetyl)-sn-glycero-3-phosphocholine is a phosphocholine containing an azide-reactive propargyl on one of its tails and a positively charged quaternary amine head.

HY-173569

DBCO-propargyl-PEG5-TFP ester		DBCO Alkynes
DBCO-propargyl-PEG5-TFP ester is an amine-reactive labeling reagent. DBCO-propargyl-PEG5-TFP ester contains a DBCO group, which can undergo a strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with molecules containing an azide group ^{[1] ^.}

HY-W020546

DBCO-amine TFA 1 Publications Verification		DBCO
DBCO-amine TFA is a simple building block containing a DBCO moiety and an amine group. Amine is very reactive with NHS ester. DBCO is commonly used for copper-free Click Chemistry reactions.

HY-W591390

6-Azidohexanoic acid STP ester		Azide
6-Azidohexanoic Acid STP Ester is an amine-reactive, water-soluble labeling reagent with an azide group and a terminal 4-Sulfo-2,3,5,6-tetrafluorophenyl (STP) group. 6-Azidohexanoic Acid STP Ester is used to modify proteins, antibodies, and other amine-containing biopolymers in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. STP esters can react with primary amines, forming covalent amide bonds, and typically display much better stability toward hydrolysis in aqueous media, resulting in more efficiency and better reproducible labeling of biopolymers.

HY-W800653

N-(Azido-PEG3)-NH-PEG3-t-butyl ester		Azide
N-(Azido-PEG3)-NH-PEG3-t-butyl ester is a click chemistry reagent with a terminal azide group and secondary amine NH group. NH group is reactive with NHS ester, The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The azide group can participate in Click Chemistry.

Cat. No.	Product Name		Classification

HY-W441011

DSPE-NHS		Phospholipids
DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. The NHS-ester is reactive with N-terminal of protein/peptide or other amine molecule to form a stable amide linkage. DSPE-NHS labels antibodies. DSPE-NHS can be used to prepare liposomes as agent nanocarrier .

HY-W441013

DSPE-PEG1000-NHS		Pegylated Lipids
DSPE-PEG1000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG1000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG1000-NHS can be used in the study of drug delivery .

HY-172516

1-Palmitoyl-2-(propargylacetyl)-sn-glycero-3-phosphocholine		Phospholipids
1-Palmitoyl-2-(propargylacetyl)-sn-glycero-3-phosphocholine is a phosphocholine containing an azide-reactive propargyl on one of its tails and a positively charged quaternary amine head.

HY-W440927

Stearic acid-PEG2000-NHS		Pegylated Lipids
Stearic acid-PEG2000-NHS is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond. Reagent grade, for research purpose.

HY-W441005

Amino-Gly-Gly-DSPE hydrochloride		Phospholipids
Amino-Gly-Gly-DSPE (hydrochloride) is a specially modified phospholipid that has been used to synthesize liposomes. The terminal amine is reactive with an NHS ester compound or carboxylic acid molecule in the presence of activator, such as HATU or EDC.

HY-W440991

DOPE-PEG2000-Amine DOPE-PEG2000-NH2		Pegylated Lipids
DOPE-PEG-Amine (MW 2000) is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring.

HY-W440883

DSPE-PEG2000-Ald		Pegylated Lipids
DSPE-PEG2000-Ald is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.

HY-W440885

DSPE-PEG5000-Ald		Pegylated Lipids
DSPE-PEG5000-Ald is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond.

Targets Recommended: Amine N-methyltransferase Reactive Oxygen Species (ROS) Trace Amine-associated Receptor (TAAR) VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W1048843AG

4-Arm PEG5000-NH2 4-Arm PEG5000-amine	Biochemical Assay Reagents	Others
4-Arm PEG5000-NH2 (GMP) (4-Arm PEG5000-amine (GMP)) is 4-Arm PEG-NH2 (HY-W1048843A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. 4-Arm PEG5000-NH2 is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

HY-42360G

SMCC	ADC Linker	Inflammation/Immunology Cancer
SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

HY-W1048843AGL

4-Arm PEG5000-NH2 (GMP Like) 4-Arm PEG5000-amine (GMP Like)	Biochemical Assay Reagents	Others
4-Arm PEG5000-NH2 (GMP Like) (4-Arm PEG5000-amine (GMP Like)) is 4-Arm PEG-NH2 (HY-W1048843A) produced by using GMP like guidelines. GMP like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. 4-Arm PEG5000-NH2 is a multi-arm PEG derivative with amine groups at each end of four arms attached to a pentaerythritol core. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds .

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