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catalytic

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566

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5

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12

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34

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37

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5

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42

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34

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11

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67

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8

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2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10461
    PF-573228
    30+ Cited Publications

    		 FAK Apoptosis Cancer
    PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK.
    PF-573228
  • HY-W001187
    Tempo
    10+ Cited Publications

    		 Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species (ROS) Cancer
    Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
    Tempo
  • HY-Y0006
    XPhos

    2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl

    		 Biochemical Assay Reagents Others
    XPhos is a dual aryl monophosphine ligand. XPhos is an efficient and stable palladium catalytic ligand. XPhos can be used for amination of aryl sulfonate esters .
    XPhos
  • HY-172437
    Secutrelvir

    S-892216

    		 Virus Protease SARS-CoV Infection
    Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC50 values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19) .
    Secutrelvir
  • HY-12056
    BIX02189
    5+ Cited Publications

    		 MEK ERK Cancer
    BIX02189 is a potent and selective MEK5 inhibitor with an IC50 of 1.5 nM. BIX02189 also inhibits ERK5 catalytic activity with an IC50 of 59 nM.
    BIX02189
  • HY-10114
    TGX-221
    15+ Cited Publications

    		 PI3K Cancer
    TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment.
    TGX-221
  • HY-P1004A
    Luciferase, firefly

    		Fluorescent Dye Others
    Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. Luciferase, firefly catalytic substrate is D-luciferin (HY-12591B) .
    Luciferase, firefly
  • HY-122886
    XL 188
    1 Publications Verification

    		 Deubiquitinase Cancer
    XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer .
    XL 188
  • HY-161762
    RA-0002034

    RA-2034

    		 CHIKV Virus Protease Infection
    RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .
    RA-0002034
  • HY-135318
    NBDHEX
    2 Publications Verification

    		 Apoptosis Autophagy Glutathione S-transferase Cancer
    NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .
    NBDHEX
  • HY-B2188
    S-Methyl-L-cysteine
    2 Publications Verification

    L-S-Methylcysteine

    		 Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease
    S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.
    S-Methyl-L-cysteine
  • HY-N8245
    2',3'-cGMP sodium

    Guanosine 2',3'-cyclic monophosphate sodium salt

    		 Drug Intermediate Others
    2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase .
    2',3'-cGMP sodium
  • HY-134398
    Kinetin triphosphate

    6-Fu-ATP; KTP

    		 PINK1/Parkin Neurological Disease Cancer
    Kinetin triphosphate(6-Fu-ATP; KTP) is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate can be used in Parkinson's disease research .
    Kinetin triphosphate
  • HY-18081
    PF 750

    		FAAH Autophagy Neurological Disease Metabolic Disease
    PF 750 is a selective, covalent and brain-penetrant fatty acid amide hydrolase (FAAH) inhibitor. PF 750 covalently carbamylates FAAH's catalytic serine nucleophile to inactivate the enzyme .
    PF 750
  • HY-104001
    BAY-524
    1 Publications Verification

    		 Ser/Thr Kinase Cancer
    BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents .
    BAY-524
  • HY-148161
    L82-G17

    		DNA/RNA Synthesis Cancer
    L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity .
    L82-G17
  • HY-122594
    BNS-22

    		Topoisomerase Cancer
    BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .
    BNS-22
  • HY-W008137
    5-Bromo-2-fluoropyrimidine

    		Biochemical Assay Reagents Others
    5-Bromo-2-fluoropyrimidine is a polyhalogenated pyrimidine and chemoselective amination substrate.5-Bromo-2-fluoropyrimidine undergoes chemoselective amination at the C-2 position (C-F bond) with no amination at the C-5 position (C-Br bond) in the presence of a Cu(II)/PTABS catalytic system .
    5-Bromo-2-fluoropyrimidine
  • HY-D0172
    Tetrabutylammonium bromide

    AP 6G; Actiron 43-65; Aliquat 100

    		 Biochemical Assay Reagents Others
    Tetrabutylammonium bromide is an organic ammonium compound, which is often used in catalytic reactions and separation and purification processes. It has a significant catalytic effect in some organic synthesis reactions, and can be used as a surfactant, stabilizer and antibacterial agent, etc. In addition, in some laboratory studies, this compound has also been used as an ion exchanger, solvent extractant, etc.
    Tetrabutylammonium bromide
  • HY-P3823
    Asp-Asp-Asp-Asp-Asp-Asp

    		Influenza Virus Infection
    Asp-Asp-Asp-Asp-Asp-Asp is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.
    Asp-Asp-Asp-Asp-Asp-Asp
  • HY-12055
    BIX02188
    3 Publications Verification

    		 MEK ERK Cancer
    BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM.
    BIX02188
  • HY-59125
    (R,R)-(+)-Hydrobenzoin

    		Endogenous Metabolite Others
    (R,R)-(+)-Hydrobenzoin is a chiral secondary alcohol that can be used as a key substrate or a chiral auxiliary reagent in various catalytic reactions and synthetic experiments .
    (R,R)-(+)-Hydrobenzoin
  • HY-134398A
    Kinetin triphosphate tetrasodium

    6-Fu-ATP tetrasodium; KTP tetrasodium

    		 PINK1/Parkin Neurological Disease Cancer
    Kinetin triphosphate(6-Fu-ATP) tetrasodium is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate tetrasodium can be used in Parkinson's disease research .
    Kinetin triphosphate tetrasodium
  • HY-136276
    DMNB-caged-Serine

    		Amino Acid Derivatives Others
    DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation .
    DMNB-caged-Serine
  • HY-P3414A
    Proteasome-activating peptide 1 TFA
    3 Publications Verification

    		 Proteasome Neurological Disease
    Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .
    Proteasome-activating peptide 1 TFA
  • HY-P2931
    Triosephosphate isomerase

    TPI

    		 Endogenous Metabolite Others Cancer
    Triosephosphate isomerase (TPI) is a glycolytic enzyme. Triosephosphate isomerase fast interconverts dihydroxyacetone phosphate and D: -glyceraldehyde-3-phosphate, its catalytic site is at the dimer interface .
    Triosephosphate isomerase
  • HY-N8245R
    2',3'-cGMP sodium (Standard)

    Guanosine 2',3'-cyclic monophosphate sodium salt (Standard)

    		 Drug Intermediate Reference Standards Others
    2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase .
    2',3'-cGMP sodium (Standard)
  • HY-D2188
    IMP-2373

    		Deubiquitinase Cancer
    IMP-2373 is a low-toxicity activity-based probe targeting covalent pan-deubiquitinase (DUB), which modulates and monitors DUB activity via covalent binding to the catalytic cysteine and active site of DUB. IMP-2373 enables real-time tracking of dynamic intracellular DUB activity in physiologically relevant living cell systems, and quantitative analysis of activity changes induced by pharmacological inhibition or MYC dysregulation. IMP-2373 can be used for research on related diseases such as B-cell lymphoma .
    IMP-2373
  • HY-16138
    Ivaltinostat

    CG-200745

    		 HDAC MDM-2/p53 Apoptosis Cancer
    Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects .
    Ivaltinostat
  • HY-16138A
    Ivaltinostat formic

    CG-200745 formic

    		 HDAC MDM-2/p53 Apoptosis Inflammation/Immunology Endocrinology Cancer
    Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects .
    Ivaltinostat formic
  • HY-P2961
    Glutathione S-transferase

    		Glutathione S-transferase Cancer
    Glutathione S-transferase is a phase II metabolic enzyme consisting of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione S-transferase possesses various catalytic activities such as catalytic detoxification and thiol transfer, as well as chaperone function. GSTP1, a subtype of Glutathione S-transferase, is highly expressed in malignant tissues and serves as a tumor marker .
    Glutathione S-transferase
  • HY-P10939
    Ac-DMLD-CMK

    		Caspase Pyroptosis Inflammation/Immunology Cancer
    Ac-DmLD-CMK is a caspase 3 inhibitor and a GSDME inhibitor. Ac-DmLD-CMK binds directly to the catalytic domain of caspase-3, blocks caspase-3-mediated cleavage of GSDME, inhibits the activation of caspase 3 and Gsdme in the caspase 3-Gsdme signaling pathway, and reduces the levels of pyroptosis and apoptosis as well as the expression of LDH, IL-6, IL-1β and IL-18. Ac-DmLD-CMK alleviates renal function deterioration, renal tubular epithelial cell injury, inflammatory cytokine secretion, pulmonary structural damage, and chemotherapy-induced nephrotoxicity .
    Ac-DMLD-CMK
  • HY-P2208
    Z-IETD-AFC

    		Fluorescent Dye Cancer
    Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .
    Z-IETD-AFC
  • HY-115383
    Roflupram
    1 Publications Verification

    		 Phosphodiesterase (PDE) Neurological Disease Inflammation/Immunology
    Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors .
    Roflupram
  • HY-P10463
    ssK36

    		Histone Methyltransferase Cancer
    ssK36 is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 is designed for the SETD2 protein, a specific PKMT. ssK36 is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency .
    ssK36
  • HY-132233A
    DDO-2093 dihydrochloride

    		Histone Methyltransferase Cancer
    DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex .
    DDO-2093 dihydrochloride
  • HY-176556
    EGFR-IN-167

    		EGFR Cancer
    EGFR-IN-1671 is a selective EGFR inhibitor with an IC50 of 0.19 nM. EGFR-IN-167 exhibits good potency against various EGFR mutants (IC50 = 0.109 nM, 0.75 nM and <0.05 nM against EGFR (L858R), EGFR (C797S) and EGFR (del19), respectively). EGFR-IN-1671 covalently engages the catalytically conserved lysine of EGFR in live mammalian cells. EGFR-IN-1671 demonstrates excellent anti-proliferative activity by inhibiting EGFR autophosphorylation. EGFR-IN-1671 can be used for the study of non-small-cell lung carcinomas (NSCLC), glioblastoma and many solid tumors .
    EGFR-IN-167
  • HY-E70039
    alpha-2-3,6,8-Sialidosidase (SpNanA)

    		Others Others
    alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .
    alpha-2-3,6,8-Sialidosidase (SpNanA)
  • HY-ER019
    Benzyltributylammonium chloride

    N-Benzyl-N,N-dibutylbutan-1-aminium chloride

    		 Biochemical Assay Reagents Others
    Benzyltributylammonium chloride is an organic salt compound, usually used in catalytic reactions and surfactants. It can play a catalytic role in some organic synthesis reactions, and can be used as a cleaning agent, lubricant and emulsifier. In addition, the compound is widely used in certain industrial fields, such as in the plastic, rubber and textile manufacturing processes.
    Benzyltributylammonium chloride
  • HY-Y1422J
    Lipase,Burkholderiacepacia (Immobilized)

    		Biochemical Assay Reagents Lipase Others
    Lipase,Burkholderiacepacia (Immobilized) comes from Burkholderiacepacia and can be used for catalytic reaction .
    Lipase,Burkholderiacepacia (Immobilized)
  • HY-W031536
    2-Imidazolidone, 96%

    2-Oxoimidazolidine, 96%

    		 Biochemical Assay Reagents Others
    2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.
    2-Imidazolidone, 96%
  • HY-P3811A
    Autocamtide-3 acetate

    		CaMK Neurological Disease
    Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca 2+/calmodulin-dependent kinase II) (CaMK) substrate .
    Autocamtide-3 acetate
  • HY-W088065S
    Formate-13C sodium

    Sodium [13C]formate; Sodium formate-13C

    		 Isotope-Labeled Compounds Others
    Formate- 13C (sodium) is the 13C labeled Sodium formate.Sodium formate is a biochemical assay reagent. Sodium formate can react with zinc sources (such as ZnCl2) on the surface of alpha alumina support to form a zinc oxide layer. Sodium formate acts as a deprotonating agent, promoting the deprotonation of ligands (such as 2-methylimidazole) at high temperatures. Sodium formate provides the required reducing force in the catalytic oxidation of methane to methanol by methane monooxygenase (sMMO) and inhibits further oxidation of methanol .
    Formate-13C sodium
  • HY-W088065S1
    Sodium formate-13C,d1

    		Isotope-Labeled Compounds Others
    Sodium formate- 13C,d1 is the deuterium and 13C labeled Sodium formate.Sodium formate is a biochemical assay reagent. Sodium formate can react with zinc sources (such as ZnCl2) on the surface of alpha alumina support to form a zinc oxide layer. Sodium formate acts as a deprotonating agent, promoting the deprotonation of ligands (such as 2-methylimidazole) at high temperatures. Sodium formate provides the required reducing force in the catalytic oxidation of methane to methanol by methane monooxygenase (sMMO) and inhibits further oxidation of methanol .
    Sodium formate-13C,d1
  • HY-P10463A
    ssK36 TFA

    		Histone Methyltransferase Cancer
    ssK36 TFA is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2) , and ssK36 TFA is designed for the SETD2 protein, a specific PKMT. ssK36 TFA is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 TFA can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 TFA can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency .
    ssK36 TFA
  • HY-132233
    DDO-2093

    		WDR5 Cancer
    DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex .
    DDO-2093
  • HY-P3414
    Proteasome-activating peptide 1

    		Proteasome Neurological Disease
    Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .
    Proteasome-activating peptide 1
  • HY-122735
    Inh2-B1

    		Ser/Thr Kinase Bacterial Infection
    Inh2-B1 is a Ser/Thr protein kinase (STK1) inhibitor. Inh2-B1 specifically inhibits STK1 activity by directly binding to its ATP-binding catalytic domain. Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) clearly .
    Inh2-B1
  • HY-179237
    MK2-IN-8

    		MAPKAPK2 (MK2) Others
    MK2-IN-8 (Compound 42) is a covalent MK2 kinase inhibitor. MK2-IN-8 forms a unique covalent bond with the catalytic lysine, thereby demonstrating that the fluorosulfonate can effectively target the catalytic lysine in kinases.
    MK2-IN-8
  • HY-W157144
    Diethyl disulfide

    		Biochemical Assay Reagents Others
    Diethyl disulfide, an organosulfur compound, is a chemical reactant and an industrial catalyst with excellent catalytic activity .
    Diethyl disulfide

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