138 Results for "

cellular responses

" in MedChemExpress (MCE) Product Catalog:
Products (138)

138 Results for "cellular responses" in MCE Product Catalog:

61
D-Glucose
D-Glucose
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61 Publications Verification
Cat. No.: HY-B0389
CAS No.: 50-99-7
Synonyms: Glucose; D-(+)-Glucose; Dextrose
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Food Research Monosaccharides

Target:  

Environmental Pollutants Endogenous Metabolite

D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .
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30
Cyclic AMP
Cyclic AMP
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30 Cited Publications
Cat. No.: HY-B1511
CAS No.: 60-92-4
Synonyms: Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP
Category:  

Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .
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30
Cyclic AMP sodium
Cyclic AMP sodium
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30 Cited Publications
Cat. No.: HY-B1511A
CAS No.: 37839-81-9
Synonyms: Cyclic adenosine monophosphate sodium; Adenosine cyclic 3', 5'-monophosphate sodium; cAMP sodium
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes .
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20
NADPH
NADPH
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20 Cited Publications
Cat. No.: HY-113324
CAS No.: 53-57-6
Purity:  99.49%
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Endogenous Metabolite

NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .
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19
c-di-AMP disodium
c-di-AMP disodium
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19 Cited Publications
Cat. No.: HY-12326A
CAS No.: 2734909-87-4
Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
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19
c-di-AMP diammonium
c-di-AMP diammonium
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19 Cited Publications
Cat. No.: HY-12326B
Purity:  99.36%
Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
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14
Diprovocim
Diprovocim
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14 Cited Publications
Cat. No.: HY-123942
CAS No.: 2170867-89-5
Purity:  98.82%
Target:  

Toll-like Receptor (TLR) TNF Receptor p38 MAPK NF-κB

Research Areas:  

Inflammation/Immunology Cancer

Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC50=110 pM). Diprovocim stimulates the release of TNF-α from mouse macrophages (EC50=1.3 nM). Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses .
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14
Succinyl phosphonate trisodium salt
Succinyl phosphonate trisodium salt
0 Images
14 Cited Publications
Cat. No.: HY-12688A
CAS No.: 864167-45-3
Purity:  ≥98.0%
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β

Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .
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11
Aldosterone
Aldosterone
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11 Cited Publications
Cat. No.: HY-113313
CAS No.: 52-39-1
Purity:  98.93%
Category:  

Cardiovascular Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .
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10
I-BRD9
I-BRD9
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10 Cited Publications
Cat. No.: HY-18975
CAS No.: 1714146-59-4
Target:  

Epigenetic Reader Domain

Research Areas:  

Inflammation/Immunology Cancer

I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways .
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9
2'-Deoxycytidine (hydrochloride)
2'-Deoxycytidine (hydrochloride)
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9 Cited Publications
Cat. No.: HY-17564
CAS No.: 3992-42-5
Synonyms: 2'-Deoxycytidine monohydrochloride; Deoxycytidine hydrochloride; NSC 83251
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Nucleoside Antimetabolite/Analog

2'-Deoxycytidine hydrochloride (2'-Deoxycytidine monohydrochloride; NSC 83251) is an orally active nucleic acid biosynthesis enzyme inhibitor. 2'-Deoxycytidine hydrochloride competes with nucleic acid biosynthesis enzymes and nucleoside transporters, thereby reducing the toxicity of cytarabine. 2'-Deoxycytidine hydrochloride can be used in the research of L1210 lymphoblastic leukemia .
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4
ChX710
ChX710
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4 Cited Publications
Cat. No.: HY-112951
CAS No.: 2438721-44-7
Purity:  99.91%
Target:  

STING

Research Areas:  

Cancer

ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
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2
Polyinosinic acid sodium
Polyinosinic acid sodium
0 Images
2 Cited Publications
Cat. No.: HY-148980A
CAS No.: 33378-44-8
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Inflammation/Immunology

Polyinosinic acid sodium is the sodium form of Polyinosinic acid (HY-148980). Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation .
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1
D-Glucose-13C
D-Glucose-13C
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1 Cited Publications
Cat. No.: HY-B0389S10
CAS No.: 101615-88-7
Synonyms: Glucose-13C; D-(+)-Glucose-13C; Dextrose-13C
D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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1
Abagovomab
Abagovomab
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1 Cited Publications
Cat. No.: HY-P99276
CAS No.: 792921-10-9
Synonyms: Anti-Human CA-125 Recombinant Antibody

Target:  

Transmembrane Glycoprotein

Research Areas:  

Cancer

Abagovomab (Anti-Human CA-125 Recombinant Antibody) is a mouse monoclonal anti-idiotypic antibody that targets the tumor-associated antigen CA-125 (binding affinity: 0.5 nM). Produced by mouse hybridoma cells, Abagovomab mimics human TAA, CA-125. Abagovomab also induces humoral and cellular immune responses against ovarian cancer (oc) .
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1
Cyclic GMP
Cyclic GMP
0 Images
1 Cited Publications
Cat. No.: HY-113469
CAS No.: 7665-99-8
Purity:  99.43%
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite

Target:  

Endogenous Metabolite

Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .
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1
D-Glucose (Standard)
D-Glucose (Standard)
0 Images
1 Cited Publications
Cat. No.: HY-B0389R
CAS No.: 50-99-7
Synonyms: Glucose (Standard); D-(+)-Glucose (Standard); Dextrose (Standard)
Category:  

Endogenous metabolite Saccharides Monosaccharides

Target:  

Reference Standards Endogenous Metabolite

D-Glucose (Standard) is the analytical standard of D-Glucose. This product is intended for research and analytical applications. D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .
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1
D-Glucose-13C2-4
D-Glucose-13C2-4
0 Images
1 Cited Publications
Cat. No.: HY-B0389S15
CAS No.: 138079-87-5
Synonyms: Glucose-13C2-4; D-(+)-Glucose-13C2-4; Dextrose-13C2-4
D-Glucose- 13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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1
Cyclic GMP sodium
Cyclic GMP sodium
0 Images
1 Cited Publications
Cat. No.: HY-113469A
CAS No.: 40732-48-7
Purity:  99.89%
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .
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1
ZEN-3694
ZEN-3694
0 Images
1 Cited Publications
Cat. No.: HY-125236
CAS No.: 1643947-30-1
Purity:  99.74%
Synonyms: BET-IN-19
Target:  

Epigenetic Reader Domain Apoptosis

Research Areas:  

Cancer

ZEN-3694 (BET-IN-19) is an orally active BET inhibitor. ZEN-3694 regulates the function of BET proteins, thereby downregulating pathways involved in cell cycle regulation, ER signaling, AR signaling, AR splice variants, MYC, GR, cell growth, inflammation, and cellular immune responses. ZEN-3694 inhibits proliferation, induces apoptosis, reverses the upregulation of CDK6 and CCND1, restores cell cycle arrest, and inhibits CDK6 via miR-34a-5p. ZEN-3694 can be used in research related to HER2 breast cancer and metastatic castration-resistant prostate cancer .
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