19 Results for "

complement factor H

" in MedChemExpress (MCE) Product Catalog:
Products (19)

19 Results for "complement factor H" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P72137
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cfb; Bf; H2-Bfcomplement factor B; EC 3.4.21.47; C3/C5 convertase; complement factor B Ba fragment; complement factor B Bb fragment
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Cat. No.: HY-NP004
Synonyms: CVF
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .
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Cat. No.: HY-P991067
CAS No.: 2724922-85-2
Synonyms: KP-104

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .
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Cat. No.: HY-P2969
CAS No.: 80295-66-5
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .
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Cat. No.: HY-P990955
CAS No.: 2839652-75-2
Synonyms: ADX-097

Target:  

CD3 Complement System

Research Areas:  

Inflammation/Immunology

Ebribafusp alfa (ADX-097) comprising a humanized anti-C3d monoclonal antibody linked to two moieties of the first five consensus repeats of factor H (fH1-5). Ebribafusp alfa binds C3d and related fragments, catalyzes AP convertase dissociation, acts as a factor I co-factor for C3b cleavage, and delivers fH1-5 moieties to C3d-deposited tissues for local complement inhibition without systemic blockade. Ebribafusp alfa reduces glomerular C3 deposition, proteinuria, urine albumin-creatinine ratios, and urine soluble C5b-9 levels, preserves podocyte foot-process architecture, inhibits skin complement activation, and localizes to UVB-damaged primate skin. Ebribafusp alfa can be used for the research of membranous nephropathy, bullous pemphigoid, discoid lupus erythematosus, C3 glomerulopathy, IgA nephropathy, and lupus nephritis .
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Cat. No.: HY-P7890A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHucomplement factor H/CFH, His; complement factor H; CFH
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Cat. No.: HY-P7890
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHucomplement factor H/CFH, His; complement factor H; CFH
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Cat. No.: HY-P7830
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rMucomplement factor H/CFH, His; complement factor H; Protein beta-1-H; CFH
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Cat. No.: HY-P991954

Target:  

Complement System Syk

Research Areas:  

Inflammation/Immunology Cancer

GT103 is a human-derived monoclonal antibody targeting complement factor H (CFH). GT103 binds to a conformationally distinct epitope of CFH on tumor cells. GT103 activates the classical complement pathway, induces complement-dependent cytotoxicity, and triggers antibody-dependent cellular phagocytosis (ADCP) of tumor cells. GT103 increases calreticulin translocation to tumor cell plasma membranes. GT103 mediates B-cell activation via Syk kinase phosphorylation. GT103 inhibits tumor growth and metastasis in animal models. GT103 can be used for the research of non-small cell lung cancer .
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Cat. No.: HY-P74232
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: complement factor H; Protein beta-1-H; CFH
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Cat. No.: HY-P72946
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: complement factor H; H factor 1; CFH; HF; HF1; HF2
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Cat. No.: HY-P72946Y
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: complement factor H; H factor 1; CFH; HF; HF1; HF2
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Cat. No.: HY-P83616
Synonyms: AHUS1; AMBP1; ARMD4; ARMS1; beta1H; CFH; CFHL3; complement factor H; isoform b; factor H; factor H like 1; FHL1; HF1; HF2; HUS

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human

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Cat. No.: HY-P704903
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cfb; Bf; H2-Bfcomplement factor B; EC 3.4.21.47; C3/C5 convertase; complement factor B Ba fragment; complement factor B Bb fragment
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Cat. No.: HY-P70055
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHucomplement factor H-related 1/CFHR1, His; complement factor H-Related Protein 1; FHR-1; H factor-Like Protein 1; H-factor-Like 1; H36; CFHR1; CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2
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Cat. No.: HY-P70031
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHucomplement factor H-related protein 2/CFHR2, His; complement factor H-Related Protein 2; FHR-2; DDESK59; H factor-Like 3; H factor-Like Protein 2; CFHR2; CFHL2; FHR2; HFL3
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Cat. No.: HY-P70102
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHucomplement factor H-related protein 5/CFHR5, His; complement factor H-related protein 5; CFHR5; CFHL5; FHR5
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Cat. No.: HY-P72690
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: complement factor H-related protein 4; FHR-4; CFHR4; CFHL4
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Cat. No.: HY-P72691
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: complement factor H-related protein 3; FHR-3; DOWN16; CFHR3; CFHL3
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