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Results for "

licorice

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (1) AMPK (2) Bacterial (7) Biochemical Assay Reagents (2) Caspase (1) Cytochrome P450 (1) Environmental Pollutants (2) Estrogen Receptor/ERR (1) Fungal (2) Influenza Virus (1) Interleukin Related (1) Keap1-Nrf2 (4) Monoamine Oxidase (1) mTOR (1) NOD-like Receptor (NLR) (1) Oxidative Phosphorylation (2) PI3K (1) PPAR (2) Prostaglandin Receptor (1) Proteasome (2) Reactive Oxygen Species (ROS) (4) Reference Standards (6) Stearoyl-CoA Desaturase (SCD) (1) TNF Receptor (1) Tyrosinase (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (11) Inflammation/Immunology (12) Metabolic Disease (8) Neurological Disease (3)

By Targets:

Acyltransferase (1)

Akt (1)

AMPK (2)

Bacterial (7)

Biochemical Assay Reagents (2)

Caspase (1)

Cytochrome P450 (1)

Environmental Pollutants (2)

Estrogen Receptor/ERR (1)

Fungal (2)

Influenza Virus (1)

Interleukin Related (1)

Keap1-Nrf2 (4)

Monoamine Oxidase (1)

mTOR (1)

NOD-like Receptor (NLR) (1)

Oxidative Phosphorylation (2)

PI3K (1)

PPAR (2)

Prostaglandin Receptor (1)

Proteasome (2)

Reactive Oxygen Species (ROS) (4)

Reference Standards (6)

Stearoyl-CoA Desaturase (SCD) (1)

TNF Receptor (1)

Tyrosinase (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Infection (11)

Inflammation/Immunology (12)

Metabolic Disease (8)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0765

Isoliquiritin 2 Publications Verification	Fungal	Infection Neurological Disease Inflammation/Immunology
Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity .

HY-N4193

Glabrol 3 Publications Verification	Acyltransferase	Cardiovascular Disease
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-N7056

4'-Hydroxychalcone 3 Publications Verification	Oxidative Phosphorylation Proteasome	Inflammation/Immunology Cancer
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

HY-N4113

Glycycoumarin	Keap1-Nrf2 AMPK	Cancer
Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N6980

Licorice glycoside C2 1 Publications Verification	Others	Others
Licorice glycoside C2 is an acylated flavonoid glycoside found in the underground part of Glycyrrhiza uralensis .

HY-W009731

Dibenzoylmethane	Environmental Pollutants Keap1-Nrf2	Metabolic Disease Cancer
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N6983

Licoricesaponin G2	TNF Receptor PI3K Akt mTOR Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Licoricesaponin G2 is an orally active component found in Licorice. Licoricesaponin G2 significantly ameliorates Bleomycin (HY-108345)-induced pulmonary fibrosis by inhibiting the TNF-α signaling pathway, reducing epithelial-mesenchymal transition, and decreasing extracellular matrix deposition. Licoricesaponin G2 inhibits cancer cells proliferation, migration, inhibits PI3K/AKT/mTOR signaling pathway and increases ROS production. Licoricesaponin G2 can be used for the research of lung cancer and pulmonary fibrosis .

HY-154795

Magnesium isoglycyrrhizinate hydrate	Caspase NOD-like Receptor (NLR)	Inflammation/Immunology
Magnesium isoglycyrrhizinate hydrate is the active component found in licorice plant (Glycyrrhiza glabra). Magnesium isoglycyrrhizinate hydrate exhibits anti-inflammatory activity through NLRP3 inflammasome pathway, and attenuates the chronic obstructive pulmonary disease in rats .

HY-N4194

Glabrone 1 Publications Verification	PPAR Influenza Virus	Infection Metabolic Disease
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-N2920

β-Amyrenonol 11-Oxo-β-amyrin	Cytochrome P450	Inflammation/Immunology Cancer
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids .

HY-N6911

Licorice-saponin H2 (18β,20α)-Glycyrrhizic acid	Others	Metabolic Disease
Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .

HY-N2417

Stearyl glycyrrhetinate	Bacterial	Infection
Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects .

HY-N3960

Glycyrin	PPAR Bacterial	Infection Metabolic Disease
Glycyrin is a PPAR-γ ligand of licorice. Glycyrin can decrease the blood glucose levels of genetically diabetic mice. Glycyrin also shows antibacterial activity .

HY-N3386

Licoricone	Bacterial	Infection
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-N3388

Licoisoflavone B	Stearoyl-CoA Desaturase (SCD)	Infection Inflammation/Immunology Cancer
Licoisoflavone B is an orally active flavonoid found in licorice. Licoisoflavone B alleviates psoriasis via SCD1-targeted lipid metabolism reprogramming and suppression of Th17/IL-17-mediated inflammation. Licoisoflavone B inhiibits superoxide anion generation and superoxide anion-induced lipid peroxidation. Licoisoflavone B binds tightly to Lassa virus nucleoprotein and can be used as a nucleoprotein antagonist of Lassa virus. Licoisoflavone B exhibits anti-mutagenic activity against carcinogenic mutagen, by preventing DNA damage. Licoisoflavone B can be used for the research of psoriasis, Lassa fever, inflammation and cancer .

HY-N11111

Glycyrrhizin-6'-methylester	Others	Others
Glycyrrhizin-6'-methylester is a natural product that can be isolated from licorice (Glycyrrhiza glabra) .

HY-142099

Hispaglabridin A	Reactive Oxygen Species (ROS)	Others
Hispaglabridin A is an isoflavone derivative extracted from licorice roots. Hispaglabridin A is an antioxidant that is effective at inhibiting lipid peroxidation .

HY-116992

Chloroneb Demosan; TERSAN SP(R)	Environmental Pollutants Bacterial	Infection
Chloroneb (Demosan) is a pesticide with fungicidal and plant-protective activities. Chloroneb can be used to detect organochlorine pesticide residues, showing good selectivity, stability and reproducibility. Chloroneb has been applied to the detection of licorice, cucumber, river water and soil samples with satisfactory results .

HY-142101

3,4-Didehydroglabridin	Others	Inflammation/Immunology
3,4-Didehydroglabridin is a natural product that can be found in licorice. 3,4-Didehydroglabridin exhibits protective activities against carbon tetrachloride-induced HepG2 cells injury. 3,4-Didehydroglabridin has the potential for the research of liver injury .

HY-N3943

Glabrene	Tyrosinase	Neurological Disease
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC₅₀ of 3.5 μM .

HY-N6982

Licoricesaponin A3	Others	Metabolic Disease
Licoricesaponin A3 is a terpenoid saponin identified from licorice .

HY-N3947

Glepidotin B	Bacterial	Infection
Glepidotin B is a dihydroflavonol compound isolated from the extracts of American licorice, Glycyrrhiza lepidota (Leguminosae). Glepidotin B is an antimicrobial agent .

HY-N11034

*24-Hydroxy-licorice-saponin A3*	Others	Others
24-Hydroxy-licorice-saponin A3 is an oleanane-type triterpene saponin (OTS). 24-Hydroxy-licorice-saponin A3 can be isolated from G. uralensis. .

HY-N11771

Glyurallin B	Reactive Oxygen Species (ROS)	Others
Glyurallin B is a flavonoid, that can be isolated from licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Glyurallin B shows ABTS ⁺ radical scavenging activity and the inhibitory activity on lipid peroxidation, with EC₅₀ values of 11.9 ± 0.58 μM and 15.3 ± 1.26 μM, respectivley .

HY-N6911B

Licorice-saponin H2 ammonium (18β,20α)-Glycyrrhizic acid ammonium	Others	Metabolic Disease
Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) ammonium is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 ammonium accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .

HY-N9329

Glicoricone	Monoamine Oxidase Estrogen Receptor/ERR	Metabolic Disease
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-N4113R

Glycycoumarin (Standard)	Reference Standards Keap1-Nrf2 AMPK	Cancer
Glycycoumarin (Standard) is the analytical standard of Glycycoumarin. This product is intended for research and analytical applications. Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N11975

Glycyrrhizin-6′,6′′-dimethylester	Others	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

HY-N11976

Glycyrrhizin-6′′-methylester	Others	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-N1471R

Liquiritin apioside (Standard)	Reference Standards Others	Inflammation/Immunology
Liquiritin apioside (Standard) is the analytical standard of Liquiritin apioside. This product is intended for research and analytical applications. Liquiritin apioside, a main flavonoid component of licorice, possesses antitussive effects .

HY-N0765R

Isoliquiritin (Standard)	Reference Standards Fungal	Infection Neurological Disease Inflammation/Immunology
Isoliquiritin (Standard) is the analytical standard of Isoliquiritin. This product is intended for research and analytical applications. Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity .

HY-W009731R

Dibenzoylmethane (Standard)	Reference Standards Keap1-Nrf2	Metabolic Disease Cancer
Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-116992R

Chloroneb (Standard) Demosan (Standard); TERSAN SP(R) (Standard)	Bacterial Reference Standards	Infection
Chloroneb (Standard) is the analytical standard of Chloroneb. This product is intended for research and analytical applications. Chloroneb (Demosan) is a pesticide with fungicidal and plant-protective activities. Chloroneb can be used to detect organochlorine pesticide residues, showing good selectivity, stability and reproducibility. Chloroneb has been applied to the detection of licorice, cucumber, river water and soil samples with satisfactory results .

HY-N18824

Licorice oil	Bacterial	Infection Inflammation/Immunology
Licorice oils, derived from the roots and rhizomes of the licorice plant (Glycyrrhiza glabra), are rich in bioactive compounds like glycyrrhizin, flavonoids, and triterpenoid. Licorice oil has anti-inflammatory and antibacterial properties, which can effectively soothe irritated skin, reduce redness, control eczema, and fight acne.

HY-N15622

Neouralenol	Biochemical Assay Reagents	Others
Neouralenol is a free radical scavenger. Neouralenol can be isolated from licorice roots. Neouralenol scavenges hydroxyl radicals and hydroperoxyl radicals .

HY-N9767

Gancaonin O	Others	Others
Gancaonin O is an active compound isolated from the genus Licorice .

HY-W680956

2,3-Dihydro-3-methylfuran	Others	Others
2,3-Dihydro-3-methylfuran is a melanin-like metabolite produced by the processing of licorice .

HY-E71181

11-oxo-β-Amyrin 30-oxidase	Biochemical Assay Reagents	Others
11-oxo-β-Amyrin 30-oxidase (EC 1.14.13.173) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice).

HY-N12571A

(E/Z)-3-Hydroxylicochalcone A	Reactive Oxygen Species (ROS) Interleukin Related Prostaglandin Receptor	Inflammation/Immunology
(E/Z)-3-Hydroxylicochalcone A (Compound 1) is a flavonoid found in licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis), with antioxidant and anti-inflammatory activity. (E/Z)-3-Hydroxylicochalcone A inhibits lipid peroxidation in rat liver microsomes. (E/Z)-3-Hydroxylicochalcone A inhibits LPS (HY-D1056)-induced ROS, NO, IL-6, and PGE2 production .

HY-N7056R

4'-Hydroxychalcone (Standard)	Reference Standards Proteasome Oxidative Phosphorylation	Inflammation/Immunology Cancer
4'-Hydroxychalcone (Standard) is the analytical standard of 4'-Hydroxychalcone (HY-N7056). This product is intended for research and analytical applications. 4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

Cat. No.	Product Name

HY-L209

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library	1,978 compounds
The Ancient Chinese Classical Formulas, released by the State Administration of Traditional Chinese Medicine, selects the classic prescriptions from more than 100,000 prescriptions contained in more than 100 representative ancient medical books. Experts said that the classic prescription derived from ancient books, with thousands of years of human experience, is widely used in common diseases, frequented diseases, chronic diseases and other fields, and its development and utilization can fill the gap in medical drugs for some diseases in China, and effectively alleviate the increasingly severe medical needs brought by a series of social problems such as aging and chronic diseases in China. MCE has collected and sorted out these monomer compounds from the sources of ancient Chinese classical formulas, including licorice, ginseng, pinellia and other traditional Chinese medicine sources, which help to provide new ideas and new strategies for modern drug development. MCE ancient Chinese classical formulas traditional Chinese medicine active compound library has 1,978 traditional Chinese medicine monomer compound, which can be used in the research fields of new drug development and drug target identification.

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

1,978 compounds

The Ancient Chinese Classical Formulas, released by the State Administration of Traditional Chinese Medicine, selects the classic prescriptions from more than 100,000 prescriptions contained in more than 100 representative ancient medical books. Experts said that the classic prescription derived from ancient books, with thousands of years of human experience, is widely used in common diseases, frequented diseases, chronic diseases and other fields, and its development and utilization can fill the gap in medical drugs for some diseases in China, and effectively alleviate the increasingly severe medical needs brought by a series of social problems such as aging and chronic diseases in China. MCE has collected and sorted out these monomer compounds from the sources of ancient Chinese classical formulas, including licorice, ginseng, pinellia and other traditional Chinese medicine sources, which help to provide new ideas and new strategies for modern drug development.

MCE ancient Chinese classical formulas traditional Chinese medicine active compound library has 1,978 traditional Chinese medicine monomer compound, which can be used in the research fields of new drug development and drug target identification.

Isoliquiritin 2 Publications Verification	Chalcones Flavonoids Neurological Disease Classification of Application Fields Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Fungal
Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity .

Glabrol 3 Publications Verification	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Acyltransferase
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

4'-Hydroxychalcone 3 Publications Verification	Chalcones Monophenols Flavonoids Classification of Application Fields Leguminosae Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Oxidative Phosphorylation Proteasome
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

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