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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
proinflammatory caspases
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "proinflammatory caspases" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-N0260
CAS No.: 110642-44-9
Synonyms: Epimedin-C; Baohuoside-VI
Category:
Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology
Target:
3
3
3 Cited Publications
Target:
Research Areas:
NLRP3 agonist 1 (Compound 23) is an orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms .
3
3 Cited Publications
Cat. No.: HY-N1431A
CAS No.: 29479-00-3
1
1
Target:
Research Areas:
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment .
Cat. No.: HY-130413
CAS No.: 660430-03-5
Synonyms: Neuroprotectin D1; NPD1
Cat. No.: HY-159520
CAS No.: 2731294-23-6
Synonyms: Ofirnoflast; HT-6184
Research Areas:
Ofirnoflastum (Ofirnoflast) is an orally active first-in-class allosteric NEK7 inhibitor with an IC50 of 46 nM. Ofirnoflastum binds an allosteric site adjacent to NEK7’s ATP-binding pocket, induces conformational shifts, disrupts NEK7-NLRP3 binding, blocks NLRP3 inflammasome assembly, spares NEK7’s physiological functions, and suppresses caspase-1, caspase-8, NF-κB, and TNF activity. Ofirnoflastum reduces pro-inflammatory cytokine production, suppresses ASC specks, IL-1β release, pyroptotic cell death, and leukemic burden, induces apoptosis and erythroid differentiation, restores hematopoiesis, and improves outcomes in colitis models. Ofirnoflastum can be used for the research of myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia .
Cat. No.: HY-N6866
CAS No.: 69176-52-9
Cat. No.: HY-N6017
CAS No.: 19906-72-0
Cat. No.: HY-160229
Synonyms: R-1075 sodium
Target:
Toll-like Receptor (TLR) MyD88 Caspase Reactive Oxygen Species (ROS) Autophagy Pyroptosis HIV
Research Areas:
ssRNA40 sodium (R-1075 sodium) is a single-stranded RNA40 derived from HIV-1. ssRNA40 sodium activates the TLR7, TLR8, TLR2, RIG-I, MDA5, MyD88, Caspase-3, IRE1α, NLRP3 inflammasome and IRF7 signaling pathways. ssRNA40 sodium alters mRNA expression in neutrophils, induces pro-inflammatory cytokines, ROS, autophagy (autophagy), pyroptosis (pyroptosis), neuronal death, neurodegeneration, aggregate formation and NK cell activation. ssRNA40 sodium activates the expression of CD62L, CD11b, CD69, MX1, OAS1, ATG7, LC3B and XBP1 in immune cell and neuronal populations. ssRNA40 sodium causes cortical neuron loss and axonal damage in mice in a TLR7-dependent manner. ssRNA40 sodium can be used in research on HIV-1 infection, neurodegeneration, COVID-19 and HIV-associated neurological disorders .
Cat. No.: HY-P4547
CAS No.: 189275-74-9
Synonyms: AC-WEHD-AMC
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a fluorescent peptide caspase-1 substrate. Ac-Trp-Glu-His-Asp-AMC is cleaved by caspase-1, enabling the measurement of caspase-1 proteolytic activity. Ac-Trp-Glu-His-Asp-AMC is cleaved by proinflammatory caspases but not by proapoptotic caspases. Ac-Trp-Glu-His-Asp-AMC requires higher enzyme concentrations to detect active caspase-1 .
Cat. No.: HY-W748591
CAS No.: 76735-57-4
Category:
Cat. No.: HY-N2125
CAS No.: 174972-80-6
Category:
Cat. No.: HY-P5345
CAS No.: 184240-26-4
Research Areas:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease
Cat. No.: HY-N12717
CAS No.: 79786-01-9
Target:
Research Areas:
FPR2 agonist 2 is a potent and CNS-penetrant FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
