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" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (6) ADC Linker (1) ADC Payload (2) Adenosine Receptor (1) Amylin Receptor (2) Amyloid-β (3) Antibiotic (3) Apoptosis (4) ASK1 (1) Autophagy (3) AUTOTACs (2) Bacterial (7) Biochemical Assay Reagents (6) c-Fms (1) CCR (1) CD28 (1) CDK (3) COX (1) CRFR (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (3) DNA Stain (3) DNA/RNA Synthesis (12) Dopamine Receptor (3) Dopamine Transporter (1) Dopamine β-hydroxylase (2) Drug Derivative (2) EAAT (1) EGFR (1) Endogenous Metabolite (6) Endonuclease (1) Enteropeptidase (1) Epigenetic Reader Domain (2) ERK (2) Eukaryotic Initiation Factor (eIF) (2) FAAH (2) FAP (1) Fluorescent Dye (13) GCGR (2) GSK-3 (3) HCV (3) Histone Demethylase (2) iGluR (3) Insulin Receptor (2) Interleukin Related (5) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Lipocalin Family (1) MDM-2/p53 (1) mGluR (1) mRNA (1) nAChR (2) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (1) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (1) Phosphoglycerate Kinase (PGK) (1) Prostaglandin Receptor (1) PSMA (2) Pyruvate Kinase (1) Radionuclide-Drug Conjugates (RDCs) (2) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Renin (1) Serotonin Transporter (1) Small Interfering RNA (siRNA) (6) Somatostatin Receptor (2) Src (1) Syk (1) Tau Protein (2) TNF Receptor (3) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1) TREM receptor (1) Trk Receptor (1) TRP Channel (1) VEGFR (2) Virus Protease (1) YAP (1) α-synuclein (1)
By Research Areas:	Cancer (36) Cardiovascular Disease (6) Endocrinology (1) Infection (11) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (42)
Oligonucleotides:	Thymine Nucleotide (1) Guanine Nucleotide (1) Nucleotide Analogs (3) Rat Pre-designed siRNA Sets (1) Transcription Factors (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (4) Cytidine Nucleotide (1) siRNAs (6)

127

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cuprizone 3 Publications Verification	Dopamine β-hydroxylase	Neurological Disease
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .

Thiostrepton 20+ Cited Publications	Bacterial Antibiotic YAP	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

7-Aminoactinomycin D 5+ Cited Publications 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

TMA-DPH 10+ Cited Publications	Fluorescent Dye	Others
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .

Zenagamtide sodium Amycretin sodium; NN 9487 sodium	Amylin Receptor Insulin Receptor GCGR	Metabolic Disease
Zenagamtide (Amycretin; NN 9487) sodium is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide sodium is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide sodium improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide sodium may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases .

LysoTracker Blue DND-22	Fluorescent Dye	Neurological Disease Cancer
LysoTracker blue DND-22 is a blue fluorescent dye (Ex/Em: 373/422 nm). LysoTracker blue DND-22 stains acidic regions in living cells. LysoTracker blue DND-22 is used in the researches of neurodegenerative diseases and leukemia .

Bepranemab UCB 0107	Tau Protein	Neurological Disease
Bepranemab is a humanized IgG4 monoclonal antibody that binds to the central region of tau protein. Bepranemab inhibits the seeding, aggregation of pathological tau protein and the spread of tau pathology to distal brain regions. Bepranemab is applicable to research related to Alzheimer's disease .

Horse Serum Albumin	Biochemical Assay Reagents	Others
Horse Serum Albumin is an abundant, multifunctional mammalian plasma protein and transport molecule. Horse Serum Albumin acts as an allergen, exhibits high cross-reactivity with serum albumins from other mammals, and contains epitope regions recognizable by antibodies. Horse Serum Albumin binds a variety of metabolites, drugs, nutrients, metals and other molecules .

TMA-DPH (solution)	Fluorescent Dye	Others
TMA-DPH (solution) is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined . Solvent and concentration: DMSO: 10 mM

A 1070722	GSK-3	Neurological Disease Cancer
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a K_i of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion .

BIA 10-2474 2 Publications Verification	FAAH Autophagy	Neurological Disease
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ values of 50 to 70mg/kg in various rat brain regions.

Seco-DUBA	ADC Payload DNA/RNA Synthesis	Inflammation/Immunology Cancer
Seco-DUBA hydrochloride is a DNA-targeting cytotoxic agent. Seco-DUBA hydrochloride binds to the minor groove of A-T-rich DNA regions, alkylates the adenine N3 residue, and undergoes spontaneous spirocyclization to generate active DUBA (HY-160969). Seco-DUBA hydrochloride exerts cytotoxic activity against human cancer cells. The reduced hydrophobicity of Seco-DUBA hydrochloride supports the development of antibody-drug conjugates .

PF-06273340	Trk Receptor	Neurological Disease
PF-06273340 is a peripherally restricted pan-Trk inhibitor with IC₅₀ values of 6, 4, 3 nM for TrkA, TrkB, and TrkC receptors. PF-06273340 binds in a DFG-out conformation, targeting less conserved kinase ligand binding domain regions outside the ATP binding pocket. PF-06273340 exhibits anti-hyperalgesic and analgesic effects. PF-06273340 can be used for the research of pain .

Atibuclimab 2 Publications Verification IC14	Toll-like Receptor (TLR)	Infection Neurological Disease Inflammation/Immunology
Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .

eIF4A-IN-3	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A-IN-3, Silvestrol (HY-13251) analogue, is an eIF4A inhibitor. eIF4A-IN-3 blocks protein translation initiation by interfering with eIF4F complex assembly, preferentially inhibiting translation of mRNAs with long, highly structured 5'-untranslated regions. eIF4A-IN-3 inhibits proliferation of human breast cancer cells. eIF4A-IN-3 has moderate apical to basolateral permeability in intestinal cell monolayers and a low efflux ratio .

Galiximab IDEC 114; Anti-Human CD80 Recombinant Antibody	CD28 Apoptosis	Cancer
Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors .

Anti-IL11 Antibody (X203, Mouse IgG)	Interleukin Related	Inflammation/Immunology
Anti-IL11 Antibody (X203, Mouse IgG) is a chimeric antibody composed of humanized variable regions and a mouse IgG backbone. Anti-IL11 Antibody (X203, Mouse IgG) is a mouse-derived IgG antibody inhibitor, targeting to human IL-11.

PBA-1105	AUTOTACs Autophagy	Neurological Disease Cancer
PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates .

REV7/REV3L-IN-1 1 Publications Verification	DNA/RNA Synthesis	Cancer
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC₅₀ of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions .

AMT-NHS	Others	Others
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .

Ivicentamab GEN-3009	Transmembrane Glycoprotein	Cancer
Ivicentamab (GEN-3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research .

Di-4-ANEPPS	Fluorescent Dye	Cardiovascular Disease
Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC₅₀ remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias .

Mosapramine Clospipramine	Drug Derivative Dopamine Receptor 5-HT Receptor	Neurological Disease
Mosapramine (Clospipramine) is an orally active antipsychotic agent and one of the metabolites of Clocapramine (HY-B2073) after oral absorption. Mosapramine exerts its effects by specifically binding to striatal dopamine D2 receptors and frontal lobe 5-HT2 receptors, with a D2/5-HT2 receptor occupancy ratio of 7.4. Mosapramine induces typical neuropharmacological responses in rat brain regions, including extrapyramidal symptoms, hyperprolactinemia, increased salivation, constipation, and upregulated Fos protein expression. Mosapramine also features a reduced incidence of weight loss. Mosapramine is applicable to research related to schizophrenia .

Donanemab (Mouse IgG2b)	Amyloid-β	Neurological Disease
Donanemab (Mouse IgG2b) is a chimeric antibody composed of humanized variable regions and a mouse IgG2b backbone. Donanemab (Mouse IgG2b) is an anti-amyloid inhibitor used in Alzheimer's disease research.

SJ572403 3 Publications Verification SJ403	CDK	Others
SJ572403 (SJ403) is a p27 ^Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a K_d value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) .

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is an orally active WRN helicase inhibitor (pIC₅₀=7.6). GSK_WRN4 induces DNA damage markers (p21, p-γH2AX, p-KAP1). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage .

N-Acetylmannosamine 6-phosphate sodium salt ManNAc-6P sodium salt	Endogenous Metabolite	Others
N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy .

Micrococcal nuclease	Endonuclease	Infection
Micrococcal nuclease is an endonuclease derived from Staphylococcus aureus. Micrococcal nuclease is able to digest both single and double-stranded DNA (ssDNA and dsDNA) and RNA, and can cleave and hydrolyze the AT or AU-rich regions specifically. Micrococcal nuclease could be used as an indicator of Staphylococcus aureus contamination .

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .

Bac7(1-35)	Bacterial	Infection
Bac7(1-35) is a proline-rich antimicrobial peptide. Bac7(1-35) efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) demonstrates in vitro activity against P. aeruginosa strains .

BI-655064	TNF Receptor	Inflammation/Immunology
BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA) .

Asante potassium green-2 (TMA) APG-2 (TMA)	Fluorescent Dye	Neurological Disease
Asante potassium green-2 (APG-2) TMA is a cell-impermeable K ⁺ (potassium ion) fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration. Its excitation/emission maxima are 525/545 nm , respectively.

DMPX 3,7-Dimethyl-1-propargylxanthine	Adenosine Receptor	Neurological Disease
DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A_2A adenosine receptor (A_2A AR) antagonist that crosses the blood-brain barrier, with a K_i of 11 μM for rat A₂ adenosine receptor and a K_i of 45 μM for rat A₁ adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease .

Anti-Mouse 2C TCR Antibody (1B2)	Nuclear Factor of activated T Cells (NFAT)	Others
Anti-Mouse 2C TCR Antibody (1B2) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse 2C TCR. Anti-Mouse 2C TCR Antibody (1B2) recognizes determinants on the variable regions of both the α and β subunits of the TCR (T cell receptor) expressed by the mouse cytotoxic T lymphocyte clone 2C. Anti-Mouse 2C TCR Antibody (1B2) can be used for the detections of immunofluorescence and flow cytometry .

SSTR4 agonist 4	Somatostatin Receptor	Neurological Disease
SSTR4 agonist 4 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 4 has the potential for the research of pain (extracted from patent WO2021233428A1, compound 14) .

DL-Leucyl-DL-phenylalanine	Biochemical Assay Reagents	Others
DL-Leucyl-DL-phenylalanine is a dipeptide and can be used as a substrate to detecte two regions of dipeptidase staining on a gel in Drosophila simulans as well as in Drosophila melanogaster .

Aspartylglutamate Asp-Glu	Endogenous Metabolite	Neurological Disease
Aspartylglutamate (Asp-Glu) is a dipeptide that exhibits excitatory activity, as it has been shown to depolarize CA1 pyramidal neurons and increase conductance in response to stimulation. Aspartylglutamate selectively binds to certain glutamate receptors and demonstrates potent effects in specific regions of the hippocampus, particularly in the stratum radiatum where it enhances excitatory neurotransmission.

Terminal deoxyribonucleotidyltransferase TdT	DNA/RNA Synthesis	Others Cancer
Terminal deoxyribonucleotidyltransferase (TdT) catalyses the condensation of deoxyribonucleotide triphosphates onto the 3' hydroxyl ends of DNA strands and adds N-regions to gene segment junctions during V(D)J recombination. Terminal deoxyribonucleotidyltransferase is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells .

KMG-104AM	Fluorescent Dye	Others
KMG-104AM is a Mg ²⁺fluorescent probe. KMG-104AM is a membrane-permeable ester-modified derivative of KMG-104, which serves as a reporter and imaging agent. KMG-104AM can track the increase in intracellular free magnesium ion concentration induced by mitochondrial uncoupling. KMG-104AM enables visualization of the three-dimensional distribution of intracellular magnesium ion concentration. KMG-104AM is applicable to research related to the functions of intracellular magnesium ions .

N-Docosanoyl taurine	TRP Channel	Neurological Disease
N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions .

Or5m3b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Or5m3b Mouse Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the Or5m3b (Mouse) gene, as well as a negative control, a FAM-labeled negative control, and a positive control.

PD-1/PD-L1-IN 3	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases .

Bac7(1-35) acetate	Bacterial	Infection
Bac7(1-35) acetate is a proline-rich antimicrobial peptide. Bac7(1-35) acetate efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) acetate demonstrates in vitro activity against P. aeruginosa strains .

Nile Blue Methacrylamide	Fluorescent Dye	Others
Nile Blue Methacrylamide is a pH-responsive probe. Nile Blue Methacrylamide exhibits pH-sensitive absorption and fluorescence emission in the physiological pH range, with spectral shifts occurring between acidic and near-physiological pH conditions . (Ex/Em = 590/670-700 nm)

ST4070	FAAH	Neurological Disease
ST4070 is a potent, orally active, and selective reversible fatty acid amide hydrolase (FAAH) inhibitor. ST4070 increases endocannabinoid (eCB) brain levels and counteracts neuropathic pain in animal models. ST4070 enhances the endogenous eCB tone in specific brain regions engaged in emotional control, and induces remarkable anxiolytic-like behaviours in rodents. ST4070 can be used for neuropathic pain and anxiety disorders research .

Cuprizone (Standard)	Reference Standards Dopamine β-hydroxylase	Neurological Disease
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .

Cat. No.	Product Name

HY-L925

Cysteine Protease Focused Library

9,188 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors.

This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

HY-L191

Tibetan Medicine Compound Library

1,136 compounds

Tibetan medicine, as one of the treasures of traditional Chinese medicine, carries the profound cultural heritage of the Tibetan people and their unique understanding of health. Tibet is the birthplace of Tibetan medicine, and its plateau climate and unique ecological environment have nurtured its rich medicinal resources. Among them, cordyceps, saffron and snow lily are favored by people for their excellent medicinal value and unique growth characteristics. Tibetan medicine, with its profound heritage, plays a crucial role in the management of diseases that are unique to high-altitude regions, such as altitude stress. It facilitates a swifter adaptation to high-altitude conditions and mitigates the symptoms of altitude sickness by meticulously recalibrating the internal environment within the human body. For rheumatic diseases, cardiovascular diseases, etc., Tibetan medicine has also shown its remarkable effect.

MCE included 1,136 natural products from Tibetan medicine, including animal, plant and mineral sources.

HY-L082

Antiparasitic Compound library

644 compounds

A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs.

MCE has a unique collection of 644 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

HY-L238

Mongolian Medicine Compound Library

2,380 compounds

Mongolian medicine refers to drugs used for disease prevention and treatment under the guidance of Mongolian medical theory. Originating from the vast grasslands and desert regions of northern China, Mongolian medicine developed under specific natural conditions and a nomadic lifestyle, forming a unique theoretical system and treatment methods. It emphasizes the balance between the human body and the natural environment and has demonstrated distinct efficacy in treating digestive system diseases, rheumatism, skin diseases, and various chronic conditions. For example, Mongolian medicine often uses Chinese red date for palpitations and angina pectoris, sea buckthorn to relieve coughs, reduce phlegm, promote blood circulation, and remove blood stasis, and scabious to clear lung heat and treat liver heat diseases. The application of these characteristic Mongolian medicines embodies the profound wisdom of Mongolian medical practice.

With the advancement of modern technology, research on Mongolian medicine continues to deepen. Systematic studies on the chemical composition and pharmacological effects of Mongolian medicines can provide new ideas and methods for modern drug development.

MCE has collected 2,380 characteristic natural products derived from Mongolian medicines, with 400+ plant sources of Mongolian medicine.

Cat. No.	Product Name	Type

HY-D1020

7-Aminoactinomycin D 5+ Cited Publications 7-AAD	Fluorescent Dye
7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-D0986

TMA-DPH 10+ Cited Publications	Fluorescent Dye
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .

HY-D1775

LysoTracker Blue DND-22	Fluorescent Dye
LysoTracker blue DND-22 is a blue fluorescent dye (Ex/Em: 373/422 nm). LysoTracker blue DND-22 stains acidic regions in living cells. LysoTracker blue DND-22 is used in the researches of neurodegenerative diseases and leukemia .

HY-DY1057

TMA-DPH (solution)

Fluorescent Dye

TMA-DPH (solution) is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .
Solvent and concentration: DMSO: 10 mM

HY-129763

Di-4-ANEPPS

Fluorescent Dye

Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC₅₀ remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias .

HY-D2481

Asante potassium green-2 (TMA) APG-2 (TMA)	Fluorescent Dye
Asante potassium green-2 (APG-2) TMA is a cell-impermeable K ⁺ (potassium ion) fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration. Its excitation/emission maxima are 525/545 nm , respectively.

HY-128536

KMG-104AM

Fluorescent Dye

KMG-104AM is a Mg ²⁺fluorescent probe. KMG-104AM is a membrane-permeable ester-modified derivative of KMG-104, which serves as a reporter and imaging agent. KMG-104AM can track the increase in intracellular free magnesium ion concentration induced by mitochondrial uncoupling. KMG-104AM enables visualization of the three-dimensional distribution of intracellular magnesium ion concentration. KMG-104AM is applicable to research related to the functions of intracellular magnesium ions .

HY-D1463

Nile Blue Methacrylamide	Fluorescent Dye
Nile Blue Methacrylamide is a pH-responsive probe. Nile Blue Methacrylamide exhibits pH-sensitive absorption and fluorescence emission in the physiological pH range, with spectral shifts occurring between acidic and near-physiological pH conditions . (Ex/Em = 590/670-700 nm)

HY-DY1099

7-Aminoactinomycin D (solution) 7-AAD (solution)	Fluorescent Dye
7-Aminoactinomycin D (solution) (7-AAD (solution)) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects . Solvent and concentration: DMSO: 1 mg/mL

HY-D0992

PerCP

Peridinin-chlorophyll-protein complex

Fluorescent Dye

PerCP is a peridinin-chlorophyll protein complex derived from the dinoflagellate *Glenodinium*, suitable for immunofluorescence staining of formalin-fixed, paraffin-embedded human tumor sections. As a red fluorescent dye, PerCP enables clear differentiation between antibody-bound tumor regions and yellow-green autofluorescence of tissues. PerCP allows simultaneous observation of tissue morphology without counterstaining. PerCP can be used in cancer research (Ex/Em = 482/677 nm) .

HY-D3195

CDr15

Fluorescent Dye

CDr15 is a deep-red fluorescent probe (Ex=733 nm) that can selectively intercalate into and label bacterial extracellular DNA (eDNA). CDr15 exhibits extremely high specificity for biofilm imaging and cannot effectively bind to mammalian nuclear DNA. CDr15 enables real-time visualization of the microcolony structure and developmental process of three-dimensional *Pseudomonas aeruginosa* biofilms, and accurately localizes biofilm-forming regions of microorganisms in a mouse corneal infection model. With low background interference signals, CDr15 serves as an ideal diagnostic tool for research fields including bacterial biofilms and corneal infections .

HY-D3210

DCM-KPV

Fluorescent Dye

DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λ_ex=480 nm, λ_em=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group .

HY-D3198

NIR‐fluorescent ceramide

Fluorescent Dye

NIR-fluorescent ceramide is a neutral near-infrared (NIF) fluorescent probe (λ_em=650 nm) based on the C-bridged nitrobenzoxadiazole SCOTfluor core, which enables visualization of lipid metabolic processes such as sphingolipid trafficking. The emission signal of NIR-fluorescent ceramide increases significantly in liposomal environments. NIR-fluorescent ceramide acts as an intracellular trafficking tracer, localizing to regions surrounding the endoplasmic reticulum and Golgi apparatus within a short period, and then translocating to recycling lysosomes over a longer period, thus enabling real-time visualization of sphingolipid trafficking and biological lipid functions in living cells. NIR-fluorescent ceramide also generates metabolic uptake profiles and provides multiple metabolic readouts in human cancer cell lines .

HY-D3189

5GluAF-2MeTG

Fluorescent Dye

5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens .

Cat. No.	Product Name	Type

HY-NP008

β-Lactoglobulin

Biochemical Assay Reagents

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-NP002J

Horse Serum Albumin	Biochemical Assay Reagents
Horse Serum Albumin is an abundant, multifunctional mammalian plasma protein and transport molecule. Horse Serum Albumin acts as an allergen, exhibits high cross-reactivity with serum albumins from other mammals, and contains epitope regions recognizable by antibodies. Horse Serum Albumin binds a variety of metabolites, drugs, nutrients, metals and other molecules .

Cat. No.	Product Name	Target	Research Area

HY-B0990

Thiostrepton 20+ Cited Publications	Bacterial Antibiotic YAP	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

HY-P11274A

Zenagamtide sodium Amycretin sodium; NN 9487 sodium	Amylin Receptor Insulin Receptor GCGR	Metabolic Disease
Zenagamtide (Amycretin; NN 9487) sodium is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide sodium is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide sodium improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide sodium may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases .

HY-P11274

Zenagamtide Amycretin; NN 9487	Amylin Receptor GCGR Insulin Receptor	Metabolic Disease
Zenagamtide (Amycretin; NN 9487) is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases .

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .

HY-P5731

Bac7(1-35)	Bacterial	Infection
Bac7(1-35) is a proline-rich antimicrobial peptide. Bac7(1-35) efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) demonstrates in vitro activity against P. aeruginosa strains .

HY-103048

PD-1/PD-L1-IN 3	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases .

HY-P5731A

Bac7(1-35) acetate	Bacterial	Infection
Bac7(1-35) acetate is a proline-rich antimicrobial peptide. Bac7(1-35) acetate efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) acetate demonstrates in vitro activity against P. aeruginosa strains .

HY-P10613

RERMS	Amyloid-β	Neurological Disease
RERMS are bioactive peptides produced from the active regions of amyloid-β and A4 protein precursors that promote fibroblast growth and can be used in the study of neurodegenerative diseases .

HY-P4037

HCV Core Protein (107-114)	HCV	Infection
HCV Core Protein (107-114) is a least immunogenic residue of the major linear HCV core regions. HCV Core Protein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV Core Protein (107-114) might be a potential site for dissemination of HCV serotypes .

HY-P11550

VPGVG	Biochemical Assay Reagents	Others
VPGVG is a repeating sequence that constitutes elastin-like peptides. VPGVG is derived from sequences found in the hydrophobic regions of vertebrate elastin. Elastin-like peptides are temperature-responsive biomaterials .

HY-120757

LP-130	Virus Protease	Others
LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.

HY-P4027

HCV-1 e2 Protein (554-569)	HCV	Infection
HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-P4027A

HCV-1 e2 Protein (554-569) TFA	HCV	Infection
HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-P10744

BQ7859	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) . BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P1609

CP-69799	Renin Enteropeptidase	Cardiovascular Disease
CP-69799 is an azahomostatine-containing oligopeptide transition-state analogue inhibitor with a hog renin IC₅₀ of 6e-9 M, human plasma renin IC₅₀ of 3e-7 M and K_i of 0.310 μM, and endothiapepsin K_i of 0.27 μM. CP-69799 binds endothiapepsin’s active site cleft in extended conformation, fills S4 to S3' pockets, displaces native solvent molecules, induces domain rotation, and reduces thermal mobility of endothiapepsin’s flap and helix regions. CP-69799 acts as a transition-state analogue inhibitor of hog renin and human plasma renin. CP-69799 contains a polar lysine residue at the P2' position, with a nitrogen atom replacing the P1' Cα atom of the hydroxyethylene dipeptide isostere. CP-69799 can be used for the research of hypertension .

Cat. No.	Product Name

HY-K0552A

Mycoplasma Detection Plus Kit (PCR)

MCE Mycoplasma Detection Plus Kit (PCR) employs polymerase chain reaction (PCR) technology for rapid and sensitive detection of mycoplasma contamination in cultured cells and related biological samples. The kit contains a PCR premix and mycoplasma-specific primers designed against conserved regions of the 16S rRNA gene. Cell culture supernatant or cell lysates can be used directly as templates for specific amplification of mycoplasma DNA, enabling rapid identification of mycoplasma contamination.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99471

Bepranemab UCB 0107	Tau Protein	Neurological Disease
Bepranemab is a humanized IgG4 monoclonal antibody that binds to the central region of tau protein. Bepranemab inhibits the seeding, aggregation of pathological tau protein and the spread of tau pathology to distal brain regions. Bepranemab is applicable to research related to Alzheimer's disease .

HY-P99008

Atibuclimab 2 Publications Verification IC14	Toll-like Receptor (TLR)	Infection Neurological Disease Inflammation/Immunology
Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .

HY-P99293

Galiximab IDEC 114; Anti-Human CD80 Recombinant Antibody	CD28 Apoptosis	Cancer
Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors .

HY-P991736

Anti-IL11 Antibody (X203, Mouse IgG)	Interleukin Related	Inflammation/Immunology
Anti-IL11 Antibody (X203, Mouse IgG) is a chimeric antibody composed of humanized variable regions and a mouse IgG backbone. Anti-IL11 Antibody (X203, Mouse IgG) is a mouse-derived IgG antibody inhibitor, targeting to human IL-11.

HY-P99674

Ivicentamab GEN-3009	Transmembrane Glycoprotein	Cancer
Ivicentamab (GEN-3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research .

HY-P991046

Donanemab (Mouse IgG2b)	Amyloid-β	Neurological Disease
Donanemab (Mouse IgG2b) is a chimeric antibody composed of humanized variable regions and a mouse IgG2b backbone. Donanemab (Mouse IgG2b) is an anti-amyloid inhibitor used in Alzheimer's disease research.

HY-P99830

Conbercept KH902	VEGFR TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology Cancer
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a VEGF inhibitor (IC₅₀ = 8.8 pM) and is a soluble receptor decoy that blocks all isoforms of VEGF-A (K_d = 0.5 pM), VEGF-B (K_d = 8 pM), VEGF-C, and PlGF (K_d = 5 pM). Conbercept has anti-inflammatory effects, can lower the levels of VEGF, TNF-α and IL-6, and reduce the infiltration of inflammatory cells. Conbercept decreases tumor growth in several oncology studies. Conbercept can be used for various eye diseases such as polypoidal choroidal vasculopathy (PCV), diabetic macular edema (DME) and pathologic myopia choroidal neovascularization (pmCNV) .

HY-P991513

BI-655064	TNF Receptor	Inflammation/Immunology
BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA) .

HY-P990303

Anti-Mouse 2C TCR Antibody (1B2)	Nuclear Factor of activated T Cells (NFAT)	Others
Anti-Mouse 2C TCR Antibody (1B2) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse 2C TCR. Anti-Mouse 2C TCR Antibody (1B2) recognizes determinants on the variable regions of both the α and β subunits of the TCR (T cell receptor) expressed by the mouse cytotoxic T lymphocyte clone 2C. Anti-Mouse 2C TCR Antibody (1B2) can be used for the detections of immunofluorescence and flow cytometry .

HY-P990693

Tarperprumig ALXN-1820	Inhibitory Antibodies	Inflammation/Immunology
Tarperprumig is an anti-ALB/CFP monoclonal antibody composed of 2 heavy chain variable regions linked together .

HY-P991512

SGN-30	Apoptosis	Cancer
SGN-30 is a chimeric antibody derived from a mouse antihuman CD30 antibody, AC10, with the variable regions of AC10 and human α 1 heavy chain and κ light chain constant regions. SGN-30 induces apoptosis and cell-cycle arrest in cancer cells. SGN-30 can be used for the study of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) .

HY-P991572

MM-151	EGFR	Cancer
MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. MM-151 binds multiple regions of the EGFR extracellular domain (ECD) and reduces its mutations in circulating cell-free tumor DNA with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth. MM-151 can be used for drug-resistant cancers research, such as colorectal, non-small cell lung and triple negative breast cancer .

HY-P990162

*Anti-Mouse T15 VH and T15 VL regions* of IgM Antibody (HB33)** AB1-2	Inhibitory Antibodies	Others
Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is an anti-mouse *T15 VH and T15 VL regions* of IgM** IgG1 monoclonal antibody. Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is used in studies of the MHC class I heavy chain FcRn heterodimers and their interaction with IgG .

HY-P991132

Efclarofusp alfa	VEGFR	Cardiovascular Disease Cancer
Efclarofusp alfa is a CHO-expressed humanized antibody consisting of VEGFR-1 and VEGFR-2 regions fused to human IgG1 Fc. Efclarofusp alfa is an angiogenesis inhibitor .

HY-P990995A

Etalanetug (Mouse IgG2a) 7G6 Antibody; 7G6-IgG2a	Tau Protein	Neurological Disease
Etalanetug (Mouse IgG2a) (7G6 Antibody) is a mouse monoclonal antibody targeting the HVPGG motif in the microtubule-binding domain of tau protein. Etalanetug (Mouse IgG2a) reduces the levels of insoluble tau protein in multiple brain regions and inhibits the seeding and spread of pathological tau protein. Etalanetug (Mouse IgG2a) is applicable to research related to Alzheimer's disease .

HY-P991534

PF-04382923	Amyloid-β	Neurological Disease
PF-04382923 is a humanized IgG2Δa monoclonal antibody. PF-04382923 binds with high affinity to the free C-terminal regions of the amyloid-β peptides Aβ1-40 and Aβ1-42. PF-04382923 is indicated for the study of geographic atrophy (GA) associated with dry age-related macular degeneration (ARMD) .

HY-P991949

EV1007	c-Fms	Inflammation/Immunology
EV1007 is a fully human antibody with a neutralizing effect on GM-CSF activity. EV1007 can be used for the research of autoimmune diseases .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86949

	Lambda Light Chain Antibody (YA6642) Constant region of lambda light chains antibody; Ig lambda chain C regions antibody; IGLC antibody; Immunoglobulin lambda constant 1 antibody; Mcg marker antibody;	WB, ICC/IF, IHC-P, FC	Human
	Lambda Light Chain Antibody (YA6642) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lambda Light Chain.

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Cat. No.	Product Name		Classification

HY-RS29488

Or5m3b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Or5m3b Mouse Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the Or5m3b (Mouse) gene, as well as a negative control, a FAM-labeled negative control, and a positive control.

HY-RS14805

TNFRSF13C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFRSF13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the TNFRSF13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS15466

UNC13C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
UNC13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the UNC13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS15674

VPS13C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VPS13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the VPS13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS16280

FAM-labeled P3H1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FAM-labeled P3H1 Human Pre-designed siRNA Set A is a FAM-labeled P3H1 siRNA. FAM-labeled P3H1 Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the P3H1 (Human) gene, as well as a negative control, a FAM-labeled negative control, and a positive control .

HY-185272

3'-O-(2-Nitrobenzyl)-dCTP		Nucleotide Analogs Cytidine Nucleotide
3'-O-(2-Nitrobenzyl)-dCTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dCTP can be recognized and incorporated by polymerases, thereby temporarily terminating primer extension during DNA synthesis. After incorporation into the extending DNA strand, 3'-O-(2-Nitrobenzyl)-dCTP temporarily halts the DNA polymerase extension reaction, and its 3'-O-(2-nitrobenzyl) blocking group can be removed by laser irradiation to regenerate a free 3'-OH for subsequent primer extension cycles. 3'-O-(2-Nitrobenzyl)-dCTP is applicable for resolving homopolymeric regions in DNA templates .

HY-RS27429

Dpy30 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dpy30 Rat Pre-designed siRNA Set A includes three pairs of siRNAs designed to target different regions of the Dpy30 (Rat) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-174479

Mouse Mef2c mRNA		mRNA Transcription Factors
Mouse Mef2c mRNA encodes the mouse myocyte enhancer factor 2C (Mef2c) protein, a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Mef2c controls cardiac morphogenesis and myogenesis, and is also involved in vascular development, neurogenesis and the development of cortical architecture.

HY-185273

3'-O-(2-Nitrobenzyl)-dGTP		Nucleotide Analogs Guanine Nucleotide
3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies .

HY-185274

3'-O-(2-Nitrobenzyl)-dTTP		Nucleotide Analogs Thymine Nucleotide
3'-O-(2-Nitrobenzyl)-dTTP acts as a reversible terminator for DNA chain elongation. 3'-O-(2-Nitrobenzyl)-dTTP interacts with 9°N polymerase (exo-) A485L/Y409V, gets recognized and incorporated into the elongating DNA chain, thereby temporarily terminating the polymerase reaction. 3'-O-(2-Nitrobenzyl)-dTTP carries a 3'-O-(2-nitrobenzyl) blocking group, which can be removed by laser irradiation to regenerate the free 3'-OH ⁻ group and restore polymerase activity. 3'-O-(2-Nitrobenzyl)-dTTP is applicable in DNA sequencing studies .

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