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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
194 Results for "
tissue factor
" in MedChemExpress (MCE) Product Catalog:
Products (194)
194 Results for "tissue factor" in MCE Product Catalog:
159
159 Publications Verification
Target:
Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Interleukin Related NO Synthase Heme Oxygenase (HO)
Áreas de investigación:
Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .
34
Target:
Áreas de investigación:
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
34
Target:
Áreas de investigación:
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
17
Target:
Áreas de investigación:
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action .
17
Target:
Áreas de investigación:
Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action .
10
10 Cited Publications
Synonyms: PQQ; Methoxatin
Category:
Quinones Animal Benzene Quinones Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
10
10 Cited Publications
Synonyms: PQQ disodium salt; Methoxatin disodium salt
Category:
Quinones Benzene Quinones Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
8
Áreas de investigación:
8
Áreas de investigación:
7
7 Cited Publications
Synonyms: Methylmaleic acid; Citraconate
6
6 Cited Publications
Referencia número: HY-B1614
No. CAS: 21898-19-1
Synonyms: NAB-365 hydrochloride
Category:
Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology
Target:
3
Target:
Áreas de investigación:
Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes .
3
3 Cited Publications
Referencia número: HY-P7054
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINF1; Testis tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment Epithelium-Derived factor; Serpin F
Species:
Human
Source:
E. coli
3
3 Cited Publications
Synonyms: Vitamin K2-7; Vitamin K2(35); Vitamin MK-7
Target:
Áreas de investigación:
Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .
3
3 Cited Publications
Synonyms: EC 3.4.21.1; Chymotrypsin A
3
3 Cited Publications
Referencia número: HY-108910A
No. CAS: 9004-07-3
Synonyms: EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)
Target:
Áreas de investigación:
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) (MS grade) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin (MS grade) downregulates the TLR4/NF-κB signaling pathway, inhibits the release of inflammatory factors, reduces cell infiltration and tissue damage, and also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54). It can also be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin (MS grade) has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions, and can be used in the research of diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin (MS grade) can be used in studies of inflammation, edema, and expectoration .
2
2 Cited Publications
Referencia número: HY-P99288
No. CAS: 946415-13-0
Synonyms: Pamrevlumab; Anti-Human CTGF Recombinant Antibody
Target:
Áreas de investigación:
2
2 Cited Publications
Referencia número: HY-P72154
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCN2; CCN Family Member 2; Prev. CTGF; IBP-8; IGFBP8; SEMDLSL; Connective tissue Growth factor; IGFBP-8; Hypertrophic Chondrocyte-Specific Protein 24; NOV2; Insulin-Like Growth factor-Binding Protein 8; KMD; IGF-Binding Protein 8; Cellular Communication Network factor 2; HCS24
Species:
Mouse
Source:
E. coli
2
2 Cited Publications
Referencia número: HY-P72153
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCN2; CCN Family Member 2; Prev. CTGF; IBP-8; IGFBP8; SEMDLSL; Connective tissue Growth factor; IGFBP-8; Hypertrophic Chondrocyte-Specific Protein 24; NOV2; Insulin-Like Growth factor-Binding Protein 8; KMD; IGF-Binding Protein 8; Cellular Communication N
Species:
Human
Source:
E. coli
2
2 Cited Publications
Referencia número: HY-P4744
No. CAS: 597562-32-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
