41 Results for "

visual

" in MedChemExpress (MCE) Product Catalog:
Products (41)

41 Results for "visual" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-W004500
CAS No.: 116-31-4
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .
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1
1 Cited Publications
Cat. No.: HY-W110883
CAS No.: 3618-43-7
Xylenol orange tetrasodium salt, IND is commonly used as a colorimetric indicator for metal titration and possesses Zn 2+ chelating activity. Xylenol orange tetrasodium salt, IND binds Zn 2+ under physiological pH, and its Zn-XO complex allows visual differentiation between tartrate and malate ions. Xylenol orange tetrasodium salt, IND undergoes decolorization upon oxidation by hydrogen peroxide, undergoes a Co (II)-catalyzed pseudo-second-order reaction in a strong alkaline environment, and regulates the ferrous ion oxidation process mediated by peroxy radicals. Xylenol orange tetrasodium salt, IND forms colored ternary complexes with various anions, cations and iron-alanine, which is suitable for spectrophotometric quantification and can also be used for alanine irradiation dose detection. Xylenol orange tetrasodium salt, IND is applicable to EDTA metal titration analysis under acidic conditions .
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1
1 Cited Publications
Cat. No.: HY-137016A
CAS No.: 51239-26-0
Purity:  ≥99.0%
Target:  

HCN Channel

Research Areas:  

Neurological Disease

8-Pcpt-cGMP sodium is the sodium salt form of 8-Pcpt-cGMP (HY-137016). 8-Pcpt-cGMP sodium is an agonist for cyclic nucleotide-gated (CNG) channel with an EC50 of 0.5 μM. 8-Pcpt-cGMP sodium exhibits good membrane permeability. 8-Pcpt-cGMP sodium can be used in studies about the function of CNG channels in visual signal transduction and olfactory transduction .
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Cat. No.: HY-P99116
CAS No.: 1607793-29-2
Synonyms: RG7716; RO-6867461
Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO) .
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Cat. No.: HY-129420
CAS No.: 1593024-78-2
Purity:  99.31%
WSP-5 is a H2S-selective fluorescent probe (Ex/Em = 502/525 nm). WSP-5 enables visual monitoring of H2S released and accumulated from peptide-H2S donor conjugates in glioma cells. WSP-5 is applicable to glioma research .
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Cat. No.: HY-116711
CAS No.: 564-87-4
Synonyms: 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde
11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model .
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Cat. No.: HY-D1247
CAS No.: 63451-35-4
Hydroxynaphthol Blue is an azo dye and serves as a metal indicator. Hydroxynaphthol Blue binds to specific metal ions to form stable complexes with distinct color and fluorescence properties. Hydroxynaphthol Blue is used for the visual monitoring of isothermal nucleic acid amplification results. A visible color difference appears between positive and negative nucleic acid amplification reactions, allowing result discrimination by the naked eye without opening the reaction tube .
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Cat. No.: HY-160116
CAS No.: 1565797-17-2
α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia .
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Cat. No.: HY-19720A
CAS No.: 1141934-97-5
Synonyms: ACU-4429 hydrochloride
Target:  

RPE65

Research Areas:  

Metabolic Disease

Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .
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Cat. No.: HY-Y0699
CAS No.: 493-52-7
Methyl red is a pH-sensitive acid-base indicator and colorimetric reagent with a pKa of 5.1. Methyl red achieves visual judgment of the titration endpoint through reversible structural changes of protonation (red, pH < 4.4) and deprotonation (yellow, pH > 6.2). Methyl red is widely used in acid-base titration in chemical analysis and buffer pH monitoring in biochemistry .
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Cat. No.: HY-W800703
CAS No.: 1872449-19-8
Target:  

Fluorescent Dye

Research Areas:  

Others

Alexa Fluor 594 azide is an azide-modified fluorescent dye and also a FRET acceptor reactant. Owing to its negligible direct absorption under 488 nm excitation light, excellent photostability, and the ability of its azide group to participate in the CuAAC reaction, Alexa Fluor 594 azide can be paired with a donor dye for single-molecule imaging via TIRFM, thereby enabling the visual monitoring of CuNP-catalyzed click reactions .
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Cat. No.: HY-19720
CAS No.: 1141777-14-1
Synonyms: ACU-4429
Target:  

RPE65

Research Areas:  

Metabolic Disease

Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .
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Cat. No.: HY-NP163A
Synonyms: WGA-AF488
Wheat germ agglutinin-AF488 (WGA-AF488) is a cell membrane-specific staining agent prepared by conjugating wheat germ agglutinin with the Alexa Fluor 488 (HY-D1304) fluorescent dye, and it binds to cell surface glycoproteins with high affinity. Wheat germ agglutinin-AF488 is applied in fluorescence microscopy and confocal imaging techniques, and it can clearly label the membrane structures of various cells including breast cancer cells, enabling high-resolution visual observation. Wheat germ agglutinin-AF488 is used in studies of breast cancer and triple-negative breast cancer to observe cell morphology and membrane dynamic changes .
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Cat. No.: HY-N2125
CAS No.: 174972-80-6
Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC50 of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .
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Cat. No.: HY-D2864
Aza-CyBz is a NaCl-responsive near-infrared heptamethine cyanine fluorescent probe. Aza-CyBz has an excitation wavelength of 740 nm and detects signals in the range of 760-900 nm. NaCl induces Aza-CyBz to form ordered aggregates, resulting in fluorescence quenching. Aza-CyBz shows no obvious response to interfering substances such as plant carbohydrates, hormones, PEG and ROS. Aza-CyBz can enter plant mitochondria and reflect changes in their salt concentration, and can be used for visual imaging of salt stress in Arabidopsis thaliana root tips and living plants .
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Cat. No.: HY-P1615
CAS No.: 1006388-38-0
Synonyms: UPARANT
Cenupatide (UPARANT) is a uPAR and FPR antagonist with anti-angiogenic, anti-inflammatory, and vascular barrier regulatory activities, as well as high stability and resistance to enzymatic degradation in blood/plasma. Cenupatide blocks the uPAR-FPR interaction, reduces VEGF-induced phosphorylation levels of AKT, VEGFR-2, STAT3, JNK, p38 MAPK, ERK1/2, and NF-κB p65, and inhibits αvβ3 integrin activation. Cenupatide suppresses endothelial cell migration, invasion, tube formation, and angiogenic signaling pathways, restores tight junctions and blood-retinal barrier integrity, reduces pro-inflammatory marker levels, and inhibits apoptosis. Cenupatide reduces retinal neovascularization, renal fibrosis, and vascular leakage, and restores visual function in preclinical models. Cenupatide is applicable to research related to retinopathy, diabetic complications, ocular diseases, cancer, and inflammatory diseases .
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Cat. No.: HY-121650A
CAS No.: 13575-86-5
Purity:  98.0%
ADTN hydrobromide is a long-acting dopamine agonist. ADTN hydrobromide significantly decreases the behavioral visual threshold of DA-IPC-depleted zebrafish .
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Cat. No.: HY-W016568
CAS No.: 529-69-1
Category:  

Natural Products Animals

Target:  

Endogenous Metabolite

Isoxanthopterin is a heterocyclic compound belonging to the pteridine family and its activity is mainly reflected in its optical properties. Isoxanthopterin can form a reflective layer in the eyes of animals, enhancing visual function. The main regulatory mechanism of isoxanthopterin involves its ability to form a crystalline structure within organisms, which achieves a high refractive index through specific hydrogen bonding patterns and molecular arrangements. Isoxanthopterin can be used for research in materials science and optical engineering .
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Cat. No.: HY-100743
CAS No.: 6323-99-5
Purity:  ≥98.0%
Synonyms: 2-Amino-4-phosphonobutyric acid
Target:  

mGluR

DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .
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Cat. No.: HY-175663
Target:  

RPE65

Research Areas:  

Metabolic Disease

EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
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