2. PROTAC JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. PROTACs EGFR
  4. SJF-1521

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells.

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SJF-1521 Chemical Structure

SJF-1521 Chemical Structure

CAS No. : 2230821-40-4

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1 mg USD 400 In-stock
5 mg USD 980 In-stock
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SJF-1521 Related Antibodies

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Description

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells[1].

Molecular Weight

1074.65

Formula

C57H61ClFN7O9S
CAS No.
Appearance

Solid

Color

Light green to yellow

SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (93.05 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9305 mL 4.6527 mL 9.3054 mL
5 mM 0.1861 mL 0.9305 mL 1.8611 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9305 mL 4.6527 mL 9.3054 mL 23.2634 mL
5 mM 0.1861 mL 0.9305 mL 1.8611 mL 4.6527 mL
10 mM 0.0931 mL 0.4653 mL 0.9305 mL 2.3263 mL
15 mM 0.0620 mL 0.3102 mL 0.6204 mL 1.5509 mL
20 mM 0.0465 mL 0.2326 mL 0.4653 mL 1.1632 mL
25 mM 0.0372 mL 0.1861 mL 0.3722 mL 0.9305 mL
30 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7754 mL
40 mM 0.0233 mL 0.1163 mL 0.2326 mL 0.5816 mL
50 mM 0.0186 mL 0.0931 mL 0.1861 mL 0.4653 mL
60 mM 0.0155 mL 0.0775 mL 0.1551 mL 0.3877 mL
80 mM 0.0116 mL 0.0582 mL 0.1163 mL 0.2908 mL
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SJF-1521 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJF-15212230821-40-4SJF1521SJF 1521PROTACsEGFREpidermal growth factor receptorErbB-1HER1PROTACTargeted DegradationReceptor Tyrosine KinasesHER2c-MetVHLInhibitorinhibitorinhibit

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