SJF-1521
Based on 1 Customer Validation
SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research.
(Pink: EGFR ligand (HY-177379); Blue: VHL ligand (HY-125845); Black: linker (HY-128804)).
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 2230821-40-4
- Formula: C57H61ClFN7O9S
- Molecular Weight:1074.65
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Protein Kinase Compound Library
HY-L196
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Biological Activity
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VHL |
SJF-1521 (25 nM-10 μM; 24 h) selectively degrades EGFR in OVCAR8 cells, while it has no effect on HER2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR8 cells
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Concentration:25 nM, 100 nM, 250 nM, 1 μM, 2.5 μM, 10 μM
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Incubation Time:24 h
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Result:Significantly reduced the levels of EGFR, and did not affect the levels of HER2.
Chemical Information
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CAS No. 2230821-40-4
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Appearance Solid
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Molecular Weight 1074.65
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Formula C57H61ClFN7O9S
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Color Light green to yellow
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 200 mg/mL (186.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9305 mL | 4.6527 mL | 9.3054 mL | 23.2634 mL |
| 5 mM | 0.1861 mL | 0.9305 mL | 1.8611 mL | 4.6527 mL | |
| 10 mM | 0.0931 mL | 0.4653 mL | 0.9305 mL | 2.3263 mL | |
| 15 mM | 0.0620 mL | 0.3102 mL | 0.6204 mL | 1.5509 mL | |
| 20 mM | 0.0465 mL | 0.2326 mL | 0.4653 mL | 1.1632 mL | |
| 25 mM | 0.0372 mL | 0.1861 mL | 0.3722 mL | 0.9305 mL | |
| 30 mM | 0.0310 mL | 0.1551 mL | 0.3102 mL | 0.7754 mL | |
| 40 mM | 0.0233 mL | 0.1163 mL | 0.2326 mL | 0.5816 mL | |
| 50 mM | 0.0186 mL | 0.0931 mL | 0.1861 mL | 0.4653 mL | |
| 60 mM | 0.0155 mL | 0.0775 mL | 0.1551 mL | 0.3877 mL | |
| 80 mM | 0.0116 mL | 0.0582 mL | 0.1163 mL | 0.2908 mL | |
| 100 mM | 0.0093 mL | 0.0465 mL | 0.0931 mL | 0.2326 mL |
SJF-1521 Related Classifications
HY-131865 Related Classifications
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