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Cat. No.: HY-170826

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SMARCA2 ligand-14

SMARCA2 ligand-14 is the ligand for SMARCA2 that can be used for synthesis of PROTAC degrader SMD-3236 (HY-170824).

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Formule: C₃₀H₄₁N₇O₄S
Masse moléculaire:595.76

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SMARCA2 ligand-14 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

SMARCA2 ligand-14 is the ligand for SMARCA2 that can be used for synthesis of PROTAC degrader SMD-3236 (HY-170824)^[1].

IC₅₀ & Target

VHL

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase :

Voir tous les produits spécifiques à Isoform SWI/SNF Complex :

Chemical Information

Masse moléculaire 595.76
Formule C₃₀H₄₁N₇O₄S
SMILES

O=C(N1[C@H](C(N[C@@H](CN2CCOCC2)C3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C1)[C@H](C(C)(C)C)N5N=NC(C)=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yang L, et al., Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers. J Med Chem. 2025 Jan 23;68(2):1155-1178. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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