TFCP2 - transcription factor CP2 Gene

Also Known as LSF; SEF; LBP1C; LSF1D; TFCP2C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7024

About TFCP2

Cytogenetic location: 12q13.12-q13.13 Genomic coordinates (GRCh38): 12:51,093,656-51,173,135 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in appendix (RPKM 10.8), lymph node (RPKM 10.8) and 25 other tissues.

Summary

This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many Other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

TFCP2 Products (3)

mRNA	Protein	Name
NM_001173452.2	NP_001166923.1	alpha-globin transcription factor CP2 isoform 2
NM_001173453.2	NP_001166924.1	alpha-globin transcription factor CP2 isoform 3
NM_005653.5	NP_005644.2	alpha-globin transcription factor CP2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16263792	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9685356	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription factor binding	IPI IPI: Inferred from physical interaction	11003662	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11003662	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12089154	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16263792	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11003662	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11003662	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	16263792	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFCP2 Protein Structure

CP2

0
100
200
300
400
502 a.a.

Protein Preferred Names	Protein Names
alpha-globin transcription factor CP2	SAA3 enhancer factor

TFCP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TFCP2	Q12800	SHTN1	Homo sapiens	A0MZ66-7	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	SHTN1	Homo sapiens	A0MZ66-7	Validated Y2H	25416956
Intra	TFCP2	Q12800	TRAPPC12	Homo sapiens	Q53QD4	Validated Y2H	25416956
Intra	TFCP2	Q12800	TRAPPC12	Homo sapiens	Q53QD4	Y2H Array	25416956
Intra	TFCP2	Q12800	TRAPPC12	Homo sapiens	Q53QD4	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	EPHA10	Homo sapiens	Q5JZY3-3	Y2H Array	25416956
Intra	TFCP2	Q12800	NPEPL1	Homo sapiens	Q8NDH3-4	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	NPEPL1	Homo sapiens	Q8NDH3-4	Validated Y2H	25416956
Intra	TFCP2	Q12800	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	25416956
Intra	TFCP2	Q12800	YJU2	Homo sapiens	Q9BW85	Validated Y2H	25416956
Intra	TFCP2	Q12800	YJU2	Homo sapiens	Q9BW85	Validated Y2H	32296183
Intra	TFCP2	Q12800	TDRD1	Homo sapiens	Q9BXT4-2	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	TDRD1	Homo sapiens	Q9BXT4-2	Validated Y2H	25416956
Intra	TFCP2	Q12800	DPH1	Homo sapiens	Q9BZG8	Validated Y2H	25416956
Intra	TFCP2	Q12800	DNAJC27	Homo sapiens	Q9NZQ0	Validated Y2H	32296183
Intra	TFCP2	Q12800	DNAJC27	Homo sapiens	Q9NZQ0	Validated Y2H	25416956
Intra	TFCP2	Q12800	DNAJC27	Homo sapiens	Q9NZQ0	Y2H Array	25416956
Intra	TFCP2	Q12800	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	25416956
Intra	TFCP2	Q12800	POLL	Homo sapiens	Q9UGP5-2	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	MRPL40	Homo sapiens	Q9NQ50	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	MRPL40	Homo sapiens	Q9NQ50	Validated Y2H	25416956
Intra	TFCP2	Q12800	MRPL40	Homo sapiens	Q9NQ50	Y2H Array	25416956
Intra	TFCP2	Q12800	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	TFCP2	Q12800	FANCL	Homo sapiens	Q9NW38	Y2H Array	25416956
Intra	TFCP2	Q12800	FANCL	Homo sapiens	Q9NW38	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	TSPAN12	Homo sapiens	O95859	Validated Y2H	25416956
Intra	TFCP2	Q12800	TSPAN12	Homo sapiens	O95859	Y2H Array	25416956
Intra	TFCP2	Q12800	PIMREG	Homo sapiens	Q9BSJ6	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	ASAP3	Homo sapiens	Q8TDY4	Validated Y2H	25416956
Intra	TFCP2	Q12800	ASAP3	Homo sapiens	Q8TDY4	Y2H Array	25416956
Intra	TFCP2	Q12800	UBP1	Homo sapiens	Q9NZI7	Y2H Array	20211142
Intra	TFCP2	Q12800	UBP1	Homo sapiens	Q9NZI7	Anti Tag CoIP	33961781
Intra	TFCP2	Q12800	POLR3GL	Homo sapiens	Q9BT43	Validated Y2H	25416956
Intra	TFCP2	Q12800	POLR3GL	Homo sapiens	Q9BT43	Y2H Array	25416956
Intra	TFCP2	Q12800	POLR3GL	Homo sapiens	Q9BT43	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	C19orf73	Homo sapiens	Q9NVV2	Y2H Array	25416956
Intra	TFCP2	Q12800	NHSL2	Homo sapiens	Q5HYW2	Validated Y2H	32296183
Intra	TFCP2	Q12800	PITPNM1	Homo sapiens	O00562	Validated Y2H	25416956
Intra	TFCP2	Q12800	PITPNM1	Homo sapiens	O00562	Y2H Array	25416956
Intra	TFCP2	Q12800	PITPNM1	Homo sapiens	O00562	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	NABP1	Homo sapiens	Q96AH0	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	NABP1	Homo sapiens	Q96AH0	Validated Y2H	25416956
Intra	TFCP2	Q12800	PLCB1	Homo sapiens	Q9NQ66	Y2H Array	25416956
Intra	TFCP2	Q12800	BAG6	Homo sapiens	P46379	Y2H Array	25416956
Intra	TFCP2	Q12800	BAG6	Homo sapiens	P46379	Validated Y2H	25416956
Intra	TFCP2	Q12800	PPP3R2	Homo sapiens	Q96LZ3	Validated Y2H	25416956
Intra	TFCP2	Q12800	PPP3R2	Homo sapiens	Q96LZ3	Y2H Array	25416956
Intra	TFCP2	Q12800	PPP3R2	Homo sapiens	Q96LZ3	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	PPIG	Homo sapiens	Q13427	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	PPIG	Homo sapiens	Q13427	Validated Y2H	25416956
Intra	TFCP2	Q12800	PHF1	Homo sapiens	O43189	Validated Y2H	25416956
Intra	TFCP2	Q12800	PHF1	Homo sapiens	O43189	Y2H	21516116
Intra	TFCP2	Q12800	MRPL11	Homo sapiens	Q9Y3B7	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	MRPL11	Homo sapiens	Q9Y3B7	Y2H Array	25416956
Intra	TFCP2	Q12800	RBMS1	Homo sapiens	P29558	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Array	31515488
Intra	TFCP2	Q12800	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	TFCP2	Q12800	EIF5B	Homo sapiens	Q8N5A0	Validated Y2H	25416956
Intra	TFCP2	Q12800	ADPRH	Homo sapiens	P54922	Y2H Array	25416956
Intra	TFCP2	Q12800	TCEA2	Homo sapiens	Q15560	Validated Y2H	25416956
Intra	TFCP2	Q12800	TCEA2	Homo sapiens	Q15560	Y2H Array	25416956
Intra	TFCP2	Q12800	CBX8	Homo sapiens	Q9HC52	Y2H Array	25416956
Intra	TFCP2	Q12800	CBX8	Homo sapiens	Q9HC52	Validated Y2H	25416956
Intra	TFCP2	Q12800	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	TFCP2	Q12800	STMN2	Homo sapiens	Q93045	Y2H Array	25416956
Intra	TFCP2	Q12800	PPP1R1B	Homo sapiens	Q9UD71	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	PPP1R1B	Homo sapiens	Q9UD71	Validated Y2H	25416956
Intra	TFCP2	Q12800	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	TFCP2	Q12800	TLK1	Homo sapiens	Q9UKI8	Validated Y2H	32296183
Intra	TFCP2	Q12800	FBXL18	Homo sapiens	Q96D16	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	ZCCHC12	Homo sapiens	Q6PEW1	Validated Y2H	25416956
Intra	TFCP2	Q12800	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Array	25416956
Intra	TFCP2	Q12800	GPANK1	Homo sapiens	O95872	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	GPANK1	Homo sapiens	O95872	Validated Y2H	25416956
Intra	TFCP2	Q12800	GPANK1	Homo sapiens	O95872	Y2H Array	25416956
Intra	TFCP2	Q12800	PSMD5	Homo sapiens	Q16401	Validated Y2H	25416956
Intra	TFCP2	Q12800	PSMD5	Homo sapiens	Q16401	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	PSMD5	Homo sapiens	Q16401	Y2H Array	25416956
Intra	TFCP2	Q12800	EAF1	Homo sapiens	Q96JC9	Y2H Array	25416956
Intra	TFCP2	Q12800	EAF1	Homo sapiens	Q96JC9	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	SUMO1	Homo sapiens	P63165	Validated Y2H	25416956
Intra	TFCP2	Q12800	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	UBE2I	Homo sapiens	P63279	Validated Y2H	27107012
Intra	TFCP2	Q12800	UBE2I	Homo sapiens	P63279	BFG-2H	27107012
Intra	TFCP2	Q12800	CDC73	Homo sapiens	Q6P1J9	Y2H Array	25416956
Intra	TFCP2	Q12800	CDC73	Homo sapiens	Q6P1J9	Validated Y2H	25416956
Intra	TFCP2	Q12800	IRAK1BP1	Homo sapiens	Q5VVH5	Validated Y2H	25416956
Intra	TFCP2	Q12800	MOB3C	Homo sapiens	Q70IA8	Y2H Prey Pooling	25416956
Intra	TFCP2	Q12800	MOB3C	Homo sapiens	Q70IA8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spindle Cell Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma	Adult Pleomorphic Rhabdomyosarcoma Anaplastic Rhabdomyosarcoma Pleomorphic Rhabdomyosarcoma, Adult Type
Glanders	Farcy Pipes Infection Due To Pseudomonas Mallei Burkholderia Mallei Burkholderia Mallei Infection Equina Equine Glanders Farcy Farcy Buds Farcy Cords Infection Due To Actinobacillus Mallei Infection Due To Malleomyces Mallei Maliasmus Malleus Farce Actinobacillosis Actinobacillus Infection
Colorectal Cancer, Hereditary Nonpolyposis, Type 2	HNPCC2 Fcc2 Coca2 Hereditary Nonpolyposis Colorectal Cancer Type 2 Colon Cancer, Familial Nonpolyposis, Type 2 Familial Nonpolyposis Colon Cancer Type 2 Hereditary Non-Polyposis Colorectal Cancer 2 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Lynch Syndrome I	Lynch Syndrome 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 HNPCC1 Fcc1 Lynch Syndrome Ii Colon Cancer, Familial Nonpolyposis, Type 1 Coca1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Type 1 Hereditary Non-Polyposis Colorectal Cancer 1 Hereditary Non-Polyposis Colorectal Cancer 3 Hnpcc3 Lynch Cancer Family Syndrome Lynch Syndrome Lynch Syndrome Type I Lynch Syndrome Type Ii Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1 Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer, Hereditary Nonpolyposis, Type 3 Hereditary Non-Polyposis Colon Cancer Type 2
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12834A	MK2-IN-1 hydrochloride	Inhibitor	98.36%	Unkown
HY-12834	MK2-IN-1	Inhibitor	99.04%	Unkown
HY-162934	TFCP2L1-IN-1	Inducer	99.66%	Unkown
HY-180913	FQI2-34	Inhibitor	99.80%	Unkown
HY-RS14415	TFCP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14416	TFCP2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20112	Tfcp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26616	Tfcp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TFCP2	MGD	MGI:98509
Macaca mulatta	TFCP2	VGNC	VGNC:78323
Felis catus	TFCP2	VGNC	VGNC:66113
Rattus norvegicus	TFCP2	RGD	RGD:1306738
Canis familiaris	TFCP2	VGNC	VGNC:47290
Bos taurus	TFCP2	VGNC	VGNC:35784
Others	TFCP2	NCBI