1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU-1545

VU-1545 

Cat. No.: HY-16951
Handling Instructions

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.

For research use only. We do not sell to patients.

VU-1545 Chemical Structure

VU-1545 Chemical Structure

CAS No. : 890764-63-3

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Description

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM[1].

IC50 & Target[1]

mGluR5

156 nM (Ki)

mGluR5

9.6 nM (EC50)

In Vitro

VU-1545 (10 and 100 μM) promotes AKT activation. VU-1545 at the concentrations of 0.1 and 1.0 μM efficiently promots Akt activation above basal levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Neuronal cells
Concentration: 10 and 100 μM
Incubation Time: 5 minutes
Result: Promoted Akt phosphorylation as efficiently at the concentration of 10.0 μM as at the concentration of 100.0 μM.
Molecular Weight

402.38

Formula

C₂₂H₁₅FN₄O₃

CAS No.

890764-63-3

SMILES

O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3F)C4=CC=C([N+]([O-])=O)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

VU-1545VU1545VU 1545mGluRMetabotropic glutamate receptorsmGluR5PAMInhibitorinhibitorinhibit

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Product Name:
VU-1545
Cat. No.:
HY-16951
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