2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. CFMTI

CFMTI 

Cat. No.: HY-100402 Purity: ≥98.0%
COA Handling Instructions

CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively.

For research use only. We do not sell to patients.

CFMTI Chemical Structure

CFMTI Chemical Structure

CAS No. : 864864-17-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 226 In-stock
Solution
10 mM * 1 mL in DMSO USD 226 In-stock
Solid
5 mg USD 205 In-stock
10 mg USD 290 In-stock
25 mg USD 570 In-stock
50 mg USD 1050 In-stock
100 mg USD 2000 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CFMTI Related Antibodies

Top Publications Citing Use of Products

View All mGluR Isoform Specific Products:

View All Isoforms
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively[1].

IC50 & Target

Human mGluR1a

2.6 nM (IC50)

Rat mGluR1a

2.3 nM (IC50)

Molecular Weight

349.36

Appearance

Solid

Formula

C19H16FN5O
CAS No.
SMILES

O=C1N(C2CC2)CC3=C1C=CC(C4=C(C)N(C5=CC=CN=C5F)N=N4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 3.7 mg/mL (10.59 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8624 mL 14.3119 mL 28.6238 mL
5 mM 0.5725 mL 2.8624 mL 5.7248 mL
10 mM 0.2862 mL 1.4312 mL 2.8624 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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CFMTI Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CFMTI864864-17-5mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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