1. Apoptosis
  2. Caspase
  3. EP1013

EP1013 (Synonyms: F1013)

Cat. No.: HY-10397 Purity: >97.0%
Handling Instructions

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

For research use only. We do not sell to patients.

EP1013 Chemical Structure

EP1013 Chemical Structure

CAS No. : 223568-55-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 222 In-stock
Estimated Time of Arrival: December 31
1 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

IC50 & Target[1]

Caspase

 

In Vivo

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal rate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

382.38

Formula

C₁₈H₂₃FN₂O₆

CAS No.

223568-55-6

SMILES

O=C(O)C[[email protected]](NC([[email protected]](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)C(CF)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (261.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6152 mL 13.0760 mL 26.1520 mL
5 mM 0.5230 mL 2.6152 mL 5.2304 mL
10 mM 0.2615 mL 1.3076 mL 2.6152 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

EP1013F1013EP 1013EP-1013F 1013F-1013CaspaseInhibitorinhibitorinhibit

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EP1013
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HY-10397
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