5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
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5-HT1 Receptor
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5-HT2 Receptor
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5-HT3 Receptor
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5-HT4 Receptor
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5-HT5 Receptor
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5-HT6 Receptor
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5-HT7 Receptor
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
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5-HT Receptor Antagonists
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5-HT Receptor Activators
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5-HT Receptor Modulators
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1774)
Related Products (1774)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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5-HT2A&5-HT2C agonist-1
0 Images5-HT2A&5-HT2C agonist-1 (Example 2) is a 5-HT2A & 5-HT2C agonist, with IC50s of 196 nM and 0.9 nM respectively. 5-HT2A&5-HT2C agonist-1 can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders.
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5-HT2C agonist-6
0 ImagesCat. No.: HY-175194CAS No.: 2755671-89-55-HT2C agonist-6 (Compound 13), a tricyclic psychedelic psychoplastogen, is a 5-HT2C agonist with an EC50 of 13.8 nM. 5-HT2C agonist-6 can be used for neurological diseases research.
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ASP-2205
0 ImagesCat. No.: HY-167677CAS No.: 1334440-09-3ASP-2205 is a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM). ASP-2205 enhances the pudendal nerve-mediated urethral closure reflex through the 5-HT2C receptor, thereby preventing urinary incontinence.
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BMS-442606
0 ImagesCat. No.: HY-120627CAS No.: 477930-31-7BMS-442606, the S-enantiomer of 6-hydroxybuspirone (6OHB), is an orally active 5-HT1A partial agonist. BMS-442606 can be used for generalized anxiety disorder (GAD) research.
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PRX933
0 ImagesCat. No.: HY-100171ACAS No.: 313658-33-2Synonyms: BVT-933
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5-HT1AR agonist 2
0 ImagesCat. No.: HY-1693945-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM). 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM). 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice.
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5-Benzyloxytryptamine
0 ImagesCat. No.: HY-148032CAS No.: 20776-45-8Synonyms: 5-BT5-Benzyloxytryptamine (5-BT) is a selective partial agonist for 5-hydroxytryptamine 1D/1B (5-HT1D/1B) receptors with an IC50 value of 40 nM for bovine caudate 5-HT1D and reduced affinity for other receptors (5-HT2 IC50>470 nM). 5-Benzyloxytryptamine inhibits adenylate cyclase to decrease neurotransmitter release and downregulate cAMP signaling. 5-Benzyloxytryptamine is promising for research of neurotransmitter imbalance-related disorders like migraine.
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8 Hydroxy PIPAT oxalate
0 ImagesCat. No.: HY-101225CAS No.: 1451210-48-28 Hydroxy PIPAT oxalate is a 5-HT1A receptor agonist that promotes histamine release. 8 Hydroxy PIPAT oxalate selectively activates 5-HT1A receptors, thereby triggering mast cell degranulation and histamine release. 8 Hydroxy PIPAT oxalate is applicable to research related to irritable bowel syndrome.
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(Rac)-Rotigotine
0 ImagesSynonyms: N-0437(Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
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Adoprazine hydrochloride
0 ImagesCat. No.: HY-14782ACAS No.: 222551-05-5Synonyms: SLV313 hydrochlorideAdoprazine (SLV313) hydrochloride is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine hydrochloride is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics.
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Eletriptan
0 ImagesCat. No.: HY-A0039CAS No.: 143322-58-1Synonyms: UK-116044Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine.
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Jimscaline
0 ImagesCat. No.: HY-171232CAS No.: 890309-57-6Jimscaline (compound R-(-)2) is a 5-HT2A agonist and mescaline analogue that can be utilized in neurological research.
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Prucalopride hydrochloride
0 ImagesCat. No.: HY-14152CAS No.: 179474-80-7Prucalopride hydrochloride is an orally active, selective and specific 5-HT4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride hydrochloride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride hydrochloride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride hydrochloride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.
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Frovatriptan-d3 succinate
0 ImagesCat. No.: HY-B1658BSSynonyms: (R)-Frovatriptan-d3 succinate; SB 209509-d3 succinate; VML 251-d3 succinateFrovatriptan-d3 (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research.
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(S)-LY-41
0 ImagesCat. No.: HY-165624ACAS No.: 136296-40-7(S)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S)-LY-41 is a potent and selective 5-HT1A receptor agonist. (S)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S)-LY-41 can induce the 5-HT behavioral syndrome. (S)-LY-41can be used for the research of neurological disease, such as depression and anxiety.
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5-HT2A agonist 10
0 ImagesCat. No.: HY-183577CAS No.: 3001269-25-35-HT2A agonist 10 is a 5-HT2A receptor agonist with an EC50 of 9 nM. 5-HT2A agonist 10 is applicable to research related to central nervous system diseases.
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Vilazodone-d8 hydrochloride
0 ImagesCat. No.: HY-14262S1Synonyms: EMD 68843-d8; SB659746A-d8Vilazodone-d8 hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders.
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5-HT2A receptor agonist-12
0 ImagesCat. No.: HY-175657CAS No.: 2956765-08-35-HT2A receptor agonist-12 (compound 161-2) is a potent 5-HT2A agonist with an EC50 value of <100 nM for h5-HT2A.
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Cizolirtine citrate
0 ImagesCat. No.: HY-127141CAS No.: 251375-82-3Synonyms: E-4018Cizolirtine citrate (E-4018) is an analgesic agent. Cizolirtine citrate has significant analgesic and anti-hyperalgesic action in neuropathic pain models.
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AGH-107
0 ImagesCat. No.: HY-167893CAS No.: 2172907-10-5AGH-107 is a high selective and brain-penetrant agonist of 5-HT7 receptor, with a Ki of 6 nM and EC50 of 19 nM. AGH-107 exhibits high selectivity over related CNS targets, high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.
